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485 articles for “Mechanism” (ranking capped at the first 2,000 matches — narrow the search to see the rest)
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Diet-Gene Interactions in Farm Animals: Molecular Dynamics, Gene Expressions, Signalling Pathways and Precision Nutrition for Sustainable Productivity
Abstract: Diet-gene interactions represent a central mechanism through which nutrition influences growth, health, and productivity in farm animals. Recent advances in molecular biology and genetics have revealed that nutrients act not only as metabolic substrates but also as signalling molecules capable of modulating gene expression, cellular pathways, and epigenetic regulation. This review synthesizes current knowledge on the molecular dynamics of nutrient utilization in farm animals, with emphasis on nutrigenomic responses, nutrient …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 4, Issue 1, 2026 Read article
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Hybrid Braking System: Electromagnetic + Disc Braking
Abstract: The Hybrid Braking System combines electromagnetic braking and traditional disc braking to enhance vehicle safety, improve braking response, and reduce mechanical wear. This system integrates sensor fusion technologies, including ultrasonic and infrared sensors, to enable adaptive braking based on real-time road conditions. A PID-based control algorithm optimizes braking force distribution, ensuring a smooth and controlled deceleration. Additionally, the incorporation of regenerative braking allows for energy recovery, increasing vehicle efficiency and …
Published in International Journal of Mechanical Dynamics and Systems Analysis · Vol. 4, Issue 1, 2026 · pp. 8–14 Read article
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STRUCTURAL–EPIGENOMIC ATLAS: CNV/SV- DRIVEN PROGNOSTIC REFINEMENT ACROSS CANCERS
Abstract: Structural genomic alterations, including copy number variations (CNVs) and structural variants (SVs), play a central role in cancer initiation and progression. These alterations extend beyond gene dosage effects and interact dynamically with epigenomic mechanisms such as DNA methylation, histone modifications, and three-dimensional chromatin organization. Recent pan-cancer studies have demonstrated that CNV burden and SV signatures reflect key oncogenic processes including chromothripsis, homologous recombination deficiency, enhancer hijacking, and extrachromosomal DNA (ecDNA) …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 4, Issue 1, 2026 Read article
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A Constraint-Driven Generative Design Methodology for Modular Actuated Robotic Components in Decentralized Manufacturing
Abstract: This work formalizes a constraint-driven generative design framework for actuator-integrated robotic components intended for decentralized additive manufacturing. Conventional topology optimization typically prioritizes structural efficiency while treating actuator integration, modular interfaces, and fabrication constraints as secondary considerations. In contrast, the proposed methodology encodes these requirements as first-order geometric and mechanical constraints prior to automated material redistribution. The framework defines preserved actuator geometry, bounded design envelopes, representative loading abstractions, and manufacturability-aware domains …
Published in International Journal of Robotics and Automation in Mechanics · Vol. 4, Issue 1, 2026 Read article
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Integrating Network Pharmacology and Molecular Docking to Assess Rutin’s Pharmacological Properties
Abstract: Objectives: In the present research, the network pharmacology process was applied to determine the underlying mechanism of the pharmacological properties of Rutin. Network pharmacology was utilized to reveal the interactions between medications and the targets of illnesses, and it is capable of completely articulating the complexity between diseases and medications. The identification of diverse drug-target interactions using network pharmacology may be utilized to discover novel medications for difficult conditions like …
Published in International Journal of Molecular Biotechnological Research · Vol. 1, Issue 1, 2023 · pp. 20–33 Read article
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Production of Disinfectant Using Aloe Vera (Aloe barbadensis miller) Plant Extracts
Abstract: This research work demonstrates the production of a disinfectant using aloe vera (Aloe barbadensis Miller) as main source of the raw material. The liquid content of the aloe vera was extracted using mechanical and unit operation mechanisms and the obtained raw material was subjected to heating to evaluate the effect of temperature on the characteristics of the physiochemical properties of pH, total ash, crude fat, fibre and protein, total carbohydrate, …
Published in International Journal of Pollution: Prevention & Control · Vol. 1, Issue 1, 2023 · pp. 17–30 Read article
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Stress Level and Coping Strategies Among the Students Preparing for Common Entrance Test in Coaching Classes of a Selected City
