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189 articles for “ADME”
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Anti-hyperglycemia Effects of Plant Secondary Metabolites Towards PKA/CREB Pathway Activation in Diabesity
Abstract: Objective: Diabesity, the amalgamation of diabetes and obesity, presents a significant global health challenge. This research carefully examines how plant secondary metabolites influence glucose regulation in diabetes using the PKA/CREB pathway, paying particular attention to diabesity—the combination of diabetes and obesity. Understanding the complex ways in which these metabolites affect metabolic health will help to identify new treatment approaches for managing diabetes and its associated problems. By conducting a thorough …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 2, Issue 1, 2024 · pp. 33–50 Read article
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Data Representation and Abstraction in Computer Systems: An Interactive Study
Abstract: Data abstraction simplifies data, while data representation stores or encodes it. Data abstraction in programming involves constructing a data type that hides data representation. This lets consumers concentrate on the data’s primary features rather than its implementation. Data abstraction is common in object-oriented programming and database administration. Computers store data in binary format. The smallest binary unit is a bit, or “binary digit”. Bytes typically have eight bits. Data abstraction …
Published in International Journal of Data Structure Studies · Vol. 2, Issue 2, 2024 · pp. 22–31 Read article
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Molecular Docking of Nigella Sativa Phytocompound as Inhibitors of Transcription Factors NF-KB Implicated in Rheumatoid Arthritis
Abstract: Objectives: Nigella sativa, a plant considered around the world as the most treasured nutrient-rich herb for centuries together in different civilizations, is exceptionally known for its high levels of antioxidant properties. Free radical intensification due to oxidative stress plays a key role in the pathogenesis of rheumatoid arthritis by activating the NF-KB protein that regulates the expression of the genes involved in inflammation. Methods: This study involves in-silico approach to …
Published in International Journal of Molecular Biotechnological Research · Vol. 2, Issue 2, 2024 · pp. 42–55 Read article
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Rooftop Garden: An Initiative of Sovanagar High School
Abstract: This paper examines the rooftop garden initiative at Sovanagar High School (HS), Malda, West Bengal, a project aimed at addressing a growing rural institution's environmental and educational needs. As the school's expansion reduced available green spaces, the administration sought an innovative solution that would restore greenery and serve as an educational resource. The rooftop garden integrates sustainable practices such as rainwater harvesting, vermicomposting, and the use of recycled materials, aligning …
Published in International Journal of Trends in Horticulture · Vol. 1, Issue 1, 2024 · pp. 10–17 Read article
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A Study to Evaluate the Effectiveness of a Computer-assisted Teaching Program on Knowledge About the Distribution and Use of Iron and Folic Acid Tablets During the Antenatal Period Among Primigravida Mothers in Selected Villages of Holenarasipura Taluk, Karnataka
Abstract: Pregnancy is a critical period in a mother’s life, and proper knowledge about managing pregnancy is essential for maternal and fetal health. This study aimed to evaluate the effectiveness of a computer-assisted teaching program in improving knowledge about the distribution and use of iron and folic acid tablets among primigravida mothers in selected villages of Holenarasipura taluk. A one-group pre-test and post-test pre-experimental design was employed, using non-probability convenience sampling …
Published in International Journal of Midwifery Nursing And Practices · Vol. 2, Issue 2, 2024 · pp. 28–40 Read article
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Evaluate the Impact of a Structured Educational Program on Postnatal Mothers’ Understanding of Kangaroo Mother Care in a Tertiary Care Hospital
Abstract: Background and Aims:Kangaroo mother care (KMC) is an innovative method for caring for low-birth-weight infants. The main goal of this study is to evaluate the effectiveness of a structured teaching program in enhancing knowledge about KMC among postnatal mothers admitted at a tertiary care hospital. Material and Methods: Pre-experimental one-group pre-test and post-test designs were used and selected 80 postnatal mothers who met the inclusion criteria the experimental group received …
Published in International Journal of Midwifery Nursing And Practices · Vol. 2, Issue 2, 2024 · pp. 1–9 Read article
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A Review Article on Spice up the Solution of Inflammation Through Phytomedicines
