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251 articles for “Inhibitor”
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Evaluation of Bio-Based Polymer Composites Containing Guava Leaf Extract for Antimicrobial Functionality
Abstract: This study explores the formulation of an herbal soap using guava leaf extract as a primary ingredient. Guava leaves are a rich source of biopolymers like pectin and cellulose, which may contribute to the binding properties in the soap. The antimicrobial activity of the soap was evaluated against common skin pathogens (Staphylococcus aureus, Trichoderma spp., Aspergillus spp.). The formulated soap exhibited inhibitory effects against all tested pathogens. The weight, foaming …
Published in Journal of Polymer & Composites · Vol. 13, Issue 1, 2025 · pp. 875–880 Read article
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Corrosion and Corrosion Protection of Unio in Carbonic Acid Medium
Abstract: Unio is a calciferous animal, and its outer surface is made of calcium carbonate. It usually happens in sources of sweet water. They create carbonic acid by absorbing carbon dioxide. It changes the pH of sweet water sources thus water becomes acidic. It develops corrosive environment for Unio. Carbonic acid interacts with Unio to form corrosion cells on the interface of Unio. This acid oxidizes calcium carbonate into calcium ions …
Published in Journal of Water Pollution & Purification Research · Vol. 12, Issue 1, 2025 · pp. 22–31 Read article
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Role of PI3K/AKT/mTOR Signaling Pathways in Breast Cancer
Abstract: Abstract: Breast cancer is among the most commonly diagnosed cancers and remains a leading cause of mortality among women globally. Although early detection and interventions aimed at curtailing tumor progression have significantly improved breast cancer survival rates, there is an ongoing demand for more potent systemic therapies to effectively prevent metastasis. A central pathway frequently associated with the growth, survival, and motility of breast cancer cells is the PI3K/AKT/mTOR signaling …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 14, Issue 1, 2025 · pp. 23–34 Read article
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Effect of Different Incubation Times on the Effectiveness of Oyster Mushrooms Towards the Growth of Some Fungal Isolates
Abstract: The study was conducted by preparing the filtrate of the oyster mushroom Pleurotus ostreatus, where the effectiveness of the fungal filtrate prepared from growing the fungus in the liquid Potato Dextrose Broth (PDB) medium was selected for two different periods (14, 28 days) in inhibiting some types of fungi (Aspergillus Spp : Aspergillus niger ،Aspergillus flavus, Aspergillus terreus) and some types of fungi (Candida Spp: Candida albicans, Candida tropicalis, Candida …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 15, Issue 2, 2025 · pp. 1–8 Read article
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Computational Identification of Antigenic Proteins and Epitopes in Hantavirus sp. for Drug Repurposing
Abstract: Hantavirus is an emerging virus that spreads from animals to humans and can cause serious illnesses like hantavirus pulmonary syndrome (HPS) and hemorrhagic fever with renal syndrome (HFRS). there are no FDA-approved treatments available for these diseases. This study explores in-silico drug repurposing as a strategy to identify potential therapeutic candidates. The physicochemical, secondary structure, antigenicity, and post-translational modification analysis of hantavirus proteins – specifically the glycoprotein precursor, N protein, …
Published in International Journal of Molecular Biotechnological Research · Vol. 3, Issue 1, 2025 · pp. 20–26 Read article
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The Rising Burden of Heart Attacks: Causes, Trends, and Prevention Strategies
Abstract: Heart attacks, or myocardial infarctions, remain a leading cause of morbidity and mortality worldwide, with their incidence rising steadily across diverse populations. This review explores the increasing prevalence of heart attacks, emphasizing traditional risk factors, such as poor diet, physical inactivity, smoking, and medical conditions like hypertension, diabetes, and hyperlipidemia. It also highlights emerging risk factors, such as chronic infections, pollutants, substance abuse, and the lasting cardiovascular effects of COVID-19. …
Published in Research and Reviews : Journal of Surgery · Vol. 14, Issue 2, 2025 · pp. 1–11 Read article
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A Systematic Review on Peptic Ulcer Disease and its Pharmacological Treatment
Abstract: A chronic gastrointestinal condition known as Peptic Ulcer Disease (PUD) is typified by the formation of ulcers or mucosal erosions in the proximal duodenum and stomach. In the pathophysiology of PUD, the equilibrium between defensive processes like mucus and bicarbonate secretion, mucosal blood flow, and prostaglandin production, and aggressive factors such stomach acid secretion, pepsin activity, and Helicobacter pylori infection, is upset. Although stress and food have historically been blamed, …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 16, Issue 1, 2026 · pp. 76–84 Read article
