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1953 articles for “phosphoinositol-3-kinase pathway” (ranking capped at the first 2,000 matches — narrow the search to see the rest)
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Advancing Cancer Vaccine Development through CRISPR/Cas9 Technologies and Future Opportunities
Abstract: The advent of CRISPR/Cas9 genome editing has revolutionized the cancer immunotherapy market, offering unprecedented precision and versatility in the development of next-generation cancer vaccines. This review examines how CRISPR technologies are being integrated into various stages of cancer vaccine development including neoantigen discovery, dendritic cell engineering, cancer cell reprogramming, and tumor microenvironment modulation. In the area of neoantigen discovery, CRISPR enables rapid identification and validation of tumor-specific mutations, thereby supporting …
Published in International Journal of Vaccines · Vol. 2, Issue 2, 2025 Read article
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Green Fabrication of Glutaraldehyde-Crosslinked Chitosan/PVA Biocomposite for Heavy Metal Removal from Wastewater
Abstract: Chitosan (CS) and Polyvinyl alcohol (PVA) are polymers that possess biodegradable, biocompatible, and non-toxic properties, making them suitable for wastewater treatment applications. The primary objective of this research is to chemically modify chitosan in a novel manner to enhance its ability to remove hexavalent chromium Cr(VI) from aqueous solutions. In this study, a composite material was synthesized by crosslinking PVA and CS with glutaraldehyde (GA), resulting in the formation of …
Published in Journal of Water Pollution & Purification Research · Vol. 12, Issue 3, 2025 · pp. 59–83 Read article
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Multifunctional Materials for Electro-Mechanical Applications: Synergistic Integration of Strength and Conductivity
Abstract: The integration of mechanical strength and electrical conductivity within a single material system has emerged as a critical requirement in the development of next-generation multifunctional materials. These materials are increasingly sought after in fields such as aerospace, flexible electronics, energy storage, and structural health monitoring, where the traditional separation of structural and functional materials leads to inefficiencies in weight, space, and overall performance. The convergence of these properties enables compact …
Published in International Journal of Electro-Mechanics and Material Behaviour · Vol. 3, Issue 1, 2025 · pp. 1–6 Read article
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Hybrid Material Systems for Flexible Electronics Electro-Mechanical Performance and Future Prospects
Abstract: Flexible electronics are transforming the landscape of modern electronic systems, enabling devices that are lightweight, stretchable, and adaptable to complex surfaces. These technologies are particularly impactful in applications such as wearable health monitors, soft robotics, energy harvesting systems, and implantable biomedical devices. At the heart of this evolution are hybrid material systems—engineered composites that combine organic polymers and inorganic nanomaterials to achieve synergistic electro-mechanical properties. These materials address the limitations …
Published in International Journal of Electro-Mechanics and Material Behaviour · Vol. 3, Issue 1, 2025 · pp. 7–12 Read article
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A Comprehensive Review on Piezoelectric Composites for Energy Harvesting and Sensing
Abstract: The capacity of piezoelectric composites to transform mechanical energy into electrical energy and vice versa has drawn a lot of interest recently. This property makes them very appealing for use in energy harvesting and sensing applications. These materials combine the high piezoelectric performance of ceramics with the mechanical flexibility and processability of polymers or other matrices, enabling a wide range of practical uses in flexible electronics, wearable systems, and embedded …
Published in International Journal of Electro-Mechanics and Material Behaviour · Vol. 3, Issue 1, 2025 · pp. 19–24 Read article
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Accelerating Unsupervised Feature Learning: Parallelized Training of Denoising Autoencoders
Abstract: Unsupervised representation learning has become a cornerstone of contemporary machine learning, enabling algorithms to extract informative features from un-labelled, high-dimensional data. This work investigates the efficacy of stacked denoising autoencoders (SDAEs) trained via parallelized stochastic gradient descent (SGD) as a scalable approach to feature extraction. By strategically leveraging multi-threaded computation, our study systematically examines the trade-offs between increased parallelism, training efficiency, and the preservation of model accuracy. Experiments on the …
Published in Journal of Image Processing & Pattern Recognition Progress · Vol. 12, Issue 3, 2025 · pp. 56–64 Read article
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Integration of Polymer Chemistry in the Development of an Occlusal Plane Analysis Device
