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1146 articles for “Derivate”
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Inhibition of MDA-MB-231 Breast Cancer Cell Proliferation by Simple Diphenyl Chalcone and Its Chlorinated Derivatives
Abstract: The pharmacological activities of chalcones and their derivatives are well documented. Chalcones are an important class of natural products that occur in edible plants such as spices, tea, fruits and other vegetables. In vitro studies have shown that chalcones inhibit proliferation of breast cancer cells by inducing apoptosis and blocking cell cycle progression. Substituent effects, namely, adding electron-withdrawing substituents to the chalcone structural motif, and the extents to which those …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 1, Issue 2, 2012 · pp. 7–12 Read article
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A Particle-Derived Nonlinear Dynamical Framework for Bubble Oscillations: Reduced-Order Modeling, Bifurcation Analysis, and Optimal Stabilization
Abstract: Particle-based fluid simulation has emerged as a powerful computational framework for modeling complex multiphase flows involving large deformations, moving interfaces, and nonlinear fluid interactions that challenge conventional mesh-based approaches. In this work, a nonlinear dynamical systems framework is developed for particle-resolved bubble oscillations by constructing a reduced-order model that preserves the dominant physical mechanisms governing bubble interface evolution. The formulation represents the bubble dynamics through coupled radial and shape deformation …
Published in Recent Trends in Fluid Mechanics · Vol. 13, Issue 2, 2026 · pp. 11–33 Read article
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Double Dirichlet Average of cosh x and Fractional Derivative
Abstract: In this paper we derive the some results of Double Dirichlet average of
Published in Research & Reviews: Discrete Mathematical Structures · Vol. 2, Issue 2, 2015 · pp. 15–20 Read article
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Chromatic Curling Number of Certain Derived Graphs
Abstract: The curling number of a graph G is dened as the number of times an element in the degree sequence of G appears the maximum number of times. Graph colouring is an assignment of colours, labels or weights to the vertices or edges of a graph. A colouring C of colours c1, c2,..., cl is said to be a minimum parameter colouring if C consists of minimum number of colours …
Published in Research & Reviews: Discrete Mathematical Structures · Vol. 5, Issue 1, 2018 · pp. 10–20 Read article
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Dirichlet Average of Generalization of K4: Function and Fractional Derivative
Abstract: In this paper Dirichlet average of a new Special function called as generalization of K4 – function, which is recently given by Ahmad Faraj , Tariq Salim , Safaa Sadek, Jamal Ismail has been obtained. This function is an extension of R- function which is introduced by Lorenzo and Hartly (1999). This is the modification of K4 – function given by Kishan Sharma and these functions have recently found essential …
Published in Research & Reviews: Discrete Mathematical Structures · Vol. 2, Issue 1, 2015 · pp. 20–23 Read article
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Synthesis, Characterization and Biological Activity: Co(II), Ni(II), Cu(II) and Zn(II) Complexes of Schiff Bases Derived from 4-Cyanobenzaldehye and 4-Amino-5-Mercapto-3-Methyl/Ethyl-1,2,4-triazoles
Abstract: Co(II), Ni(II), Cu(II) and Zn(II) complexes of bidentate Schiff bases derived from the condensation of 4-amino-5-mercapto-3-methyl-1,2,4-triazole and 4-amino-3-ethyl-5-mercapto-1,2,4-triazole with 4-cyanobenzaldehyde have been synthesized. The synthesized Schiff bases and their metal complexes were then characterized by elemental analysis, spectroscopic methods (IR, NMR, electronic spectra), magnetic moment measurement and thermogravimetric techniques. The electronic spectra and magnetic moment studies suggest octahedral geometry for Co(II), Ni(II) and Zn(II) complexes and square planar geometry for …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 5, Issue 2, 2014 · pp. 27–36 Read article
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Synthesis and Characterization of Schiff Bases Derivatives of Heterotrimetallic [Al(III); Sn(II); Ti(IV)]-µ-oxoisopropoxide-µ-oxon-propoxide [SnO2TiAl(OPri )2(OPrn )3]
Abstract: Tin diacetate and aluminium isopropoxide in equimolar proportion in xylene affords the complex [(OAc)SnOAl(OPri )2] which on reaction with Ti(OPrn )4 in 1:1 molar ratio yielded a new organoheterotrimetallic-μ-oxoisopropoxide-μ-oxon-propoxide [SnO2TiAl(OPri )2(OPrn )3] with continuous liberation of isopropyl acetate and propyl acetate formed during the course of reaction. The preparation of Schiff base complexes of the compound [SnO2TiAl(OPri )2(OPrn )3] was carried out in refluxing benzene by the reaction of µ- …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 7, Issue 2, 2016 · pp. 27–37 Read article
