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829 articles for “disorders”
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Exploring the Role of MAPK3 in Major Depressive Disorder: Molecular Docking, Dynamics, and Binding Free Energy Analysis of Natural Compounds as Alternatives to Conventional Drugs
Abstract: Major Depressive Disorder (MDD) is a prevalent neuropsychiatric disorder with limited treatment efficacy and significant side effects associated with conventional antidepressants. Recent studies have highlighted the role of mitogen-activated protein kinase 3 (MAPK3) in the mechanisms underlying MDD, positioning it as a potential target for the development of novel therapeutic drugs. In this study, we employed various computational approaches to explore natural compounds as viable alternatives to synthetic antidepressants. Researchers …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 3, Issue 2, 2025 · pp. 53–68 Read article
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Understanding the Cervical Spine Disorder: A Cross-sectional Survey Study
Abstract: Cervical spine disorders encompass a spectrum of conditions including degenerative spondylosis, disc herniation, traumatic injuries, and myelopathy that impair quality of life through chronic pain, neurological deficits, and functional limitations. Globally, neck pain affects over 200 million individuals, with an age-standardized prevalence of 2666 per 100000 population and an incidence of 816 per 100000 person-years, contributing to significant years lived with disability (YLDs). Economic analyses estimate annual direct healthcare costs …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 15, Issue 3, 2025 · pp. 80–97 Read article
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An Integrative Review of Male Sexual Disorders and the Therapeutic Role of Unani Aphrodisiacs
Abstract: Sexual health is a vital component of overall well-being, encompassing physical, emotional, and psychosocial dimensions. Male sexual dysfunction – including conditions, like erectile dysfunction, premature ejaculation, and low libido – can significantly impact quality of life and intimate relationships. Aphrodisiacs, derived from the Greek goddess Aphrodite, are substances that stimulate sexual desire and performance. Historically, natural aphrodisiacs have been used in various cultures and include plant-based substances such as Yohimbine, …
Published in Research & Reviews : A Journal of Unani, Siddha and Homeopathy · Vol. 12, Issue 3, 2025 · pp. 8–15 Read article
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Molecular Docking of Abroma augusta Phytocompounds Against Estrogen Receptor Alpha (Er-Α) for the Treatment of Menstrual Disorders
Abstract: Menstrual disorders, including dysmenorrhea (painful menstruation), amenorrhea (absence of menstruation), and irregular menstrual cycles, significantly impact women’s reproductive health and overall well-being. These conditions often arise from hormonal imbalances, inflammation, and uterine dysfunction, necessitating effective therapeutic interventions. Current treatments, such as hormonal therapies (oral contraceptives, progestin-only pills), NSAIDs, and surgical procedures (endometrial ablation, hysterectomy), provide relief but often target symptoms rather than addressing the underlying causes. Consequently, there is a …
Published in International Journal of Molecular Biotechnological Research · Vol. 3, Issue 2, 2025 · pp. 1–12 Read article
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Gene Expression Profiling in Autism Spectrum Disorder: A Microarray Analysis Using Gse42133
Abstract: Autism Spectrum Disorder (ASD) is a diverse neurodevelopmental disorder characterized by difficulties in social interaction, communication impairments, and restricted or repetitive patterns of behavior. Despite its increasing prevalence, the underlying molecular mechanisms remain poorly understood. Advances in transcriptomics offer opportunities to investigate the gene expression changes that may contribute to ASD pathophysiology. In this study, the microarray dataset GSE42133 was analyzed, which comprises gene expression profiles from peripheral blood samples …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 13, Issue 1, 2026 · pp. 37–48 Read article
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Immunological Mechanisms Underlying Autoimmune Disorders: Recent Advances and Therapeutic Implications
Abstract: A diverse range of illnesses known as autoimmune disorders are typified by dysregulated immune responses against self-antigens, which result in tissue damage and persistent inflammation. Understanding the genetic, epigenetic, and environmental variables that contribute to autoimmune pathogenesis has advanced significantly during the last ten years. Current disease models have been transformed by new understandings of immunological tolerance mechanisms such as the functions of regulatory T cells, cytokine networks, and the …
Published in Research and Reviews : A Journal of Immunology · Vol. 16, Issue 1, 2026 · pp. 21–25 Read article
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A Comprehensive Review on the Role of Antacids in the Management of Stomach Disorders