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Revolutionizing Blood Cancer Treatment: Emerging Therapies and Future Perspectives
Abstract: Blood cancer inclusive of leukemia, lymphoma and multiple myeloma poses a significant threat in the world today because of its multifactorial process and its non-amenable to standard therapies. Some of such approaches are immunotherapy, gene-editing technology and targeted small molecule inhibitors that have altered the nature of treatments. CAR T cell therapy is a molecular targeted therapy for cancers and several clinical studies have reported a huge success. Also, the …
Published in International Journal of Biomedical Innovations and Engineering · Vol. 3, Issue 2, 2025 Read article
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Drug Resistance in Targeted Cancer Treatment: Clinical Difficulties, Molecular Mechanisms, and Emerging Strategies
Abstract: Targeted cancer therapy, which selectively inhibits the molecular mechanisms responsible for tumor growth and development, has revolutionized modern oncology. Targeted therapies have lower systemic toxicity and better therapeutic efficacy when compared to traditional chemotherapy. However, the emergence of medication resistance often limits the long-term efficacy of these treatments, ultimately resulting in treatment failure and disease progression. Drug resistance develops through a number of intricate biological processes and can be innate …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 17, Issue 1, 2026 · pp. 130–138 Read article
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In Silico Identification of Therapeutic Agents for Dengue Virus by Molecular Docking
Abstract: The dengue virus causes serious health issues and a loss of quality of life. Dengue poses a yearly threat to half of the world’s population. The drugs that are based on allopathy are expensive and also exhibit toxic effects on tissues and biological activities. It is also generally accepted that most pharmacologically active drugs, including those derived from medicinal plants, are isolated from natural sources. The present study is directed …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 13, Issue 2, 2026 · pp. 01–14 Read article
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Cell Membranes as Therapeutic Targets: Implications in Infectious and Metabolic Disorders
Abstract: This is a review of the crucial role played by cell membranes in health and disease with respect to their contribution to infectious and metabolic diseases. Dysfunction of membranes, such as membrane transporter changes and changes in lipid content, has been associated with a variety of diseases, including diabetes, cardiovascular disease, and cancer. The present therapeutic approaches are focused on attacking membrane constituents by disrupting the entry of pathogens or …
Published in International Journal of Membranes · Vol. 3, Issue 1, 2026 · pp. 47–53 Read article
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Pharmacoepigenomics of Replication Timing: How Anti- Cancer Drugs Reshape Chromatin Domains and Mutational Landscapes.
Abstract: DNA replication timing serves as a fundamental epigenetic feature that organizes genome function during the cell cycle (3), while anti-cancer drugs profoundly alter this process to disrupt tumor growth(4). These agents target chromatin architecture, shifting replication domains and reshaping mutational patterns critical for cancer evolution (1,5). DNA replication timing (RT) domains serve as dynamic epigenetic organizers, partitioning the genome into early- and late-replicating regions that correlate with chromatin states, gene …
Published in International Journal of Molecular Biotechnological Research · Vol. 4, Issue 1, 2026 Read article
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Monitoring the Effectiveness of Water-Based Plants for the Inhibition of Metal
Abstract: The temperature performance profile of the plant extracts shows that inhibition efficiency increased with increasing temperature of the system until at about 323K at 9.00hrs immersion time where a decline in inhibition efficiency occurred implying the opposite at higher temperatures and longer immersion time. Corrosion rate parameters changed with rise in temperature and exposure – immersion time. Plots of rates of corrosion against the volume(s) of the test inhibitor(s) in …
Published in Journal of Thin Films, Coating Science Technology & Application · Vol. 13, Issue 1, 2026 · pp. 37–46 Read article
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Vitamin D Mitigates Inflammation and Downregulates Importin α3 in Non-Alcoholic Fatty Liver Disease (NAFLD)
