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202 articles for “PD”
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Computational Investigation of Phytochemicals Targeting AKT1 for Major Depressive Disorder: A Molecular Docking and ADMET Study
Abstract: Major depressive disorder (MDD) is a prevalent neuropsychiatric condition affecting approximately 280 million individuals worldwide, with women exhibiting a 50% higher likelihood of diagnosis than men. Despite significant advancements in treatment, MDD remains a chronic and relapsing disorder, necessitating the exploration of novel therapeutic interventions. This study focuses on the AKT1 gene, a key player in neuropsychiatric disorders, and investigates its interactions with natural phytochemicals as potential alternatives to conventional …
Published in Research and Reviews : Journal of Computational Biology · Vol. 14, Issue 2, 2025 Read article
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A Comprehensive Review on Neturaceuticals in Alzheimer's and Neurodegenerative Disease an Cognitive Enhancement
Abstract: Neurodegenerative diseases, including Alzheimers disease (AD), Parkinsons disease (PD), and related cognitive disorders, represent a significant and growing public health challenge, particularly in aging populations. Despite advances in pharmacological treatments, therapeutic options for cognitive decline and neurodegeneration remain limited. Recent interest has shifted towards nutraceuticals— bioactive compounds derived from food or natural sources—as promising adjuncts or alternatives in the management of these conditions. This review examines how nutraceuticals can help …
Published in International Journal of Brain Sciences · Vol. 2, Issue 1, 2025 · pp. 1–9 Read article
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Synthesis, Characterization, Biological evaluation, and in silico study of aniline derivatives
Abstract: In many hospitals worldwide, bacterial infections brought on by resistant strains are wreaking havoc, particularly in patients who are already impaired by age, disease, and other conditions. Due to the bacterial resistance, it is required to search for newer antibacterial drugs or molecules. In the current study, we aimed to develop aniline derivatives, followed by their anti-bacterial and in silico studies. Out of all the synthesized derivatives, compound 4d was …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 16, Issue 2, 2025 · pp. 25–32 Read article
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Performance Evaluation of Hybrid Polymer Composite Materials for Electromagnetic Interference Shielding in Flexible and Wearable Electronic Devices
Abstract: Wearable electronic devices require novel hybrid polymer composites that offer flexible, lightweight and highly effective EMI shielding characteristics. The development and characterization of flexible polymer composites combining hard magnetic nanoparticles and electrically conductive fillers are explored. The suitability of thermoplastic polyurethane (TPU), polydimethylsiloxane (PDMS) and epoxy resins for use as EMI shielding composite matrices was evaluated in terms of their flexibility, stability and biocompatibility. Hybrid filler systems were developed to …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 630–648 Read article
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Exploring Oroxylum indicum Phytochemicals as VEGFR-2 Inhibitors: A Molecular Docking Approach for Cancer Management
Abstract: Cancer is still a major health problem around the world and is one of the top causes of death. A protein called VEGFR-2 (vascular endothelial growth factor receptor 2) is important because it helps blood vessels grow by supporting the survival, movement, and growth of certain cells. This process is essential for tumors to grow and spread to other parts of the body. This study focused on evaluating the binding …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 3, Issue 2, 2025 · pp. 48–62 Read article
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Comprehensive Review of Adenoid Cystic Carcinoma: Pathogenesis, Diagnosis, and Emerging Therapeutic Approaches
Abstract: Adenoid cystic carcinoma (ACC)is an infrequent neoplasm, highly malignant, that develops mainly in the salivary glands with the potential to exist in any secretory glandular sites, including the lacrimal glands, breast, and respiratory tract. ACC usually has a benign initial course, but conversely, it is notoriously aggressive in behavior with high incidence of perineural invasion, local recurrence, and distant metastasis, mostly to the lungs. The tumor’s molecular features are characterized …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 14, Issue 3, 2025 · pp. 1–17 Read article
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MediSense AI - Smart Health Analysis System
