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1924 articles for “(2” (ranking capped at the first 2,000 matches — narrow the search to see the rest)
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Key Regulatory Requirements and Guidelines for the Registration of a Drug in Canada
Abstract: Drug product registration is an important step in the process of a drug development from raw material to finished product to making it available to the public. Drug regulatory authorities play an important role in this process. Health Canada is the regulatory authority in Canada which manages the drug submission and approval of drug product in Canada. The guidelines from the Food and Drugs Act and Regulations for drug products …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 2, Issue 2, 2015 · pp. 28–37 Read article
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Simultaneous Estimation of Atenolol and Nifedipine to be incorporated in Buccal Patch: Method Development and Validation by UV-Spectrophotometric Approach
Abstract: A simple, precise, accurate and reproducible spectrophotometric method has been developed for the simultaneous estimation of Atenolol and Nifedipine. Atenolol and Nifedipine are used in combined dosage form for cardiovascular diseases. Hence, it is necessary to develop a method to analyze the two drugs simultaneously by UV-spectroscopic method. Simulated salivary fluid of pH 6.8 was used as the medium. Simultaneous equation method was developed as per ICH guidelines. The absorption …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 2, Issue 1, 2015 · pp. 28–32 Read article
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Comparative Evaluation of In Vitro Antioxidant Activity of Bark, Flowers and Fruit Extracts of Pongamia pinnata
Abstract: In Indian history, the use of herbal remedies for various diseases has proved its efficacy. Free radicals are the main cause of disease such as diabetes, hypertension, inflammation, etc. The various parts of plant Pongamia pinnata possess good antioxidant activities. The objective of the study was to determine free radical scavenging activity of various plant parts by in vitro free radical scavenging assay such as DPPH assay, ABTS radical decolorization …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 2, Issue 2, 2015 · pp. 14–21 Read article
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Synthesis, Characterization and Biological Evaluation of Some Novel Phenazine Derivatives
Abstract: Novel phenazine analogues (PZ1‑PZ6) were synthesized, characterized by the spectral analysis and screened for anti-arthritis activity by bovin serum and egg albumin protein denaturation method. The synthetic route involves the equimolar mixture of ortho-phenylenediamine and ammonium persulphate which were dissolved in 1 M HCl to give 2,3-diaminophenazine(I). Different substituted aromatic aldehydes were added to the 2,3-diaminophenazine(I) and dissolved in methanol. The reaction mixture was stirred for 1‑2 h and then …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 6, Issue 3, 2019 · pp. 31–37 Read article
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Quantitative Analysis of Eucalyptus Umbellata Essential Oil Extracts from Microwave Assisted Extraction Through GC-MS
Abstract: Microwave assisted extraction was green technology for extraction of essential oil from natural plants and herbs. Microwave extraction extracted the eucalyptus essential oil from eucalyptus umbellata leaves using microwave heating at atmospheric pressure. The two operating parameters involved in MAE, which was extraction time and microwave power. The extracted oil was analyzed through the gas chromatograph – mass spectrometer, which was used for investigating the composition of eucalyptus umbellata essential …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 2, Issue 2, 2015 · pp. 22–26 Read article
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An Insight to Epidemiology, Diagnosis and Treatment of COVID-19
Abstract: Abstract Since late December, 2019 an outbreak of a novel coronavirus disease was reported in Wuhan, China with severe acute respiratory syndrome (SARS). It is commonly known as COVID-19 means a disease caused by coronavirus and the first case was identified in 2019. The WHO declared the COVID-19 a global pandemic in March, 2020 because it affected more than 100 countries worldwide. In this review we summarize epidemiology, diagnosis and …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 7, Issue 2, 2020 · pp. 13–22 Read article
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Validation and Forced Degradation Studies for the Determination of Erlotinib in Bulk and Pharmaceutical Dosage Forms by RP-HPLC
Abstract: A new reverse phase-high performance liquid chromatography (RP-HPLC) have been developed and validated for the determination of Erlotinib in bulk drug and pharmaceutical dosage form. The developed method is rapid, accurate, precise, simple and economical. The separation was carried out using column Hypersil ODS C-18 (150 mm x 4.6 mm 5 μm particle size) in isocratic mode, using mobile phase composition of 0.1% orthophosphoric acid: Acetonitrile in the ratio of …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 3, Issue 2, 2016 · pp. 44–53 Read article
