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634 articles for “B-Cell”
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Anaphylaxis: Pathophysiology, Risk Factors, and Clinical Management
Abstract: Anaphylaxis is a syndrome characterized by broncho-constriction, vasodilatation, and hypovolemia, potentially fatal exposure to known or unknown antigens. It can be an immune-mediated (IgE & non-IgE) disease. Immunoglobulin G (IgG), complement related (C3a/C5a), bradykinin, leukotrienes, prostaglandin E2, and ligands of certain G-protein coupled receptors (GPCR) can directly activate mast cells, basophils, eosinophils, neutrophils, endothelial cells and smooth muscles. Serum tryptase level during episodes of anaphylaxis, skin test, and basophil activation …
Published in Research and Reviews : A Journal of Immunology · Vol. 15, Issue 2, 2025 · pp. 1–11 Read article
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Clone-Specific Drug Delivery Systems: Targeted Approaches and Future Clinical Applications
Abstract: Clone-specific drug delivery systems represent a transformative frontier in personalized medicine, addressing the longstanding challenge of clonal heterogeneity within diseases such as cancer, infectious diseases, and autoimmune disorders. Traditional drug delivery platforms often fail to discriminate between pathogenic and healthy cells, leading to systemic toxicity and reduced therapeutic efficacy. In contrast, clone-specific systems aim to selectively target and eliminate disease-driving cellular clones based on unique molecular signatures, thereby improving treatment …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 12, Issue 2, 2025 · pp. 21–29 Read article
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Exploring the Role of Thin Film Coatings in Solar Energy Harvesting
Abstract: With notable gains in efficiency, longevity, and affordability, thin film coatings have become a key technology in the field of solar energy harvesting. These coatings, typically composed of materials like titanium dioxide (TiO₂), cadmium telluride (CdTe), and amorphous silicon (a-Si), are applied to photovoltaic (PV) cells to enhance their ability to absorb and convert sunlight into electricity. This review article delves into the various types of thin film coatings used …
Published in Journal of Thin Films, Coating Science Technology & Application · Vol. 11, Issue 2, 2024 · pp. 15–19 Read article
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Studying the effects of Exposure to Chemicals on The brain and Nervous System and The risk of Chemical Pollution
Abstract: Scientific research and studies on chemical pollution show that exposure of the brain and nervous system to chemicals causes serious damage ranging from cognitive, motor, and nerve cell disorders to chronic diseases such as Alzheimer's and neurological paralysis. These substances (such as lead ions, mercury, solvents that combine and dissolve easily in the blood, and pesticides) disrupt neurotransmitters and cause cell damage, especially during the early stages of body development. …
Published in International Journal of Brain Sciences · Vol. 3, Issue 1, 2026 Read article
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Performance Improvement of Polymer and Silicon Solar Cells Using Transition Metal Oxide Interfaces
Abstract: Fossil fuels are running out, which is contributing to greenhouse gas emissions and climate change due to the world's growing energy demand. Renewable energy, which is environmentally friendly, is crucial for balancing the demand and supply of energy in our society.The non-traditional energy source with the fastest rate of growth is solar cells, which use photovoltaic technology to convert sunlight into electrical power.Conjugated polymers and large molecules are used in …
Published in Journal of Polymer & Composites · Vol. 12, Issue 5, 2024 · pp. 66–75 Read article
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Pharmacoinformatic Based Screening Of Phytocompound Epigallocatechin Gallate To Identify As A Potential Bcl-2 Inhibitor
Abstract: Objectives: The B-cell lymphoma-2 (Bcl-2) is a protein that is particularly though to be involved in preventing apoptosis. Bcl-2 family members also essential for cancer survival, and its over expression has been linked to tumor genesis, development and resistance to anticancer treatments. The Bcl-2 family of members that inhibit apoptosis is a promising target for the creation of anticancer drugs. Methods: The study was based on computational approach using different …
Published in International Journal of Bioinformatics and Computational Biology Read article
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The Multifaceted Vitamin B6: Metabolism, Cardiovascular Health, Cognition, and Cancer
Abstract: Vitamin B6 is hydrophilic and plays a crucial role in various metabolic processes. It acts as a cofactor in different enzymatic reactions. Vitamin B6 exists in various forms, including pyridoxal 5'-phosphate (PLP), the most active form. Vitamin B6 is essential for amino acid metabolism, such as PLP is essential for transamination, the process of transferring amino groups between amino acids. This is vital for synthesizing non-essential amino acids and breaking …
