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153 articles for “metabolite”
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Acetaminophen: Current Understanding and Future Directions in Pharmacology
Abstract: In this review, acetaminophen is described as one of the most widely used analgesic and antipyretic medications worldwide due to its effectiveness and reduced gastrointestinal toxicity compared with traditional NSAIDs. Its precise mode of action is still unclear despite widespread therapeutic use. Acetaminophen has little peripheral anti-inflammatory effect and largely acts within the central nervous system, in contrast to NSAIDs, which mainly block peripheral cyclooxygenase (COX) enzymes and lower inflammation. …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 17, Issue 2, 2026 Read article
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A Novel Approach for Extraction of Polyphenols
Abstract: Polyphenols are class of compounds which are found in fruits, vegetables, walnuts, olives, tea leaves and many more. Polyphenols are antioxidant phyto-chemicals that prevent or neutralize the damaging effects of free radicals. They are secondary metabolites of plants and are generally involved in defence against ultra-violet radiation or aggression against pathogens. Polyphenols are various alcoholic compounds containing two or more benzene rings that each has at least one hydroxyl group …
Published in Emerging Trends in Chemical Engineering · Vol. 1, Issue 1, 2014 · pp. 31–36 Read article
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Leucoanthocyanidin Reductase (LAR) Gene Analysisin Reductase
Abstract: Leucoanthocyanidin reductase (LAR) catalyzes the synthesis of catechin that is first step in PA biosynthesis. LAR involved in production of the flavan-3-ol. LAR gene is involved in proanthocyanidine production in several plants. Proanthocyanidins are plant secondary metabolites and occur in a wide range of plants and play an important role in defense against herbivores. The analysis of 50 proteins by global alignment of EF148325 with other ortholog sequences which have …
Published in Research and Reviews : A Journal of Immunology · Vol. 3, Issue 2, 2013 · pp. 15–27 Read article
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Isolation and Characterization of Rhamnolipid from Pseudomonas aeruginosa: Assessment of Biofilm Disruption Potential
Abstract: Biosurfactants are microbial metabolites bearing typical amphiphilic structure of a surfactant. This study is aimed at isolation and characterization of Rhamnolipid (RL) biosurfactant from Pseudomonas aeruginosa MTCC 2488. Characterization of biosurfactant was assessed by oil displacement test, foaming test, thin layer chromatography (TLC) and antimicrobial activity for the same was evaluated against planktonic/sessile microbes including Staphylococcus aureus, Bacillus subtilis and Candida albicans. Keywords: Biosurfactant, rhamnolipid, biofilm, Pseudomonas aeruginosaCite this ArticleKaur …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 8, Issue 2, 2018 · pp. 26–33 Read article
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Promising Antimicrobial Compounds from an Endophytic Fungus Penicillium daleae EF 4 Isolated from the Seaweed Enteromorpha flexuosa Linn.
Abstract: AbstractThe present aim of the study is to isolate the endophytic fungi from various seaweeds and to screen their bioactivity, to analyze the β-lactamase inactivator and to evaluate the interactions between the crude extract of Endophytic fungi Penicillium daleae EF 4 and two antibiotics (penicillin G and tetracycline), against some antibiotic resistant bacterial strains. Seaweeds collected from various places of Bay of Bengal coast was subjected to Endophytic fungal isolation. …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 9, Issue 1, 2019 · pp. 26–39 Read article
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Bacilli: The Keystone Biocontrol Agents Eradicating Phytopathogens
Abstract: As a result of the niches provided by plants to microbes, multitude of interactions occurred some of which are detrimental to the plants, including pathogenicity which results in diseased plants caused by harmful microbial community inhabiting a plant. Studies have shown that pesticides are applied to control the disease-causing microbes, but the adverse effects of the pesticides have necessitated the need for biocontrol agents that are eco-friendly. In this article, …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 13, Issue 1, 2023 · pp. 22–32 Read article
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Arsenic as a Cause of Cancer
Abstract: Inorganic Arsenic (iAs) is a pervasive and ubiquitous environmental toxin that has created world-wide human health problems. Populations exposed to high concentrations of arsenic-contaminated drinking water suffer serious health consequences ranging from acute toxicities to development of malignancies, including alarming cancer incidence and death rates. Epidemiologic studies have shown a relationship between chronic arsenic exposure and disease of the skin, lung, urinary bladder, and conceivably liver, kidney, and prostate in …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 5, Issue 3, 2016 · pp. 8–21 Read article
