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1969 articles for “quantum mechanics/molecular mechanics (QM/MM)” (ranking capped at the first 2,000 matches — narrow the search to see the rest)
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Anti-hyperglycemia Effects of Plant Secondary Metabolites Towards PKA/CREB Pathway Activation in Diabesity
Abstract: Objective: Diabesity, the amalgamation of diabetes and obesity, presents a significant global health challenge. This research carefully examines how plant secondary metabolites influence glucose regulation in diabetes using the PKA/CREB pathway, paying particular attention to diabesity—the combination of diabetes and obesity. Understanding the complex ways in which these metabolites affect metabolic health will help to identify new treatment approaches for managing diabetes and its associated problems. By conducting a thorough …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 2, Issue 1, 2024 · pp. 33–50 Read article
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Whispers of the Microbial World: Unveiling Bacterial Dialogues through Quorum Sensing
Abstract: Quorum sensing is a special way of bacteria by which they can regulate their own gene expression as per the population density of the bacteria. It is basically a type of cell-to-cell communication pathway used by the microbes. The signal molecule which helps in this mechanism are called auto inducer(AI). As the mechanism depends by changes in the cell density, so when the cell density reaches to the threshold cell …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 14, Issue 3, 2024 · pp. 1–8 Read article
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Butrin Tackles Retinoblastoma – A Clinical Hypothesis †
Abstract: Breach of association of legumain protein activities to the corresponding cellular components results in over-expression of legumain, and constitutes a key biomarker for a variety of life-taxing sicknesses like cancer, Alzheimer’s/Parkinson’s and acute kidney injury. To suppress the functions of legumain, it is hypothesized that a water soluble and edible biomolecule, namely, butrin (7, 3’, 4’-trihydroxy flavanone-7, 3’-diglucoside) may have the therapeutic potential owing to its special ability to bind …
Published in International Journal of Advance in Molecular Engineering · Vol. 2, Issue 1, 2024 · pp. 26–30 Read article
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Synthesis and Characterization of Short Fiber Reinforced Biocomposite Materials
Abstract: The fabrication and characterization of a biocomposite reinforced with banana fiber is proposed in this proposal. The substance used for the grid was epoxy. Hand-layup preparation was the last step in the biocomposite's manufacturing. Biocomposites with various fiber and grid compositions were produced. After treating banana strands with NaOH in the composites manufacturing process, a comparative analysis between biocomposites reinforced with treated and untreated filaments was conducted. The antacid treatment …
Published in Journal of Experimental & Applied Mechanics · Vol. 15, Issue 2, 2024 · pp. 42–53 Read article
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An Experimental Investigation on Surface Roughness of Laser Beam Machining of Aluminium Alloy
Abstract: Laser beam machining (LBM) is a cutting-edge technique widely utilized for precision machining of advanced materials. This experimental investigation focuses on the surface roughness of aluminum alloy (Al 6061) during LBM. The study systematically examines the impact of process parameters such as laser power, cutting speed, and gas pressure on surface roughness (Ra). The significance of surface roughness in determining the quality and functionality of machined components is emphasized. The …
Published in Journal of Polymer & Composites · Vol. 12, Issue 6, 2024 · pp. 82–104 Read article
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Optimizing Heat Transfer Performance in CO2 Finned-Tube Gas Coolers: A Comparative CFD Study of Design Variations
Abstract: Computational fluid dynamics (CFD) simulations and mathematical analysis are used in this study to examine the heat transfer efficiency of CO2 fined tube gas coolers. To maximize heat transfer efficiency, CFD simulations were carried out on a variety of gas cooler designs with variable fin geometry, including offset strip fins, using the ANSYS Fluent program. Under the baseline design, there was a finned tube cooler measuring 610 mm in length, …
Published in Recent Trends in Fluid Mechanics · Vol. 11, Issue 3, 2024 · pp. 1–13 Read article
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Understanding Programmed Cell Death
Abstract: Recent studies emphasize the critical role of various types of programmed cell death (PCD) such as apoptosis, autophagy, pyroptosis, and necroptosis, as well as their respective signaling pathways. These processes are essential for regulating cellular balance, responding to stress, and triggering immune defenses. Apoptosis, commonly known as "cellular suicide," is a tightly controlled mechanism that allows cells to die without inducing inflammation. This process is key for tissue development, immune …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 14, Issue 3, 2024 · pp. 42–50 Read article
