Search
109 articles for “Mediation Effect”
-
Limits to Knowledge-Sharing by Computers
Abstract: The rapid advancement of artificial intelligence (AI) and machine learning (ML) has significantly enhanced the capabilities of computers in processing, analyzing, and disseminating knowledge. However, despite these advancements, there are inherent limits to the extent that knowledge-sharing can be fully realized through computer systems. This study explores the various barriers that hinder the effective sharing and transfer of knowledge through machines, including technological limitations, ethical concerns, and the complexities of …
Published in Current Trends in Information Technology · Vol. 15, Issue 2, 2025 · pp. 01–05 Read article
-
Influence of Reptin on acute pancreatitis model of the rat
Abstract: Background and Aim: In acute pancreatitis, hyperproduction of inflammatory mediators, including inflammatory cytokines, exacerbation of tissue injury due to microcirculatory disturbances, secondary activation of inflammatory cells in distant organs, and the cascade are the pathogenic basis of pancreatitis severity. Therefore, inhibition of pancreatic enzyme activity, blocking production, and preventing the activation of inflammatory cells is a practical way to prevent the development of severe acute pancreatitis and multiorgan failure. In …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 11, Issue 2, 2022 · pp. 36–40 Read article
-
Food Allergy-practical Approach
Abstract: There is a consistent increase in prevalence of food allergy (FA). The diagnosis of FA is based on thorough history supported by positive skin test, specific IgE (extract-and component-based), Basophil activation test (BAT) to reduce the need for Oral food challenge (OFC). OFC procedures may be conducted in cases of diagnostic uncertainty or to assess the presence or development of tolerance. Effective management of food allergy involves a comprehensive three-pronged …
Published in Research and Reviews : A Journal of Immunology · Vol. 14, Issue 1, 2024 · pp. 32–53 Read article
-
Magnetic and Radioactive Nanoparticles for Improved Theranostics and AI Assisted Radiation Therapy
Abstract: Nanoparticles based therapeutic and theranostics technique is becoming an active area of research in nanomedicine. The sensitivity, biocompatibility, and stability of magnetic and radioactive nanoparticles determine their functionality. This research highlights the impacts of magnetic and radioactive nanoparticles on therapeutic techniques namely, cell therapy, gene therapy, and tissue regeneration. Then, it is intended to brief a principal role of these therapeutic techniques to envisage theranostics medicine and radiation therapy using …
Published in International Journal of Advance in Molecular Engineering · Vol. 3, Issue 2, 2025 · pp. 10–21 Read article
-
Experimental Study on the Effect of Membranous Milkvetch and Ledebouriella divaricate Immunomodulatory Tablets on cytokine production in allergic rhinitis model mice
Abstract: We have established allergic rhinitis models for use in the treatment of allergic rhinitis with the help of the traditionall Koryo medicine administration, lade-screen Powder-extracted Membranous Milkvetch and Ledebouriella divaricate immunomodulatory tablet and the effect of lade-screen Powder on cytokine production in allergic rhinitis model mice. In the allergic rhinitis model, the administration of Membranous Milkvetch and Ledebouriella divaricate immunomodulatory tablets, along with Lade-screen Powder, demonstrated significant therapeutic effects. These …
Published in Research and Reviews : A Journal of Immunology · Vol. 15, Issue 3, 2025 Read article
-
Drug-Induced Liver Injury: Hepatotoxicity and Treatment - A Literature Review
Abstract: Drug-induced liver injury (DILI) is a major clinical and regulatory challenge, posing risks to patient safety and drug development worldwide. As the primary organ responsible for xenobiotic metabolism, the liver is particularly susceptible to toxic injury from prescription drugs, over-the-counter medications, herbal products, and dietary supplements. Drug-induced liver injury (DILI) accounts for a substantial proportion of acute liver failure cases and remains a leading cause of post-marketing drug withdrawal. Its …
Published in Research and Reviews: A Journal of Toxicology · Vol. 16, Issue 1, 2026 · pp. 1–17 Read article
-
Rheumatoid Arthritis and Stem Cell Therapies Perspectives for It
Abstract: Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by systemic inflammation, primarily affecting synovial joints, leading to joint destruction and systemic complications. The pathogenesis involves immune system dysregulation, autoantibody production, and enzymatic imbalances. Enzymes, including matrix metalloproteinases (MMPs), serine proteases, and kinases, play crucial roles in these processes. Their dysregulation contributes significantly to disease progression through the imbalance of pro-inflammatory cytokines, oxidative stress, and extracellular matrix (ECM) degradation. MMPs, …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 15, Issue 2, 2025 · pp. 20–28 Read article
