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412 articles for “Gene targeting”
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Nanoparticle and Lipid-Based Vaccine Delivery Systems: A Systematic Review of Platforms, Stability, Pharmacokinetics, and Immune Modulation
Abstract: The rapid evolution of vaccine technologies over the past decade has highlighted the transformative role of nanoparticle (NP) and lipid-based delivery systems in modern immunization practices. These platforms – including polymeric nanoparticles, lipid nanoparticles (LNPs), liposomes, nanoemulsions, and solid lipid nanoparticles (SLNs) – enable enhanced antigen stability, improved cellular uptake, targeted antigen delivery, and potent immune activation. This systematic review critically examines the physicochemical foundations, manufacturing approaches, stability challenges, pharmacokinetic …
Published in Research and Reviews: A Journal of Toxicology · Vol. 16, Issue 1, 2026 · pp. 18–36 Read article
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Adaptive Maximum Power Point Tracking Using Improved Cuckoo Search for Solar Panels During Variable Sunlight and Shaded Conditions
Abstract: India's government seeks to keep up with the country's quickly increasing energy needs, which are mostly satisfied by burning coal and oil. By 2030, 40% of the country's energy is expected to originate from renewable sources, according to official plans. By 2022, New Delhi hopes to generate 175 GW of renewable energy, primarily from solar and wind power, with a target of 100 gigawatts. Although India has very few renewable …
Published in Journal of Thermal Engineering and Applications · Vol. 10, Issue 3, 2023 · pp. 34–45 Read article
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Molecular Docking Evaluation of Cedrus deodara Secondary Metabolites as a Potent Anti-ovarian Cancer Agent
Abstract: Objective: According to the statistics for the year 2022 it was seen that cancer total cases is 14,61,427. After breast cancer, ovarian cancer is the second most frequent cancer among women. The estrogen receptor (PDB ID: 1X7E), progesterone receptor (PDB ID: 1A28), and Phosphoinositide 3-kinases (PDB ID: 4FJY) can be considered as target protein for ovarian cancer. The plant Cedrus deodara and its phytochemicals were chosen in this study to …
Published in International Journal of Molecular Biotechnological Research · Vol. 1, Issue 1, 2023 · pp. 77–93 Read article
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Long Non-Coding RNAs: Key Regulators of Gene Expression in Development and Disease
Abstract: Long non-coding RNAs (lncRNAs) are RNA molecules that do not make proteins but are essential for controlling how genes are turned on or off in the body. These molecules help with various biological functions, such as guiding cell growth, shaping development, and influencing the progression of diseases. Recent advancements in genomics and transcriptomics have revealed the vast and complex roles of lncRNAs, with an increasing recognition of their involvement in …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 3, Issue 1, 2025 · pp. 11–15 Read article
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Optimal Size and Location of Capacitor Bank for Reactive Power Compensation Using Genetic Algorithm
Abstract: Power system operators are always faced with the dilemma of how to reduce the transmission loss. There are many ways to attain this target. In this thesis, new method for optimal capacitor placement for transmission loss minimization is planned. Proposed methods are based on the optimal capacitor placement formulations, which allow the cost benefit analysis and multi-objective optimization consideration of reactive power support investment. For better design of proposed methods, …
Published in Journal of VLSI Design Tools and Technology · Vol. 9, Issue 2, 2019 · pp. 28–34 Read article
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Engineering Anti-Tau Monoclonal Antibodies for Alzheimer’s Disease and Parkinsonian Tauopathies: A Biotechnological Perspective
Abstract: Neurodegenerative disorders such as Alzheimer’s disease and Parkinson’s disease are characterized by progressive neuronal loss associated with abnormal protein aggregation. Among these, tauopathies are defined by the accumulation of hyperphosphorylated tau protein, which plays a central role in disease progression. Advances in biotechnology have enabled the development of anti-tau monoclonal antibodies (mAbs) as promising therapeutic agents aimed at neutralizing pathological tau species and inhibiting their propagation. This review provides a …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 16, Issue 1, 2026 · pp. 52–58 Read article
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An Extensive In vitro Approach in Development of Next Generation Drugs Against Trehalose-6-Phosphate Phosphatases Involved in Pathogenicity of Many Microorganisms