Abstract: Antacids are among the most widely used over-the-counter medications for the symptomatic management of acid-related gastrointestinal disorders, including dyspepsia, gastroesophageal reflux disease (GERD), gastritis, and peptic ulcer disease. These agents provide rapid relief by neutralizing gastric hydrochloric acid, thereby increasing intragastric pH and reducing mucosal irritation. In addition to their therapeutic benefits, the long-term and excessive use of antacids may be associated with adverse effects and toxicological concerns, including electrolyte …
Published in International Journal of Toxins and Toxics · Vol. 3, Issue 2, 2026 Read article
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A Review on Detection of Autism Spectrum Disorder Using Signal Processing
Abstract: AbstractAutism is a neural developmental disability associated with impairments in communication and social interaction; it can be detected by various methods such as Magnetic Resonance Imaging (MRI) and Electroencephalography (EEG). MRI is a technique which captures the image of various sections of brain. It is categorised as structural MRI (sMRI) and functional MRI (fMRI). The detection involves capturing the image, removing the unwanted regions of brain, segmenting the images and …
Published in Current Trends in Signal Processing · Vol. 8, Issue 2, 2018 · pp. 12–24 Read article
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Alzheimer disorders diagnosis system design using machine learning for EEG signal
Abstract: The diagnosis of Alzheimer's disorders (AD), a prevalent neurological disorder, can created by utilising a range of therapeutic methods, including the electroencephalogram (EEG), which has been especially successful in the past. The objective for this study is to develop a computer-aided diagnosis tool which may recognize AD from EEG data. The EEG information was cleaned up with a band-pass elliptic digital filter to remove any interference or disruptions. The filtered …
Published in Journal of Control & Instrumentation · Vol. 14, Issue 1, 2023 · pp. 9–22 Read article
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Musculoskeletal disorder and psychosocial work demands in Insurance industry: A case study
Abstract: ABSTRACTIntroduction- Insurance sector is a group of professionals who perform under time pressure. The use of computer increases in the insurance industry which is linked with musculoskeletal pain. The objective of the study is to analyze the prevalence of MS pain during past 12 months and to correlate it with these work related factors. Methods- Insurance office workers from various companies in Punjab responded to the questionnaire which is related …
Published in Journal of Industrial Safety Engineering · Vol. 4, Issue 3, 2017 · pp. 37–42 Read article
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The Contextual Effect of Vowels on Correct Production of Retroflex in Kannada Speaking Children with Speech Sound Disorder: A Case Study
Abstract: Contextual based interaction of speech sounds, coarticulation, is the main component of intelligible continuous speech. This interaction between speech sounds within and across the words is affected in children with speech sound disorders (SSD). Literature reports on certain contexts facilitating the production of different speech sounds. Thus, these contextual considerations are vital for the selection of target stimuli during articulation therapy for faster learning. As phonotactics and coarticulation are language …
Published in Research and Reviews : Journal of Computational Biology · Vol. 7, Issue 2, 2018 · pp. 46–66 Read article
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Assessment and Associated Factors of Adjustment Disorder with Mixed Depression and Anxiety of Hospitalized Patients with Pandemic Disease, COVID-19 in Ethiopia, East Africa, 2020
Abstract: AbstractBackground: Globally, the 2019 coronavirus disease (COVID-19) pandemic has raised international concern. According to world meters report, 4,545,167 cases, 1,715862 recoveries, 303,847 deaths and spread to 213 countries, and significant number increasing from day to day since December 2019. Mental health is becoming an issue that cannot be ignored in our fight against it. This study aimed to explore the prevalence, and factors linked to anxiety and depression in hospitalized …
Published in Research and Reviews: A Journal of Health Professions · Vol. 10, Issue 2, 2020 · pp. 57–65 Read article
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A Review on Binge Eating Disorder in Youth with Diabetes Mellitus
Abstract: The repetitive scenes of voraciously consuming food without normal compensatory conduct, for example, regurgitating or purgative maltreatment are portrayed as binge dietary issue. It is exceptionally regular in the fat gathering, yet it is not restricted to those individuals. Many empirical studies and reports suggest that about 58% of young women (aged 18–30 years) with insulin-dependent diabetes mellitus (IDDM) may be at high risk of developing eating disorders. Binge disorder …
Published in Research and Reviews: A Journal of Health Professions · Vol. 11, Issue 1, 2021 · pp. 1–10 Read article
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How to Treat Mental Health Disorder during COVID-19 Pandemic?