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Synthesis and Evaluation of Novel 3-(5-phenyl-3H-1,2,4] Dithiazol-3-yl)-4H-chromen-4-one Derivatives for Antimicrobial Activity
Abstract: A novel 3-(5-phenyl-3H-1,2,4] dithiazol-3-yl)-4H-chromen-4-one derivatives 16a–d were synthesized and evaluated for antimicrobial activity, i.e., antifungal and antibacterial activities. The in vitro antifungal evaluation revealed that the compounds 16d showed maximum activity against Geotrichum candidum. The compound 16a showed significantly good activity against Candidum tropicalis. The compounds 16b and 16c did not show any significant antifungal activity. The in vitro antibacterial activity showed no significant results against different bacterial strains. It …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 4, Issue 2, 2013 · pp. 16–22 Read article
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Comparison Study of the Reactivity of 2-Acetyl Heterocyclic Compound toward Aldol Condensation with Benzaldehyde Derivatives
Abstract: Some new chalcones have been synthesized by condensation of 2-acetyl pyrrol, 3-acetyl pyridine and 3-acetyl indole with various aromatic aldehydes in 25% alcoholic alkali. The synthesized compounds were identified by spectral and physical methods. From the time of reactions and the yield of the products, we can state that there were some obvious differences in the reactivity between the heterocyclic compounds used. Keywords: Reactivity, chalcone, aldol condensation, heterocyclic compounds, benzaldehyde …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 7, Issue 1, 2016 · pp. 34–38 Read article
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Future Prospects and Economical Impacts of Algae Derived Biofuel
Abstract: The economic strength of a country depends mainly on the fuel, which is depleting at a spontaneous rate and also polluting the atmosphere, making it incompatible for the human survival and growth of other living beings. Looking at the current scenario, crucial efforts have been initiated in the areas of biofuels like biodiesel, bioethanol etc. The diesel is used worldwide at a very massive frequency in different sectors such as …
Published in OmniScience: A Multi-disciplinary Journal · Vol. 6, Issue 1, 2016 · pp. 8–15 Read article
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Computational study of some heterocyclic scaffolds derived from quinazoline and Mannich base Sydnone
Abstract: AbstractThe current study reports design and diversity-oriented synthesis of novel heterocycles incorporating thioureido linkage and mesoionic compounds could find new applications in biology. Employing reagent-based skeletal diversity approach; a facile synthesis of quinazoline and sydnone moiety has been accomplished. The synthesized compounds were characterized by IR and 1H NMR-spectral data, and elemental analysis. The structural and electronic properties of newly synthesized compounds have been explored theoretically by performing semi-empirical molecular …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 9, Issue 3, 2018 · pp. 8–12 Read article
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Analysis of Docking Study on Protein Neprilysin (Neutral Endopeptidase) Inhibition for Anti-aging Treatment by Aloe Emodin and Aloe Emodin Carbonyl Derivative
Abstract: Attempts were made to perform comparative docking study of Aloe emodin and its derivative on Neprilysin (PDB code: 1R1J) by using VLife MDS software to ascertain the activity of both. From all the interactions (Hydrogen bond and vander waals) it was observed that, the common amino acids which interacts with the common ligand were ASN542A, ALA543A, ARG102A, ASN542A, VAL580A. The result showed that the AEC (–1790.15 KCal) showed high total …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 1, Issue 3, 2014 · pp. 6–11 Read article
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SUBSTITUTED TRI-PEPTIDE DERIVATIVES SYNTHESIS, CHARACTERIZATION
Abstract: By using amino acid residues the peptides can be synthesized using either solid phase peptide synthesis or solution phase peptide synthesis. In this research article we preferred solution phase peptide synthesis because the formed intermediate unnecessary products can be easily isolated and purified. On through literature survey we found that the solution phase synthesis of tripeptides employing HATU/HOBt as coupling agent by using microwave irradiation[720 watts] has been mentioning in …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 10, Issue 1, 2023 · pp. 52–63 Read article
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Crosslinked Starch Polymer for Coating on Fruit/Vegetable for Preservation Derived from Waste De-Oiled Soybean Cake
Abstract: Cross-linked starch films have been prepared by reacting starch extracted from de-oiled soybean cake (waste material from oil industry) with bio-based acids citric acid and tartaric acid. The obtained films were characterized by spectroscopic, thermal and surface morphological techniques. Thermal analysis showed that thin film has good thermal stability. The micrographs obtained from scanning electron microscopy showed the film surface has smooth and uniform morphology. Biological properties like cytocompatibility, antimicrobial …
