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136 articles for “treatment-resistant”
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Comprehensive Review of Adenoid Cystic Carcinoma: Pathogenesis, Diagnosis, and Emerging Therapeutic Approaches
Abstract: Adenoid cystic carcinoma (ACC)is an infrequent neoplasm, highly malignant, that develops mainly in the salivary glands with the potential to exist in any secretory glandular sites, including the lacrimal glands, breast, and respiratory tract. ACC usually has a benign initial course, but conversely, it is notoriously aggressive in behavior with high incidence of perineural invasion, local recurrence, and distant metastasis, mostly to the lungs. The tumor’s molecular features are characterized …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 14, Issue 3, 2025 · pp. 1–17 Read article
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Aloe vera: A Review on Its Medicinal Importance
Abstract: Today, one of the main causes of human infection is the antibiotic resistance of bacteria due to the use of antibiotics which causes the emergence and spread of antibiotic-resistant bacterial strains. The search for the discovery of healthy and effective antimicrobial agents continues. Aloe vera can be used for both therapeutic and preventive purposes in the case of a broad range of bacterial infections. Aloe vera is a medicinal plant …
Published in Research and Reviews : Journal of Crop science and Technology Read article
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Mechanical Characterization of Kevlar 49 and Pina Fiber Hybrid Composites
Abstract: The pursuit of sustainable yet high-performance materials has accelerated research into hybrid composites that combine synthetic and natural fibers. This study investigates the fabrication and characterization of a Kevlar 49/Pina fiber hybrid composite using epoxy resin as the matrix. Kevlar 49, known for its exceptional tensile strength and energy absorption, was employed as the face sheet material, while Pina fiber, a biodegradable reinforcement extracted from pineapple leaves, was incorporated as …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 301–316 Read article
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Overview of Virulence Factor of Staphylococcus sp.
Abstract: Staphylococcus is a highly virulent genus of bacteria that can cause a range of infections in humans and animals. The production of toxins, enzymes, and biofilms contributes to its ability to establish infections and evade host defenses. Understanding the characteristics and virulence factors of Staphylococcus is crucial for the development of effective prevention strategies and treatment options. Staphylococcus aureus is a significant etiological agent of nosocomial infections on a global …
Published in International Journal of Toxins and Toxics · Vol. 1, Issue 1, 2024 · pp. 25–31 Read article
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Postbiotics Unveiled: Mechanistic Insights and Therapeutic Implications in Obesity.
Abstract: The burgeoning global obesity epidemic necessitates innovative therapeutic approaches, and postbiotics, bioactive compounds arising from microbial fermentation, have emerged as promising contenders in reshaping obesity management. This comprehensive review explores the multifaceted mechanisms by which postbiotics impact obesity, from modulating gut microbiota composition to influencing metabolic pathways and enhancing energy expenditure. The exploration of postbiotics is rooted in a deeper understanding of the gut–brain axis and bidirectional communication between gut …
Published in Emerging Trends in Metabolites · Vol. 3, Issue 1, 2026 · pp. 11–28 Read article
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Infectious Diseases: Current Epidemiology, Pharmacotherapeutic Strategies, and Global Health Perspectives
Abstract: Infectious diseases are still a major health challenge in the world, and there is increased strain on the health systems of nations. This review examines the most important issues in the management of infectious diseases, such as the distribution and effect of infectious diseases across the world, pharmacotherapeutic approaches, and the functions of public health interventions. New threats such as antimicrobial resistance (AMR), the contribution of climate change, and the …
Published in Recent Trends in Infectious Diseases · Vol. 3, Issue 1, 2026 · pp. 10–18 Read article
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Advances in Membrane Technology: A Comprehensive Review of Materials, Processes, and Applications
Abstract: Membrane technology has become a critical platform for sustainable separation processes across water treatment, energy generation, chemical processing, and healthcare. Over recent decades, advances in materials, fabrication methods, and process design have dramatically expanded the performance, efficiency, and applications of membrane-based systems. Polymeric membranes dominate the industry due to cost-effectiveness and scalability, while ceramic, metallic, and composite membranes offer enhanced thermal and chemical resistance for specialized environments. Nanostructured and bio-inspired …