Abstract: The COVID-19 pandemic is a major health crisis affecting all nations. The present study discussed the mental health condition during COVID-19 occurrence among healthcare professionals, patients and huge population. The COVID-19 epidemic has been spreading at a fast pace in India, USA, Russia, China, Italy, France and other Asian and European countries. This COVID-19 epidemic has rapidly increased attention all over the world. The patients, healthcare professionals, medical equipment providers …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 10, Issue 3, 2020 · pp. 1–4 Read article
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Ceftriaxone and Gallbladder Disorders: A Case Report in Adult Patient.
Abstract: AbstractCeftriaxone is one of wide spectrum antibiotic against both gram +ve and gram –ve organism, one of known complication in pediatric patients is gall bladder disorders, ranging from asymptomatic biliary sludge up to symptomatic actue choleycystitis. This condition also affects adult patients although not so common, as it seen here in our case report. Keywords: Ceftiaxone, Choleycyst, Gallstones, Nephrolithasis, Pseudolithasis Cite this ArticleGhada Seifeldin Mohmed Ahmed. Ceftriaxone and Gallbladder Disorders: …
Published in Research and Reviews : Journal of Surgery · Vol. 9, Issue 2, 2020 · pp. 1–5 Read article
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Machine Learning Approach to Detect and Analyze Attention-Deficit/Hyperactivity Disorder
Abstract: Attention-Deficit/Hyperactivity Disorder (ADHD) is a neurodevelopmental disorder characterized by difficulties with attention, impulse control, behavioral regulation, and daily functioning that persist across childhood and adulthood. Clinical diagnosis is predominantly based on behavioral assessments and expert interpretation, which may result in subjectivity and delayed clinical decisions. To reduce reliance on subjective evaluation, this study introduces an automated ADHD identification framework that integrates resting-state functional Magnetic Resonance Imaging (rs-fMRI) with advanced machine …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 16, Issue 2, 2026 · pp. 22–26 Read article
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Unveiling Nature’s Potential: In Silico Exploration and Identification of Herbal Remedies for Major Depressive Disorder Through Molecular Interaction Studies
Abstract: Major depressive disorder (MDD), a globally discussed mental health condition, has drawn significant attention because of its unique and intricate nature. This is marked by the enduring presence of negative emotions stemming from a lack of interest, diminished self-esteem, and excessive rumination. Despite the widespread availability of various antidepressant medications, their effectiveness is hindered by low response rates, prolonged treatment durations, and the prevalence of side effects, such as headaches, …
Published in Research and Reviews : Journal of Computational Biology · Vol. 13, Issue 1, 2024 · pp. 54–62 Read article
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Development of Spanish Version of Home-Based Video Module of Balance Exercises for Peripheral Vestibular Disordered Patients
Abstract: Any disturbances affecting one or more of the balance organs lead to imbalance difficulties and as a consequence, the quality of life of the affected individuals can be seriously affected, especially if the episodes end with injuries or even fatal accidents. Bal Ex is the first home-based video guided workout that was created by Zainun and her colleagues in 2009. Ten languages are currently supported by Bal Ex, including Cantonese, …
Published in International Journal of Brain Sciences · Vol. 1, Issue 2, 2024 · pp. 33–41 Read article
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Role of Neuropeptides in the Treatment of Major Depression Disorder: The Recent Updates
Abstract: Revelation of the part of neuropeptides as signaling atoms within the nervous system raised trust within the pharmaceutical field approximately 25. long time back Many neuropeptides, especially CRH, AVP, and substance P . whose receptors are presently focused on by little atoms to diminish side effects of discouragement and uneasiness, shows up to be related to the improvement and movement of temperament disarranges trouble. Neurotrophins, not exactly neuropeptides, may also …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 14, Issue 3, 2024 · pp. 1–12 Read article
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Stiff Person Syndrome: Advances in Understanding, Diagnosis, and Treatment of a Rare Autoimmune Disorder
Abstract: Stiff Person Syndrome (SPS) is a rare and complex autoimmune neurological disorder characterized by progressive muscle stiffness, rigidity, and painful spasms. This chapter provides a comprehensive overview of SPS, exploring its pathophysiology, clinical presentation, diagnostic challenges, and current treatment approaches. We discuss the latest research findings, including the role of autoantibodies, genetic factors, and environmental triggers in the development of SPS. The chapter examines various diagnostic methods, emphasizing the importance …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 14, Issue 3, 2024 · pp. 35–43 Read article