Published in Research & Reviews : Journal of Food Science & Technology · Vol. 14, Issue 2, 2025 · pp. 33–39 Read article
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Extra Philadelphia in CML Due to Isodicentric 22: A Case Report
Abstract: Introduction: Chronic Myelogenous Leukemia is a malignancy that affects the hematopoietic stems cells (HSC) of the bone marrow, leading to the rapid and continual proliferation of granulocytes and precursor blast cells. This is caused due to a reciprocal translocation that occurs between chromosomes 9 and 22, leading to the formation of derivative 22 also called as Philadelphia (Ph) chromosome. The Ph chromosome then encodes a fusion oncoprotein that functions as …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 14, Issue 3, 2025 · pp. 18–22 Read article
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Modelling and Interpretation of A Novel Battery-Motor amalgamated Thermal Management System using rGO/CO3O4 based Hybrid Nano-composite Coolant for Electric Vehicle Applications
Abstract: Battery and motor have to be given equivalent importance to maintain the lifetime, thermal characteristics, efficiency and safety of Electric Vehicles (EVs). Thermal management of EVs need to be considered for battery and motor because of dynamic loading conditions. This research proposes a novel Battery-Motor Integrated Thermal Management System (BMITMS) for EV applications. An EV assembled with LiFePO4 battery pack and a three-phase induction motor has been considered on this …
Published in Journal of Polymer & Composites · Vol. 13, Issue 4, 2025 · pp. 225–243 Read article
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Overcoming Obstacles to an HIV-1 Cure: Advances in Genome Editing, Immune System Reprogramming, and Viral Reservoir Elimination
Abstract: Human immunodeficiency virus type-1 (HIV-1) continues to represent a major global health challenge despite the remarkable success of antiretroviral therapy (ART). Although ART effectively suppresses viral replication and prolongs survival, it cannot eradicate the virus due to the persistence of long-lived latent reservoirs. In recent years, innovative therapeutic strategies have been explored with the aim of achieving either a functional remission or complete viral elimination. Advances in genome-editing technologies, particularly …
Published in International Journal of Virus Studies · Vol. 3, Issue 2, 2026 Read article
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Comparative Proteomics: From Cell Lines to Clinical Samples
Abstract: Comparative proteomics is a powerful tool for understanding the molecular differences between various biological samples. It entails identifying and measuring proteins in complex biological samples to assess their abundance, modifications, and interactions under various conditions. This approach plays a crucial role in advancing biomedical research, especially in disease understanding, biomarker discovery, and therapeutic development. While cell lines are widely used for proteomic studies due to their controlled environments and reproducibility, …
Published in Research and Reviews : Journal of Computational Biology · Vol. 13, Issue 3, 2024 · pp. 30–34 Read article
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Utilizing circulation-derived cancer cells to evaluate patients with surgically treated stages I–IIIA NSCLC throughout the preoperative phase
Abstract: Context: When a tumor is considered resectable, surgery is viewed as the primary treatment approach for both early-stage and locally advanced non-small cell lung cancer (NSCLC). One of the most exciting areas of cancer research in the past ten years is liquid biopsy, which offers a practical non-invasive method for cancer detection and tracking. Circulating tumor cells (CTCs) have been linked to a worse prognosis and increased chance of relapse …
Published in Research and Reviews : Journal of Surgery · Vol. 13, Issue 3, 2024 · pp. 17–28 Read article
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The Study of Nutritional Requirements and Physiological Changes in Space Station
Abstract: This article focuses on the impact of physiological adaptations to weightlessness on nutrient and food requirements in space. These modifications entail reductions in body water and plasma volume, which affect the cardiovascular and renal systems. Spaceflight poses intricate and predominantly detrimental effects on the human body, spanning both short and long durations. Long-term weightlessness leads to significant issues like muscle atrophy, skeletal deterioration, cardiovascular function deceleration, reduced red blood cell …
Published in International Journal of Nutritions · Vol. 1, Issue 2, 2024 · pp. 7–10 Read article
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Classification and Detection of Brain Tumor using Convolutional Neural Network