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Assessment of Suitability of Inland Wetland Fishes in Gujarat, India, for Human Consumption: A Focus on Organochlorine Pesticides
Abstract: The work described in this study evaluated the organochlorine pesticide (OCP) residues in the inland wetland fishes of Gujarat, India, and their suitability for human consumption. Among the various OCPs analyzed, isomers of hexachlorocyclohexane (HCH), γ-HCH and β-HCH were detected in 70%–80% of samples. The p,p’-DDE, metabolites of DDT were detected in higher load. Of the nine species of fishes tested, the maximum load of ∑HCH and ∑DDT was recorded …
Published in Research and Reviews: A Journal of Toxicology · Vol. 2, Issue 3, 2012 · pp. 7–14 Read article
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Mercury-induced Biochemical Changes in Perna viridis Exposed in Chronic Toxicity Test
Abstract: In the present study, the Asian green mussel, Perna viridis, was exposed to 50, 75, 113, 160 and 253 µg/L Hg concentrations under chronic toxicity for the assessment of biochemical biomarkers. Higher levels of glutathione S-transferase (GST), reduced glutathione (GSH), lipid peroxidation (LPO) and lower levels of protein, catalase (CAT) and acetylcholinesterase (AchE) were found. The values were found to be significant at P < 0.01. This study suggests that …
Published in Research and Reviews: A Journal of Toxicology · Vol. 2, Issue 1, 2012 · pp. 15–22 Read article
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Gossypetin Inhibits ROS Generation in HeLa and HepG2 Cell Lines
Abstract: Antioxidants are known for their ability to neutralize the reactive oxygen species present within the living system. These antioxidants are mainly secondary metabolites present in plant products and are generally known as nutraceuticals or bioactive compounds. Antioxidant can be categorized into many categories based upon their structure and activities like flavonoids, anthrocyanins and carotenoids. Flavonoids are heterogeneous polyphenolic compounds having beneficiary effect on human body and are also known to …
Published in Research and Reviews: A Journal of Toxicology · Vol. 7, Issue 1, 2017 · pp. 25–31 Read article
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Effects of Sub Chronic Dermal Exposure of Gasoline Blended with Varying Concentration of Benzene on Hepatic Mixed Function Oxidases in Rats
Abstract: Interaction of chemicals in a mixture, their biotransformation and adverse impact, if any, on environment and workroom atmosphere needs to be evaluated to identify the nature of potential toxic effects elicited by constituent chemical(s) in a mixture. The nature of chemical interaction(s) through which an individual chemical in a mixture undergoes metabolism and/or biotransformation in the target tissue could be helpful in evaluation of its toxic potential. Gasoline is a …
Published in Research and Reviews: A Journal of Toxicology · Vol. 3, Issue 1, 2013 · pp. 1–5 Read article
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Toxicity Evaluation of a Few PAHs on a Local Freshwater Fish—Rasbora daniconius
Abstract: Polycyclic Aromatic Hydrocarbons (PAHs) have become ubiquitous pollutants of water resulting mainly from petroleum products. These are absorbed into the living systems and converted into secondary metabolites which show bioaccumulation in the living systems and have several deleterious effects on them. The present study attempts to evaluate toxicity of two such PAHs— Naphthalene and Anthracene—on the freshwater fish, Rasbora daniconius, using pure PAHs dissolved in dichloromethane. LC50 values were seen …
Published in Research and Reviews: A Journal of Toxicology · Vol. 10, Issue 1, 2020 · pp. 42–46 Read article
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Systematic Hydroponic Review and Cultivation Strategies for Bacopa Monnieri
Abstract: Bacopa monnieri (L.) Wettst. (Brahmi; Plantaginaceae) is a medicinally important herb whose nootropic, antioxidant and anti-inflammatory properties derive largely from a group of triterpenoid saponins known as bacosides. Rising global demand for such compounds has made reliable, high-yield production a research priority and has prompted a search for cultivation systems superior to conventional field cultivation. This review compares field cultivation, in vitro micropropagation, bioreactor culture, hydroponics and elicitation for their …
Published in International Journal of Trends in Horticulture · Vol. 3, Issue 2, 2026 · pp. 23–28 Read article
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Copper sulphate enhanced synthesis of azurin from Pseudomonas aeruginosa MTCC 2453
