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218 articles for “Drug toxicity”
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Synthesis and Characterization of PF-127 Stabilized Metformin Encapsulated Chitosan-TPP Nanoparticles
Abstract: Metformin is widely used to manage Type 2 Diabetes, but its effectiveness is limited by low intestinal absorption, high dose requirements, and a short half-life. To tackle these challenges, several nano-drug delivery systems have been designed to optimize the delivery of metformin and enhance its therapeutic efficacy. Nanoparticles (NPs) have emerged as key players in medicine, biology, and pharmacology, gaini considerable attention for their potential applications. Polymeric NPs are among …
Published in Nano Trends – A Journal of Nano Technology & Its Applications · Vol. 27, Issue 1, 2025 · pp. 34–38 Read article
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An Insight to Diagnosis and Management of Druginduced Hepatotoxicity: An Overview
Abstract: (ADRs) Adverse Drug Reactions are constitute and mutual chief health problem. Throughout the last period liver toxicity has remained one of the most recurrent reasons for pharmacovigilance protection intelligences and the withdrawal from the marketplace of an accepted medicinal product. Liver is a main organ elaborate in the systemic deposition and decontamination of exogenous and endogenous ingredients. Liver disfunction challenges not only health care specialists but also the pharmaceutical manufacturing …
Published in Trends in Drug Delivery · Vol. 8, Issue 2, 2023 · pp. 39–54 Read article
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Novel Synthesis of Encapsulated Super Paramagnetic Iron Nanoparticles (Fe3O4) and its Evaluation in Drug Delivery System
Abstract: Nanoparticles can be defined as solid, submicron, colloidal particles ranging in size from 10–100 nm in diameter, generally but not necessarily made of natural or synthetic polymers, in which drugs can be adsorbed, entrapped, that exhibit new or enhanced size-dependent properties as compared to microparticles. Iron oxide nanoparticles are often magnetic by nature, which means that they obey Coulomb’s law, and can be manipulated by an external magnetic field gradient. …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 7, Issue 2, 2016 · pp. 11–24 Read article
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Pharmaceutical Cocrystals of Pain Relieving Drugs
Abstract: Cocrystallisation of two components into one crystal form can enhance the solid-state properties of drug compounds. Cocrystals are considered as the next generation modified-active pharmaceutical ingredients with improved physical-chemical, (aqueous solubility, dissolution, hygroscopicity, bioavailability, stability, increase of melting point, purity of an active pharmaceutical ingredients (API), intellectual property positions) and pharmacokinetic properties. Cocrystal formation may overcome dissolution problems of highly lipophilic APIs because the new crystalline lattice being formed often …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 6, Issue 1, 2015 · pp. 16–27 Read article
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Piezoelectric Nanoparticles Loaded with Curcumin for Cancer Treatment
Abstract: Conventional cancer chemotherapy treatments are often compromised by systemic toxicity which starts from the lack of tumor specificity of administered anticancer drugs. The side effects limit the dose of the drug that can be administrated, making effective cancer treatment difficult. Nanoparticle-based drug delivery has the potential to overcome this challenge by targeted delivery to tumor and taking the advantage of tumor’s natural leaky vasculature to increase the accumulation of drug-loaded …
Published in Journal of Nanoscience, NanoEngineering & Applications · Vol. 6, Issue 2, 2016 · pp. 1–6 Read article
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Using Artificial Intelligence for The Design of Polymeric Drug Delivery Systems
Abstract: AI is cost effective and time efficient process. Artificial intelligence is a method which uses high speed calculation, the improvement regarding algorithm along with collection about biological and chemical features in pharmaceutical exploration and development .Present day because continuous progress towards machine learning (ML),Artificial intelligence an effective statistics analysing technology might have been broadly utilized in drug design .In pharmaceutical exploration and research employ of AI in target identification, compound …
Published in Journal of Polymer & Composites · Vol. 13, Issue 1, 2025 · pp. 1018–1027 Read article
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Biodegradable Polymer Nano Composites for Enhanced Drug Bioavailability
Abstract: Polymer-based nanoparticles have emerged as a revolutionary approach in drug delivery systems, particularly in enhancing the bioavailability of poorly soluble and unstable drugs. These nanoparticles, composed of both natural and synthetic polymers, serve as effective vehicles for encapsulating a wide range of therapeutic agents. Their surface characteristics can also be modified to enable targeted drug delivery, increasing the concentration of drugs at the site of action while minimizing side effects. …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 433–443 Read article
