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164 articles for “drug release”
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Gastro Retentive Drug Target System: Its Needs, Advantages, Limitation and Approaches
Abstract: Background: Gastro retentive drug delivery systems (GRDDS) address limitations of oral therapy for drugs with poor solubility, instability at intestinal pH, or narrow absorption windows by prolonging gastric residence and increasing contact with the gastric mucosa. Objectives: To review GRDDS approaches—floating systems, mucoadhesive systems, and super porous hydrogels—with emphasis on formulation strategies and polymer–excipient selection to enhance gastric retention, modulate buoyancy/swelling/adhesion, and ultimately improve oral bioavailability and therapeutic outcomes for …
Published in Trends in Drug Delivery · Vol. 13, Issue 2, 2026 Read article
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Fabrication and Characterization of Diacerein Loaded Nanosponge for Topical Delivery
Abstract: Diacerein, an anti-inflammatory drug, which comes under BCS class II, commonly used in treatment of osteoarthritis has limited by its poor solubility and bioavailability when administered topically. This study aimed to develop and evaluate diacerein-loaded nanosponges gel using varying concentrations of ethyl cellulose and polyvinyl alcohol (PVA) to enhance its delivery. Nanosponges were prepared using an emulsion solvent evaporation technique, with different ratios of ethyl cellulose (0.05-0.250%) and PVA (0.2-0.3%). …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 12, Issue 2, 2025 · pp. 26–46 Read article
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Advances in Biodegradable Polymer-based Drug Delivery Systems
Abstract: An intriguing new approach to manage medication release that may assist with issues like making the therapeutic impact last longer, reducing the danger of side effects, and persuading patients to follow through with their treatment programs is biodegradable polymer-based drug delivery systems (DDS). By developing systems that can break down within the body, biodegradable polymers have revolutionised the way medications are administered. They so have less negative effects and do …
Published in Journal of Polymer & Composites · Vol. 13, Issue 4, 2025 · pp. 326–338 Read article
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Strategies for the Development and Optimization of Orally Disintegrating Tablets (ODTs) to Improve Bioavailability and Patient Compliance
Abstract: Background: Pharmaceutical scientists have developed Orally Disintegrating Tablets (ODTs) to advance patient drug acceptance and biological system availability through simplified medi-cation delivery especially for children and senior citizens and people who cannot swallow pills regularly. The oral disintegrating tablets dissolve in the mouth within thirty seconds or less (USP 701) while needing no additional liquid thus making them suitable for both emergency treatments. Objective: The research examines ODT development strategies …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 13, Issue 2, 2026 Read article
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A Comprehensive Analysis of Novel Liposomes: Categorization, Approach, Description, and Present Formulations
Abstract: Liposomes have gained attention as a promising drug delivery system, which come with the advantages of biocompatibility, ability to load hydrophilic and hydrophobic drugs, and they can function for targeted drug delivery. In this regard, this paper offers a comprehensive overview on novel liposomes, including classification, formulation strategies, detailed structures, and current pharmaceutical applications. Recent advances in liposomal drug delivery systems includes, new liposomal architectures (i.e. stealth, targeted, stimuli-responsive, hybrid …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 12, Issue 2, 2025 · pp. 15–20 Read article
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AI-Powered Drug Delivery: Revolutionizing Formulation Science
Abstract: Artificial Intelligence (AI) is emerging as a groundbreaking tool in revolutionizing Drug Delivery Systems (DDS), offering promising advancements in precision, efficiency, and personalized treatment strategies. The integration of AI technologies into pharmaceutical research and development is transforming how drugs are formulated, delivered, and monitored in real time. By leveraging machine learning algorithms and data analytics, researchers can design drug delivery models that are not only more effective but also tailored …
Published in Trends in Drug Delivery · Vol. 13, Issue 1, 2026 · pp. 48–61 Read article
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Polymer Nanocomposites As Emerging Platforms in Pharmaceutical Nanotechnology
Abstract: Nanotechnology allows the handling of materials in the 1–100 nm range, where distinct physicochemical phenomena, including quantum effects and higher surface-to-volume ratio, enable disruptive uses in pharmaceuticals and biomedicine. Significant challenges in solubility, stability and targeted biodistribution of therapeutics can be overcome by incorporating nanostructured polymers and polymer-based composites into drug delivery systems. PLGA nanoparticle and other nanocarriers, such as PLGA micelles, dendrimers, and hydrogels, have revealed promising effects on …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 268–278 Read article
