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412 articles for “Gene targeting”
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Drug Repurposing of Anticancer Agents JP-8g and REDX05358 Against the Target Protein Plectin 1a in Epidemolysis Bullosa Simplex with Muscular Dystrophy (EBS-MD)
Abstract: Epidermolysis Bullosa Simplex with Muscle Dystrophy is a genetic disease affecting the skin and muscles which can be seen at birth or start at adulthood due to the mutation in the protein Plectin 1a (PLEC gene) causing skin blisters and muscle weakness. This protein is seen in sarcolemma, Z disks in skeletal muscles, hemidesmosomes in skin and cardiac muscles giving stability to cytoskeleton, playing a crucial role in neuromuscular transmission …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 3, Issue 2, 2025 · pp. 22–34 Read article
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Study on Chemical Insights into Alzheimer's Disease: Amyloid Beta and Tau Protein Interactions
Abstract: Background: Alzheimers disease (AD) is the most prevalent form of dementia, affecting millions of individuals worldwide and posing significant challenges to healthcare systems. The disease is characterized by a gradual decline in cognitive functions, particularly memory, reasoning, and the ability to perform daily activities. Aim & objective: To study chemical insights in alzheimers disease, especially amyloid beta and tau protein interactions Results & discussion: The results of this review highlight …
Published in International Journal of Brain Sciences · Vol. 2, Issue 1, 2025 · pp. 37–46 Read article
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Generative AI for Designing Sustainable Polymer Composites for Renewable Energy Applications
Abstract: Sustainable polymer composites are increasingly required for renewable energy devices, yet conventional trial-and-error formulation cannot efficiently balance performance, processability, recyclability, and environmental constraints. This study proposes a generative artificial intelligence framework for designing polymer composites for photovoltaic encapsulation, dielectric energy storage, polymer electrolytes, and thermal-management systems. Public polymer-property and composite datasets were curated from open databases and published supplementary records. Chemical descriptors, molecular fingerprints, polymer embeddings, processing variables, and sustainability …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 1232–1257 Read article
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Progeria Syndrome Unveiled: A Scientific Odyssey into Premature Aging Mechanisms and Therapeutic Frontiers
Abstract: Progeria, or Hutchinson-Gilford Progeria Syndrome (HGPS), is a rare and fatal genetic disorder in childhood, exhibiting features akin to premature aging. Despite normal appearances in infancy, affected children face accelerated aging with distinct facial characteristics, including micrognathia, dental malformations, lower body weight, early hair loss, decreased joint mobility, lipodystrophy, etc. The cause of HGPS is a point mutation that occurs at the exon 11 of the LMNA gene which normally …
Published in Research and Reviews: A Journal of Health Professions · Vol. 14, Issue 2, 2024 · pp. 52–68 Read article
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Unveiling the Role of Lead Molecules in CADD: A Systematic Review
Abstract: The word "medicate plan" alludes to the objective creation of modern drugs. Arbitrary screening of engineered compounds, engineered of organically dynamic compounds based on actually happening drugs, amalgamation of basic analogs of actually happening lead particles, and usage of the bioisosteric hypothesis are a few of the strategies that have been utilized. As a result, the most recent drift in medicate plan is to either completely enhance a lead or …
Published in International Journal of Membranes · Vol. 1, Issue 1, 2024 · pp. 37–43 Read article
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Strengthening Neurological and Familial Interventions: Adult Coping Following Pediatric Brain Injury and Comorbidity
Abstract: Background: Pediatric traumatic brain injury (PTBI) contributes to long-term physical, cognitive, and emotional difficulties and is a major cause of mortality and disability in children. An estimated 200,000 fatalities in India each year are attributed to traumatic brain injuries, with PTBI accounting for a significant share of these cases. Accidents, abuse, and sports injuries are just a few of the causes of post-traumatic brain injury (PTBI), which can result in …
Published in International Journal of Emergency and Trauma Nursing and Practices · Vol. 2, Issue 2, 2024 · pp. 7–15 Read article
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Innovations in Tuberculosis Management: Advancements in Drug-Resistant TB Treatment and Rapid Diagnostics
