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162 articles for “Molecular Mechanism”
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Epidermolysis Bullosa and Its Role in Cervical Cancer: An Overview
Abstract: Epidermolysis Bullosa is a group of uncommon genetic disorders that primarily affect the skin and mucous membranes. It is marked by severe skin fragility and the formation of blisters even after minor trauma. Traditionally, the focus of Epidermolysis Bullosa research has been on its dermatological manifestations, which include recurrent blistering, scarring, and the potential for infections due to the compromised skin barrier. However, recent advancements in Epidermolysis Bullosa research have …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 2, Issue 2, 2024 · pp. 14–18 Read article
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Effectiveness of PTFE-Based Nano-coatings in Improving Corrosion and Wear Resistance of Stainless Steel
Abstract: Polytetrafluoroethylene (PTFE) has emerged as a highly effective material for enhancing the durability and performance of metal surfaces, particularly in environments requiring superior corrosion resistance and low friction. This study investigates the application of PTFE coatings on various metallic substrates, with a focus on stainless steel and carbon steel, to improve their corrosion resistance, wear protection, and tribological performance. Utilizing advanced deposition techniques such as sol-gel and plasma spray, PTFE …
Published in International Journal of Photochemistry and Photochemical Research · Vol. 2, Issue 2, 2024 · pp. 32–38 Read article
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Heterocyclic Substituted Flavones: Bridging Natural Products and Medicinal Chemistry
Abstract: Heterocyclic substituted flavones represent a unique and promising class of flavonoid derivatives, gaining significant attention in recent years due to their diverse and enhanced biological activities. These compounds are characterized by the incorporation of heterocyclic moieties such as quinoline, pyridine, thiazole, imidazole, oxazole, and pyrazole into the flavone structure, which significantly alters and often enhances their bioactive properties. This structural modification has made heterocyclic flavones particularly appealing as candidates for …
Published in International Journal of Tropical Medicines · Vol. 2, Issue 1, 2025 · pp. 23–30 Read article
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Computational Simulations in Drug Discovery: Modeling Protein Folding and Drug Binding
Abstract: Computational simulations have become essential tools in drug discovery, offering unprecedented insights into molecular behavior at the atomic level. These simulations, particularly in the domains of protein folding and drug binding, allow for the exploration of complex biological systems that are often difficult to study experimentally. Protein folding, a critical aspect of drug discovery, involves the transition of a polypeptide chain from an unfolded to a biologically active structure. Understanding …
Published in Research and Reviews : Journal of Computational Biology · Vol. 14, Issue 1, 2025 · pp. 23–29 Read article
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Recombinant Human EGF in Wound Healing: 3D Computational Insights
Abstract: A Growth Factor represents a naturally-occurring compound with the remarkable ability to incite cellular growth, proliferation, and differentiation. Typically manifesting as either a protein or a steroid hormone, these factors wield significant influence over an array of cellular activities. Their pivotal role lies in the regulation of diverse cellular processes, often serving as catalysts for cell specialization and maturation, a characteristic that distinguishes them from one another. For instance, bone …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 11, Issue 2, 2024 · pp. 6–10 Read article
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Genetic Authentication of Acacia Senegal (L.) Wild
Abstract: A study was carried out to ascertain the taxonomic identity and phylogenetic lineage of three presumed Acacia senegalensis using molecular markers. Three (3) varieties of seeds presumed to belong to Acacia spp. were collected from the Rubber Research Institute of Nigeria (RRIN) Benin City and three BP haplotypes (A, B, and C) was used as control for the analysis. These seeds were processed at the Applied Biotech International Laboratory Nigeria …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 2, Issue 2, 2024 · pp. 33–39 Read article
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Integrating Biotechnology, Physiology, and Agroecological Practices for Sustainable Crop Production and Protection
Abstract: Global agriculture is currently confronting a wide range of complex challenges, including a rapidly growing population, climate change, increasing pest and disease pressures, soil degradation, water scarcity, and the urgent need for sustainable intensification of crop production. Addressing these issues requires integrated strategies that combine crop improvement (through modern breeding and biotechnology), precision agronomic practices related to soil, irrigation, and nutrition, as well as advancements in plant physiology, molecular biology, …
