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480 articles for “Drug Delivery”
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Controlled Drug Delivery of Furosemides Using Floating Tablet System
Abstract: The development of gastroretentive drug delivery systems (GRDDS) has gained interest, particularly for drugs like furosemide with narrow absorption windows in the upper gastrointestinal (GI) tract. Furosemide, a commonly used diuretic, faces challenges due to limited bioavailability and rapid elimination, requiring frequent dosing and affecting patient compliance. This review highlights the formulation and evaluation of floating furosemide tablets as an effective strategy to enhance therapeutic efficacy. Floating tablets allow prolonged …
Published in International Journal of Membranes · Vol. 2, Issue 1, 2025 · pp. 23–31 Read article
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A Novel Approach of Protein Peptide Drug Delivery System
Abstract: Protein and peptides perform vital functions in body and are essential for life. They show various roles as therapeutic agents in treatment of cancer and diabetes. Various routes are available for the delivery of proteins and peptides such as oral route, transdermal route, pulmonary route, parenteral route, ocular route, nasal route, buccal route. However physicochemical properties of protein and peptides make them challenging for exogenous administration, especially in oral administration. …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 7, Issue 2, 2020 · pp. 44–59 Read article
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Recent Update on Advanced Drug Delivery System
Abstract: Over the past decade, there has been a growing interest in the use of artificial intelligence (AI) technology for analysing and interpreting biological or genetic data, accelerating drug discovery, and identifying selective small-molecule modulators or rare molecules in addition to predicting their behaviour. The use of artificial neural networks (ANNs) for the rapid analysis of massive amounts of data, the development of novel hypotheses and treatment plans, the prediction of …
Published in International Journal of Advance in Molecular Engineering · Vol. 1, Issue 1, 2023 · pp. 22–30 Read article
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Study Review: Molecular Mechanisms of Nanoparticle-Cell Interaction – Implications for Drug Delivery and Toxicity
Abstract: The application of nanoparticles in drug delivery and biomedical therapies holds great promise, yet their interaction with cells and the underlying molecular mechanisms remains areas of active research. This study explores the molecular mechanisms of nanoparticle-cell interactions, focusing on the effects of gold nanoparticles (AuNPs) and silica nanoparticles (SiNPs) in human cancer cell lines (HeLa and MCF-7). The study examines how nanoparticles are internalized by cells, their impact on cellular …
Published in Research and Reviews: A Journal of Toxicology · Vol. 15, Issue 2, 2025 · pp. 31–40 Read article
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Design and Development of Self Microemulsyfying Drug Delivery System of Olmesartan Medoxomil
Abstract: Olmesartan Medoxomil is poorly water soluble drug. It comes into the BCS II drug. Hence oral bioavailability of Olmesartan Medoxomil is less (26%). The purpose of this study is to develop novel dosage form of the self-microemulsifying drug delivery systems (SMEDDS) for the Olmesartan Medoxomil for enhancing its solubility hence the oral bioavailability. Before the formulation of SMEDDS, solubility study was performed in different excipients and select excipients on basis …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 3, Issue 3, 2013 · pp. 1–14 Read article
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Nanoformulation Strategies: Emerging Innovations in Drug Delivery Systems
Abstract: Nanotechnology is significantly advancing the pharmaceutical industry by introducing nanosystems that improve drug delivery, therapeutic efficacy, and patient outcomes. Various nanosystems-such as liposomes, dendrimers, polymeric nanoparticles, solid lipid nanoparticles, carbon nanotubes, and metallic nanoparticles-offer benefits like enhanced bioavailability, targeted delivery, improved stability, and reduced side effects. Innovative formulation strategies, including surface functionalization, particle size optimization, and use of biodegradable carriers, support controlled and sustained drug release. Additionally, production in non-aqueous …
Published in International Journal of Toxins and Toxics · Vol. 3, Issue 1, 2026 · pp. 54–67 Read article
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Synthesis, Characterization and Drug Delivery Application of Poly (Acid Fuchsin) Based Triblock Copolymer
