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132 articles for “toxicity test.”
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In Silico Exploration of Podophyllum Hexandrum-Derived Phytocompounds as Potential Therapeutics Against Small Cell Lung Cancer (SCLC): A Molecular Docking Approach
Abstract: Small Cell Lung Cancer (SCLC) is a fast-growing and aggressive type of lung cancer that spreads quickly strongly associated with smoking. It is characterized by symptoms, such as persistent cough, breathing difficulties, or hoarseness, though it can sometimes be asymptomatic which makes early detection challenging. The tumor suppressor gene TP53 is critical in regulating the cell cycle and preventing uncontrolled cell division. Mutations in TP53 result in the loss of …
Published in International Journal of Molecular Biotechnological Research · Vol. 3, Issue 1, 2025 · pp. 1–11 Read article
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Cytotoxic, Anthalmintic and Analgesic Activities of the Methanol Extract of Ricinus communis (Family: Euphorbiaceae)
Abstract: The aim of this study was to evaluate the phytochemical screening, cytotoxicity, anthelmintic activity and analgesic properties of the methanol extract (leaves) of Ricinus communis (Family: Euphorbiaceae). The methanol extract of the leaves showed mild cytotoxic activity with the LC50 value 6.456 µg/mL compared to vincristine sulfate (LC50 0.812 µg/mL) using brine shrimp lethality bioassay. The anthelmintic activity was performed by observing the time of paralysis and the time of …
Published in Research and Reviews: A Journal of Toxicology · Vol. 5, Issue 1, 2015 · pp. 27–35 Read article
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Synthesis and Evaluation of Novel Peroxisome Proliferator Activated Receptor-γ (PPAR-γ) Agonists for the Treatment of Diabetes
Abstract: A series of novel thiazolidinedione derivatives as peroxisome proliferator activated receptor-gamma (PPAR-gamma) agonists bearing different fatty acid esters and amides as substituents in the positions 3 and 4 of the benzylidene moiety have been designed, synthesized and tested as potential antihyperglycemic agents. The compounds containing stearic acid (A1TU, A2TU, A3TU, A2TS and A3TS) exhibited the maximum activity (64.7-70.3 % BG reduction) among all the synthesized compounds. The capric acid containing …
Published in Research and Reviews: A Journal of Toxicology · Vol. 6, Issue 2, 2016 · pp. 1–12 Read article
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Molecular Pharmacokinetics and Structural Docking of Phenolic Acids for Targeting NF-κB Pathway Components in Inflammation and Fibrosis: A Computational Approach Toward Therapeutic Discovery
Abstract: Inflammation and Fibrosis are critical pathological processes associated with various chronic diseases, often mediated by the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling pathway. This study investigates the therapeutic potential of phenolic acids as modulators of the NF-κB pathway, aiming to identify novel ligands that can effectively interact with key components of this signaling cascade. A comprehensive computational approach was employed, utilizing molecular docking, pharmacological screening, and post-docking …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 3, Issue 1, 2025 · pp. 14–31 Read article
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Formulation And Evaluation of Herbal Handwash
Abstract: An herbal hand wash was created utilizing extracts from the neem, hibiscus, and reetha plants. The produced herbal hand wash was tested for antibiotic sensitivity against skin infections using Disc. Comparison between the diffusion method and outcomes and the antiseptic soap that goes for commercially. The main sites of infection are the hands. Microbiological infections have become a serious problem for both workers and children. Hand washing is very important …
Published in Research & Reviews : Journal of Herbal Science · Vol. 13, Issue 3, 2024 · pp. 39–46 Read article
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Phyto-Entrapped Carbon Dots as Emerging Nanomaterials for Anti-Cancer Activity
Abstract: Phytoconstituent-loaded carbon dots (C-dots) represent an innovative approach in targeted cancer therapy, combining the therapeutic power of plant-derived compounds with the advanced capabilities of nanotechnology. These ultra-small, biocompatible nanostructures offer excellent fluorescence, tunable surface chemistry, and low toxicity, making them ideal for drug delivery, bioimaging, and theranostic applications. Traditional phytochemicals often face challenges like poor solubility, low bioavailability, and high first-pass metabolism barriers that C-dots help overcome. C-dots synthesized through …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 16, Issue 3, 2025 · pp. 51–63 Read article