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A Brief Review on Novel (COVID-19) Corona Virus and Its Management – The Global Pandemic Situation
Abstract: AbstractCOVID -19 is a respiratory disease that is contagious, first detected in china and worldwide spread in December 2019. The novel (new) coronavirus (nCoV) coronavirus disease 2019, or COVID-19 that cause illness ranging from the common cold to more severe diseases such as Middle East Respiratory Syndrome (MERS-CoV) and Severe Acute Respiratory Syndrome(SARS-CoV). A novel coronavirus is a new strain that has not been previously identified in humans. Genus Coronaviruses …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 7, Issue 2, 2020 · pp. 1–7 Read article
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Development and Validation of an Analytical Method for Determination of Modafinil in Bulk and Formulations using First Order Derivative UV Spectrophotometer
Abstract: Analytical method validation is an important tool to determine the absolute concentration of drug in the formulation. In the case where a drug is not able to produce characteristic peak shape, a simple, accurate, precise and sensitive method, which will be governed through the software conversion of UV spectra into the first-order derivative, can be used as an alternative method for the estimation of modafinil in bulk and pharmaceutical dosage …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 6, Issue 3, 2019 · pp. 23–29 Read article
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Determination of the Antidiabetic Drug Miglitol in Pharmaceuticals by Ultra-Performance Liquid Chromatography
Abstract: Miglitol (MGL) is a drug used in the treatment of type-2 diabetes mellitus. A new analytical method employing ultra-performance liquid chromatography (UPLC) with UV-detection is presented for the determination of MGL in bulk drug and tablet forms. Analysis was performed in less than 3 min in isocratic mode on a reversed phase BEH C18 (100 mm × 2.1 mm; 1.7 µm particle size) column using phosphate buffer of pH 3.7-acetonitrile …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 9, Issue 2, 2018 · pp. 11–26 Read article
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A Comprehensive Review on Phytochemical and Pharmacological Aspects of Ailanthus Excelsa (Maha-Neem)
Abstract: *Author for CorrespondencePardeep ChauhanE-mail: chpardeep777@gmail.com Reseacher, Department of Pharmacy, Alwar Pharmacy College, MIA, Alwar, Rajasthan, India Received Date: March 07, 2022Accepted Date: April 25, 2022Published Date: April 30, 2022 Citation: Pardeep Chauhan, Praveen Kumar Goyal, G. Jeyabalan. A Comprehensive Review on Phytochemical and Pharmacological Aspects of Ailanthus Excelsa (Maha-Neem). Research & Reviews: A Journal of Pharmacology. 2022; 12(1): 19–27p.Ailanthus excelsa Roxb., a member of Simaroubaceae family known as Maha-Neem. Traditional …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 12, Issue 1, 2022 · pp. 19–27 Read article
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A STUDY ON IMPACT AND OUTCOMES OF PHARMACOVIGILANCE AND ITS IMPLICATIONS, PRACTICES OVER ADR IDENTIFICATION, REPORTING AND MONITORING IN PROMOTION OF RATIONAL DRUG USAGE.
Abstract: The present study reports on impact of pharmacovigilance and drug safety monitoring practices in promotion of rational drug usage in General Medicine Department of ESI hospital with an objective of identification and reporting of adverse drug reactions. It is a prospective, observational study & was conducted for a period period of 8 months from Jan 2022 to Aug 2022. A sample size of 126 patients were randomly opted for this …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 12, Issue 3, 2022 · pp. 8–27 Read article
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Assessment of Alcohol Abuse and Associated Factors among Other Health Science Students of Jimma University, South West Ethiopia
Abstract: Background: The World Health Organization (WHO) estimates that there are about 140 million people with alcohol abuse worldwide and almost about 50 percentage of men and 75 percentage women do not consume alcohol. The mechanisms that causes alcohol abuse are 50–60 percentage genetically influence and 40–50 percentage environmental factors.Objective: The present study aims to assess alcohol abuse and associated factors among health science student of Jimma University, Ethiopia.Methods: A cross …
Published in Trends in Drug Delivery · Vol. 4, Issue 2, 2017 · pp. 1–10 Read article
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Development and Validation of Spectrophotometric and Colorimetric Method for the Determination of Ritonavir in its Bulk and Pharmaceutical Dosage Form