Abstract: Inflammation is a complex, protective immune response essential for healing and combating infection. However, prolonged inflammation is associated with chronic diseases, such as arthritis, cardiovascular disorders, diabetes, and neurodegenerative conditions. Traditional nonsteroidal anti-inflammatory drugs (NSAIDs) and corticosteroids can exhibit adverse effects, particularly with chronic administration. This challenge has encouraged the exploration of natural alternatives. Among various natural anti-inflammatory agents, spices, such as ginger, garlic, turmeric, cardamom, and black pepper have …
Published in Emerging Trends in Metabolites · Vol. 2, Issue 1, 2025 · pp. 1–10 Read article
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An Investigation to Evaluate the Awareness of Obesity and Its Long-term Consequences Among Adolescents from a Chosen Higher Secondary School in Bagalkot
Abstract: Using descriptive research methodology and a descriptive survey strategy, teenagers from a selected higher secondary school in Bagalkot were asked to rank their awareness of obesity and its long-term implications. To satisfy the objectives of the study and assess teenagers’ knowledge of obesity in light of the nature of the issue, a systematic, self-administered knowledge questionnaire was created. Interaction with guides and experts in the nursing and medical domains verified …
Published in International Journal of Community Health Nursing And Practices · Vol. 2, Issue 2, 2024 · pp. 33–37 Read article
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A Descriptive Study to Assess Knowledge Regarding POSH Act Among Staff of Chirayu Medical College and Hospital, Bhopal, Madhya Pradesh
Abstract: Introduction: Sexual harassment is a significant health issue with severe effects on employees’ self-respect, physical mental health, and dignity. This descriptive study aimed to assess knowledge scores regarding the POSH (Prevention of Sexual Harassment) Act among staff of Chirayu Medical College and Hospital. A convenience sampling method was employed, and data were gathered using a self-designed knowledge questionnaire. The findings indicated that 41% of the staff had poor knowledge, while …
Published in International Journal of Community Health Nursing And Practices · Vol. 3, Issue 1, 2025 · pp. 1–10 Read article
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Effects of Boko Haram and Environmental Hazard on the People of Borno and Adamawa State, Nigeria
Abstract: This study focuses on the effects of environmental hazards and Boko harams on the people of Borno and Adamawa State. Environmental hazards and Boko haram disasters especially, those that occur as a result of natural phenomena as one of the greatest threats to humanity and economic development. Causes and the effect of Boko Haram and the Environmental hazard were studied. Man-made disasters such as conflicts, crisis and wars also use …
Published in International Journal of Climate Conditions · Vol. 2, Issue 1, 2025 · pp. 35–42 Read article
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Targeting PTPN22 in Arthritis: Molecular Docking and Pharmacokinetic Evaluation of Artemisia vestita Compounds
Abstract: Rheumatoid arthritis (RA) is a long-term autoimmune condition characterized by inflammation of the synovial membrane, commonly resulting in swelling, pain, stiffness, and overall fatigue. Protein tyrosine phosphatase non-receptor type 22 (PTPN22) has been identified as a risk factor linked to various autoimmune diseases, including RA. In the PTPN22 gene, two missense Single nucleotide polymorphisms (SNPs) are associated with autoimmune conditions. The R620W (C1858T, rs247660) variant in exon 14 has been …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 3, Issue 1, 2025 · pp. 20–31 Read article
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Innovative Approaches in Pediatric Drug Formulation Catering to Specialized Need: Review Article
Abstract: This detailed article review examines innovations in pediatric drug formulation, highlighting developments that cater to children’s specific healthcare needs. It covers pediatric pharmacology and advanced solutions like nanoparticle drug delivery and taste-making techniques, focusing on improving the safety, effectiveness, and acceptability of medications for young patients. The review highlights the benefits for patients, including improved adherence to treatment, fewer side effects, and better overall treatment outcomes. It also addresses regulatory …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 3, Issue 1, 2025 · pp. 35–43 Read article
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In Silico Exploration of Podophyllum Hexandrum-Derived Phytocompounds as Potential Therapeutics Against Small Cell Lung Cancer (SCLC): A Molecular Docking Approach
Abstract: Small Cell Lung Cancer (SCLC) is a fast-growing and aggressive type of lung cancer that spreads quickly strongly associated with smoking. It is characterized by symptoms, such as persistent cough, breathing difficulties, or hoarseness, though it can sometimes be asymptomatic which makes early detection challenging. The tumor suppressor gene TP53 is critical in regulating the cell cycle and preventing uncontrolled cell division. Mutations in TP53 result in the loss of …
Published in International Journal of Molecular Biotechnological Research · Vol. 3, Issue 1, 2025 · pp. 1–11 Read article
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Tobacco and COVID-19: Molecular Interactions and Public Health Challenges – A Review