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Bioinspired Nanocomposite Bone Pins: Fabrication, Evaluation, and Suitability for Orthopedic Implant Applications
Abstract: Bone tissue engineering (BTE) requires scaffolds that mimic bone’s mineral–organic composition, offering mechanical strength, bioactivity, and degradation rates compatible with regeneration. Conventional metallic implants face corrosion and toxic ion release risks, while ceramics like hydroxyapatite (HAp) are bioactive but brittle. This study reports a multifunctional hybrid scaffold combining HAp for osteoconductivity; polycaprolactone (PCL) and collagen for flexibility and biocompatibility with sodium citrate for nanoparticle dispersion, ferrocene (Fc) for catalytic bioactivity; …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 526–540 Read article
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Investigating The Mechanical Properties of Sisal/Areca/Sisal Natural Fiber Reinforced Composite Material Treated with NaOH and Filled with Al2O3 and Tio2
Abstract: Biopolymer-based composites which are obtained from the natural resources like plants, animal or mineral based have recently attracted significant interest because they can be used in interesting ways in biology and materials science. These materials are generally non-toxic, reusable, and recyclable, which are useful in many situations where sustainability and environmental protection are important. Plant Based fibers like Bamboo, Coir, Kenaf, Banana, Sisal, hemp and jute are proving their potentiality …
Published in Journal of Polymer & Composites · Vol. 13, Issue 3, 2025 · pp. 413–425 Read article
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Comparative Study on Bioremediation for Oil Spills Using Microbes
Abstract: This research work was designed to compare and evaluate the capacity of microbes in bioremediating and biodegrading of hydrocarbons which are the major constituents of petroleum oil. An oil spill is a leakage from ocean-going tankers, pipelines or other oil sources. Bioremediation for oil spills is a technique that uses microbes to eliminate contamination of hydrocarbons from water and soil, thereby making them safe for aquatic and terrestrial species. Bioremediation …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 4, Issue 1, 2017 · pp. 16–24 Read article
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Detection of Different Adulterant in Different Milk Samples
Abstract: The study is carried out keeping in view the recently emerging concern of adulteration of natural milk with various illegal substances to increase its marketability. This study explains in detail the hygienic status of milk supplied to various cafes, small hotels and other public and educational institutions. A total of 50 samples were collected from different localities in Delhi/NCR, India and tested for determination and extent of adulteration. Qualitative analyses …
Published in Research and Reviews : Journal of Dairy Science and Technology · Vol. 6, Issue 3, 2017 · pp. 17–29 Read article
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Investigations Into the Potential for Anthracene Decomposition of Novel Soil Bacterium, Pseudomonas putida P7
Abstract: Bioremediation of hazardous contaminants holds immense importance for the preservation of a clean and healthy environment. Conversely, the accumulation of toxicants can be mitigated with the assistance of microorganisms capable of breaking down these harmful substances into benign molecules. Anthracene is frequently used as a model molecule for studies on PAH pollution because it is found in many carcinogenic PAHs. Therefore, the hunt for new microorganisms with the ability to …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 14, Issue 2, 2024 · pp. 29–44 Read article
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Cytogenotoxicity Assessment of Asphalt Plant Discharge Water using Plant Assay
Abstract: The Allium cepa assay test was used to evaluate cytogenotoxic effects of asphalt plant discharge water at the concentrations of 10, 20, 30, 40, 50, 60, 70, 80, 90 and 100% (v/v) asphalt plant discharge water/distilled water. The distilled water served as the negative control. The analysis of the physicochemical properties and heavy metals concentrations showed that most parameters were higher than the established standards of WHO and FMENV. The …
Published in Journal of Water Pollution & Purification Research · Vol. 12, Issue 3, 2025 · pp. 100–110 Read article