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1953 articles for “phosphoinositol-3-kinase pathway” (ranking capped at the first 2,000 matches — narrow the search to see the rest)
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Deciphering the Pathophysiology of Migraine: Understanding Trigeminovascular System Activity and the Importance of the Gut-Brain Axis
Abstract: Migraine, a prevalent and disabling neurological condition, manifests in distinct phases: premonitory, aura, headache, postdrome, and interictal. Being a primary contributor to adult disability, it presents a substantial economic challenge on a global scale. Even with extensive research spanning centuries, the complete grasp of its root causes continues to evade us. This intricate neurovascular disorder primarily involves local vasodilation of intracranial and extracerebral blood vessels, coupled with simultaneous stimulation of …
Published in International Journal of Molecular Biotechnological Research · Vol. 2, Issue 1, 2024 · pp. 50–61 Read article
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Lived Experience of Married Middle-aged Women Regarding Marital Satisfaction
Abstract: Introduction: Marital satisfaction is a significant contributor to general sense of happiness. A fulfilling marital relationship meets the intimacy requirements of both partners and contributes to their overall physical and mental well-being. However, elderly couples in today's era face new challenges associated with prolonged longevity. A study was conducted to explore the lived experience of marital satisfaction among married middle-aged women in selected community in Kannur. Objective of study was …
Published in International Journal of Women's Health Nursing And Practices · Vol. 2, Issue 1, 2024 · pp. 47–51 Read article
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Knowledge Regarding Various Government Child Health Schemes Among Mothers in Kerala: A Descriptive Study
Abstract: The study was conducted to check the knowledge regarding child health schemes among mothers of children who were attending pediatric outpatient department of Institute of Maternal and Child Health. The primary aim of the research was to evaluate mothers' understanding of child health programs, explore the relationship between their knowledge and various sociodemographic factors, and develop an informational booklet on child health schemes. The study involved 250 mothers, who were …
Published in International Journal of Evidence Based Nursing And Practices · Vol. 2, Issue 1, 2024 · pp. 1–6 Read article
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Assessment of Knowledge Regarding Venous Thromboembolism Prophylaxis Among Staff Nurses at Intensive Care Units in a Selected Hospital in Palakkad
Abstract: The present study was conducted to assess the knowledge regarding venous thromboembolism prophylaxis among staff nurses in intensive care units in a selected hospital in Palakkad. The objectives of the study were to assess the knowledge regarding venous thromboembolism prophylaxis among staff nurses in intensive care units, and to associate nurses’ knowledge regarding venous thromboembolism prophylaxis with sociodemographic variables. A quantitative, nonexperimental descriptive exploratory research design was selected. Thirty samples …
Published in International Journal of Emergency and Trauma Nursing and Practices · Vol. 2, Issue 1, 2024 · pp. 14–21 Read article
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A Simplistic Review of the Soundex Algorithm: The Magic of Phonetics
Abstract: As a human, we always make mistakes while pronouncing words, names, and terms that sound alike. As a result of which those spellings are difficult to identify. To simplify this problem, we have discussed an algorithm called Soundex algorithm which provides a solution to pronunciation problems by giving a similar code with 1-letter and 3-digit code as a syntactical solution to all terms that sound alike. In this study, we …
Published in International Journal of Algorithms Design and Analysis Review · Vol. 2, Issue 1, 2024 · pp. 1–8 Read article
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Human Deep Skin Surface Vibration Frequency Detection from CT and DT Signals Using Genetic Algorithms
Abstract: To diagnose respiratory problems early on, a contactless, non-invasive, real-time assessment of human vibration is a crucial prerequisite. Optoelectronic plethysmography (OEP) and the forced oscillation technique (FOT), are two widely utilized methodologies, depending on variations in each patient’s local chest impedance. Calibration of the devices before each measurement is hence the primary problem of these approaches. This report presents a simulation-based analysis to assess the effectiveness of the CT and …
Published in International Journal of Algorithms Design and Analysis Review · Vol. 2, Issue 1, 2024 · pp. 9–16 Read article
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Concern for Public Health: Periodontitis