Abstract: Occlusal plane analysis has been transformed by the use of polymer-based materials in dental applications. The present study explores the integration of polymer chemistry into the design and manufacturing of a novel occlusal plane analysis device. Key polymeric materials such as polymethyl methacrylate (PMMA), polyetheretherketone (PEEK), and fiber-reinforced polymer composites (FRPCs) are assessed for ease of fabrication, mechanical qualities, and biocompatibility. The study also highlights the role of polymer processing …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 180–187 Read article
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Ecological, Economic, and Medical Roles of Fungi: Insights from Mycology in Addressing Global Challenges"
Abstract: The large and diverse kingdom of fungi is vital to ecosystems, industry, agriculture, and medicine. Due to its ecological and biotechnological value, mycology has grown in importance. Fungi are crucial to natural systems and human life, decomposing organic materials, developing mutualistic interactions with plants, and producing antibiotics and fermented products. Recent advancements in molecular biology and genomics have significantly enhanced our understanding of fungal diversity, physiology, and evolutionary processes. These …
Published in International Journal of Fungi · Vol. 2, Issue 2, 2025 Read article
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Polymer-Nanowire Hybrid Composites Based on PEDOT: PSS and AgNWs for High-Performance Conductive Films in Flexible Devices
Abstract: The growing demand for flexible photovoltaic and wearable optoelectronic devices has intensified research into polymer-based conductive composites that provide transparency, flexibility, and electrical efficiency. In this work, we report the fabrication and characterization of a hybrid polymer nanocomposite electrode comprising silver nanowires (AgNWs) embedded within a PEDOT:PSS matrix, deposited on flexible polyethylene terephthalate (PET) substrates. The PEDOT:PSS polymer phase, modified with 5 vol% dimethyl sulfoxide (DMSO) and 0.1 vol% Zonyl …
Published in Journal of Polymer & Composites · Vol. 13, Issue 5, 2025 · pp. 236–250 Read article
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Integration of Semi-Interpenetrating Polymer Networks and Quantum Dot–Polymer Nanocomposites for Low-Cost, Flexible OLED Display
Abstract: Flexible OLED displays need advanced material systems to integrate capabilities for mechanical flexibility as well as thermal stability and environmental durability at low costs. Semi-interpenetrating polymer networks (SIPNs) combined with quantum dot (QD)-polymer nanocomposites serve to improve OLED performance capabilities. They combine a stable structural design along with a flexible matrix through the matrix capabilities of SIPNs which result in efficient luminescence and pure color output courtesy of CdSe/ZnS QDs …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 919–932 Read article
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Comprehensive Review of Nanomaterials Synthesis Methods, Characterization and Multifaceted Applications in Medical Field
Abstract: Nanomaterials associated by special qualities derived from their nanoscale size nanomaterials have tremendous potential in a variety of industries like, medicine & healthcare. Due to today busy life & unhealthy life schedule many abnormal cell growth take place in our body & affect the other organ. Sometimes it may leads to cancer & others dangerous diseases, nanomaterials such as nanotubes, liposomes & polymeric micelles are help for designing the drugs …
Published in Journal of Polymer & Composites · Vol. 13, Issue 5, 2025 · pp. 657–669 Read article
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Magnetic and Radioactive Nanoparticles for Improved Theranostics and AI Assisted Radiation Therapy
Abstract: Nanoparticles based therapeutic and theranostics technique is becoming an active area of research in nanomedicine. The sensitivity, biocompatibility, and stability of magnetic and radioactive nanoparticles determine their functionality. This research highlights the impacts of magnetic and radioactive nanoparticles on therapeutic techniques namely, cell therapy, gene therapy, and tissue regeneration. Then, it is intended to brief a principal role of these therapeutic techniques to envisage theranostics medicine and radiation therapy using …
Published in International Journal of Advance in Molecular Engineering · Vol. 3, Issue 2, 2025 · pp. 10–21 Read article
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Evaluation of Mechanical Properties of Terminalia Chebula and Teak Wood Sawdust Reinforced Polymer Hybrid Composites
Abstract: This study examines the mechanical characteristics of polymer hybrid composites augmented with sawdust from teak wood and Terminalia chebula (Kadukkai). To examine their effects on mechanical performance, the composites were made with different percentages of biofiller (10%, 20%, 30%, 40%, and 50%) while keeping the proportions of the two reinforcements same. Tensile, flexural, and impact tests were performed to assess their strength properties. The findings showed that flexural strength varied …
Published in Journal of Polymer & Composites · Vol. 13, Issue 5, 2025 · pp. 469–476 Read article
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Development and Assessment of Mechanical Characteristics in Sisal-Glass Fiber Reinforced Epoxy Composites