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Harnessing Polymer Chemistry for Pharmaceutical Technology
Abstract: Polymer chemistry has emerged as a cornerstone of modern pharmaceutical technology, offering unprecedented control over drug formulation, delivery, and therapeutic performance. This review highlights the pivotal role of polymers—both synthetic and natural—in revolutionizing drug delivery systems across various routes, including oral, parenteral, transdermal, ocular, nasal, and pulmonary administration. Special emphasis is placed on the structural and functional versatility of polymers, which allows for tailored drug release profiles, enhanced bioavailability, and …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 1–6 Read article
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pH-Triggered In-Situ Nasal Gel Systems for Migraine Therapy: A Review
Abstract: Intranasal drug delivery has gained considerable attention as a non-invasive route for delivering drugs to both systemic circulation and the central nervous system, particularly for the treatment of migraine. Traditional nasal formulations such as sprays and drops often show poor therapeutic performance due to rapid mucociliary clearance and limited retention within the nasal cavity. To overcome these challenges, in-situ gel systems have been designed, which transform from a liquid to …
Published in Trends in Drug Delivery · Vol. 13, Issue 2, 2026 Read article
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Innovative Approaches in Excipient Co-Processing: A Comprehensive Review
Abstract: Co-processing of existing excipients is an innovative strategy in pharmaceutical formulation that offers a cost-effective, efficient alternative to the development of entirely new excipients. This process involves combining two or more well-established excipients to create new material with enhanced properties, thereby improving the functionality, performance, and manufacturability of pharmaceutical products. By leveraging the unique characteristics of each excipient, co-processing can significantly enhance attributes, such as flowability, compressibility, solubility, stability, and …
Published in Trends in Drug Delivery · Vol. 12, Issue 2, 2025 · pp. 34–51 Read article
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Advances in Polymer Chemistry for Coronary Artery Disease
Abstract: Coronary artery disease (CAD) remains the leading cause of morbidity and mortality worldwide, driving ongoing innovation in therapeutic materials and device design. Polymer chemistry has emerged as a cornerstone in the development of advanced cardiovascular interventions, offering versatile platforms to improve the safety, efficacy, and functionality of implantable devices. This review explores recent advances in the synthesis and application of biodegradable and biostable polymers, focusing on their roles in drug-eluting …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 710–716 Read article
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Biomedical Coatings: Surface Engineering for Enhanced Biocompatibility and Performance
Abstract: Biomedical coatings have become essential in modern healthcare, significantly improving the performance, durability, and biocompatibility of medical implants and devices. These coatings serve multiple functions, including reducing infection risks, enhancing osseointegration, promoting tissue integration, and enabling localized drug delivery. Advances in surface engineering have led to the development of innovative coatings with superior properties such as antimicrobial resistance, bioactivity, and controlled biodegradation. Various materials are employed in biomedical coatings, including …
Published in Journal of Thin Films, Coating Science Technology & Application · Vol. 12, Issue 1, 2025 · pp. 8–15 Read article
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Microneedles and the paradigm shift in the field of dentistry: A Review Article
Abstract: Needle-based instruments are advancing as a promising tool for both diagnosis and treatment within the medical realm. They possess versatility, being capable of drug delivery and fluid extraction, catering to both systemic and local requirements. Unlike traditional drug delivery methods, which necessitate repeated dosing in the oral cavity due to saliva presence, there's a growing demand for delivery systems like needle-based devices that can offer sustained drug release orally. These …
Published in Research and Reviews: A Journal of Dentistry Read article
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Bioinformatics-based Preparation and Characterization of Silver Nanoparticles Synthesized from Pterocarpus marsupium
