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389 articles for “and proteins”
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Molecular Docking and Interaction of Anthocyanin Derivatives in Regulating Hippo-taz Pathway for Renal Injuries
Abstract: Introduction: The Hippo pathway plays a pivotal role in renal disease, with Yes-associated protein (YAP) exhibiting promise for combined treatments. The crucial evaluation of YAP-targeted drug safety and efficacy through preclinical studies is imperative. Additionally, α-SMA and SMAD3 emerge as potential therapeutic targets in renal fibrosis, driving ongoing research toward innovative interventions. Materials and Methods: In the systematic identification of therapeutic secondary metabolites, Anthocyanin derivatives were methodically retrieved from the …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 2, Issue 1, 2024 · pp. 23–38 Read article
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In Situ Investigation of Hemidesmus indicus Phytocompound Extracts as a Therapeutic Target for Acute Myeloid Leukemia
Abstract: Objective: Acute myeloid leukemia (AML) is an apoptotic condition in the hematopoietic system induced by the differentiation and maturation of stem cells into erythrocytes, and leukemic cell proliferation is suppressed as the PI3K-Akt-mTOR pathway is pharmacologically targeted with certain inhibitors. As a result, in silico molecular docking of compounds against AML receptors, CTMP, was used in computational research on Hemidesmus indicus to uncover therapeutic phytochemicals for AML. Thus, this study …
Published in Research and Reviews : Journal of Computational Biology · Vol. 13, Issue 1, 2024 · pp. 38–53 Read article
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Targeting Dystrophin Restoration and Neuroprotection in Duchenne Muscular Dystrophy: Insights from Withania somnifera
Abstract: Duchenne muscular dystrophy is a genetic disorder. This disease affects men more common than women. Main objective of the present study was to identify the naturally active phytocompounds from Withania somnifera (Ashwagandha). Ashwagandha has a great value in the field of Ayurveda and Indian medicine and is used for treating muscular and neurological disorders. Toxicity prediction, molecular docking, statistical information, drug illness prediction, and Absorption, distribution, metabolism, excretion, and toxicity …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 15, Issue 2, 2024 · pp. 64–84 Read article
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Defensive Mechanisms and Key Strategies with Its Specified Role in Mulberry Silkworm (Bombyx mori L.)
Abstract: Silkworms (Bombyx mori L.) possess a variety of defense mechanisms that play a vital role in protecting them against microbial infections and environmental stressors. These defense systems are primarily innate, relying on cellular and humoral responses. Cellular defenses include hemocytes which are responsible for processes like phagocytosis, encapsulation, and nodule formation. Humoral responses involve the production of antimicrobial peptides (AMP’s), such as cecropins, moricins, and lysozymes, which target invading pathogens. …
Published in International Journal of Insects · Vol. 1, Issue 2, 2024 · pp. 10–14 Read article
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Proximate Composition and Nutritive Value of Red Seaweed (Rhodophyta) and Green Seaweed (Chlorophyta) as Livestock Feed
Abstract: Seaweeds have been recognized globally as the biological and ecologically potential sources of proteins, lipids, fibers, and minerals for livestock. The study was carried out for a period of 3 months from April to June 2023 in Saint Martin’s Island, Bangladesh, to explore the potentials of red seaweed (Rhodophyta) and green seaweed (Chlorophyta) as livestock feeds. Samples were collected from Saint Martin’s Island and analyzed for dry matter (DM), crude …
Published in Research and Reviews : Journal of Veterinary Science and Technology · Vol. 13, Issue 3, 2024 · pp. 01–10 Read article
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Development of a Polymeric Detection System for Salivary Annexin-1: A Potential Tool for Point-of-Care Diagnostics in Periodontal Disease
Abstract: Salivary annexin-1, a protein with anti-inflammatory properties, has emerged as a potential biomarker for periodontal disease. However, current detection methods, like ELISA, are often complex and require laboratory settings. This study explores the development of a novel polymeric detection system for the rapid and sensitive identification of salivary annexin-1. This system could leverage the unique properties of polymers to create a point-of-care diagnostic tool for: (1) early detection and monitoring …
Published in Journal of Polymer & Composites · Vol. 12, Issue 5, 2024 · pp. 101–110 Read article
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Biochemical Changes in Chickpea (Cicer arietinum L.) Plants Induced by Flooding