Published in International Journal of Trends in Horticulture · Vol. 2, Issue 2, 2025 · pp. 1–6 Read article
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Decoding Innate Immunity: Mechanisms, Components, and Clinical Implication
Abstract: Innate immunology represents the body's first line of defense against pathogens, acting as a rapid, non-specific response to a wide array of microbial invaders. This part of the immune system depends on pattern recognition receptors (PRRs) to identify pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs), leading to the activation of immune cells such as macrophages, dendritic cells, and neutrophils. The innate immune system also plays a crucial role …
Published in Research and Reviews : A Journal of Immunology · Vol. 15, Issue 2, 2025 Read article
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Fabrication and Analysis of PBAT/Cyperus Rotundus Micro Crystalline Cellulose Biofilms for Food Packaging Applications
Abstract: Global plastic waste crisis has gained an increasing attention and many efforts have been made recently to develop biodegradable polymers as food packaging alternatives. Solution casting is used for fabrication and characterization of reinforced polybutylene adipate-co-terephthalate (PBAT) biofilm with Cyperus rotundus microcrystalline cellulose (CRC). PBAT-CRC biofilms with different CRC loadings (1%, and 2%) had been prepared and their structural, mechanical, thermal and morphological properties of fabricated biofilms were analyzed to …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 591–599 Read article
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Nutrient Sensing and Microbiota Crosstalk: Driving Determinants Shaping Metabolic Stability and Adaptive Physiology for Animal Health
Abstract: Nutrient sensing is a fundamental cellular process that enables animals to adapt to fluctuating dietary inputs while maintaining metabolic homeostasis and health. Recent advances reveal that the gut microbiota functions as an active metabolic partner, producing bioactive metabolites that directly influence host nutrient-sensing pathways and downstream cellular responses. This review synthesizes current knowledge on the integration of key signalling networks, including adenosine monophosphate activated protein kinase (AMPK), mechanistic target of …
Published in International Journal of Molecular Biotechnological Research · Vol. 4, Issue 2, 2026 Read article
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Dissipative Particle Dynamics Simulation Study on the Evolution of Photoinitiated Free Radical Polymerization Crosslinked Networks
Abstract: Gradient polymer materials overcome the limitations of conventional homogeneous polymers by integrating multiple distinct functionalities within a single continuous structure. Although photoinitiated free-radical polymerization offers excellent spatial and temporal control, the underlying microscopic mechanisms governing network evolution under non-uniform light fields remain poorly understood. In this study, a mesoscale dissipative particle dynamics (DPD) model was successfully developed to couple free-radical polymerization kinetics—including initiation, propagation, crosslinking, and termination—with exponential light attenuation …
Published in Journal of Polymer & Composites · Vol. 14, Issue 4, 2026 · pp. 142–158 Read article
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Experimental and Process Optimization Study on Thermal Stress Reduction in TiC–Steel Brazed Joints Using Polymer-Derived Composite Interlayers
Abstract: In this, an experimental investigation aimed at reducing crack formation due to thermal stress in TiC-steel brazed joints through optimization of key process parameters is presented. The primary objective was to develop an integrated and reliable brazing strategy by examining the effects of filler material selection, brazing gap, cooling conditions and type of flux. In this study, polymer-derived composite interlayers were developed through controlled synthesis and nanocomposite engineering to mitigate …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 524–540 Read article
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Polymer–Gel Composite Phase Change Materials: A Functional Polymer Composite Approach for Solar-Thermal Energy Storage in Building Facades
Abstract: This study investigates polymer–composite phase change materials (PCMs) in the form of polymer–gel hybrids as multifunctional systems for solar–thermal energy storage in building façades. Paraffin- and PEG-based PCMs were embedded into polyurethane and acrylic gel matrices to create shape-stabilized polymer–composites with high PCM loading (70–80 wt%). Differential Scanning Calorimetry (DSC) confirmed distinct melting/freezing transitions at ~56°C (paraffin) and ~42°C (PEG), with enthalpy values of 120–150 J/g, closely matching theoretical predictions, …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 36–51 Read article
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Role of Electron Donors in MgCl2 Supported Ziegler-Natta Catalysis: DFT Approach