Abstract: Background: Pro-inflammatory cytokines, such as TNF-α, IL-1β, IL-6, and IL-8, seem to play a crucial role in the progression of NAFLD as they activate the transcription factor NF-кB. The activated NF-кBp50/RelA subunits are translocated to the nucleus by Importin α3 and Importin α4. Numerous studies have indicated a negative association between NAFLD and vitamin D levels. Low vitamin D levels have been correlated with histological severity, necro-inflammation, and fibrosis in …
Published in International Journal of Cheminformatics · Vol. 4, Issue 1, 2026 · pp. 1–16 Read article
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pH-Responsive Smart Polymer Nanocomposites for Anti-Corrosive Coatings
Abstract: Metallic corrosion under adverse marine and industrial conditions imposes gigantic financial burdens and risks worldwide. Conventional waterproofing waterborne epoxy has passive barrier protection, but is also inherently microporous, lacking intrinsic repair ability against mechanical damage and thus rapidly decays. This is a critical gap that this work tries to bridge by designing a new pH-responsive hybrid polymer nanocomposite by using polyethyleneimine-tannic acid-cerium functionalized boron nitrate nanosheets with chitosan-capped mesoporous silica …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 201–213 Read article
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Molecular Docking Analysis of Phytocompounds from Ficus hispida Aagainst Epidermal Growth Factor Receptor Kinase Domain
Abstract: The Epidermal Growth Factor Receptor (EGFR) kinase domain plays a key role in cancer, as it promotes tumour growth and helps cancer cells survive, making it an important focus for developing treatments. Through comprehensive computational analysis, this study investigates the anticancer potential of phytocompounds from Ficus hispida, a medicinal plant renowned for its diverse bioactive compounds, as novel EGFR inhibitors. Molecular docking techniques using Py Rx software were employed to …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 3, Issue 2, 2025 Read article
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Molecular Docking Analysis of Phytocompounds from Ficus hispida Against Epidermal Growth Factor Receptor Kinase Domain
Abstract: The Epidermal Growth Factor Receptor (EGFR) kinase domain plays a key role in cancer, as it promotes tumour growth and helps cancer cells survive, making it an important focus for developing treatments. Through comprehensive computational analysis, this study investigates the anticancer potential of phytocompounds from Ficus hispida, a medicinal plant renowned for its diverse bioactive compounds, as novel EGFR inhibitors. Molecular docking techniques using Py Rx software were employed to …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 3, Issue 2, 2025 · pp. 48–62 Read article
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Acetaminophen: Current Understanding and Future Directions in Pharmacology
Abstract: In this review, acetaminophen is described as one of the most widely used analgesic and antipyretic medications worldwide due to its effectiveness and reduced gastrointestinal toxicity compared with traditional NSAIDs. Its precise mode of action is still unclear despite widespread therapeutic use. Acetaminophen has little peripheral anti-inflammatory effect and largely acts within the central nervous system, in contrast to NSAIDs, which mainly block peripheral cyclooxygenase (COX) enzymes and lower inflammation. …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 17, Issue 2, 2026 Read article
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Identification of Some Imported Lubricating Oil Additives Used in Libya and Synthesis of the Most Consumed Ones from the Local Raw Materials
Abstract: This paper presents the identified six additives imported under trade names used in the lubricating oil blending factory of A-Zawia-Libya. Their structures have been completely confirmed by examining their physical properties and using modern analytical techniques such as nuclear magnetic resonance spectroscopy (NMR), infra-red (IR), atomic absorption (AAS) and gas chromatography (GC). The synthesis of most important and more consumed additives in lubricating oils in Libyan oil industry from local …
Published in Journal of Catalyst & Catalysis · Vol. 3, Issue 3, 2016 · pp. 10–17 Read article
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Bioconversion of butanol from waste paper
Abstract: Bio-butanol production from lignocellulosic biomass considered promising and Economically feasible. This paper provides an development of lignocellulose-based bio-butanol production with a focus on the understanding of the structure of the feedstock, pretreatment technologies, and fermentation processes. To enhance butanol production from lignocellulose materials, strategies in terms of inhibitors detoxification, strains improvement and process integration and optimization are also addressed. Besides, there researchers attempts to shed light on the challenges and …
Published in Journal of Petroleum Engineering & Technology · Vol. 8, Issue 3, 2018 · pp. 28–31 Read article