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282 articles for “site”
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Molecular Docking, QSAR Modeling, and ADMET Evaluation of Novel Pyrazolo-Pyrimidine Derivatives as Potential CDK-2 Inhibitors for Cancer Therapy
Abstract: Cyclin-dependent kinase-2 (CDK-2) is an essential regulator in cell cycle progression and is an important therapeutic target in cancer drug development. In the present study, an integrated computational approach involving molecular docking studies, QSAR modeling, ADMET prediction, and artificial intelligence-based analysis was used to identify pyrazolo-pyrimidine derivatives as potential CDK-2 inhibitors. Based on the molecular docking results, it was found that selected compounds exhibited high binding affinity towards the ATP …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 16, Issue 2, 2026 Read article
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DEVELOPMENT OF POLYMERSOMES AS MACROMOLECULAR PLATFORMS FOR NANOMEDICINE
Abstract: The conventional method of drug delivery is plagued with instability, low targeting and low bioavailability. A solution to these shortcomings is the use of polymer Somes, artificial vesicles that are produced through self-assembly of amphiphilic block copolymer, and they are suggested as universal nanoscale carriers. They have stiff, tunable membranes (thickness = 2-50 nm) due to accurate control of polymer chemistry, chain length, and hydrophilic mass fraction (f), which allows …
Published in Journal of Polymer & Composites · Vol. 14, Issue 5, 2026 Read article
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Structural, Optical, Surface and Gas-Sensing Properties of rGO/Sn1-xZnxO₂ Nanocomposites
Abstract: rGO/Sn₁₋ₓZnₓO₂ nanocomposites with x = 0.00–0.75 were synthesized by sol–gel auto-combustion followed by wet impregnation with reduced graphene oxide. The adopted synthesis route enabled homogeneous Zn incorporation into the SnO₂ matrix and uniform distribution of rGO, leading to improved structural integrity and interfacial contact between the two components. XRD confirmed a dominant tetragonal cassiterite SnO₂ structure, while FTIR, FESEM, EDS, UV–visible, and BET analyses verified oxide–rGO coupling, Zn-dependent structural modification, …
Published in Journal of Polymer & Composites · Vol. 14, Issue 4, 2026 Read article
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Zeolite-Y Encapsulated Copper (II) and Cobalt (II) Species as Hybrid Nano-catalysts: Structural and Catalytic Aspects
Abstract: Special properties inherent to zeolites in facilitating the construction of novel upramolecular assemblies by encapsulation of guest molecules (metal complexes) into their large cages can be utilized to use these assembled materials as novel catalysts. These modified solids have the advantages of both behaving as the homogeneous and the heterogeneous catalytic system. In the present work, copper (II) and cobalt (II) complexes of 2-amino ethanoic acid (2-AEA) encapsulated in the …
Published in Journal of Catalyst & Catalysis Read article
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Intelligent Transportation System Avoids Collision by Disseminate the Warning Messages in Vehicular Ad Hoc Network
Abstract: Roads overload leftovers a critical issue while they are invariably increased so as to increase their capacity and enhance their effectiveness. This can be likely to cause many troubles specified ecologically, financially, and socially. The progress of urban traffic management systems, structure and development of roads are solutions to handle this problem and acquire better the performance of the road transmission, but these solutions are high-priced and need extra space …
Published in Journal of Telecommunication, Switching Systems and Networks Read article
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Inhibitory Potentials of Datura Metel to Prevent Mild Corrosion
Abstract: The resistance of mild steel to corrosion was evaluated by immersing it in well water and determining the weight it lost after being allowed to return to room temperature after the submersion. The effectiveness of mild steel's ability to withstand corrosion was evaluated using this approach. A reduction in total body mass has an influence that is connected to and helps play a role in the prevention of rusting from …
Published in Journal of Polymer & Composites Read article
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Construction and Development of pSB111 Bar Plasmid Vector for Activation Tagging
Abstract: To get desired traits and to know the precise expression patterns of genes in the plant, Agrobacterium tumefaciens has been widely employed in the generation of transgenic plants using plasmid vectors. Many methods are come forward to establish the gene expression of unknown genes but in these techniques gene alteration isthe main drawback orsometimesit islethal to organisms also, to overcome these problems activator tag method developed to know the specific …