Abstract: Flooding is a significant environmental stressor that affects the growth, development, and productivity of chickpea (Cicer arietinum L.), a crucial pulse crop grown worldwide, especially in India. This study investigates the biochemical changes in chickpea plants subjected to prolonged and sudden flooding. Key parameters analyzed include carbohydrate metabolism, protein content, chlorophyll levels, amylase activity, and proline accumulation. Results show that flooding significantly reduces total sugar content in leaves, stems, and …
Published in Research & Reviews : Journal of Agricultural Science and Technology · Vol. 13, Issue 3, 2024 · pp. 1–9 Read article
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Mystic Malignant Melanoma Modalities
Abstract: Melanoma is a highly aggressive form of cancer with four recognized subtypes. In about 90% of cases, melanoma is diagnosed as a primary tumor, without signs of spreading. If caught early, the survival rate is quite high, reaching around 94%. However, for metastatic melanoma, the survival rate drops significantly to about 40%. Diagnosing melanoma can be tricky, as it shares features with benign conditions like seborrheic keratosis, benign moles, blue …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 13, Issue 3, 2024 · pp. 1–10 Read article
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The Intersection of Bioinformatics and Cellular Function in Disease Modeling
Abstract: The integration of bioinformatics and cellular biology has revolutionized our understanding of disease mechanisms, offering unprecedented opportunities to model complex biological systems. Bioinformatics is an interdisciplinary field that merges biology, computer science, and statistics, offering advanced tools to analyze vast biological datasets. Cellular functions, including gene expression, protein interactions, and metabolic pathways, form the foundation of physiological and pathological states. Disruptions in these processes can result in diseases like cancer, …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 2, Issue 2, 2024 · pp. 1–7 Read article
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Moringa Leaf Powder: A Natural Superfood with Nutritional Potential
Abstract: Malnutrition can be described by excesses, imbalances, or shortages in an individual’s energy and nutritional intake, according to the World Health Organization (WHO). The plant Moringa oleifera, which is indigenous to India, thrives in tropical and subtropical regions all over the world. The nutritional properties of Moringa are high and it is rich in calcium. The nutritional value of fresh moringa leaf is ranged as protein 6.9 g, ash 1.5–2.5%, …
Published in Emerging Trends in Metabolites · Vol. 2, Issue 1, 2025 · pp. 28–34 Read article
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Antimicrobial Peptides in Fiddler Crabs: Structural Analysis and Potential Applications
Abstract: Crustaceans represent the largest and most ecologically and economically significant group of marine and aquatic arthropods. Their biomass and critical role in ecosystems highlight their importance. Among crustaceans, decapods are frequently used as model organisms in studies of immune responses due to their significant commercial value and the need to mitigate disease outbreaks in shellfish aquaculture. Antimicrobial host-defense peptides (AMPs) are pivotal in metazoan immunity, especially for invertebrates lacking adaptive …
Published in International Journal of Cheminformatics · Vol. 2, Issue 2, 2024 · pp. 26–32 Read article
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Investigating The Alkalizing Potential of Chandanasava For Restoring Acid-Base Homeostasis in Renal Tubular Acidosis: A Computational and In Silico Pharmacological Study
Abstract: Chandanasava, a traditional Ayurvedic formulation, is recognized for its potential alkalizing properties, which may help restore acid-base homeostasis in conditions such as renal tubular acidosis (RTA). This study aims to investigate the active components of Chandanasava and their interactions with key renal target proteins, Pendrin and Carbonic Anhydrase II, which are essential for maintaining acid-base balance. An in silico approach was utilized to explore the pharmacological potential of the phytochemicals …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 3, Issue 2, 2025 · pp. 28–52 Read article
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Integrative Network Biology Analysis of GSE6011 Uncovers Molecular Signatures in Duchenne Muscular Dystrophy
Abstract: Duchenne muscular dystrophy (DMD) is a rare, severe neuromuscular disorder demonstrated by progressive skeletal muscle deterioration and premature mortality. Despite advances in supportive care, no definitive cure exists, highlighting the need to explore novel molecular targets. The current study aimed to uncover key dysregulated genes and molecular pathways in DMD through a dataset-specific network biology approach. Publicly available microarray data (GSE6011) from DMD quadriceps muscle biopsies of 22 patients and …
Published in Research and Reviews : Journal of Computational Biology · Vol. 14, Issue 3, 2025 · pp. 36–48 Read article
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Utilization of Whey in Functional Dairy Beverages: Nutritional, Technological, and Industrial Perspectives