Abstract: In many different fields, including tensile strength, reduced thermal expansion, and an amazing strength-to-weight ratio, fiber-reinforced polymer composites are gradually replacing conventional materials. This work mostly addresses the development and evaluation of the mechanical characteristics of epoxy composites improved with glass fibers and sisal. Among the benefits are biodegradability, lower weight, and more specific strength. Sisal polymer composites are included under natural fiber composites. Including sisal strands into glass fiber-reinforced …
Published in Journal of Polymer & Composites · Vol. 13, Issue 5, 2025 · pp. 708–719 Read article
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A Review on Unmasking Merkel Cell Polyomavirus: From Discovery to Cancer Driver
Abstract: Merkel cell polyomavirus (MCPyV) is a small, non-enveloped, circular double-stranded DNA virus belonging to the Polyomaviridae family, first characterized in 2008. Epidemiological data suggest widespread exposure, with seroprevalence rates approaching 80% in adults. While primary infection is typically asymptomatic, rare integration events in Merkel cells can initiate oncogenesis, yielding Merkel cell carcinoma (MCC), a neuroendocrine skin cancer with a five-year survival rate under 60%. This review integrates findings from six …
Published in International Journal of Virus Studies · Vol. 2, Issue 2, 2025 · pp. 6–11 Read article
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Dr. Somenath Dutta, Discoverer of Micro-RNA (MiRNA) Therapeutic to Prevent Harmful Zika Virus for Liver Cancer: A Scientometric Portrait
Abstract: Dr. Somenath Dutta allies Rahul is a global recognized scientist for his outstanding recent discovery of “miRNA therapeutics for the Zika virus” at the age of 26 years, which can be cured Liver Cancer and allied health problems due to Zika virus disease. This study covers his 12 publications in variety of forms including 07 journal articles (59%), 03 conference papers (25%), 01 dissertation, and 01-chapter paper during 2019-2024. All …
Published in International Journal of Virus Studies · Vol. 2, Issue 2, 2025 · pp. 22–36 Read article
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Exploring the Therapeutic Potential of Ilāj-Bil-Ghizā (Dietotherapy) in Depression: A Systematic Review
Abstract: Background: Depression is a common mental health condition characterized by feelings of sadness, diminished interest in activities, and physical symptoms that disrupt daily activities functioning. Emerging research indicates that nutrition and dietary habits can significantly influence the management of depression. This review aims to explore the connection between diet and mental health, highlighting how nutritional approaches may complement traditional treatments for depression. Objective: This review aims to evaluate the relationship …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 14, Issue 3, 2025 · pp. 10–18 Read article
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Influence of Personality Traits on Motivation and Engagement among Adolescents During Online Education
Abstract: This study investigates how the Big Five personality traits—openness, conscientiousness, extraversion, agreeableness, and neuroticism—affect motivation and engagement among adolescents in online education settings. During the COVID-19 pandemic, online learning became a necessity, but not all students adapted equally. A sample of 600 students aged 16 to 19 years from 30 inter colleges in the Gwalior district participated in this research. Data were collected using a structured questionnaire measuring personality traits …
Published in International Journal of Education Sciences · Vol. 2, Issue 2, 2025 Read article
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ChatGPT vs. Google Search Engine: Usage and Popularity Among Bangladeshi University Students
Abstract: The cultivation of new educational technologies, particularly artificial intelligence (AI), has transformed the world of education. AI-based systems like ChatGPT are quickly emerging as the go-to platform for students. This study intends to analyze and evaluate the use and reliability of ChatGPT and Google search engine as resources for learning among public and private university students in Bangladesh. The study used Google Forms questionnaires with 31 respondents, mostly students, and …
Published in Journal of Web Engineering & Technology · Vol. 12, Issue 3, 2025 · pp. 01–14 Read article
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To Study The Drug Utilization Pattern of Drugs Used in Treatment of Thyroid Patients in Tertiary Care Hospital, Bathinda
Abstract: Aim: This study aimed to assess the drug prescription trends for thyroid disorders in a tertiary care setting, with a focus on medication choice, dosage patterns, and patient self-medication behaviour. Methods: A prospective observational study was conducted on 84 patients diagnosed with thyroid disorders. Data were collected regarding the type of disorder, prescribed drugs (dose and frequency), comorbidities, and self-medication practices. Descriptive statistics were applied to identify prescription trends. Results: …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 15, Issue 3, 2025 · pp. 59–66 Read article