Published in Research & Reviews : Journal of Botany Read article
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Computational Molecular Docking Studies to Design Novel 2, 3-Substituted-1-(4-(Piperidin-1-yl) butyl)-1H- indol-5-ol Derivatives for Estrogen Receptor Alfa in AF-2 Domain
Abstract: The present manuscript describes the designing of novel 2, 3-Substituted-1-(4-(Piperidin-1-yl) butyl)- 1H-indol-5-ol derivatives as specific estrogen receptor alfa modulators and their screening by docking studies to determine the binding interaction for the best-fit conformations in the binding site of the ERα receptor. Based on the results of docking studies, the selected ligands reveal the all- important functional groups of the ligands that interact with active amino acid residues in the …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 12, Issue 3, 2025 · pp. 15–49 Read article
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An Insight to Diagnosis and Management of Druginduced Hepatotoxicity: An Overview
Abstract: (ADRs) Adverse Drug Reactions are constitute and mutual chief health problem. Throughout the last period liver toxicity has remained one of the most recurrent reasons for pharmacovigilance protection intelligences and the withdrawal from the marketplace of an accepted medicinal product. Liver is a main organ elaborate in the systemic deposition and decontamination of exogenous and endogenous ingredients. Liver disfunction challenges not only health care specialists but also the pharmaceutical manufacturing …
Published in Trends in Drug Delivery · Vol. 8, Issue 2, 2023 · pp. 39–54 Read article
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AQUASOMES: A Vesicular, Self-assembled Ceramic Nanoparticulate Drug Carrier
Abstract: Nano-biopharmaceutics involves delivery of biopharmaceutical product through different biomaterials like multi-functional nanoparticles, quantum dots, aquasomes, super-paramagnetic iron oxide crystals, and liposomes dendrimers. Aquasomes are considered as one of the most recently developed delivery systems for bioactive molecules like peptides, proteins, hormones, antigens and genes to specific sites. Aquasomes have a spherical shape and a particle size of 60–300 nm. These are three layered self-assembled nano-particulate carrier system. This three-layered structure …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 12, Issue 3, 2025 · pp. 1–14 Read article
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Assessment of Heavy Metals in Underground Water Situated at Automobile Workshops in Ede Metropolis
Abstract: The study investigated the determination of heavy metals concentration (Co, Cd, Ni, Pb, and Cr) in underground water situated in auto-mobile workshops in Ede metropolis. Four different samples were collected, two from the auto-mobiles workshop while two were collected 50 meters away from the Auto-mobiles workshop in both local governments which served as control. The result was Cr-0.416– 0.477 mg/L; Cd-0.018–0.040 mg/L; Pb-0.038–0.066 mg/L; Ni-0.042–0.052 mg/L; Co-0.043–0.200 mg/L. Cobalt has …
Published in Research & Reviews : Journal of Statistics Read article
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Distinctive Approaches for Improving the Aqueous Solubility of BCS Class II Drugs
Abstract: The most difficult feature of many novel chemical entities is their solubility behaviour, as 60 percent of new promising products suffer solubility limitations. This is the most common reason for novel medicine compounds failing to reach the market or performing to their full potential. The proportion of the aqueous phase when the solution is in equilibrium with the pure substance in its normal phase is referred to as aqueous solubility. …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 8, Issue 3, 2023 · pp. 52–56 Read article
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Cultural Heritage of Punjab: A Shift in Outlook and Output—A Case Study of the Historical Town of Sirhind
Abstract: Cultural heritage is an expression of ways of living developed by a community and passed on from generation to generation. This could be the tangible assets, such as buildings, monuments, archaeological sites, artifacts, landscape, and intangible assets such as oral traditions, folklore, language, and knowledge. Though all these can be viewed, analyzed, studied separately, they cannot be experienced as standalone entities. The understanding of our cultural heritage is fragmented and …
Published in International Journal of Architectural Design and Planning Read article
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Factors Affecting Uptake of COVID-19 Vaccines Among Adults: A Cross Sectional Survey