Abstract: An insight into the nature of carbonate-based electron donors in high-activity MgCl2 supported Ziegler-Natta (Z-N) catalysts has been studied and compared with conventional phthalate and diether systems by employing density functional theory (DFT) calculations. In the catalyst activation (one of the important processes to produce the active catalyst sites), the conventional monometallic and recently characterized bimetallic (TiCl2(Et)–Cl–AlEt2) active site are studied in the presence/absence of electron donors. These active sites …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 16, Issue 2, 2025 · pp. 51–81 Read article
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Light-Matter Interactions in Molecular Photochemistry
Abstract: Molecular photochemistry explores the ways of molecules interaction with light, absorb photons, and excited‐state processes, and ultimately conversion of photon energy into chemical change. Core concepts of this innovative and relevant field are matter interaction like electronic, vibrational, and rotational transitions; non‐adiabatic couplings; energy & electron transfer; and light–matter coupling in weak and strong regimes. This article briefly surveys the multiplicity of these interactions, from the fundamentals of photon absorption …
Published in International Journal of Photochemistry and Photochemical Research · Vol. 3, Issue 2, 2025 · pp. 33–42 Read article
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A Review on Unmasking Merkel Cell Polyomavirus: From Discovery to Cancer Driver
Abstract: Merkel cell polyomavirus (MCPyV) is a small, non-enveloped, circular double-stranded DNA virus belonging to the Polyomaviridae family, first characterized in 2008. Epidemiological data suggest widespread exposure, with seroprevalence rates approaching 80% in adults. While primary infection is typically asymptomatic, rare integration events in Merkel cells can initiate oncogenesis, yielding Merkel cell carcinoma (MCC), a neuroendocrine skin cancer with a five-year survival rate under 60%. This review integrates findings from six …
Published in International Journal of Virus Studies · Vol. 2, Issue 2, 2025 · pp. 6–11 Read article
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Sequence analysis, DNA Methylation and Molecular therapy of Oral cancer caused by Human Papilloma Virus
Abstract: DNA methylations with oral cancer are been associated with high-risk Human Papillomavirus (HPV) and Epstein-Barr Virus (EBV) onco-proteins interactions may cooperate to increase disease severity. The work focused on human papillomavirus strain 16, a high-risk, sexually transmitted responsible for 95% of all cervical cancers and a large portion of oropharyngeal cancers. The prediction of genes from has shown seven genes from HPV16 strain. Based on gene identification studies, Human papilloma …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 4, Issue 2, 2026 · pp. 1–9 Read article
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Long Non-Coding RNAs: Key Regulators of Gene Expression in Development and Disease
Abstract: Long non-coding RNAs (lncRNAs) are RNA molecules that do not make proteins but are essential for controlling how genes are turned on or off in the body. These molecules help with various biological functions, such as guiding cell growth, shaping development, and influencing the progression of diseases. Recent advancements in genomics and transcriptomics have revealed the vast and complex roles of lncRNAs, with an increasing recognition of their involvement in …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 3, Issue 1, 2025 · pp. 11–15 Read article
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Photoreceptor Dynamics: Light Sensing and Cellular Responses for Photochemistry
Abstract: Photoreceptor dynamics represent a fundamental aspect of photochemistry, encompassing the mechanisms by which biological systems detect and respond to light stimuli. Photoreceptors are specialized proteins that undergo structural and functional changes upon photon absorption, initiating a cascade of molecular events that translate light signals into cellular responses. These proteins are ubiquitous across life forms, including microbial rhodopsins, plant phytochromes, and animal opsins, each finely tuned to specific wavelengths and light …
Published in International Journal of Photochemistry and Photochemical Research · Vol. 3, Issue 2, 2025 · pp. 28–32 Read article
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Nano-Chemical Revolution in Vaccinology: A Study
Abstract: The development of traditional vaccines, reliant on attenuated pathogens or purified proteins, has historically been limited by slow development timelines, poor stability, and low immunogenicity requiring potent, often non-specific, adjuvants. This synthesis argues that the convergence of nano-material science and meticulous chemical engineering represents the next major paradigm shift in preventative medicine. Nano-materials, particularly Lipid Nanoparticles (LNPs) and various polymeric or inorganic scaffolds, have transitioned from theoretical constructs to essential …
Published in Research and Reviews : A Journal of Immunology · Vol. 16, Issue 1, 2026 Read article