Abstract: Tumors are masses created when brain cells multiply uncontrollably. A brain tumor is the medical term for this condition. Brain tumors are a serious and aggressive disease that can lead to a reduced life expectancy. Developing a treatment plan is essential to raising a patient's standard of living. Tumors in different regions of the body are evaluated using a variety of imaging techniques, with MRI pictures being utilized mostly for …
Published in International Journal of Cheminformatics · Vol. 1, Issue 1, 2023 · pp. 8–13 Read article
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Integration of Modular Multilevel Converter Topology in the Design and Control of Hybrid Electric Vehicles
Abstract: A back-to-back modular multilevel converter (BMMC) based plug-in hybrid electric vehicle power conversion system is proposed to solve the problems of traditional MMC-EV. The local AC harmonics generated by the operation of MMC-EV accelerate the battery degradation and reduce the battery life. Currently, electric vehicles are in great demand due to the rising oil prices and environmental pollution concerns. Since the backbone of electric vehicles is the energy storage system, …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 1195–1205 Read article
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Understanding the Corrosion Behaviour of Graphite in Peat Environment for Environmental and Sustainability Applications
Abstract: Graphite, which is one of the most remarkable carbon materials for industrial applications, is a heat exchanger component material in the phosphoric acid industry, bipolar layer or electrode material in vanadium redox flow batteries, electrode material for advanced oxidation processes, electrode material for lead-acid batteries, electrode material in fuel cells and microbial fuel cells, and more interesting, as moderator or core material in nuclear reactors used. Corrosion, one of the …
Published in Journal of Polymer & Composites · Vol. 13, Issue 1, 2025 · pp. 728–737 Read article
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Whispers of the Microbial World: Unveiling Bacterial Dialogues through Quorum Sensing
Abstract: Quorum sensing is a special way of bacteria by which they can regulate their own gene expression as per the population density of the bacteria. It is basically a type of cell-to-cell communication pathway used by the microbes. The signal molecule which helps in this mechanism are called auto inducer(AI). As the mechanism depends by changes in the cell density, so when the cell density reaches to the threshold cell …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 14, Issue 3, 2024 · pp. 1–8 Read article
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Review on the Efficacy of Ayurvedic Formulations in Diabetes Management
Abstract: Diabetes mellitus is one of the most prevalent metabolic disorders globally, characterized by persistent hyperglycemia resulting from defects in insulin secretion, insulin action, or both. It leads to serious complications affecting the cardiovascular, renal, and nervous systems, imposing a significant health and economic burden. In Ayurveda, diabetes is described as Madhumeha, a subtype of Prameha, primarily caused by the vitiation of Kapha dosha, Meda dhatu (fat metabolism), and Agnimandya (impaired …
Published in Research and Reviews : A Journal of Ayurvedic Science, Yoga and Naturopathy · Vol. 13, Issue 1, 2026 · pp. 16–22 Read article
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Mechanical and Physicochemical Characteristics of Nano-Hydroxyapatite Polymer Composites
Abstract: This study focuses on the development and characterization of nano-hydroxyapatite (nHAp)-reinforced poly (lactic acid) (PLA) composites for biomedical applications. The composites, prepared with varying nHAp content (5–25 wt%), were evaluated for their mechanical and physicochemical properties, including tensile strength, Young’s modulus, elongation at break, thermal stability, hydrophilicity, and crystallinity. Results revealed that tensile strength increased significantly with the incorporation of nHAp, reaching a peak of 62 MPa at 15 wt%, …
Published in Journal of Polymer & Composites · Vol. 13, Issue 2, 2025 · pp. 115–125 Read article
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Alcohol, Circadian Glymphatic Dysfunction, and Neurodegenerative Protein Accumulation: An Emerging Concern in the Indian Context
Abstract: Alcohol consumption has long been identified as a major public health issue, yet its deeper and more subtle effects on the human brain are only now coming into sharper focus. Traditional explanations often emphasize direct neuronal damage, but emerging research in neuroscience suggests a more intricate story. Recent findings indicate that alcohol not only harms brain cells but also disrupts the body’s internal biological clock—the circadian rhythm—which plays a critical …
Published in International Journal of Brain Sciences · Vol. 3, Issue 1, 2026 · pp. 1–4 Read article