Abstract: Silver nanoparticles were synthesized using Pterocarpus marsupium bark extract in combination with silver nitrate solution through a green synthesis method. Silver nanoparticles formation was confirmed by the formation of dark brown from solution of silver nitrate, where the reduction of silver ion occurs which leads to the formation of silver nanoparticles. The UV–visible spectra showed a peak at 429 nm, confirming the reduction of silver ions and the subsequent synthesis …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 11, Issue 2, 2024 · pp. 21–34 Read article
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Study Review: Molecular Mechanisms of Nanoparticle-Cell Interaction – Implications for Drug Delivery and Toxicity
Abstract: The application of nanoparticles in drug delivery and biomedical therapies holds great promise, yet their interaction with cells and the underlying molecular mechanisms remains areas of active research. This study explores the molecular mechanisms of nanoparticle-cell interactions, focusing on the effects of gold nanoparticles (AuNPs) and silica nanoparticles (SiNPs) in human cancer cell lines (HeLa and MCF-7). The study examines how nanoparticles are internalized by cells, their impact on cellular …
Published in Research and Reviews: A Journal of Toxicology · Vol. 15, Issue 2, 2025 · pp. 31–40 Read article
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Nanoformulation Strategies: Emerging Innovations in Drug Delivery Systems
Abstract: Nanotechnology is significantly advancing the pharmaceutical industry by introducing nanosystems that improve drug delivery, therapeutic efficacy, and patient outcomes. Various nanosystems-such as liposomes, dendrimers, polymeric nanoparticles, solid lipid nanoparticles, carbon nanotubes, and metallic nanoparticles-offer benefits like enhanced bioavailability, targeted delivery, improved stability, and reduced side effects. Innovative formulation strategies, including surface functionalization, particle size optimization, and use of biodegradable carriers, support controlled and sustained drug release. Additionally, production in non-aqueous …
Published in International Journal of Toxins and Toxics · Vol. 3, Issue 1, 2026 · pp. 54–67 Read article
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Studies on the Self-Assembly of Steroids and DNA Mediated by Naphthalene based Amphiphilic Block Copolymer
Abstract: Amphiphilic block copolymers have attracted considerable interest in pharmaceutical and biomedical applications, including controlled drug release, gene delivery, and biomolecular sensing. In this study, fluorescent amphiphilic block copolymers were designed to facilitate interactions with biological molecules such as DNA and antiviral agents, enabling their behavior to be monitored through fluorescence spectroscopy. Two novel block copolymers, poly(methyl methacrylate) - b - poly(dimethylaminoethyl methacrylate - co - naphthyl methacrylate) [PMMA-b-P(DMAEMA-co-NMA)] and poly(styrene) …
Published in Journal of Polymer & Composites · Vol. 14, Issue 5, 2026 Read article
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Polymer Chemistry-Driven Approaches for Improved Therapeutic Delivery
Abstract: Polymer chemistry has revolutionized pharmaceutical technology by enabling the development of advanced drug delivery systems with improved precision, stability, and therapeutic outcomes. This review explores the role of polymer design, synthesis, and functionalization in the development of responsive and targeted drug carriers. Emphasis is placed on various types of polymers—biodegradable, synthetic, natural, and stimuli-responsive—and their suitability for drug delivery platforms such as nanoparticles, micelles, hydrogels, dendrimers, and implants. The physicochemical …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 Read article
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Strategies in the Delivery of Nonsteroidal Antiinflammatory Drugs
Abstract: Non-steroidal anti-inflammatory drugs [NSAIDs]. are widely used for the management of pain, inflammation, and fever. However, their effectiveness is often limited by gastrointestinal side effects such as ulceration and bleeding, as well as systemic complications including renal toxicity and cardiovascular risks. To address these challenges, various strategies have been developed to improve the delivery of NSAIDs, aiming to enhance their therapeutic efficacy while minimizing adverse effects. This abstract provides an …
Published in Trends in Drug Delivery · Vol. 11, Issue 1, 2024 · pp. 44–61 Read article
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Polymer Chemistry and Its Applications in Pharmaceutical Composite Formulations
Abstract: Polymer chemistry plays a critical role in pharmaceutical formulations, particularly in enhancing drug stability, bioavailability, and controlled release. Polymers are widely utilized in drug delivery systems. Polymers are widely used in pharmaceutical sciences for drug delivery, controlled release, and stability enhancement. This paper explores the role of polymers in the extraction and formulation of glycyrrhetinic acid from Glycyrrhiza glabra, a bioactive compound. Various polymer-based extraction and purification techniques are discussed, …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 216–221 Read article