Abstract: Stress is a natural response of your body to any type of demand, whether it is a positive or negative experience. When individuals experience stress due to external factors, their bodies release chemicals into the bloodstream, which can be beneficial if the stress is caused by physical danger. However, if the stress is a result of an emotional situation and there is no way to channel this additional energy and …
Published in International Journal of Emergency and Trauma Nursing and Practices · Vol. 1, Issue 1, 2023 · pp. 13–21 Read article
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IoT Security: Issues, Best Practices, and Open Challenges
Abstract: The internet of things (IoT) provides the facility to connect different devices and communicate and share information over the internet. IoT has emerged as a transformative and pervasive technological paradigm, revolutionizing how we interact with our environment and infusing intelligence into everyday objects and devices. This interconnected ecosystem has unleashed a wave of innovative applications across diverse domains, including healthcare, transportation, agriculture, industrial automation, and smart cities. However, as the …
Published in International Journal of Information Security Engineering · Vol. 1, Issue 2, 2023 · pp. 7–13 Read article
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Prototype Model Development and Design Analysis of A Solar Tricycle for Physically Challenged People in India
Abstract: Society is greatly concerned about the mobility of individuals with physical disabilities. The scarcity of energy resources and the issue of pollution are currently the primary concerns. These issues can be resolved by employing alternative energy sources such as solar power. This paper presents an overview of the existing solar tricycles designed for those with disabilities. It also improves a handicapped-friendly solar-powered tricycle. The goal is to reduce handicapped people's …
Published in International Journal of Mechanical Dynamics and Systems Analysis · Vol. 1, Issue 1, 2023 · pp. 43–56 Read article
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Problems and Difficulties in the Additive Manufacturing of Composites with Carbon Fiber Reinforcement for Medical Application
Abstract: Amputation is more prevalent than one may think due to an accident, war, or disease. Prosthetics and associated orthotics have a combined global market value of $2.8 billion. Carbon fibre has found a market due to increased demand for foot prostheses. Fused deposition modeling (FDM) is a rapidly advancing three-dimensional (3D) printing technique. PEEK (polyether-ether-ketone) is a biocompatible, high-performance polymer that could potentially be utilised as an orthopedic surgery implant …
Published in International Journal of Fracture Mechanics and Damage Science · Vol. 1, Issue 1, 2023 · pp. 8–12 Read article
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Reusable Plastic Advantages, Challenges, and Impacts on Waste Management and Conservation Efforts
Abstract: The widespread utilization and ill-advised removal of single-use plastics have prompted critical natural contamination and asset consumption. Accordingly, society is progressively looking for supportable other options, with reusable plastic arising as a promising arrangement. This exploration paper intends to dig into the idea of reusable plastic, investigating its advantages, difficulties, and likely effect on squander the executives and preservation endeavors. Drawing on existing writing, contextual investigations, and mechanical progressions, the …
Published in International Journal of Pollution: Prevention & Control · Vol. 2, Issue 1, 2024 · pp. 14–22 Read article
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Periodontitis and Rheumatoid Arthritis
Abstract: This comprehensive review delves into the complex interplay between Periodontitis and Rheumatoid Arthritis, aiming to unravel the underlying mechanisms and shared inflammatory pathways that connect these seemingly distinct conditions. The review examines a wealth of current research, exploring how chronic periodontal inflammation may contribute to the development and progression of RA and vice versa. Furthermore, the review critically evaluates the clinical implications of this interrelation, emphasizing the need for interdisciplinary …
Published in International Journal of Tropical Medicines · Vol. 1, Issue 1, 2024 · pp. 31–39 Read article
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Enhancing the User Experience of Asthma Inhalers: A Redesign Approach
Abstract: Asthma is a widespread chronic respiratory condition impacting millions globally, presenting significant challenges in its management and treatment. While conventional inhalers effectively administer medication, they often encounter usability issues, hindering patient adherence and treatment outcomes. This abstract delineates the development and potential impact of a redesigned asthma inhaler aimed at addressing these challenges. Incorporating human-centered design principles, the revamped inhaler prioritizes usability, portability, and effectiveness to enhance the overall management …
Published in International Journal of Solid State Innovations & Research · Vol. 1, Issue 2, 2023 · pp. 32–36 Read article
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Effectiveness of Temporins for the Treatment of HPV Infections