Published in International Journal of Membranes · Vol. 2, Issue 2, 2025 · pp. 1–6 Read article
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Comparative Evaluation of Fiber-Reinforced Composite and Elastic Fiber Posts in Reinforcing Peri-Cervical Dentin: an In-Vitro Study
Abstract: This study evaluates the fracture resistance of short-fiber reinforced composite and elastic fiber posts compared to conventional hybrid composites in reinforcing peri-cervical dentin of endodontically treated teeth. Methods: The crowns of thirty single-canal mandibular premolars were resected to achieve a dimension of 4mm from 1mm below the highest point of the proximal cervical line. In Group 1, teeth underwent endodontic treatment with gutta-percha filled up to the cement-enamel junction (CEJ) …
Published in Journal of Polymer & Composites · Vol. 13, Issue 3, 2025 · pp. 143–149 Read article
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Antibiotics in the Modern Era: Challenges, Misuse, and the Fight Against Resistance
Abstract: Overuse and inappropriate use of antibiotics in human medicine, agriculture, and environmental pollution. It is one of the biggest public health risks of the 21st century. The discovery of new antibiotics slowdown and the emergence of multidrug-resistant (MDR) microorganisms has highlighted the urgent need to Creative approaches to fighting opposition. This review explores the current challenges in antibiotic use, the factors driving resistance, and the strategies being implemented to address …
Published in International Journal of Antibiotics · Vol. 2, Issue 1, 2025 · pp. 57–70 Read article
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The Interplay Between Hyperglycemia, Endothelial Dysfunction, and Cardiovascular Risk in the Context of COVID-19: Implications for Long-term Health
Abstract: The COVID-19 pandemic has highlighted the potential impact of hyperglycemia, especially its link to cardiovascular disease (CVD) and endothelial dysfunction. COVID-19 can cause systemic inflammation and endothelial damage, worsening complications related to hyperglycemia. Persistent inflammation and endothelial dysfunction are crucial elements in the progression of atherosclerosis and other cardiovascular diseases. The long-term health effects of COVID-19, known as “Long COVID” or post-acute sequelae of SARS-CoV-2 infection (PASC), have raised concerns …
Published in Research and Reviews: A Journal of Medicine · Vol. 14, Issue 2, 2024 · pp. 27–31 Read article
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A Decade of Viral Evolution (2015–2025): Emergence, Mutations, and Implications for Global Health
Abstract: Over the past decade (2015-2025), viral evolution has profoundly reshaped the global health landscape, challenging healthcare systems, diagnostic tools, therapeutic strategies, and vaccine efficacy. This review comprehensively analyzes the evolutionary trajectories of major human and zoonotic viruses, with a focus on pandemic-prone, drug-resistant, and emerging pathogens. Viral evolution is driven by diverse molecular mechanisms including high mutation rates, recombination, reassortment, host immune pressure, and antiviral interventions, leading to genetic diversification, …
Published in International Journal of Vaccines · Vol. 2, Issue 2, 2025 · pp. 31–40 Read article
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Comparative Study of the Mechanical and Durability Performance of Interlocking Concrete Pavement Blocks
Abstract: Interlocking concrete pavement blocks (ICPBs) have emerged as a durable, modular, and sustainable alternative to traditional pavement systems. Their performance depends heavily on the mechanical characteristics of the concrete mix, block geometry, compaction technique, and curing conditions. This review compiles and analyzes research findings related to the strength, durability, structural behavior, and long-term performance of ICPBs produced using traditional and modified concrete mixes. Key parameters evaluated include compressive strength, split …
Published in Trends in Transport Engineering and Applications · Vol. 13, Issue 1, 2026 · pp. 24–30 Read article
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Unlocking Wellness by Ayurveda with Contrasting Modern Medicine
Abstract: In the modern world, we are so subordinate to drugs that we are unable to imagine a single day without them. Like smartphones, we are also addicted to pharmaceuticals, which significantly impact our lives. Constant utilization of medicine makes resistance and dependence on the medicament. It moreover has diverse side effects that cause various health hazards. As people become aware of this, the utilization of herbal remedies has expanded worldwide. …
Published in Research and Reviews: A Journal of Medicine · Vol. 14, Issue 3, 2024 · pp. 16–20 Read article
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Mechanical Properties, Viscoelastic and Water Absorption Properties of Biocarbon-Reinforced Composites