Abstract: The dairy industry plays a vital role in global nutrition and the economy, producing a wide range of products that contribute significantly to human health. Among its by-products, whey is generated in large quantities during cheese and paneer production and has traditionally been considered a waste material, posing environmental challenges due to its high biochemical oxygen demand. However, in recent years, whey has gained considerable attention as a valuable resource …
Published in Research and Reviews : Journal of Dairy Science and Technology · Vol. 15, Issue 1, 2026 · pp. 18–23 Read article
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An Approach towards in Management of Chronic Kidney Disease
Abstract: The current international guidelines define and classify the chronic kidney disease (CKD) as decreased kidney function shown by decreased glomerular filtration rate (GFR). Glomerular filtration rate of 60 ml/min/1.73 m 2 for at least 3 months is a marker for kidney damage. The underlying causes for chronic kidney disease are proteinuria and hypertension. It is the main cause of CKD in many high-, middle- and low-income countries. In different countries, …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 12, Issue 1, 2025 · pp. 9–15 Read article
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Quality Appraisal for the Ornamental Bird, Fish, Dog, and Cat Foods Available in Bangladesh
Abstract: The study aimed to assess if the chemical composition of different avian, aquatic, dog, and cat foods commonly available in Chattogram, Bangladesh adheres to the recommended standards. Food samples were collected and subjected to proximate analysis for the dry matter (DM), crude protein (CP), crude fibre (CF), ether extract (EE), nitrogen free extract (NFE), and total ash (TA). The plant seeds used for ornamental birds exhibited substantial variability in terms …
Published in Research and Reviews : Journal of Veterinary Science and Technology Read article
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Integrating Network Pharmacology and Molecular Docking to Assess Rutin’s Pharmacological Properties
Abstract: Objectives: In the present research, the network pharmacology process was applied to determine the underlying mechanism of the pharmacological properties of Rutin. Network pharmacology was utilized to reveal the interactions between medications and the targets of illnesses, and it is capable of completely articulating the complexity between diseases and medications. The identification of diverse drug-target interactions using network pharmacology may be utilized to discover novel medications for difficult conditions like …
Published in International Journal of Molecular Biotechnological Research · Vol. 1, Issue 1, 2023 · pp. 20–33 Read article
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To evaluate the effectiveness of a structured educational program on knowledge about hypoglycemia and its management among diabetes patients living in selected urban slums of Durgapur, West Bengal
Abstract: INTRODUCTION: Diabetes Mellitus (DM) is a significant global health issue characterized by chronic hypoglycemia and an imbalance in the metabolism of carbohydrates, fats, and proteins. It has multiple underlying causes. Hyperglycemia refers to high blood glucose levels, while low blood glucose levels are known as hypoglycemia. Raising awareness about the signs and symptoms of diabetes among individuals with the condition can potentially minimize complications. OBJECTIVES: 1. To evaluate the initial …
Published in International Journal of Community Health Nursing And Practices · Vol. 1, Issue 1, 2023 Read article
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Rheumatoid Arthritis and its Relationship with Vitamin D, ESR, and Obesity
Abstract: Recent years have seen a rise in the prevalence of rheumatoid arthritis (RA), a disease marked by the destruction of articular cartilage and ankylosis of the joints, as well as other complications such as diffuse lung inflammation, sclera, pleura, pericardium, and nodular lesions, which are also common in subcutaneous tissue. Reviewing RA symptoms, diagnosis, treatment, and associations with vitamin D, ESR, and obesity was the aim of the study. Even …
Published in International Journal of Toxins and Toxics · Vol. 1, Issue 1, 2024 · pp. 06–12 Read article
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DMARDs, Biologic Agents and Novel Experimental Strategies in The Treatment of Rheumatoid Arthritis
Abstract: An inflammatory and autoimmune disease, rheumatoid arthritis (RA) causes severe pain and inflammation in affected areas of the body. According to the report, there is no known cure for RA. Therefore, reducing discomfort and halting future harm must be the goals of present therapy. For the purpose of prevention and to reduce disease activity in RA patients, significant success has been achieved with the continued development of disease-modifying antirheumatic drugs …
Published in Emerging Trends in Personalized Medicines · Vol. 1, Issue 1, 2024 · pp. 14–24 Read article