Abstract: The secondary metabolites from microorganisms play a vital role in developing new chemotherapeutics. Azurin a blue copper protein have redox properties plays a role in electron transfer as donors. Azurin reported as a potential anticancer protein against breast cancer cell lines which evoked biomedical researchers to develop an alternate method for enhanced production of azurin. Early researchers revealed the synthesis of blue copper protein azurin from different microbial sources, especially …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 1, Issue 1, 2011 · pp. 1–4 Read article
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Engineering Fatty Acid Oxidation Pathway for the Production of Yeast-based Monomers
Abstract: Yeast-based monomers have a wider application in many fields and used for polymer production. Yeast system is used to improve the production of such valuable monomers by exploiting the metabolic pathways of interest. Alkane-utilizing yeasts mediate the fatty acid catabolism inside the peroxisomes primarily through beta (β) oxidation pathway, which breaks up the long chain fatty acids resulting in the synthesis of energy producing molecules. This allows the reduced inflow …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 3, Issue 1, 2013 · pp. 6–9 Read article
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Phytochemical Screening and Trace Element Analysis of Cryptomeria japonica
Abstract: The present study was aimed to investigate the preliminary phytochemical screening of the bark of Cryptomeria japonica belonging to family Cupressaceae. The bark of the plant were subjected to successive soxhlet extraction by continuous hot percolation method using organic solvents of increasing polarity such as ethanol. Both the extracts were subjected to qualitative phytochemical screening and it showed the presence of active constituents such as alkaloid, flavonoid, phenol and carbohydrates. …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 4, Issue 2, 2014 · pp. 17–20 Read article
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Study on Efflux Pump Inhibition Activity of Marine Actinomycetes against Oflaxcin Resistsnt M. tuberculosis
Abstract: Studies were conducted to isolate marine actinomycetes active against oflaxcin resistant M. tuberculosis. Out of 25 actinomycetes isolates designated as ECRMP 4 showed potent antimycobacterial activity against all three tested Mycobacterial strains. Representative bioactive isolate was characterized using phenotypic property and identified as Micropolyspora sp. The zone of inhibition was 20 ± 0.1 mm (62% RIZD) against M. tuberculosis and 18 ± 0.6 mm (100% RIZD) against OFLR M. tuberculosis. …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 4, Issue 2, 2014 · pp. 25–30 Read article
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Dalk (massage): A Remedial Therapy for Waja Uz Zahr (Low Back Pain)
Abstract: Dalk (Massage) is one of the oldest forms of remedial therapy, It is a universal method that is potentially applicable in all reflex changes produced by pain (nociceptive stimuli). It is pleasurable, routinely brings relief and is therefore also very popular with patients. Massage has the potential to influence emotion, biochemistry and biomechanics, usually without adding excessively to the adaptation load, and is therefore uniquely placed to be able to …
Published in Research and Reviews: A Journal of Medicine · Vol. 3, Issue 2, 2013 · pp. 1–5 Read article
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Role of Polychlorinated Biphenyls (PCBs) and Polycyclic Aromatic Hydrocarbons (PAHs) on Survival of Free Ranging Birds: A Review
Abstract: The PCB contaminant levels reported in tissues individuals are not likely to have an impact on the demographic performance of the birds as a whole. However, the residues may reach levels causing decreased reproduction or survival in some years, particularly when combined with other non-anthropogenic stressors such as food scarcity. In addition, the birds normally would have more exposure to the contaminants due to their position in the food chain. …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 2, Issue 3, 2012 · pp. 9–19 Read article
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In vitro Antioxidant Activity and Phytochemical Analysis of Different Polar Solvent Extracts Obtained from Zanthoxylum rhetsa (Roxb) Bark
Abstract: This study was carried out to evaluate the phytochemical and antioxidant effectiveness of methanolic extract and different fractions (n-butanol, ethyl acetate, chloroform and n-hexane) of Z. rhetsa bark. Phytochemical activity of Zanthoxhylum rhetsa (Roxb) bark extract alkaloids, flavonoids, tannins, steroids, saponins and antraquinones was carried out. Antioxidant scavenging enzyme profile assays were done and profiles were developed for validation. The results indicated that bark extract and fractions of Z. rhetsa …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 5, Issue 3, 2015 · pp. 1–7 Read article