Abstract: Objectives: Human papillomavirus (HPV), especially high-risk variants like type-16 have been linked to the formation of malignant tumors. HPV-16 has been implicated in most cases of cervical cancer in women. This study aims to assess the effectiveness of three types of temporin molecules, i.e., antiviral peptides secreted by certain frog species, for the inhibition of the viral L1 protein. Methods: In the present study, various computational tools were used to …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 2, Issue 1, 2024 · pp. 41–53 Read article
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Human Deep Skin Surface Vibration Frequency Detection from CT and DT Signals Using Genetic Algorithms
Abstract: To diagnose respiratory problems early on, a contactless, non-invasive, real-time assessment of human vibration is a crucial prerequisite. Optoelectronic plethysmography (OEP) and the forced oscillation technique (FOT), are two widely utilized methodologies, depending on variations in each patient’s local chest impedance. Calibration of the devices before each measurement is hence the primary problem of these approaches. This report presents a simulation-based analysis to assess the effectiveness of the CT and …
Published in International Journal of Algorithms Design and Analysis Review · Vol. 2, Issue 1, 2024 · pp. 9–16 Read article
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Interaction of Bioactive Component of Aframomum melegueta on Molecular Docking
Abstract: Computational mimicry of the structure of large complexes created by di- and poly-interaction of molecules has been termed molecular docking. The purpose of molecular docking is the prediction of the three-dimensional structures of interest, this is due to that docking only produces plausible candidate structures. The docking was carried out between the bioactive compounds against 5α-reductase, 3β-hydroxy-steroid dehydrogenase, and 17β-hydroxy-steroid dehydrogenase of returned binding energy, BE (kcal/mol) between -5.9 and …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 2, Issue 1, 2024 · pp. 51–60 Read article
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A Review Paper on Friction Stir Processing on Aluminium Alloys
Abstract: Friction stir processing is a step from friction stir welding, targeted at surface modification through improving the local microstructure via localized plastic deformation. The tool consists of a rotating mechanism incorporating a shoulder and pin that are inserted into the material, traversing the designated area. When the tool's shoulder and the workpiece make contact, friction develops, generating heat that produces plastic deformation. This localized plastic deformation and heat impact result …
Published in International Journal of Fracture Mechanics and Damage Science · Vol. 2, Issue 1, 2024 · pp. 1–8 Read article
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Direct Synthetic Routes of MXenes and Their Application in Carbon Fiber Reinforced Plastics (CFRPs) As Supplementary Sizing Layer†
Abstract: Sized carbon fibers with a supplementary sizing layer of MXenes (synthesized via traditional MAX phases), bonded to carbon fibers (CFs) as well as the resin matrix via different kinds of physicochemical (van der Waals force, hydrogen bonding, covalent bonding) interactions enhanced the performance of the resulting carbon fiber reinforced plastic (CFRP) materials. This is because of the strong interface generated due to the appearance of MXene at the interface of …
Published in International Journal of Crystalline Materials · Vol. 1, Issue 1, 2024 · pp. 07–13 Read article
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Resolving International Sports Disputes: An Exploration of Mediation and Conciliation
Abstract: The globalization of sports has led to an increase in cross-border disputes, necessitating effective and efficient dispute resolution mechanisms. Traditional litigation and arbitration methods often prove time-consuming, costly, and ineffective in preserving relationships. This research explores the role of Alternative Dispute Resolution (ADR) methods, specifically mediation and conciliation, in resolving international sports disputes. Through a comparative analysis of international sports organizations and dispute resolution mechanisms, this study examines the benefits …
Published in Recent Trends in Sports · Vol. 1, Issue 2, 2024 · pp. 14–27 Read article
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SiRNA-Based Multivalent Vaccines: A Systematic Review of Potential Risks, Benefits, and Future Applications
Abstract: Background: Small interfering RNA (SiRNA) technology represents a promising innovation in vaccine development, especially for multivalent vaccines that can target multiple pathogens or antigenic variants simultaneously. siRNA-based vaccines offer a unique mechanism to induce specific immune responses, presenting an adaptable and potentially powerful tool for tackling infectious diseases and cancer. Methods: This systematic review synthesizes recent studies on siRNA multivalent vaccines, focusing on their immunogenicity, safety, and effectiveness. We reviewed …
Published in International Journal of Vaccines · Vol. 2, Issue 1, 2025 · pp. 43–49 Read article