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Drug Resistance in Targeted Cancer Treatment: Clinical Difficulties, Molecular Mechanisms, and Emerging Strategies
Abstract: Targeted cancer therapy, which selectively inhibits the molecular mechanisms responsible for tumor growth and development, has revolutionized modern oncology. Targeted therapies have lower systemic toxicity and better therapeutic efficacy when compared to traditional chemotherapy. However, the emergence of medication resistance often limits the long-term efficacy of these treatments, ultimately resulting in treatment failure and disease progression. Drug resistance develops through a number of intricate biological processes and can be innate …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 17, Issue 1, 2026 · pp. 130–138 Read article
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Kapikacchu (Mucuna pruriens): A Promising Indigenous Herbal Drug and Its Effect on Different Disease Conditions
Abstract: Mucuna pruriens is widely known as “velvet bean,” which originally belongs to eastern part of India and China where it is cultivated as vegetable crop. It has been shown that its seeds are potentially of substantial medicinal importance. Kapikacchu belongs to Fabaceae family and it is widely used for aphrodisiac purpose as well as for Parkinson disease. It has lots of pharmacological properties such as hypoglycemic activity, antioxidant activity, aphrodisiac …
Published in Research and Reviews: A Journal of Toxicology · Vol. 7, Issue 3, 2017 · pp. 1–5 Read article
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Innovations in Tuberculosis Management: Advancements in Drug-Resistant TB Treatment and Rapid Diagnostics
Abstract: Tuberculosis (TB) remains one of the deadliest infectious diseases worldwide, exacerbated by the increasing prevalence of drug-resistant strains, such as multidrug-resistant (MDR-TB) and extensively drug-resistant TB (XDR-TB). Despite advancements in first-line and second-line treatments, resistance to conventional antibiotics has complicated therapeutic strategies, necessitating novel approaches. This mini review explores emerging advancements in TB treatment, including gene editing technologies, such as CRISPR, which offer potential for precise targeting of drug-resistant bacterial …
Published in International Journal of Antibiotics · Vol. 2, Issue 2, 2025 · pp. 1–7 Read article
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Unlocking Potential: Capecitabine’s Evolution as an Anticancer Wonder Drug
Abstract: Capecitabine, a precursor to 5-fluorouracil (5-FU), is Anticancer Drug in treating solid tumors like colorectal, breast, and gastric cancers. Its mechanism involves converting to 5-FU mainly within tumor cells, reducing toxicity while maximizing effectiveness. Besides being effective alone, it is also valuable in combination therapies, showcasing its versatility in cancer treatment. This review explores the transformative journey of capecitabine as a pivotal anticancer drug. Beginning with an introduction to its …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 11, Issue 2, 2024 · pp. 17–24 Read article
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Role of Carboxylesterases in Xenobiotic Metabolism and Detoxification: Insights for Cheminformatics Approaches
Abstract: Xenobiotics, which include a wide range of environmental pollutants, food additives, drugs, and carcinogens, are foreign chemical entities that enter the human body and may accumulate, leading to toxic effects. Phase I and phase II metabolic responses are among the detoxification procedures that are necessary to lessen these negative consequences. This review highlights the pivotal role of carboxylesterases (CES), enzymes involved in the hydrolysis of ester, amide, and thioester bonds …
Published in International Journal of Cheminformatics · Vol. 2, Issue 2, 2024 · pp. 9–17 Read article
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Clone-Specific Drug Delivery Systems: Targeted Approaches and Future Clinical Applications
Abstract: Clone-specific drug delivery systems represent a transformative frontier in personalized medicine, addressing the longstanding challenge of clonal heterogeneity within diseases such as cancer, infectious diseases, and autoimmune disorders. Traditional drug delivery platforms often fail to discriminate between pathogenic and healthy cells, leading to systemic toxicity and reduced therapeutic efficacy. In contrast, clone-specific systems aim to selectively target and eliminate disease-driving cellular clones based on unique molecular signatures, thereby improving treatment …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 12, Issue 2, 2025 · pp. 21–29 Read article
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A Review of Different Polymer and Plasticizers