Abstract: Tuberculosis (TB) remains one of the deadliest infectious diseases worldwide, exacerbated by the increasing prevalence of drug-resistant strains, such as multidrug-resistant (MDR-TB) and extensively drug-resistant TB (XDR-TB). Despite advancements in first-line and second-line treatments, resistance to conventional antibiotics has complicated therapeutic strategies, necessitating novel approaches. This mini review explores emerging advancements in TB treatment, including gene editing technologies, such as CRISPR, which offer potential for precise targeting of drug-resistant bacterial …
Published in International Journal of Antibiotics · Vol. 2, Issue 2, 2025 · pp. 1–7 Read article
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The Evolution and Future Prospects of Solar Energy in India
Abstract: India has made great strides in incorporating solar energy into its renewable energy framework thanks to its plentiful solar resources. This case study examines the nation's advancements in solar energy development, the challenges it still faces, and its prospects for growth. India has aggressively pushed solar efforts to satisfy expanding energy demands responsibly and lessen reliance on fossil fuels, thanks to the country's high levels of sun irradiation in most …
Published in Journal of Energy, Environment & Carbon Credits · Vol. 15, Issue 3, 2025 · pp. 54–59 Read article
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FMR1 Key Biomarker in Fragile X Syndrome- A Comprehensive Review
Abstract: Fragile X Syndrome (FXS) is a complicated neurodevelopmental condition that causes intellectual disabilities, behavioural issues, and a variety of physical symptoms. Central to understanding FXS is the Fragile X Mental Retardation 1 (FMR1) gene, pivotal in the disorder's pathogenesis. This review examines FMR1 as a key biomarker in FXS, drawing on recent research insights. The FMR1 gene, situated on the X chromosome, encodes the fragile X mental retardation protein (FMRP), …
Published in International Journal of Brain Sciences · Vol. 1, Issue 2, 2024 · pp. 8–18 Read article
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Pharmacogenomics: Unlocking the Genetic Basis of Drug Response for Precision Medicine
Abstract: Pharmacogenomics, a fusion of pharmacology and genomics, explores how genetic variations influence individual responses to medications. This field is revolutionizing modern medicine by moving away from a one-size-fits-all approach toward personalized treatment strategies. By identifying specific genetic markers, pharmacogenomics aims to enhance drug efficacy, minimize adverse drug reactions, and improve overall patient outcomes. Key methodologies in this discipline include candidate gene analysis, genome-wide association studies, and haplotype analysis, all of …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 12, Issue 2, 2025 · pp. 52–59 Read article
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Recombinant Proteins and Nested Gene Regulation: Nutrient Driven Immune Response and Disease Resistance in Livestock
Abstract: Livestock production systems are increasingly challenged by infectious diseases, metabolic disorders, and environmental stressors that reduce productivity and compromise animal health. Advances in molecular biology and animal nutrition now offer new opportunities to strengthen disease resistance through integrated strategies that combine recombinant protein technologies, gene regulatory mechanisms, and nutrient mediated immune modulation. This review examines how recombinant proteins and nested gene regulation interact to shape nutrient driven immune responses in …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 16, Issue 1, 2026 · pp. 84–97 Read article
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In Silico Analysis of Potential Drug Targets in E. coli as Anticancer Agents
Abstract: Escherichia coli is a bacteria which grows as symbiotic and pathogenic organism in humans that expresses with genes causing several diseases. Manipulation and control of genes of E. coli can become a solution for cure of diseases like cancer. Based on QSAR studies, Partial partial charges are neutral for all selected ligands. The surface area, mass and volume for Capsaicin is predicted more compared to other selected ligands. As the …
Published in Research and Reviews : Journal of Computational Biology · Vol. 8, Issue 2, 2019 · pp. 10–18 Read article
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Targeted Delivery of Nanoparticle Based Taxanes for Breast Cancer Treatment: A Review
Abstract: The most common type of cancers in women is breast cancer. In United States, it is the second common cause of death in women. Metastatic cancer is the advanced stage of breast cancer, which is related to the distribution of cancerous cells from breast tissues to different areas of the body. Over the past numerous years, taxanes are bound to perform a huge role in the management and treatment of …
Published in Trends in Drug Delivery · Vol. 6, Issue 3, 2019 · pp. 36–51 Read article
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CRISPR/CAS9 Technology and its Application in Food