Abstract: MediSense AI is a revolutionary health analysis system that empowers users by transforming complex medical data into understandable insights. This platform utilizes advanced technologies, particularly natural language processing and machine learning, to make intricate medical terminologies accessible to individuals without a healthcare background. Leveraging Llama 3, a cutting-edge AI model developed by Meta AI, the system can analyze various forms of medical data, including the ability for users to upload …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 14, Issue 3, 2024 · pp. 20–30 Read article
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Neuroprotective Effects of Curcuma longa: A Review of Its Role in Neurodegenerative Diseases
Abstract: Curcuma longa (turmeric), a perennial herb notably utilized in traditional medication, has garnered big clinical attention due to its major bioactive compound, curcumin. Curcumin, well-known shows a couple of organic activities, together with antioxidant, anti-amyloidogenic, and neurodegenerative effects, making it a promising candidate for the management of neurodegenerative diseases (NDDs), which include Alzheimer’s illness, Parkinson’s disorder (PD), Huntington’s sickness (HD), and amyotrophic lateral sclerosis (ALS). This evaluate consolidates current findings …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 12, Issue 3, 2025 · pp. 24–32 Read article
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Design and Simulation of Full Adder-Based CMOS 4-2 Compressor using CMOS XOR-XNOR Logic
Abstract: This study utilizes the recent development of CMOS transistors to construct an energy-efficient Full adder-based CMOS 4-2 compressor. The CMOS Exclusive-OR-Exclusive-NOR component and multiplexer used in the transmission logic of the novel CMOS compressor include eight transistors. The XOR-XNOR logic style is the most efficient and effective due to its speed and reduced power consumption. Utilizing an operational supply voltage of 0.7 V and 90nm CMOS technology, the Cadence Virtuoso …
Published in Recent Trends in Electronics Communication Systems · Vol. 12, Issue 3, 2025 · pp. 1–8 Read article
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Development of a Durable Superhydrophobic EP/PDMS Coating Reinforced with Micro-CaCO₃ and Nano-ZnO for Enhanced Corrosion Protection and Multifunctional Performance on Carbon Steel
Abstract: Balancing exceptional multifunctional performance with mechanical robustness in micro-nano composite films remains a significant challenge for practical applications. In this work, a superhydrophobic coating reinforced with micro-CaCO₃ and nano-ZnO particles was fabricated through a versatile single-step brushing method. The optimized EP/PDMS@micro-CaCO₃/nano-ZnO coating achieved a water contact angle (WCA) of 173.54° ± 2.53° and a sliding angle (SA) of 1.50° ± 1.12°. Owing to its carefully engineered micro-nano hierarchical structure, the …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 216–238 Read article
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Performance Evaluation of Green Walnut Husk Waste Extract for Inhibiting Aluminium 8088 Corrosion in Acidic Solution
Abstract: The cumulative call for environmental and supportable corrosion inhibitors has obsessed curiosity in exploiting plant-based agronomic surplus resources. Presented research work discovers the corrosion inhibition probable of green walnut husk extract(GWH)—a normal and plentiful agro-waste—on Aluminium 8088 alloy in an acidic medium. Aluminium 8088, however identified for its corrosion resistance, is vulnerable to squalor in highly acidic settings, affectation trials in several industrial claims. GWH extract act as an ecologically …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 17, Issue 1, 2026 · pp. 45–59 Read article
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Stretchable Elastomer–Phase Change Composites for Passive Thermal Management in Wearable Electronics
Abstract: Elastomer-embedded phase change material (EPCM) composites are developed as stretchable, leakage-free, and electrically insulating thermal regulation layers for wearable electronics operating under stringent skin-safety requirements. The EPCM architecture comprises microencapsulated organic phase change materials (μPCM, 30–70 wt%) uniformly dispersed within soft elastomer matrices based on PDMS or SEBS-type thermoplastic elastomers, together with low loadings (1–8 wt%) of electrically insulating hexagonal boron nitride (h-BN) fillers to enhance lateral heat transport. Differential …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 30–41 Read article
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Quasar: Quantum-Accelerated Sustainable Anomaly Recognition in Climate Systems
Abstract: Accurate detection of climate anomalies is vital for disaster alleviation and policy making in a sustainable manner, but customary detection methods face the challenges of computational inefficiency and physical inconsistency. In this study, we propose a novel approach called Quantum-Optimized Fuzzy Physics-Informed Neural Networks (QFuzzy-PINNs), which integrates quantum computing, fuzzy logic, and physics-informed deep learning. As a first step, we employ quantum annealing for conventional optimization to adjust multiple Gaussian …
Published in International Journal of Climate Conditions · Vol. 2, Issue 2, 2025 · pp. 18–27 Read article