Abstract: Plasticizer and polymer are essential components in the pharmaceutical industry, especially when creating both cutting-edge and conventional drug delivery systems. The differences between synthetic, semi-synthetic, and all-natural polymers are examined in this review to highlight their diverse qualities and uses. When designing drug delivery systems to target areas, the choice of polymer is crucial. Because of their repeatability and adaptability, synthetic polymers are widely used in the creation of precision …
Published in International Journal of Membranes · Vol. 1, Issue 1, 2024 · pp. 1–7 Read article
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Potential Risk and Benefits in Developing New Nanobot Technologies and Future Posibilities
Abstract: The development of new nanobot technologies has the potential to revolutionize various fields, including medicine, manufacturing, and environmental science. However, as with any emerging technology, there are potential risks and benefits associated with nanobots. This abstract explores the potential risks, including toxicity, unintended consequences, and environmental impact, as well as the potential benefits, such as targeted drug delivery, diagnostic imaging, and tissue engineering. We also discuss the future possibilities of …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 16, Issue 1, 2025 · pp. 87–93 Read article
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A Research Project on Identification and Reporting of Adverse Drug Reactions in General Medicine Ward of an ESI Hospital
Abstract: Aim: The study aims at identifying and reporting the adverse drug reactions (ADRs) in general medicine ward of an ESI hospital, Bangalore, Karnataka, India. Objective: Prescription study, analysis and prevention of medication-related problems (ADRs), identifying and minimizing medication-related problems, improving patient safety initiatives, improving the patient health-related outcomes, reducing work burden of physicians, and providing better therapy to large number of patients. Methodology: Study Design: It was a prospective and …
Published in Research and Reviews: A Journal of Toxicology · Vol. 8, Issue 3, 2018 · pp. 9–14 Read article
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CBD: Wonder Drug of the Future
Abstract: The traditional “wonder drug” in pharmacology is aspirin, well known for its properties of pain control, lowering elevated body temperature, fighting inflammation, and decreasing blood coagulation. Aspirin, as a non-steroidal anti-inflammatory drug (NSAID) is a preventative drug as well as a therapeutic one. The Framingham heart study has concluded that a low dose aspirin regimen (81 mg/day) will help prevent cardiovascular disease and stroke. On the other hand, CBD (cannabidiol) …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 7, Issue 1, 2017 · pp. 1–5 Read article
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Bedaquiline: An In-Depth Exploration into Its Antitubercular Significance
Abstract: Tuberculosis is still a leading infectious disease and a major threat to public health. Although there has been a slow decrease in the incidence over years, its “hard to kill nature” is responsible of about 2 million deaths in HIV infected individuals annually. Bedaquiline, a Diaryl-Quinoline drug was fast-track approved as an orphan drug to combat drug resistance. It shows potent activity against Mycobacterium tuberculosis by interfering with the production …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 12, Issue 2, 2025 · pp. 06–14 Read article
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Exploring Nutool (Irrigation) as A Treatment Method in Ilaj Bit Tad-Beer (Regimenal Therapy)
Abstract: The Unani system of medicine employs four primary modes of treatment: Illaj bil ghiza (dietotherapy), Illaj bil Dawa (pharmacotherapy), Illaj bit tadbeer (Regimenal therapy), and Illaj bil yad (surgery). Illaj bit Tadbeer encompasses a range of regimenal interventions, including Hijamah (cupping), Irsal alaq (leeching), Fasd (venesection), Dalak (massage), Nutool (irrigation), Qay (Emesis), Idrar-i-Bawl (Diuresis), Tariq (Diaphoresis), Munzij and Mu'shil therapy (Concoction and purgation), Bukhoor (medicated steam), kayy (cauterization), Huqna (enema), …
Published in Research & Reviews : A Journal of Unani, Siddha and Homeopathy · Vol. 11, Issue 1, 2024 · pp. 1–6 Read article
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Review: Prodrug Concept in Drug Design
Abstract: AbstractIn the world of drug discovery and development, prodrugs have become a powerful method for improving biopharmaceutical, physicochemical or pharmacokinetic properties of pharmacologically active agents. The purpose of this review is to provide some types of prodrugs which are bioreversible derivatives of drug molecules that undergo an enzymatic and/or chemical transformation in vivo to release the active parent drug, which can then exert the desired pharmacological effect. The target of …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 9, Issue 1, 2018 · pp. 22–28 Read article