Abstract: Tobacco use exacerbates health risks, making it a significant concern during the COVID-19 pandemic. Smoking has been implicated in the upregulation of ACE2 receptors, critical for SARS- CoV-2 entry, and contributes to immune dysregulation and oxidative stress, worsening clinical outcomes. Methods: This review synthesizes evidence on the molecular mechanisms linking tobacco and COVID-19, assesses risk factors, such as smoking status and comorbidities, and explores public health challenges in managing the …
Published in International Journal of Virus Studies · Vol. 2, Issue 1, 2025 · pp. 1–6 Read article
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Personalized Medicines in Pharmaceutics: Drug Delivery System
Abstract: Pharmaceutics personalized medicine is a developing area that seeks to customize medical interventions for specific patients. Instead of a one-size-fits-all approach, personalized medicine focuses on developing treatments that consider a person’s unique characteristics, such as their genetic makeup, environment, and lifestyle. This allows for more effective treatment outcomes, as drugs are specifically designed to work best for each patient, reducing side effects and improving therapeutic results. In pharmaceutics, this involves …
Published in Emerging Trends in Personalized Medicines · Vol. 2, Issue 1, 2025 · pp. 11–22 Read article
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A Community Awareness Project on Monkeypox (Mpox) and Enhanced Nursing Care for Patients: A Comprehensive Review
Abstract: Monkeypox (Mpox), a rare viral infection transmitted from animals to humans by the monkeypox virus, has attracted increasing attention due to its ability to spread between humans and its clinical similarities to other poxvirus diseases, including smallpox and chickenpox. Enhancing nursing care for monkeypox patients is imperative to manage and contain its spread effectively. On 15th October 2024, B.Sc. Nursing Interns of Holy Family College of Nursing, University of Delhi, …
Published in International Journal of Community Health Nursing And Practices · Vol. 3, Issue 1, 2025 · pp. 11–15 Read article
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Assessing Thyroid Disorder Awareness Among Pregnant Women: A Hospital-based Study in Kottayam
Abstract: The current study was carried out at Caritas Hospital to evaluate the knowledge of pregnant women regarding thyroid disorders. The study aimed to assess the level of knowledge about thyroid disorders among pregnant women and to explore the relationship between knowledge levels and selected demographic factors. A total of 194 pregnant women attending the obstetrics and gynecology outpatient department at Caritas Hospital in Kottayam were included using a convenience sampling …
Published in International Journal of Community Health Nursing And Practices · Vol. 3, Issue 1, 2025 · pp. 16–22 Read article
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Improving Healthcare Outcomes with RF-enabled Health Information Systems
Abstract: Health Information Technology (HIT) plays a crucial role in improving healthcare by making medical data more accessible, accurate, and efficient. Using radio frequency (RF) technology, HIT enables the wireless sharing of important health information—like patient records, and treatments—between patients, doctors, and other healthcare providers. This helps reduce paperwork, cut costs, and improve the quality of care. By reducing the reliance on paper-based records, RF-based HIT helps streamline administrative processes, cut …
Published in International Journal of Radio Frequency Innovations · Vol. 3, Issue 1, 2025 · pp. 8–13 Read article
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Effectiveness of Moist Heat Application on Elderly Orthopedic Clients at Selected Urban Community Area, Bengaluru
Abstract: Pain is a distressing sensory and emotional experience that arises from actual or potential tissue damage. It is a multifaceted phenomenon that extends beyond physical discomfort, encompassing emotional and psychological aspects as well. Individuals who recognize that pain management not only enhances comfort but also accelerates the healing process are more inclined to seek or administer appropriate treatment. In order to educate the elderly orthopedic clients, this study was conducted …
Published in International Journal of Orthopedic Nursing and Practices · Vol. 3, Issue 1, 2025 · pp. 18–22 Read article
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Emerging Therapies for Diabetes Mellitus: Efficacy and Safety of USFDA-Approved Drugs and Late-Stage Clinical Trials
Abstract: This review provides a comprehensive analysis of drugs approved by the U.S. Food and Drug Administration (USFDA) for managing diabetes mellitus (DM) from 2013 to 2022, including emerging treatments from phase 3 clinical trials during this period. Over the past decade, the treatment landscape for diabetes has evolved significantly, with new therapies not only improving blood sugar control but also targeting broader health outcomes like heart and kidney health. In …
Published in International Journal of Toxins and Toxics · Vol. 2, Issue 2, 2025 · pp. 11–23 Read article