-
Host-Microbiota Crosstalk in the Rumen: Signaling Pathways for Nutrient Metabolism and Disease Resilience in Dairy Cows
Abstract: The rumen serves as a highly intricate microbial ecosystem, fundamentally responsible for the degradation of fibrous plant materials in ruminant. The intricate host-microbiota crosstalk within the rumen significantly influences nutrient metabolism, growth, and health outcomes in livestock. The interaction between the host and its microbial community, mediated through signaling pathways including the production of short-chain fatty acids (SCFAs), bile acids, and various metabolites, is crucial for enhancing nutrient absorption, fermentation …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 15, Issue 1, 2025 · pp. 29–41 Read article
-
Evaluating UX Design Factors Affecting Efficiency of Composite Material Design and Analysis Platforms
Abstract: Within engineering software platforms that involve the design, simulation and characterization of composite materials, user experience (UX) design has become a key determinant for efficient use. This research aims to quantify how user experience design parameters relate to productivity in composite engineering workflows by analyzing the relationship between usability, learnability, accessibility, complexity of the UI, navigation efficiency and users engineering results satisfaction. Computational techniques in python were used in the …
Published in Journal of Polymer & Composites · Vol. 14, Issue 4, 2026 · pp. 341–366 Read article
-
Current Trends in Crossing the Blood–Brain Barrier: A Review
Abstract: The blood-brain barrier (BBB) is a protective barrier that protects the central nervous system (CNS) from toxins and pathogens in the blood. However, the existence of BBB challenges therapy for CNS diseases and disorders as most pharmaceuticals (drugs) are restricted to enter brain. The review article focuses on the approaches involved to cross BBB with various advanced technology such as nanoparticles, intraventricular injection, chemical modifications, virus mediated distribution, exosome mediated …
Published in Trends in Drug Delivery · Vol. 10, Issue 2, 2023 · pp. 25–38 Read article
-
Gut Microbial Metabolites in Inflammatory, Metabolic, and Neurologic Disorders.
Abstract: The human gut microbiota transforms dietary and hostderived substrates into a diverse array of metabolites—including shortchain fatty acids (SCFAs), hydrogen sulfide (H₂S), bile acid derivatives, indoles, trimethylamine Noxide (TMAO), branchedchain amino acid (BCAA) derivatives, and lipopolysaccharide (LPS)—that act as key signaling mediators along epithelial, immune, endocrine, and neural axes. These metabolites regulate barrier integrity, energy homeostasis, inflammation, and gut–brain communication and are increasingly implicated in the pathogenesis of inflammatory bowel …
Published in Emerging Trends in Metabolites · Vol. 3, Issue 1, 2026 · pp. 58–64 Read article
-
A Short Discussion About E-learning
Abstract: Improvement in E-learning activities supports the country for development. At present time all education systems are based on E-learning all over the world because of digitization and covid pandemic. Web-based learning, online learning, internet-based learning, distance learning, distance education, distributed learning, computer-mediated learning, computer-assisted learning, Virtual Learning, and Blended Learning are all terms used to describe E-learning. The current study's goal is to evaluate the efficiency of e-learning in smart …
Published in Journal of Production Research & Management · Vol. 11, Issue 3, 2021 · pp. 27–31 Read article
-
Designing Engaging Interactive Animatronics: Strategies and Implementation Insights
Abstract: The field of animatronics uses robotic systems to imitate realistic movements and activities in mechanical figures. To enhance the recognition and performance of the animatronic as a relationship mediator, it is important that the animatronics in recreational games be perceived as human companions to create productive interaction scenarios. This study describes the design and implementation of a Java- based programming method, an Adriano microcontroller, an open environment, a depth camera …
Published in International Journal of Optical Innovations & Research · Vol. 1, Issue 2, 2023 · pp. 27–33 Read article
-
Unlocking Novel Drug Targets and Therapeutic Advancements Against RNA Viruses: Insights from HMPV and SARS-CoV-2
Abstract: Re-emerging RNA viruses pose a significant epidemiological welfare threat due to their high mutation rates, potential for zoonotic transmission, and capacity to cause widespread outbreaks such as Human Metapneumovirus (HMPV), Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), Influenza, etc. The rapid evolution and re-emergence of these viruses necessitate the development of novel drug targets and therapeutic strategies to combat existing and future outbreaks. This study focuses on structural as well …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 15, Issue 3, 2025 · pp. 54–86 Read article