Published in Journal of Catalyst & Catalysis · Vol. 10, Issue 4, 2023 · pp. 17–29 Read article
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Synthesis, Characterization and Antibacterial Activity of Mono- and Binuclear Co(II) and Cr(III) Mixed-Ligand Complexes Derived from α-Amino Acid and 1,10- Phenanthroline with 1,3-Diaminopropan as a Spacer
Abstract: Mixed-ligand complexes of Co(II) and Cr(III) ions were synthesized from the reaction of metals chloride salts with α-amino acid (H2L1) as a primary ligand and 1,10-phenanthroline (L2) as secondary ligand. The ligand 2-(benzo[d]thiazol-2-ylamino)-2-(2-hydroxynaphthalen-1-yl) acetic acid (H2L1) has been synthesized from the condensation reaction of inobenzothiazol with 2-hydroxy-1-naphthaldehyde in the presence of HCN as three components–one pot reaction. H2L1 considered as a tridentate chelater of ONO-coordination binding type toward the metals, …
Published in Journal of Polymer & Composites · Vol. 11, Issue 2, 2023 · pp. 107–120 Read article
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Molecular Docking Studies of Wildtype P53 with Damnacanthal and Scopoletin- Phytochemicals Derived from Morinda Citrifolia
Abstract: Cancer is a prominent cause of mortality globally, and it has the potential to impact any region of the body. The tumor suppressor protein P53 plays a significant role in inhibiting tumor growth by regulating DNA repair, inducing cell cycle arrest, promoting senescence, and triggering apoptosis when confronted with genotoxic stress. P53 is found mutated in 50% of cancers where it loses its tumor suppressive properties and gains oncogenic properties …
Published in International Journal of Molecular Biotechnological Research · Vol. 1, Issue 2, 2023 · pp. 20–31 Read article
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A Smart Investigation on Nanocomposites Composed of Carbon Dioxide-Derived, Repeatable Biological Polymers
Abstract: In recent years, an increasing number of people have begun to focus their attention on the environmental impacts that are caused by the widespread use of therapeutic polymeric composites that are generated from fossil fuels. Another factor that probably contributes to the short shelf life of biomedical polymer products is the fact that many of them are designed to be used just once before being discarded. When a biomedical polymer …
Published in Journal of Polymer & Composites · Vol. 11, Issue 3, 2023 · pp. 1–12 Read article
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Molecular Docking studies of Benzodiazepine Derivatives With GABA(B) Receptor
Abstract: Benzodiazepines (BZDs) are pharmacologically significant compounds that act by binding to GABA A neurotransmitter receptors, subsequently augmenting GABA-induced chloride ion flux, consequently inducing neuronal hyperpolarization. Benzodiazepines are commonly used in the treatment of sleep disorders, anxiety, muscle spasms, seizure disorders, and some forms of depression. The primary inhibitory neurotransmitter, GABA, functions on two types of receptors: the ligand-gated GABA A/C receptors and the G protein-coupled GABA B receptors. These neurotransmitters …
Published in International Journal of Toxins and Toxics · Vol. 1, Issue 2, 2024 · pp. 1–14 Read article
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Utilizing circulation-derived cancer cells to evaluate patients with surgically treated stages I–IIIA NSCLC throughout the preoperative phase
Abstract: Context: When a tumor is considered resectable, surgery is viewed as the primary treatment approach for both early-stage and locally advanced non-small cell lung cancer (NSCLC). One of the most exciting areas of cancer research in the past ten years is liquid biopsy, which offers a practical non-invasive method for cancer detection and tracking. Circulating tumor cells (CTCs) have been linked to a worse prognosis and increased chance of relapse …
Published in Research and Reviews : Journal of Surgery · Vol. 13, Issue 3, 2024 · pp. 17–28 Read article
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Water Hyacinth-Derived Biopolymers as Reinforcements for Sustainable Fiber-Reinforced Polymer Composites
Abstract: Composting has gained significant attention for sustainable waste management and nutrient recycling. This study investigated the efficacy of water hyacinth (Eichhornia crassipes) as a composting material to produce nutrient-rich organic fertilizer. Water hyacinth compost inoculated with nitrogen-fixing (Azotobacter chroococcum) and phosphate-solubilizing bacteria (Pseudomonas putida) exhibited increased nitrogen and phosphorus content compared to uninoculated compost or cattle dung compost. Wheat grown with biofertilizer-enriched water hyacinth compost displayed significantly improved grain yield, …
Published in Journal of Polymer & Composites · Vol. 13, Issue 1, 2025 · pp. 1012–1017 Read article