Abstract: Periodontitis, a severe form of gum disease, erodes the bone that supports teeth and results in tooth loss. It is caused by bacterial infection and inflammation of the soft tissues around the teeth. About 70% of people 65 years of age and older are affected, on average. Red, bleeding, sensitive gums, foul breath, and receding gums are hallmark indications. Depending on the severity, a full dental examination, the insertion of …
Published in Research and Reviews: A Journal of Dentistry · Vol. 15, Issue 1, 2024 · pp. 22–26 Read article
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Review on to Design High Speed and Area Three Oprend Binary Adder Using MDCLCG Architecture
Abstract: The three operands binary adder is a basic function used in the creation of modular arithmetic in various algorithms, such as the pseudorandom bit generator and cryptography. The CS3A carry save adder is commonly used to perform this operation. Nevertheless, the operation's outcome delayed the transmission of O(n) because of the ripple carry step. A dual-optoic adder for parallel prefix computation, such as the Han-Carlson method, can be used to …
Published in Journal of VLSI Design Tools and Technology · Vol. 14, Issue 1, 2024 · pp. 14–22 Read article
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The Effects of Energy Consumption on the Turning Process for Various Work-Piece Materials
Abstract: The study modified its goal to energy-intensive titanium alloys, contrasting traditional and high-speed machining processes. According to the study, a solution is needed to reduce or optimize energy use. So, a machined component energy footprint model was created. Several cutting speeds were used to calculate (k). Material removal rates were compared to cutting speeds for a range of materials and levels of detail. A strategy for selecting optimal cutting conditions …
Published in Journal of Polymer & Composites · Vol. 12, Issue 4, 2024 · pp. 54–65 Read article
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The Impact of Climate Change on Infectious Diseases: Potential Risks and Mitigation Strategies
Abstract: As we confront the pressing challenge of climate change, it's vital to recognize its intertwined connection with infectious diseases. We must now navigate a future that combines strong public health interventions, environmental stewardship, and strong policy actions as we stand at the crossroads of crises. In an attempt to lessen the drastic effects of climate change on the dynamics of disease transmission, this study identifies potential risks and creative solutions. …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 13, Issue 2, 2024 · pp. 21–32 Read article
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Oxadiazole Derivatives Recent Progress in Synthesis and Bioactivity
Abstract: Over the past few decades, significant advancements have been made in the development of heterocyclic derivatives, leading to the production of numerous novel agents, both synthetic and natural in origin. Because of its numerous biological properties, including antibacterial, antiviral, and antifungal properties, thiazole is a special five-membered heterocyclic motif among heterocyclic compounds. It is utilized as a fundamental building block in many pharmaceutically significant compounds. To the best of our …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 15, Issue 1, 2024 · pp. 62–67 Read article
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Effect of Tilt Angle on the Performance of Solar Photovoltaic Power Plant – A Quantitative Approach
Abstract: Solar photovoltaic systems have now become integral part of Indian as well as global power systems. Rooftop and ground mounted solar systems have become very popular across India these days. The ground mounted systems produce large scale power and hence, are used for industrial applications also. This paper presents a detailed analysis of a 100-kW solar photovoltaic system with the different tilt angles taken into consideration for orientation of solar …
Published in Journal of Power Electronics and Power Systems · Vol. 14, Issue 1, 2024 · pp. 12–17 Read article
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A Surgical Exploration of the Mechanism and Regulation of the Respiratory System: A Conceptual Analysis
Abstract: The respiratory system plays a vital role in facilitating the movement of air in and out of the body, comprising a complex network of anatomical pathways. It is conventionally divided into two primary sections: the upper respiratory tract and the lower respiratory tract. Within the upper respiratory tract lie structures extending from the nasal passages down to the vocal cords, crucial for phonation. These vocal cords, composed of mucous membrane …
Published in Research and Reviews : Journal of Surgery · Vol. 13, Issue 1, 2024 · pp. 56–63 Read article
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Computational Exploration of Bhrijraj-derived Phytochemicals as Potential Anti-inflammatory Agents: A Molecular Docking Study with Cyclooxygenase-II Complex