Abstract: Advances in the editing technology of genome or genes and also availability for the genome sequence for several crops has developed possibility for the researcher to precisely target the desired phenotype. Such therapy is possible due to CRISPR editing technology, which involves various cloning methods. After proving this concept in certain plants or crops which were used for the demonstration, thus targeting and improving the specific working of CRISPR/CAS9 technology. …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 8, Issue 2, 2021 · pp. 38–42 Read article
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Extrapolations of Periwinkle Secondary Metabolites as Multitarget Inhibitor of Breast Cancer Proteins
Abstract: Objective: Breast cancer is considered one of the most common and dangerous forms of cancer. It is a significant public health issue on a global scale. The study estimates that 10.0 million people will die from cancer this year, and 19.3 million people will develop the disease overall (BC). In this computation approach, nowadays emphasizes new drug discovery, the target protein epidermal growth factor receptor (EGFR) (5UGB), estrogen receptor (ER) …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 1, Issue 1, 2023 · pp. 36–49 Read article
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Amplification and in silico Study of Plasmodium vivax and Plasmodium falciparum LDH Gene
Abstract: Several arsenal as well as quinolone drugs are available for treatment of malaria; still it remains a worldwide public health problem. Malarial parasite quickly develops resistance under selective drug pressure. Hence, we require an array of new drugs for malaria treatment. Lactate dehydrogenase (LDH) is an essential enzyme for Plasmodia as they lack functional Krebs cycle in some stages of their lifecycle and thereby prove to be good targets for …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 2, Issue 3, 2012 · pp. 1–5 Read article
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Extrapolations of Periwinkle Secondary Metabolites as Multitarget Inhibitor of Breast Cancer Proteins
Abstract: Objective: Breast cancer is considered as one of the most common and dangerous forms of cancer. It is a significant public health issue on a global scale. The study estimates that 10.0 million people will die from cancer this year, and 19.3 million people will develop the disease overall (BC). In this computation approach nowadays emphasises for new drug discovery, the target protein EGFR (5UGB), ER (2QGT), and PI3KA (4OYS) …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 11, Issue 3, 2022 · pp. 22–36 Read article
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Unveiling Nature’s Potential: In Silico Exploration and Identification of Herbal Remedies for Major Depressive Disorder Through Molecular Interaction Studies
Abstract: Major depressive disorder (MDD), a globally discussed mental health condition, has drawn significant attention because of its unique and intricate nature. This is marked by the enduring presence of negative emotions stemming from a lack of interest, diminished self-esteem, and excessive rumination. Despite the widespread availability of various antidepressant medications, their effectiveness is hindered by low response rates, prolonged treatment durations, and the prevalence of side effects, such as headaches, …
Published in Research and Reviews : Journal of Computational Biology · Vol. 13, Issue 1, 2024 · pp. 54–62 Read article
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Antimicrobial Peptides and Bacteriophages as Next-Generation Alternatives to Conventional Antibiotics
Abstract: The growing threat of antibiotic-resistant bacteria has underscored the urgent need for innovative alternatives to conventional antibiotics. Antimicrobial peptides (AMPs) and bacteriophages are gaining recognition as next-generation therapeutics due to their distinct mechanisms of action and ability to target resistant pathogens effectively. AMPs, which can be natural or synthetic, disrupt microbial membranes and offer broad-spectrum antimicrobial activity with a reduced likelihood of resistance development. Bacteriophages, as bacteria-specific viruses, provide precise …
Published in International Journal of Antibiotics · Vol. 2, Issue 1, 2025 · pp. 9–27 Read article
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CTCHFA: Discovery of Circulating Tumor Cells in Metastatic Breast Cancer and Nonmetastatic Cancer by using Novel Hybrid Hierarchical Clustering Algorithm in Firefly Distance
Abstract: AbstractBlood testing for circulating tumor cells (CTCs) has emerged as one of the highest fields in cancer research. CTC detection are an early gene marker of reaction to systemic therapy, whereas their molecular characterization has a strong field that can be translated to individualized targeted treatments and spare breast cancer (BC) patients from unnecessary and ineffective therapies. Genomic research regarding CTCs monitoring for BC is limited due to the lack …
Published in Journal of Computer Technology & Applications · Vol. 6, Issue 1, 2015 · pp. 9–18 Read article