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1073 articles for “guide”
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Advanced x-Ray Analysis for Less-Crystalline and Complex Materials
Abstract: An effort to manufacture materials with the least and precise radar signature for stealth and controlled guidance respectively, essentially uses advanced techniques to characterize materials, for detecting crystal confinement in still smaller volumes, to estimate entity sizes, unwanted noise and structure factors. Raison d’etre for selection of advanced and special materials with less crystallinity, combined with precise control over weathering, to minimize crystal developments, for acquiring stealth and targeting with …
Published in Research & Reviews : Journal of Space Science & Technology · Vol. 11, Issue 2, 2022 · pp. 1–6 Read article
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Design & Implementation of Radar for Air Defence Security & Surveillance System
Abstract: With increasing threat from different countries, India must develop a strong defensive barrier againstthem. The emerging technology in war ammunition makes us one of the most well-armed countries in the world.One of the most used weapons is missiles, which were extensively developed under the guidance of Dr. APJAbdul Kalam, the architect of IGMDP (Integrated Missile Development Program). Whatever may be thetechnology it is appreciated only when human loss is avoided. …
Published in Research & Reviews : Journal of Space Science & Technology · Vol. 12, Issue 3, 2023 · pp. 16–22 Read article
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Introduction of Mathematical Method Use by Statistics
Abstract: In this review article is the first sequence of medical statistics guidelines that will be use such examples from the intensive care. This is a chance to become familiar with the information even while searching for abnormally high or low values, checking the assumptions of normality for analytical techniques, and selecting the most appropriate way to characterize the information if required. It describes and demonstrates the qualitative information and quantitative …
Published in Research & Reviews : Journal of Statistics · Vol. 11, Issue 1, 2022 · pp. 10–12 Read article
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Ethical Issues on Radioactive Disposals
Abstract: Radioactive waste disposal is a complex and ethically challenging issue that demands careful consideration of its potential impacts on human health, the environment, and future generations. This abstract explores the key ethical concerns associated with radioactive waste disposal. It highlights the principles of intergenerational equity, environmental protection, informed consent, safety, and fairness in distributing benefits and burdens. Additionally, it emphasizes the importance of long-term stewardship, alternative waste management methods, international …
Published in Research & Reviews : Journal of Physics · Vol. 12, Issue 2, 2023 · pp. 1–8 Read article
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Post Approval Life Cycle Management of Variations for Generic Drugs in Brazil
Abstract: Changes or variations in respect of any information concerning the registered or approved drug products, including information on the formulation of the registered/listed goods or other aspects of their manufacture, and the labeling of the goods, shall forthwith be notified to the agency and the change or variation shall not be implemented until approved by the agency. Changes occurs to have business continuity, if any quality problem arises, to maintain …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 4, Issue 3, 2017 · pp. 37–42 Read article
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Overview of Regulatory Scenario on Switch Mechanism for Over The Counter class in European Countries, and Assessing its Effectiveness on Self-Care Management
Abstract: Short term self-medication has tremendous power in lowering the burden of medical practitioners. Responsible self-care allows everyone to maintain their healthcare status with limited involvement in obtaining guidance from other health care practitioners such as pharmacists, etc. Although most of the EU countries have adopted to formal procedure of switch to change the class from Rx to OTC category, still there are chances to harmonize the mechanism of switch process …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 4, Issue 2, 2017 · pp. 17–23 Read article
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Method, Development and Validation of Emtricitabine and Tenofovir by Using RP-HPLC in Pharmaceutical Dosage Forms