Abstract: The molecular docking analysis was meticulously conducted using state-of-the-art computational tools, notably Chimera and Python. These tools were employed to unravel the complex interactions between the identified phytochemicals from Bhrijraj and the target protein, COX-II. The 3D structures of the phytochemicals were prepared with precision using ChemSketch, ensuring accuracy in the subsequent molecular docking simulations. This rigorous approach enhances the reliability and validity of the findings. This research aims to …
Published in Research and Reviews : Journal of Computational Biology · Vol. 13, Issue 1, 2024 · pp. 31–37 Read article
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Lignin-modified bitumen: Exploring characteristics and performance
Abstract: The surge in crude oil prices has sparked interest in finding efficient and cost-effective alternatives to bitumen, a binder used in road pavement. Bitumen, derived from crude oil distillation or natural deposits, is primarily utilized in pavement grade bitumen, accounting for 83% of its usage. However, traditional hot mix asphalt, which relies heavily on bitumen, emits significant amounts of CO2, CH4, and N2O, contributing to environmental concerns. To address these …
Published in Journal of Petroleum Engineering & Technology · Vol. 14, Issue 1, 2024 · pp. 24–30 Read article
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Design and Fabrication of Tapered Optical Fiber Related Devices
Abstract: By joining conical single-mode fibers, a Mach-Zehnder interferometer with a refractive index (RI) sensor was produced. Sensors were made directly from conical SMFs using a Vytran engine. Compared to the single-taper sensor, the dual-taper sensor turned out to be more efficient. With a 10mm gap between the two taper sites in the dual-taper sensor arrangement, the RI fluctuation was quite noticeable. The principles underlying the design and fabrication of tapered …
Published in Trends in Opto-electro & Optical Communication · Vol. 14, Issue 1, 2024 · pp. 1–7 Read article
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Water reservoir engineering and management
Abstract: This work aims to develop a practical system to store water in times of abundance and reuse it in times of scarcity. The proposed system uses natural caves, caverns, or empty underground spaces from mining or oil or gas extraction to store water. The geological structure of the water reservoir should be a non-porous substrate to avoid leakage. Water collection comes from dam discharge during thaw times or river flooding, …
Published in Journal of Water Resource Engineering and Management · Vol. 11, Issue 1, 2024 · pp. 1–12 Read article
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A simple analytical theory for the preliminary structural design of submarine
Abstract: An Underwater Vehicle (UV) is designed to function underwater and range from an Autonomous UV to a submarine. The main difficulty that UV designers face is minimizing the weight of the pressure hull to maximize payload and propulsion velocity while reducing construction cost and time by employing appropriate material and design approaches. Herein, we examine applications geared toward submarines as well as the creation and development of an analytical model …
Published in Journal of Offshore Structure and Technology · Vol. 11, Issue 1, 2024 · pp. 1–11 Read article
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In Situ Investigation of Hemidesmus indicus Phytocompound Extracts as a Therapeutic Target for Acute Myeloid Leukemia
Abstract: Objective: Acute myeloid leukemia (AML) is an apoptotic condition in the hematopoietic system induced by the differentiation and maturation of stem cells into erythrocytes, and leukemic cell proliferation is suppressed as the PI3K-Akt-mTOR pathway is pharmacologically targeted with certain inhibitors. As a result, in silico molecular docking of compounds against AML receptors, CTMP, was used in computational research on Hemidesmus indicus to uncover therapeutic phytochemicals for AML. Thus, this study …
Published in Research and Reviews : Journal of Computational Biology · Vol. 13, Issue 1, 2024 · pp. 38–53 Read article
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Revolutionizing Agriculture: Botani Scan’s Deep Learning for Plant Disease Diagnosis
Abstract: Crop disease detection is of key importance because of its role in food safety but infrastructural issues still hamper diagnosis in most regions worldwide. Accurate plant disease identification is essential to secure food, predicting yield decline and managing epidemic outbursts. The advent of digital cameras along with the progress of computer vision technology brings to light the mounting demands for the development of automated disease detection methods in precision agriculture, …
Published in Journal of Telecommunication, Switching Systems and Networks · Vol. 11, Issue 1, 2024 Read article