Abstract: Normal 0 false false false EN-IN X-NONE X-NONE MicrosoftInternetExplorer4 AbstractTrehalose-6-phosphate phosphatase (TPP) enzymes implicated in pathogenecity of number of bacteria, fungi and nematodes causing serious diseases such as tuberculosis, candedemias, aspergillosis, elephantiasis and parasitic ones. This study is an effort to target a common pathway critical to pathogenicity of different microbes but entirely absent in vertebrates and to come out with new generation drugs by an extensive in vitro approach. …
Published in Research & Reviews : Journal of Herbal Science · Vol. 7, Issue 1, 2018 · pp. 32–43 Read article
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Deciphering the Pathophysiology of Migraine: Understanding Trigeminovascular System Activity and the Importance of the Gut-Brain Axis
Abstract: Migraine, a prevalent and disabling neurological condition, manifests in distinct phases: premonitory, aura, headache, postdrome, and interictal. Being a primary contributor to adult disability, it presents a substantial economic challenge on a global scale. Even with extensive research spanning centuries, the complete grasp of its root causes continues to evade us. This intricate neurovascular disorder primarily involves local vasodilation of intracranial and extracerebral blood vessels, coupled with simultaneous stimulation of …
Published in International Journal of Molecular Biotechnological Research · Vol. 2, Issue 1, 2024 · pp. 50–61 Read article
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Paternal Pre-Pubertal Smoking: Small RNAs, Lasting Marks, and the Hidden Legacy of Early Exposure
Abstract: While the negative effects of maternal smoking during pregnancy are well-established, the lasting and transgenerational impact of paternal pre-pubertal smoking remains a critical, underexplored area. Emerging evidence in sperm epigenetics suggests that cigarette exposure during early male development may create persistent molecular imprints that can affect the health of future offspring. This phenomenon is rooted in the fact that heredity extends beyond the DNA sequence. Sperm carry a complex epigenetic …
Published in Emerging Trends in Personalized Medicines · Vol. 3, Issue 1, 2026 · pp. 1–5 Read article
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Numerical Simulation of Hybrid GSA Based Optimal Power Flow for Multi Objective Optimization Strategy
Abstract: Restricted nonlinear optimization in electric power systems engineering is a topic of Optimal Power Flow (OPF) that has been extensively investigated. It has been a long and remarkable history for the OPF, which was founded in the 1960s, of research and publication. Newcomers to OPF research face a challenging undertaking since there is so much information available and because OPF's popularity within the electric power systems community has prompted authors …
Published in Journal of Instrumentation Technology & Innovations · Vol. 11, Issue 3, 2021 · pp. 24–32 Read article
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REVIEW OF PHARMACOEPIGENETICS: BRIDGING EPIGENETICS AND PERSONALIZED MEDICINE
Abstract: Pharmacoepigenetics is an emerging field that explores how alterations in gene expression, independent of DNA sequence changes, influence individual responses to drugs. Unlike pharmacogenetics, which focuses primarily on genetic variation, pharmacoepigenetics integrates genetic, environmental, and lifestyle factors to explain interindividual differences in drug efficacy, toxicity, and resistance. Key epigenetic mechanisms including DNA methylation, histone modifications, non-coding RNAs, and RNA methylation play critical roles in regulating drug metabolism and therapeutic outcomes. …
Published in International Journal of Molecular Biotechnological Research · Vol. 4, Issue 1, 2026 · pp. 33–40 Read article
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The Renaissance and Resilience of CB1 Reverse Agonists: From Central Liabilities to Peripheral Promise
Abstract: Building upon these foundational insights, current research has increasingly focused on refining the pharmacological profile of CB1 reverse agonists to maximize therapeutic benefit while minimizing central adverse effects. The adverse neuropsychiatric outcomes associated with first-generation agents such as Rimonabant including anxiety, depression, and suicidal ideation highlighted the critical role of central CB1 receptors in mood regulation. Consequently, drug development strategies have shifted toward peripherally restricted CB1 reverse agonists that exhibit …
Published in International Journal of Cheminformatics · Vol. 4, Issue 1, 2026 · pp. 30–35 Read article
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Development of Polymersomes as Macromolecular Platforms for Nanomedicine
Abstract: The conventional method of drug delivery is plagued with instability, low targeting and low bioavailability. A solution to these shortcomings is the use of polymersomes, artificial vesicles that are produced through self-assembly of amphiphilic block copolymer, and they are suggested as universal nanoscale carriers. They have stiff, tunable membranes (thickness = 2–50 nm) due to accurate control of polymer chemistry, chain length, and hydrophilic mass fraction (f), which allows predictability …
Published in Journal of Polymer & Composites · Vol. 14, Issue 5, 2026 · pp. 71–89 Read article