Abstract: A new method was established for simultaneous estimation of Emtricitabine and Tenofovir by RP-HPLC method. The chromatographic conditions were successfully developed for these parathions of Emtricitabine and Tenofovir by using Xterra C185 µm (4.6*250 mm) column, flowrate was1ml/min, mobile phase ratio was phosphate buffer (0.05 M) pH4.6: CAN (55:45% v/v) (pH was adjusted with ortho-phosphoric acid), detection wavelength was 255nm. Theretentiontimewas2.399and3.907 min. for Emtricitabine and Tenofovir, respectively. The percentage purity …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 5, Issue 1, 2018 · pp. 37–41 Read article
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Analytical Method Development and Validation for the Simultaneous Estimation of Elvitegravir and Cobicistat by RP-HPLC Method
Abstract: A new method was established for simultaneous estimation of Elvetigravir and Cobicistat by RP-HPLC method. The chromatographic conditions were successfully developed for the separation of Elvetigravir and Cobicistat by using Xterra C18 5 µm (4.6×150 mm) column, flow rate was 1 ml/min, mobile phase ratio was phosphate buffer (0.05 M) pH 7: MEOH (30:70%v/v) (pH was adjusted with orthophosphoric acid), and the detection wave length was 270 nm. The instrument …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 5, Issue 2, 2018 · pp. 1–6 Read article
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Determination of RP-HPLC Method for Safinamide: Its Bulk and Tablet Dosage Form
Abstract: A new method was established for estimation of Safinamide by RP-HPLC method. The chromatographic conditions were successfully developed for the separation of Safinamide by using Agilent C18 column (4.6×150 mm, 5 µ); flow rate was 1 ml/min, mobile phase ratio was Methnol, Acetonitril (60:40), pH 3 (pH was adjusted with orthophosphoric acid), detection wavelength was 235 nm. The instrument used was WATERS HPLC Auto Sampler, Separation module 2695, photo diode …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 5, Issue 3, 2018 · pp. 1–6 Read article
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Drug Approval Procedure in India (CDSCO)
Abstract: A regulatory process, by which a person/organization/sponsor/innovator gets sanction to launch a drug in the market, is kenned as drug approbation process. In general, a drug approbation process comprises of sundry stages: application to conduct clinical tribulations (CT), conducting clinical tribulations, application to marketing sanction (MA) of drug and post-marketing studies (PMS). Every country has its own regulatory ascendancy, which is responsible to enforce the rules and regulations and issue …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 2, Issue 2, 2015 · pp. 20–26 Read article
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Self-Nanoemulsifying Drug Delivery System for Atorvastatin Calcium: Design, Optimization and Evaluation
Abstract: Atorvastatin calcium (ATC) is the choice of drug in the treatment of moderate to severe hypercholesterolemia. In the current study, ATC self-nanoemulsifying drug delivery systems (SNEDDS) were prepared in an attempt to improve the bioavailability by enhancing its solubility. The solubility of ATC in various oils, surfactants, and co-surfactants were determined. Based on their solubility, Capmul MCM (oil), Tween 20 (surfactant), propylene glycol (Co-surfactant) was selected for preparation of SNEDDS. …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 2, Issue 2, 2015 · pp. 27–36 Read article
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Pharmacognostic Study of Callistemon viminalis (Sol. ex Gaertn.) Byrnes Bark
Abstract: Callistemon viminalis is an evergreen tree native to Australia having a wide history of traditional uses in various folklore medicinal practices. Traditionally it is used for the treatment of gastroenteritis, diarrhea, infections of urinary tract and skin. The present study includes micromarphological and physicochemical examinations on the bark of Callistemon viminalis (Sol. ex Gaertn.) Byrnes. The shade dried bark was studied as per the guidelines of the World Health Organization. …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 5, Issue 3, 2018 · pp. 11–17 Read article
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Development and Validation of a Gradient RP-HPLC Method for Quantitative Determination of Potential Manufacturing Impurities in New Drug Apronalide and Pharmaceutical Formulations
Abstract: Three impurities in apronalide drug substance were detected and quantified using a simple isocratic reverse phase HPLC method. The chromatographic separation was achieved on a Thermo Hypersil gold-CN, 100 A0 5 µm, and 250X4.6 mm using a mobile phase consisting of phosphate buffer (pH-4.6) - Methanol with UV detection at 210 nm and flow rate of 0.8 ml/min. The column temperature was maintained at 250C throughout the analysis. This method …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 1, Issue 1, 2014 · pp. 1–10 Read article
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Drug Product Registration in US, EUROPE, JAPAN and CANADA for New Drug and Generics
