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478 articles for “ADME”
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Formulation and development of Lamivudine Nanoemulsion by using Emulsifying Polymers and It’s Evaluation
Abstract: Nanoemulsion is a novel approach to medicine delivery that helps to increase the bioavailability of drugs that aren’t particularly soluble in water. In this research work, nanoemulsion of Lamivudine was formulated by using polymers such as SPAN 80, TWEEN 80 and Whey protein concentrate with the help of Ultrasonication technology. The formulation was optimized. It was evaluated by assessing pH, viscosity, turbidity, in vitro franz diffusion study, particle size distribution, …
Published in Journal of Polymer & Composites · Vol. 12, Issue 6, 2024 · pp. 22–35 Read article
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In-silico Approach of Few Selected Phytoconstituents on Newer Cancer Targets
Abstract: Background: Cancer’s high death rates are mainly due to, drug resistance and unmet medical demands. It necessitates novel anticancer medications. AI tools aid in efficient and faster drug discovery by analyzing data, modeling processes and optimizing pipeline stages. Aim: The aim of this present study is to evaluate phytoconstituents against novel and newer cancer targets. Methodology: The ligands Daidzein, Resveratrol and Genistein were targeted against the Glutamate dehydrogenase (PDB ID …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 15, Issue 3, 2024 · pp. 12–17 Read article
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Dynamic Routing and Performance Assessment in IPv6 Networks
Abstract: In the fast-paced world of networking technologies and the growing demands of contemporary communication, it is crucial to thoroughly examine adaptive routing in IPv6 networks. This project undertakes a thorough analysis and evaluation of adaptive routing protocols, particularly OSPFv3 and Border Gateway Protocol (BGP)+, within the context of IPv6. Through meticulous scrutiny of network dynamics, traffic behavior, and routing protocol decisions, this study aims to elucidate the efficacy and adaptability …
Published in Journal Of Network security · Vol. 12, Issue 3, 2024 · pp. 18–28 Read article
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Optimized Web-based Online Food Ordering System: Design and Implementation
Abstract: Online food ordering systems have undergone a profound metamorphosis with the advent of digital technologies, catalyzing a pivotal shift in the operational dynamics of the gastronomic sector. This paper elucidates the conceptualization, design, and implementation of an advanced, web-based food ordering system, meticulously engineered to elevate the efficiency and sophistication of food service operations. Employing the rigorously structured Systems Analysis and Design Methodology (SSADM), this system represents a transformative departure …
Published in International Journal of Computer Science Languages · Vol. 2, Issue 2, 2024 · pp. 1–25 Read article
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Recent Trends in Ocular Drug Delivery: Challenges and Approaches
Abstract: Drug topically regulation can be accessed most easily in the eye. When given topically as eye drops, medication ocular bioavailability is quite low. Drug entry into specific ocular locations is complicated by the complex anatomy and physiology of the human eye. Research has long been interested in the topical administration of successful treatments. To provide a suitable ocular penetration and extend the duration of drug residence is their challenging task. …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 11, Issue 3, 2024 · pp. 22–38 Read article
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Optimizing System Management: Innovative Approaches to Shell Scripting for Automation in Large-Scale Systems
Abstract: In today’s dynamically changing technology environment, effective systems management is of utmost importance for enterprises that run their applications or services on large-scale infrastructure. In this article, I detail some of these practices as applied to shell scripting, a fundamental building block for process automation in such environments. Using these advanced scripting methods, system administrators can perform routine tasks much more efficiently than they would manually and greatly reduce the …
Published in Journal of Advances in Shell Programming · Vol. 11, Issue 3, 2024 · pp. 32–40 Read article
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To study aims to compare the pain relief effects of a single intravenous dose of paracetamol and fentanyl in patients undergoing elective surgery
Abstract: Objective: Effective pain management during and after surgery is vital for ensuring patient comfort and promoting recovery. While intravenous (IV) paracetamol and fentanyl are commonly administered for pain relief, their effectiveness in elective surgeries continues to be a subject of debate. Methods: In this future-oriented randomized controlled experiment the goal was to investigate the effectiveness of administering IV paracetamol and IV fentanyl for managing pain during and after scheduled elective …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 13, Issue 3, 2024 · pp. 1–14 Read article