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Optimized Test Suites with Small Code Coverage in Software Testing
Abstract: A common scenario in software testing is to test the data is to be generated and tester manually adds test oracles.It meausured using code coverage and fundamental problemwith common apporach is coverage the goals and how an of them are feasible. In this whole test suites are evovled covering all goals at same time.Its effectiveness not added by number of infeasible targets in code.It has a novel approach in approach …
Published in Journal of Web Engineering & Technology · Vol. 1, Issue 1, 2014 · pp. 24–27 Read article
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Melanoma Skin Cancer Detection Using Deep Learning
Abstract: Cancer as one of the major diseases rank in the World is still very challenging to diagnose and treat hence need for the technological advancements. Chemotherapy, radiation, as well as surgery therapies have several drawbacks including non-selective action, damage to healthy tissues, and multi-drug resistance. Smart nano-theranostics, an advanced integration of nanotechnology with diagnostic and therapeutic modalities, offers a next-generation approach for precision oncology. Thus, the development of multifunctional nanoparticles …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 14, Issue 2, 2025 · pp. 1–9 Read article
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A Study to Assess the Knowledge Regarding Pradhan Mantri Jan Arogya Yojana (PM-JAY) Among the General Public in a Tertiary Care Teaching Hospital, Kuppam
Abstract: Background: Ayushman Bharat, the flagship scheme of the Government of India, was launched to achieve Universal Health Coverage (UHC) as per the National Health Policy 2017. It aims to address healthcare needs comprehensively by transitioning from fragmented approaches toward a holistic system. Pradhan Mantri Jan Arogya Yojana (PM-JAY) is a pivotal component of this scheme, striving to achieve UHC by providing comprehensive healthcare services to underprivileged families. Assessing public awareness …
Published in International Journal of Community Health Nursing And Practices · Vol. 4, Issue 1, 2026 · pp. 1–6 Read article
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RNA- Based Drug Delivery, Current Advances, Pharmaceutical Applications, and Future Perspectives
Abstract: RNA-based therapeutics have emerged as a transformative approach in modern medicine due to their ability to regulate gene expression with high specificity and precision. Advances in molecular biology, RNA chemistry, and nanotechnology have accelerated the development of diverse RNA modalities, including messenger RNA (mRNA), small interfering RNA (siRNA), microRNA (miRNA), antisense oligonucleotides (ASOs), and RNA aptamers. These therapeutics offer promising strategies for the treatment of cancer, genetic disorders, infectious diseases, …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 13, Issue 2, 2026 · pp. 27–41 Read article
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APPLICATIONS OF NANOTECHNOLOGY IN CROP IMPROVEMENT: NEW ERA OF AGRICULTURE
Abstract: It represents a transformative force in agriculture, promising to improve the productivity, yield, sustainability, and food security. This review paper focused on the certain advantages of nanoscience and nanotechnology in enhancing the agricultural productivity, disease management, and food safety. By manipulating different materials and objects at the nanoscale, researchers can develop advanced tools such as smart sensors and targeted delivery systems that improve nutrient absorption and combat plant pathogens. By …
Published in Journal of Nanoscience, NanoEngineering & Applications · Vol. 15, Issue 3, 2025 · pp. 46–54 Read article
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Analysis of Efficiency Loss in AlGaAs/GaAs Hetero-junction Solar Cell
Abstract: Energy conversion efficiency is a major issue for photovoltaic cells. One of the main challenges of modern day research is to improve the efficiency level of photovoltaic devices by introducing new materials and advanced concepts. The target is to reach a high efficiency level within affordable cost, which will lead to a mass generation of electricity using photovoltaic devices. III-V hetero-junction solar cell has been introduced and characterized here, which …
Published in Journal of Energy, Environment & Carbon Credits · Vol. 6, Issue 3, 2016 · pp. 26–33 Read article
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Mast Cell Activation Disorders: Diagnosis & Management
Abstract: Mast Cell Activation Disorder (MCAD) is a broad umbrella term which includes a heterogenous group of disorders characterized by the inappropriate and excessive release of mediators from mast cells. Mast Cell Activation Syndrome represents a severe and well-defined form within the broader spectrum of Mast Cell Activation Disorders. These disorders are generally divided into clonal and non-clonal categories. Clonal conditions include Systemic Mastocytosis, Cutaneous Mastocytosis, and Monoclonal Mast Cell Activation …
Published in Research and Reviews : A Journal of Immunology · Vol. 16, Issue 2, 2026 · pp. 31–40 Read article