-
Overcoming Obstacles to an HIV-1 Cure: Advances in Genome Editing, Immune System Reprogramming, and Viral Reservoir Elimination
Abstract: Human immunodeficiency virus type-1 (HIV-1) continues to represent a major global health challenge despite the remarkable success of antiretroviral therapy (ART). Although ART effectively suppresses viral replication and prolongs survival, it cannot eradicate the virus due to the persistence of long-lived latent reservoirs. In recent years, innovative therapeutic strategies have been explored with the aim of achieving either a functional remission or complete viral elimination. Advances in genome-editing technologies, particularly …
Published in International Journal of Virus Studies · Vol. 3, Issue 2, 2026 Read article
-
Protective Role of Sulforaphane against Multiorgan Toxicity in Rats: An In-vivo and In-vitro Review Study
Abstract: Sulforaphane [1-isothiocyanate-(4R) -(methylsulfinyl) butane] is a natural dietary isothiocyanate produced by the enzymatic accomplishment of the myrosinase on glucopharanin, a 4-methylsulfinylbutyl glucosinolate contained in cruciferous vegetables such as broccoli, brussel sprouts, and cabbage. Exploring of this compound against various oxidative degenerative diseases such as hepatic, nephro and cardiac diseases is growing because of its anticarcinogenic and cytoprotective properties. In several invivo and invitro experimental paradigms proved SFN and its compounds …
Published in Research and Reviews: A Journal of Toxicology · Vol. 8, Issue 1, 2018 · pp. 1–8 Read article
-
Pharmacokinetic Profiling and Molecular Docking of Carvacrol and Structural Analogs: Targeting Quorum Sensing Proteins to Disrupt Biofilm-Mediated Antimicrobial Resistance in Multidrug-Resistant Bacterial Pathogen
Abstract: Antibiotic resistance, particularly in Pseudomonas aeruginosa, has become a major global health threat, exacerbated by the organism's ability to form biofilms and regulate virulence through quorum sensing (QS). The LuxR and LasR receptors are key regulators in this process, influencing both pathogenicity and antibiotic resistance. This study investigates potential QS inhibitors targeting these receptors as a strategy to mitigate antibiotic resistance. The primary objective was to identify novel ligands that …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 3, Issue 2, 2025 · pp. 43–61 Read article
-
The Concept of Guillain-Barré Syndrome (GBS) in Unani Medicine and the Potential Role of Unani Pharmacology in Its Management
Abstract: Introduction: Guillain–Barré Syndrome (GBS) is an autoimmune neurological disorder characterized by progressive muscle weakness and paralysis due to immune-mediated damage to the peripheral nervous system. Conventional treatments focus on immunotherapy and supportive care, but alternative approaches, such as Unani Medicine offer promising holistic management strategies. Unani Medicine attributes GBS to humoral imbalance, particularly an excess of Balgham (Phlegm) affecting nerve function, leading to weakness and dysfunction. Objective: This study aims …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 14, Issue 2, 2025 · pp. 32–52 Read article
-
Repurposing Liv-52 For Primary Sclerosing Cholangitis: A Computational Docking And Pharmacokinetic Study To Evaluate Its Bile Flow-Regulating Potential
Abstract: Primary Sclerosing Cholangitis (PSC) is a long-term liver disease where the bile ducts become inflamed and scarred over time. This scarring can block the flow of bile, leading to liver damage and, eventually, liver failure. The etiology of PSC remains largely unknown, and current treatment options are limited, highlighting the need for novel therapeutic strategies. This study aims to repurpose Liv-52, a traditional herbal formulation known for its hepatoprotective properties, …
Published in Research and Reviews : Journal of Computational Biology · Vol. 14, Issue 2, 2025 Read article
-
Evaluation of Metal Coupons Corrosions in Fresh Water Environment at Different Water Depths Using Finite Element Analysis
Abstract: This research addressed the effects of water depths and quality on corrosion of submerged metal structures in the water body considering environmental conditions. The depths considered were 30cm to 150cm. Four different metal coupons were selected (Mild Steel, Copper Steel, Carbon Steel and Stainless Steel] Galerkin`s finite element techniques was applied to evaluate the relationship between diffusion and weight loss, also velocity and weight loss at different water depths. The …
Published in International Journal of Fracture Mechanics and Damage Science · Vol. 3, Issue 1, 2025 · pp. 27–50 Read article