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Advances in Polymeric In Situ Drug Delivery and Soft Biosensors: Innovations in Biochemical Sensing and Personalized Healthcare
Abstract: Advanced healthcare and personalized medicine are undergoing a transformation thanks to in situ medication delivery systems and biochemical sensor technology. Polymeric in situ drug delivery systems form gels upon administration, releasing medications in a controlled manner and providing benefits such as ease of administration and enhanced patient compliance. Similarly, advancements in soft electronics, including flexible and stretchable biosensors, enable continuous, in situ biochemical monitoring, conforming to complex biological environments like …
Published in International Journal of Cheminformatics · Vol. 2, Issue 1, 2024 · pp. 27–32 Read article
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Assessment of Women's Knowledge of Mastitis at Indus International Hospital, Punjab
Abstract: Mastitis is a non-cancerous inflammatory condition of the breast, often resulting from infection, which can impact the mammary gland's structures. It is a relatively frequent condition, affecting between 5% and 33% of women during lactation at some point in their lives. Typical clinical signs include pain in one breast, redness (erythema), and swelling, often accompanied by flu-like symptoms such as fever, chills, and body aches. Upon examination, the affected breast …
Published in Research and Reviews: A Journal of Health Professions · Vol. 14, Issue 3, 2024 Read article
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Effect of Nano-Prepared N. sativa Seed Extract on Cardiac Tissue Structure in Tartrazine-Treated Male Albino Mice
Abstract: This study investigates the effects of Tartrazine and N. sativa nanoparticles on body weight and cardiac histology in male albino mice. Thirty-six male mice were divided into four groups: a control group receiving physiological saline, a group treated with Tartrazine (20 mg/kg), a group receiving both Tartrazine and N. sativa nanoparticles (100 mg/kg), and a group treated solely with N. sativa nanoparticles (100 mg/kg). The body weights were chronicled before …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 14, Issue 3, 2024 · pp. 119–124 Read article
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Exploring the Role of Ginkgo biloba in Investigating 7L1X in Triple-Negative Breast Cancer Through Integrative Bioinformatics
Abstract: Objectives: Triple-negative breast cancer is a very dangerous form of cancer that affects mostly Hispanic and African American women above the age of 40. It represents approximately 15–20% of the global cancer incidence. This experiment aims to investigate the use of Gingko biloba in the treatment of the disease triple-negative breast cancer. Methods: We use a variety of online tools, and websites, including the Indian Medicinal Plants, Phytochemistry, and Therapeutics …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 2, Issue 2, 2024 · pp. 1–10 Read article
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Smart Framework for Personal Fuel Expense Tracking and Carbon Emission Assessment
Abstract: This study presents a smart system that is intended to assist individuals and administrators in tracking their fuel costs and keeping an eye on their daily carbon emissions. It makes it simpler to make decisions by examining fuel consumption and its effects on the environment. The technology gathers real-time emissions data from vehicles equipped with Internet of Things devices. It can predict future trends of emissions by utilizing AI-based predictive …
Published in Journal of Thermal Engineering and Applications · Vol. 11, Issue 3, 2024 · pp. 36–44 Read article
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Histological Effects of Nano-Synthesized Particles of Nagilla Sativa Seeds Extract on Digestive System of Male Albino Mice
Abstract: This revision considers the belongings of Tartrazine and black seed nanoparticles on body mass and cardiac histology in male albino mice. Group of male mice were separated into 4 clusters: a regulator cluster getting physiological saline, other cluster preserved with Tartrazine (20 mg/kg), another cluster getting equally Tartrazine with N. sativa nanoparticles (100 mg/kg), while last cluster preserved solely besides to N. sativa nanoparticles (100 mg/kg). The assumptions confirmed an …
Published in Nano Trends – A Journal of Nano Technology & Its Applications · Vol. 27, Issue 1, 2025 · pp. 1–6 Read article
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Effect of Polymer Fiber on Concrete Made with Artificial Fine Aggregate from Demolished Buildings