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Image-Based Crack Morphology Characterisation for Electrical Failure Analysis in Conductive Polymer Composites
Abstract: Electrical performance in conductive polymer composites is strongly governed by crack-network evolution, yet failure analysis typically relies on qualitative image inspection or electrical anomaly detection in isolation. This work proposes an end-to-end framework that converts optical/SEM crack imagery into a standardised crack morphology signature and quantitatively links it to electrical degradation indicators. A two-stage learning strategy is adopted: crack-representation pretraining using the public Concrete Crack Images for Classification dataset, followed …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 1375-1386 Read article
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A Survey on Hydrogen Storage System using Composite Material and its Alloys
Abstract: The transition to a carbon-neutral energy landscape hinges on the ability to store hydrogen safely, densely, and reversibly. While high-pressure tanks and cryogenic vessels dominate today’s infrastructure, solid-state storage in metallic alloys offers a compelling alternative by combining high gravimetric capacity with intrinsic safety to form a composite material. This work presents a systematic investigation of a family of reversible hydrogen-absorbing composite material alloys—principally Mg-based intermetallics (Mg₂Ni, MgFeMn) and TiV-based …
Published in Nano Trends – A Journal of Nano Technology & Its Applications · Vol. 28, Issue 2, 2025 · pp. 35–42 Read article
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The Global and Regional Challenge of Pan-Antibiotic Resistance: A Review of Emerging Threats and Mechanisms
Abstract: Antimicrobial resistance (AMR) is one of the major and most intricate threats to the health of the 21st century as it is core to the undermined expertise of the common clinical practice and public health security worldwide. The problem is characterized by the extensive development of bacterial pathogens into extremely drug-resistant (XDR) and pan-drug-resistant (PDR) so- called superbugs faster than it can be done with therapeutics. It is a synthesis …
Published in International Journal of Antibiotics · Vol. 3, Issue 2, 2026 · pp. 28–37 Read article
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Molecular Docking Analysis of Phytocompounds from Ficus hispida Aagainst Epidermal Growth Factor Receptor Kinase Domain
Abstract: The Epidermal Growth Factor Receptor (EGFR) kinase domain plays a key role in cancer, as it promotes tumour growth and helps cancer cells survive, making it an important focus for developing treatments. Through comprehensive computational analysis, this study investigates the anticancer potential of phytocompounds from Ficus hispida, a medicinal plant renowned for its diverse bioactive compounds, as novel EGFR inhibitors. Molecular docking techniques using Py Rx software were employed to …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 3, Issue 2, 2025 Read article
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Molecular Docking Analysis of Phytocompounds from Ficus hispida Against Epidermal Growth Factor Receptor Kinase Domain
Abstract: The Epidermal Growth Factor Receptor (EGFR) kinase domain plays a key role in cancer, as it promotes tumour growth and helps cancer cells survive, making it an important focus for developing treatments. Through comprehensive computational analysis, this study investigates the anticancer potential of phytocompounds from Ficus hispida, a medicinal plant renowned for its diverse bioactive compounds, as novel EGFR inhibitors. Molecular docking techniques using Py Rx software were employed to …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 3, Issue 2, 2025 · pp. 48–62 Read article
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Development of Polymersomes as Macromolecular Platforms for Nanomedicine
Abstract: The conventional method of drug delivery is plagued with instability, low targeting and low bioavailability. A solution to these shortcomings is the use of polymersomes, artificial vesicles that are produced through self-assembly of amphiphilic block copolymer, and they are suggested as universal nanoscale carriers. They have stiff, tunable membranes (thickness = 2–50 nm) due to accurate control of polymer chemistry, chain length, and hydrophilic mass fraction (f), which allows predictability …
Published in Journal of Polymer & Composites · Vol. 14, Issue 5, 2026 · pp. 71–89 Read article
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Congenital Heart Disease (CHD) Detection Technique Based on Analysis and Classification of ECG Signal
Abstract: As per American Heart Association information, every year 125 babies out of 1000 are born with congenital heart disease (CHD). It was estimated that 36000 children are live born with CHD each year in the European Union. Child with CHD may have hole in heart up to 3–5 mm as small defects and for large defects it may go up to 5–8 mm. Depending upon the size of hole in …
Published in Current Trends in Signal Processing · Vol. 6, Issue 3, 2016 · pp. 29–27 Read article