Abstract: Synthesis, characterization and its drug delivery application of Poly (acid fuchsin) (PAF) was done under inert atmosphere. The (M0/I0) was maintained at 100. In order to increase the molecular weight and processability, it was block copolymerized with ε-caprolactone (CL) and tetrahydrofuran (THF) separately. The conductivity value of PAF was found to be decreased after the chemical conjugation with poly(ε-caprolctone) (PCL) and poly(tetrahydrofuran) (PTHF) blocks. Thus obtained triblock copolymer was subjected …
Published in Journal of Catalyst & Catalysis · Vol. 3, Issue 2, 2016 · pp. 33–43 Read article
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A Brief Review On Nanoparticles Drug Delivery System Used In Cervical Cancer
Abstract: Among cervical tumor-related deaths worldwide, cervical cancer is a major cause. The limitations of traditional methods, such as chemotherapy and radiation therapy, stem from their adverse effects and increased susceptibility to medications. Despite being seen as innovative options, immune checkpoint inhibitors (ICIs) have rather low clinical response rates. Reliable treatments for patients with metastatic or recurring cervical cancer are currently lacking. Lately, nanomaterials including polymers, liposomes, and dendrimers have been …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 15, Issue 1, 2025 · pp. 30–40 Read article
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Design and Development of Self Microemulsyfying Drug Delivery System of Olmesartan Medoxomil Smita D Patel*, M R Patel, K R Patel
Abstract: Olmesartan Medoxomil is poorly water soluble drug. It comes into the BCS II drug. Hence oral bioavailability of Olmesartan Medoxomil is less (26%). The purpose of this study is to develop novel dosage form of the self-microemulsifying drug delivery systems (SMEDDS) for the Olmesartan Medoxomil for enhancing its solubility hence the oral bioavailability. Before the formulation of SMEDDS, solubility study was performed in different excipients and select excipients on basis …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 3, Issue 3, 2013 · pp. 1–15 Read article
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Intrapocket Drug Delivery System: A Spatial Tool for Periodontitis
Abstract: Periodontitis is a disease attributable to multiple infectious agents. It results from extension of the inflammatory process initiated in the gingiva to the supporting periodontal tissues. Periodontal pockets provide natural reservoir bathed by gingival crevicular fluid that is easily accessible for the insertion of a delivery device. Intra-pocket, sustained release systems have emerged as a novel paradigm for the future research. Controlled release delivery of antimicrobials is a therapeutic intervention …
Published in Trends in Drug Delivery · Vol. 1, Issue 2, 2014 · pp. 24–29 Read article
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Advanced Local Drug Delivery Approaches for Periodontitis: A Strategic Intervention
Abstract: Periodontal disease, one of the most prevalent oral diseases is caused by the gram negative bacterial infection of periodontal pocket identified by inflammation of subgingival plaque and degeneration of alveolar bones, teeth, dental cementum and periodontal ligaments. 80% of American adult and more than 50% of Indian community suffers from this chronic inflammatory disease depicting the severity of the disease. The objectives of the available therapies are to minimize the …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 9, Issue 1, 2018 · pp. 4–11 Read article
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Personalized Medicines in Pharmaceutics: Drug Delivery System
Abstract: Pharmaceutics personalized medicine is a developing area that seeks to customize medical interventions for specific patients. Instead of a one-size-fits-all approach, personalized medicine focuses on developing treatments that consider a person’s unique characteristics, such as their genetic makeup, environment, and lifestyle. This allows for more effective treatment outcomes, as drugs are specifically designed to work best for each patient, reducing side effects and improving therapeutic results. In pharmaceutics, this involves …
Published in Emerging Trends in Personalized Medicines · Vol. 2, Issue 1, 2025 · pp. 11–22 Read article
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A Review on Gold Nano Particles in Drug Delivery
Abstract: Gold Nano particles are used in several applications like drug transfer and gene etc. due to nontoxic carriers. The gold core imparts stability in these systems. The monolayer tunes the surface properties like charge and hydro-phobicity. Gold Nano particles are widely used in various applications owing to their exclusive visual, chemical and biological properties. Surface Plasmon Resonance is the attractive features of gold Nano particles. Here using the gold Nano …
Published in Trends in Drug Delivery · Vol. 5, Issue 3, 2018 · pp. 31–34 Read article
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Microneedles: A Potential Drug Delivery System for the Treatment of Cancer