Abstract: Biocarbon-reinforced polymer composites have emerged as a sustainable alternative to conventional composites, combining environmental benefits with promising material properties. This study explores the effect of varying biocarbon content (0%, 10%, 20%, and 30% by weight) on the mechanical, viscoelastic, and water absorption properties of a polypropylene (PP) matrix. Tensile strength tests reveal that incorporating 10% biocarbon yields the highest strength at 35 MPa, attributed to enhanced interfacial bonding. However, at …
Published in Journal of Polymer & Composites · Vol. 13, Issue 2, 2025 · pp. 145–157 Read article
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Preparation of Transparent and Thermal Resistant Zirconia Reinforced Epoxy Based Polymer Matrix Composite Coatings
Abstract: This study investigates the thermal stability, structural characteristics, optical transparency, and surface wettability of epoxy-based composite coatings reinforced with 2 wt.% zirconia (ZrO₂) nanoparticles. The composite coatings were synthesized using a dip-coating technique on carbon fiber substrates and subsequently subjected to thermal treatments at 300 °C, 400 °C, and 500 °C. Structural analysis using X-ray diffraction (XRD) confirmed the amorphous nature of the epoxy matrix with no significant crystallization or …
Published in Journal of Polymer & Composites · Vol. 13, Issue 3, 2025 · pp. 171–177 Read article
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Systematic Review on: Peptic Ulcer and Its Management
Abstract: Peptic ulcer disease (PUD), which affects 5–10% of people worldwide, is still a significant global health concern. Gastric acid and pepsin's corrosive effects cause mucosal injury in the stomach, duodenum, or lower oesophagus. Long-term use of nonsteroidal anti-inflammatory drugs (NSAIDs) and Helicobacter pylori infection are the primary reasons. This review's goal is to examine PUD's aetiology, risk factors, pathophysiology, clinical symptoms, diagnostic methods, and evidence-based treatment modalities. PubMed, Google Scholar, …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 16, Issue 1, 2026 Read article
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Paediatric Epilepsy: Current Advances in Diagnosis and Management
Abstract: Paediatric epilepsy is one of the most common chronic neurological disorders of childhood, characterised by recurrent unprovoked seizures resulting from abnormal neuronal activity. Accurate diagnosis is essential and is based on a detailed clinical history, seizure semiology, neurological examination, and electroencephalography (EEG), with neuroimaging such as magnetic resonance imaging (MRI) used to identify structural abnormalities. Classification according to seizure type and underlying aetiology genetic, structural, metabolic, immune, infectious, or unknown—guides …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 16, Issue 1, 2026 · pp. 53–68 Read article
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Investigation on The Effect of Carbon Fiber Reinforcement on The Mechanical and Physical Properties of FDM 3d Printed PLA
Abstract: In this work, the effects of annealing on the physical properties and mechanical behavior of short-carbon-fiber-reinforced polylactic acid (CF/PLA) composites made using fused deposition modeling (FDM) are systematically investigated. Pristine PLA and CF/PLA composites with 10% fibers have been made and evaluated in accordance with ASTM standards. Tensile, bending, and hardness tests were used to evaluate the performance of as-received and annealed composites. The tensile and hardness properties of PLA …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 284–298 Read article
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Modern Approaches in Lung Cancer Management from Herbal Nanomedicine to Artificial Intelligence
Abstract: Lung cancer continues to be a major global health concern and one of the leading causes of cancer-related mortality worldwide. Despite significant advancements in therapy, there is still a pressing need for safer and more effective therapeutic alternatives; problems such drug resistance, side effects, metastasis, and recurrence continue to impact patient outcomes and quality of life. Examining current advancements in the use of herbal drug-loaded nanoparticles as a novel approach …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 16, Issue 2, 2026 Read article
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Common Diseases of Silkworm and Their Management – A Comprehensive Overview
Abstract: Silkworms (Bombyxmori L.), pivotal to the sericulture industry, are susceptible to various diseases that significantly impact cocoon production and quality. Common silkworm diseases include viral, bacterial, fungal, and protozoan infections. Prominent viral diseases, such as nuclear polyhedrosis (NPV) and cytoplasmic polyhedrosis (CPV) often cause mass mortality in larvae. Bacterial diseases, like flacherie, are typically induced by poor hygiene and environmental stress. Fungal infections, including muscardine caused by Beauveria bassiana, proliferate …
Published in International Journal of Insects · Vol. 2, Issue 1, 2025 · pp. 22–28 Read article