Abstract: A straightforward, exact, precise and sensitive UV spectrophotometric assay technique and a basic and sensitive colorimetric assay method have been created and validated for the quantitative estimation of Ritonavir from bulk drug and tablet formulations. UV spectrophotometric strategy which includes the assurance of Ritonavir in bulk medication and pharmaceutical dosage forms and has an assimilation greatest at 240 nm in methanol. The Beer's law was obeyed over the concentration range …
Published in Trends in Drug Delivery · Vol. 4, Issue 3, 2017 · pp. 32–41 Read article
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Formulation and Characterization of Mesoporous Nanoparticulate Drug Delivery Platform
Abstract: The aim of this study was to synthesize and characterize mesoporous silica nanoparticles, namely, SBA-15 (Santa Barbara Amorphous) and MCM-41 (Mobile Crystalline Material) as a drug delivery platform. These MSNs have been synthesized using triblock copolymer F 127, cetyl trimethyl ammonium bromide (CTAB) as a co-surfactant and tetraethyl orthosilicate (TEOS) as a silica precursor. The synthesized MSNs were characterized by scanning electron microscopy (SEM), powder X-ray diffraction (PXRD), particle size …
Published in Trends in Drug Delivery · Vol. 2, Issue 1, 2015 · pp. 21–27 Read article
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Computer Simulations on Magnetic Particles Capturing in an Implant Assisted Channel for Targeted Drug Delivery
Abstract: In this paper, we studied the effect of magnetic field, inlet velocity and particle size on capture efficiency of magnetic particles transported in an implant assisted uniform channel through computational simulations. The dominant magnetic and drag forces are included in the simulations. The couple nonlinear Navier-Stokes equation for fluid flow and Newton’s second law equation for particle transport are solved using finite element based COMSOL multiphysics software. It is found …
Published in Trends in Drug Delivery · Vol. 2, Issue 2, 2015 · pp. 1–7 Read article
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Clinical Evaluation of Vaginal Contraceptive Cream of Sapindus mukorossi, CONSAP: A Pilot Study
Abstract: Sapindus mukorossi also known as reetha is well known herb in ancient Ayurveda. The fruits of this herb contain saponins which showed excellent spermicidal activity in vitro and in vivo animal experiments. The formulation in the form of cream was prepared for human application. The safety and tolerability pilot clinical study was organized. The aim of the present study was to evaluate the contraceptive safety and efficacy of 2.5% cream …
Published in Trends in Drug Delivery · Vol. 2, Issue 3, 2015 · pp. 22–24 Read article
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New RP-HPLC Method Development and Validation for Simultanious Estimation and Forced Degradation Studies of Gallic acid and Curcumin in Solid Dosage Form
Abstract: Objective: A New method was established for simultaneous estimation of Gallic acid and curcumin by RP-HPLC method. Methods: Chromatographic separations were performed on an Inspire (4.6 x 150mm, 5m) column with a mobile phase composition of 0.1 percent OPA buffer and Acetonitrile (30:70) delivered at a flow rate of 1 ml/min, and detection was performed on a waters HPLC auto sampler, separation module 2695 with PDA detector 2996 at wavelength …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 13, Issue 1, 2022 · pp. 7–15 Read article
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Antidiabetic Activity of Triazole Derivatives: A Review
Abstract: Triazoles are the most commonly synthesized nitrogen containing hetero cyclic compounds which have a numerous biological activity viz. antifungal, antimicrobial, anthelmintic, anticancer, anti-tubercular and antiviral activities. They are 5-membered hetero ring structure containing nitrogen as heteroatom at 3 positions. Over a decade, studies are being focused on the anti-diabetic activity of 1,2,3-triazole and 1,2,4-triazole derivatives. Diabetes mellitus is a disorder in which the body doesn't produce enough insulin or does …
Published in Trends in Drug Delivery · Vol. 9, Issue 1, 2022 · pp. 1–20 Read article
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A Descriptive Study to Assess the Knowledge Attitude, Practice and Concerns Regarding Covid 19 Vaccine and its Information Sources Among General Population of Urban Health Centre of SGRD Hospital, Sri Amritsar
Abstract: The SARS CoV-2 virus, which causes the acute respiratory illness coronavirus disease 2019, was initially discovered in late 2019 in Wuhan, China. The disease then spread quickly throughout the nation, and later the entire world had to suffer and expend extra effort by putting various measures in place to manage and avoid the COVID-19 pandemic. 100 participants were recruited for a descriptive study. Data and a socio-demographic profile were used …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 14, Issue 2, 2023 · pp. 42–51 Read article