Abstract: The COVID-19 vaccination started in phased manner in India, and it was first time when a digital platform was developed for vaccine site registration. People had skepticism about newly developed vaccines and had poor understanding of using digital platform for vaccination registration. It was one of the reasons for poor vaccination coverage in marginalized section of the society. The pandemic has also affected other healthcare services as people were worried …
Published in International Journal of Community Health Nursing And Practices · Vol. 1, Issue 2, 2023 Read article
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Molecular Docking and Pharmacokinetic Profiling of the Phytocompounds of Jatropha curcas as Antagonist for Salmonella typhi
Abstract: Background: Typhoid is an infection caused by the Gram-negative bacterium, Salmonella enterica serovar typhi. The study assessed the potential use of Jatropha curcas as a typhoid fever therapy alternative to traditional medications. The ability to uncover novel drug indications for currently available medications using in silico methods has increased thanks to the wealth of pharmacological and biological knowledge that is available. Objective: In this study, we assessed the potential inhibitory …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 1, Issue 1, 2023 · pp. 67–81 Read article
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Drona-Chariot: A Medical Equipment Carrier Drone
Abstract: Caring for trauma victims in harsh environments poses numerous difficulties, especially when a rescue effort is delayed. Human-containable medical equipment may also be consumed by a single victim, making replenishment impossible prior to evacuation, especially in long-term on-site supply scenarios. This project aims to build an unmanned autonomous aerial vehicle that successfully delivers remote places with life-sustaining medical supplies where it is impossible or impractical for vehicles or pedestrians to …
Published in International Journal of Computer Science Languages · Vol. 1, Issue 1, 2023 · pp. 7–14 Read article
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A Study to Evaluate the Effectiveness of Planned Teaching Program of Environmental Health Among Community People in Selected Rural Area of Gwalior
Abstract: Context: Environmental health is the subfield of public health that focuses on identifying and altering environmental contributors to illness and injury. The state of the environment in a certain area, especially as it relates to ecological diversity and pollution. The purpose of this research was to evaluate the efficacy of an environmental health education program for the local population. This study follows a quantitative research approach for its methodology. The …
Published in International Journal of Evidence Based Nursing And Practices · Vol. 1, Issue 1, 2023 · pp. 23–32 Read article
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Evaluation of Patient-Specific Quality Assurance for RapidArc Treatment Delivery Using Dose Volume Histogram
Abstract: This study aims to evaluate the application of dose volume histogram (DVH) metrics within the patient-specific quality assurance (PSQA) protocol in various sites for RapidArc treatment delivery. Forty patients were included in this study, of which twenty each Head and Neck (H&N) and Pelvis Rapid Arc plans were evaluated. Octavius 4D 1500 detector array with vented parallel plate ion chambers was used for this study, which reconstruct the pre-treatment measured …
Published in Journal of Polymer & Composites · Vol. 11, Issue 7, 2023 · pp. 14–22 Read article
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Recent Update on Advanced Drug Delivery System
Abstract: Over the past decade, there has been a growing interest in the use of artificial intelligence (AI) technology for analysing and interpreting biological or genetic data, accelerating drug discovery, and identifying selective small-molecule modulators or rare molecules in addition to predicting their behaviour. The use of artificial neural networks (ANNs) for the rapid analysis of massive amounts of data, the development of novel hypotheses and treatment plans, the prediction of …
Published in International Journal of Advance in Molecular Engineering · Vol. 1, Issue 1, 2023 · pp. 22–30 Read article
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Grid based docking study of some 2-(4-methylsulfonyl phenyl) pyrimidine derivatives (designed after QSAR studies) with Cyclooxygenase
Abstract: Molecular docking helps in studying drug/ligand or receptor/ protein interactions by identifying the suitable active sites in protein, obtaining the best geometry of ligand-receptor complex and calculating the energy of interaction for different ligands to design more effective ligands. In Grid based docking, after unique conformers of the ligand are generated, the receptor cavity of interest is chosen and a grid is generated around the cavity. Cavity points are found …
Published in International Journal of Antibiotics · Vol. 1, Issue 1, 2024 · pp. 23–41 Read article