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Research & Reviews: A Journal of Drug Design & Discovery

DESIGN AND EVALUATION OF SANDWICH TABLET FOR SUSTAINED RELEASE DRUG DELIVERY OF DICLOFENAC SODIUM.

  1. JAIMIN B. PATEL
  2. MR. BHAVIN BHIMANI
  3. DR. HIREN KADIKAR
  4. DR. UPENDRA PATEL

Abstract

The objective of this experiment was to create bilayer sandwich pills using the model medication diclofenac. A lengthy duration of action is provided by the combination of an immediate and sustained release layer, which lengthens the effect in the body. Diclofenac sodium has excellent antipyretic, analgesic and anti-inflammatory effects. A super disintegrating carboxyl agent, such as methyl cellulose, is used for the quick release layer of a bilayer sandwich tablet containing diclofenac sodium, and a pH independent polymer, such as HPMC K4M, is used for the maintenance layer. Before and after compression, the tablets were evaluations for a number of factors, including weight fluctuation, thickness, hardness, friability, and in vitro drug release.

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