Abstract: Getting a marketing approval includes various junctures such as getting drug substances from approved vendors, finished product development, clinical studies, plant inspection, dossier writing and finally submission to authorities. US, Europe, Japan and Canada are the countries which are regulated for the approval of pharmaceutical products. These countries follow the ICH guidelines for the registration of drug of drug product. But each country has different type of application for the …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 1, Issue 3, 2014 · pp. 1–7 Read article
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Drug Product Registration and Regulatory Requirements in Australia (TGA)
Abstract: The present study aims to understand the drug product regulatory requirements and drug product registration process in Australia. Therapeutic Goods Administration (TGA) is the regulatory authority for Australia and is responsible for regulating medicines and medical devices. However, as known, each country has its own regulatory agency to enforce the rules and regulate the guidelines to market a drug substance and drug product. To get authorization of marketing of drug …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 2, Issue 1, 2015 · pp. 7–15 Read article
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In Vitro–In Vivo Correlation (IVIVC): A Strategic Tool in Drug Product Development
Abstract: In a recent era many concepts are dealing as an emerging tool for the drug delivery application like Biopharmaceutical Classification System (BCS), In vitro and In vivo study, and Bioavailability/Bioequivalence (BA/BE) study etc. To determine Therapeutic efficiency in vitro is not enough so the concept of In vitro-In vivo correlation (IVIVC) is playing as an convincing correlation with this for concept of pharmaceutical dosage forms have been a main focus …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 3, Issue 3, 2016 · pp. 31–54 Read article
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Identification and Standardization of Crude Drugs according to Ayurvedic and Modern Parameters
Abstract: Medicinal plants constitute a source of raw material for both traditional system of medicine and modern medicine. Now plant materials are employed throughout the pharmaceuticals industries, developing world as home remedies and ingredients for the industry. Standardization of herbal drugs in this globalization phase of Ayurveda bears utmost significance because this can sustain the tremendous interest that Ayurveda is witnessing across the globe. The increased use of herbal drugs and …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 4, Issue 1, 2017 · pp. 11–16 Read article
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HPTLC Method Development and Validation of Genistein and Daidzein Estimation in Mucuna cochinchinensis Seed Extracts
Abstract: Aim: The current study was designed with the objective to estimate the concentration of Genistein and Daidzein in ethyl acetate extract of Mucuna cochinchinensis by high-performance thin-layer chromatography (HPTLC).Methods: The separation of bioactive compounds was performed using mobile phase, Toluene: n-Butanol: Glacial Acetic Acid: Water (1:4:2:2) and detected at wavelength 254 nm. The method was validated for linearity, accuracy, precision, limit of detection (LOD) and limit of quantification (LOQ) by …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 7, Issue 1, 2020 · pp. 16–25 Read article
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Spectroscopic and Chromatographic Methods for Estimation of Voriconazole in Bulk and Pharmaceutical Dosage Forms
Abstract: Rapid, accurate and precise methods have been developed for estimation of voriconazole in bulk and pharmaceutical dosage forms using Ultraviolet (UV) spectroscopy and reverse phase high performance chromatography (RP-HPLC). The λmax selected in UV spectroscopy method was 255 nm and the calibration curve was linear in the concentration range of 2-50 µg/mL with correlation coefficient (r2)>0.99. In RP-HPLC method, the separation was carried out on Kromasil C18 (250 x 4.6mm, …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 8, Issue 1, 2023 · pp. 33–39 Read article
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A Review on Treatments of Gout for Future Aspects
Abstract: Gout is the most common inflammatory arthritis in adults, and is caused by excess uric acid pools in the body, which leads to the formation of monosodium urate (MSU) crystals and their deposition in and around joints where they induce inflammation, leading to acute gout attacks. The extreme inflammatory burden and pain of an acute gout attack can be unbearable. The prevalence of gout appears to be increasing and may …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 8, Issue 3, 2017 · pp. 1–6 Read article