Abstract: This research describes an experimental investigation that assesses the impact of polymer fiber and artificial fine aggregate on concrete properties. Polymer fiber, on the other hand, has the potential to function as a superplasticizer additive, which might lead to concrete's superior elasticity, higher strength, and reduced rate of water absorption. Thus, an experimental inquiry was conducted to ascertain the ideal admixture dose and investigate the consequences of admixture overdosage. Also, …
Published in Journal of Polymer & Composites · Vol. 13, Issue 1, 2025 · pp. 286–296 Read article
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In vitro and In vivo Trypanocidal Activity of Methanolic Extract of Lantana camara leaves on Trypanosoma brucei in Laboratory Mice
Abstract: In this study, the methanol extract of Lantana camara leaves were tested for their trypanocidal activity in vitro in a microtiter plate and in vivo using male laboratory mice. Five different concentrations 10mg/ml, 20 mg/ml, 30 mg/ml, 40mg/ml, and 50mg/ml of the extract were prepared and the time taken to immobilize the parasites were recorded. The in vitro results showed that the leave extract at concentrations of 50 mg/ml had …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 2, Issue 2, 2024 · pp. 32–41 Read article
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History and Historiography of Origin and Development of Maiduguri Borno State, Nigeria
Abstract: This study discussed the history of Maiduguri as pertain to its growth, economic, educational development and its administrative structure. Materials for the work were mainly retrieved from the library where extant work attributed to some to some scholarly sources were used. The internet was also a useful source as some scholarly papers placed there helped a great deal. In essence, this library research that relied heavily on previous research on …
Published in International Journal of Trends in Humanities · Vol. 2, Issue 1, 2025 · pp. 5–13 Read article
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Frequency of Failed Spinal Anesthesia and Associated Factors in Cesarean Section at Mardan Medical Complex, Mardan, KP, Pakistan
Abstract: Objective: Spinal anesthesia is the preferred choice of anesthesia for parturients having cesarean sections. Despite the high percentage of success in providing acceptable surgical anesthesia, failure of spinal anesthesia has been reported. This study aims to determine the frequency and associated factors related to failed spinal anesthesia during cesarean sections in pregnant women. Methodology: This descriptive cross-sectional study included 149 pregnant women and was conducted at Mardan Medical Complex (MMC) …
Published in International Journal of Women's Health Nursing And Practices · Vol. 2, Issue 2, 2024 · pp. 1–9 Read article
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New Employee Onboarding Process
Abstract: Set up Excel spreadsheet: Create an Excel spreadsheet template with necessary columns to store employee details such as name, position, department, contact information, etc. The existing employee onboarding portal project in ‘Automation Anywhere’ streamlines the onboarding process using automation. It utilizes Automation Anywhere capabilities to automate tasks such as gathering employee information, creating user accounts, generating documents, and reporting. The system uses an Excel spreadsheet to manage and store employee …
Published in Journal of Open Source Developments · Vol. 12, Issue 1, 2025 · pp. 16–24 Read article
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An Experimental Study to Assess the Effectiveness of Planned Teaching Program Regarding Pelvic Rocking Exercise and Dry Ginger on Knowledge and Attitude Regarding Dysmenorrhea
Abstract: Objective: Dysmenorrhea is characterized by painful menstrual cramps originating from the uterus and is a common gynaecological condition affecting women of all ages and nationalities. Primary dysmenorrhea refers to menstrual pain without any underlying organic disease, while secondary dysmenorrhea occurs due to an identifiable medical condition. Common causes of secondary dysmenorrhea include endometriosis, fibroids, adenomyosis, endometrial polyps, pelvic inflammatory disease, and the use of intrauterine contraceptive devices. Methodology: Experimental research …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 14, Issue 1, 2024 · pp. 6–10 Read article
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IoT-Based School Bus Transportation Safety and Tracking System
Abstract: The safety of children during school commutes is a growing concern for both parents and school administrations. This paper presents an IoT-based School Bus Transportation Safety System that offers real-time tracking, biometric authentication, and emergency detection to ensure the safety of school children. The system utilizes a combination of NodeMCU, Arduino Uno, GPS, fingerprint modules, and sensors to provide a secure and efficient school transportation process. Parents and administrators can …
Published in Journal of Remote Sensing & GIS · Vol. 16, Issue 1, 2025 · pp. 56–65 Read article