Abstract: Hypodermic needles, topical lotions, and transdermal patches are the most common methods for transdermal drug administration. Most medicinal drugs have a limited effect due to the stratum corneum layer of the skin, which acts as a barrier for molecules, allowing only a few molecules to reach the site of action. Microneedles are a novel type of delivery method that helps to improve medication administration through this route while also solving …
Published in Trends in Drug Delivery · Vol. 9, Issue 1, 2022 · pp. 39–61 Read article
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Pluronics®-Cyclodextrin Inclusion Complex for Targeted Drug Delivery System
Abstract: Host–Guest’ inclusion complexes have in Pluronics® and Cyclodextrins (CDs) have an enormous research attraction as drug vehicles. In addition, CDs in Pluronics® solutions has captured much attention for the researchers to develop supramolecular biomaterials by improving the solubility and stability of drugs in aqueous and gel medium by Pluronics®-CDs inclusion complexation. Keywords: Supramolecular, Pluronics®, Cyclodextrins (CDs), Inclusion complex
Published in Trends in Drug Delivery · Vol. 5, Issue 3, 2018 · pp. 1–4 Read article
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Formulation and Evaluation of Transdermal Drug Delivery of Piroxicam
Abstract: The aim of the present study was to formulate transdermal films loaded with Piroxicam (PX). Transdermal films were prepared by using sodium alginate (SA) and xanthan gum (XG) as biopolymers by varying the blend ratios viz., 10:0, 8:2, 6:4, 4:6 and 2:8 (w/w %) through solution casting method. The drug loaded membranes were evaluated for thickness, tensile behaviours, and content uniformity. In-vitro diffusion was determined by Franz diffusion cell. Piroxicam …
Published in Trends in Drug Delivery · Vol. 1, Issue 2, 2014 · pp. 8–13 Read article
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Computer Aided Drug Designing for Targeted Drug Delivery Systems
Abstract: The discovery and development of a contemporary sedate is widely acknowledged as an extremely difficult task that requires significant resources and effort. Therefore, computer-aided medication design techniques are widely utilized today to increase the productivity of the drug discovery and development process. Among structure-based and ligand-based drug design approaches, both recognized for their efficiency in drug discovery and development, various CADD (Computer-Aided Drug Design) techniques are evaluated based on specific …
Published in Trends in Drug Delivery · Vol. 11, Issue 2, 2024 · pp. 34–41 Read article
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Synthesis, Characterization and Drug delivery Application of Poly (Safranine) based triblock copolymer
Abstract: Synthesis, characterization and humidity sensor application of poly(safranin) (PSaf) was carried out under inert atmosphere. The monomer to initiator ratio [M0/I0] was maintained accurately at 100. In order to improve the molecular weight and processability it was block copolymerized with bio-compatible and bio-degradable ε-caprolactone (CL) and water-soluble tetrahydrofuran (THF) separately. Thus, the derived triblock copolymer was subjected to humidity sensor application and the results are viewed in broad approach and …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 9, Issue 2, 2018 · pp. 1–7 Read article
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DESIGN AND EVALUATION OF SANDWICH TABLET FOR SUSTAINED RELEASE DRUG DELIVERY OF DICLOFENAC SODIUM.
Abstract: The objective of this experiment was to create bilayer sandwich pills using the model medication diclofenac. A lengthy duration of action is provided by the combination of an immediate and sustained release layer, which lengthens the effect in the body. Diclofenac sodium has excellent antipyretic, analgesic and anti-inflammatory effects. A super disintegrating carboxyl agent, such as methyl cellulose, is used for the quick release layer of a bilayer sandwich tablet …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 10, Issue 2, 2023 · pp. 1–8 Read article
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Drug Delivery Systems and Innovations
Abstract: The aim of this study was to develop a controlled release system targeting antibiotic distribution to the stomach. The hydrogels were synthesized by utilizing chitosan, poly(acrylic acid) and poly(vinyl pyrrolidone) polymers cross linked with glutaraldehyde and N,N′-methylene bisacrylamide. Interpenetrating polymeric network (IPN) hydrogels were compare by varying the concentration of crosslinking agent (glutaraldehyde). The amount of chitosan, poly(acrylic acid), poly(vinyl pyrrolidone) and N, N’-methylenebisacrylamide were kept constant in all formulations. …
Published in Trends in Drug Delivery · Vol. 2, Issue 1, 2015 · pp. 10–20 Read article