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An Experimental Investigation of Machining Parameters on Aluminum Composites
Abstract: The need for a material with good mechanical, thermal, and wear resistant properties is satisfied by aluminum composite. However, the biggest obstacle to substituting it with alternative materials is the machining challenges. For this kind of hard-to-cut material, electric discharge machining is a very efficient method. Thus, using a Taguchi-based method, an attempt has been made to determine the most advantageous amount of input parameters for EDM of Al composite. …
Published in Journal of Polymer & Composites · Vol. 12, Issue 6, 2024 · pp. 8–13 Read article
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Simulation of Adder Circuit Using Reversible Gates in Verilog HDL
Abstract: The emerging field of quantum computing uses quantum logic gates. The reversibility of logic gates is an important aspect of quantum logic gates used in VLSI and quantum computing. Reversibility ensures that power consumption is minimized. This study explores the field of reversible logic and utilizes Peres gate to develop a full adder circuit that shows a significant reduction in power consumption in simulations performed in Xilinx Vivado. We have …
Published in Journal of VLSI Design Tools and Technology · Vol. 14, Issue 3, 2024 · pp. 32–38 Read article
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Optimizing MEMS-Based Energy Harvesting with Piezoelectric and Thermoelectric Polymer Composites
Abstract: This research explores the development and performance of polymer-based composites, particularly Polyvinylidene Fluoride (PVDF) and Electro active Polymers (EAPs), in MEMS-based energy harvesting systems. PVDF, a flexible piezoelectric material, is combined with ceramic powders such as lead zirconatetitanate (PZT) to enhance its piezoelectric response while retaining mechanical flexibility. EAPs, including ionic polymer-metal composites (IPMCs) and dielectric elastomers, are investigated for their ability to generate electrical power from mechanical deformations, offering …
Published in Journal of Polymer & Composites · Vol. 13, Issue 1, 2025 · pp. 221–237 Read article
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Application of Paper Mill Lime Sludge Waste in Building Construction Material: State of The Art Report
Abstract: A Comprehensive Literature review is done to find various areas of application of Lime Sludge. Temperature-treated Lime sludge proves to be highly beneficial to be used as Building material. Lime Sludge has an application area in all types of Building materials such as bricks, Tiles, Cement etc. especially, in Cement it is highly beneficial in all the phases of cement from Clinker to, mortar and as a replacement in Concrete. …
Published in Journal of Polymer & Composites · Vol. 12, Issue 7, 2024 · pp. 73–88 Read article
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Geotechnical Analysis and Performance Evaluation of Subgrade Materials in Road Construction
Abstract: Geotechnical engineering plays a pivotal role in the design, construction, and long-term maintenance of infrastructure, particularly in road construction, where subgrade conditions are directly linked to pavement performance, durability, and overall structural integrity. The performance of a road is heavily influenced by the geotechnical properties of the subgrade, making it essential to thoroughly assess these properties in the planning and construction phases. This study comprehensively investigates the geotechnical characteristics and …
Published in Journal of Geotechnical Engineering · Vol. 11, Issue 3, 2024 · pp. 24–29 Read article
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Development of a Novel Therapeutic Approach Using RNA Interference for Targeting Viral Genes
Abstract: RNA interference (RNAi) is a ground breaking therapeutic strategy that holds immense promise for targeting viral genes in the treatment of viral infections. This approach leverages the natural gene-silencing mechanisms of RNAi to inhibit viral replication and expression at the molecular level, providing a precise and adaptable method to counteract viral pathogens, including influenza, HIV, and hepatitis viruses. Recent advancements in RNAi technology have enabled the development of highly specific …
Published in International Journal of Virus Studies · Vol. 1, Issue 2, 2024 · pp. 12–22 Read article
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Emerging Trends in Drones across Multiple Sectors
Abstract: Drones, also known as unmanned aerial vehicles (UAVs), have become increasingly popular for their adaptability, affordability, and advanced functionalities. Originally developed for military purposes, they are now widely utilized across diverse sectors such as agriculture, filmmaking, and search and rescue missions. The impact of drones has been significant in various domains, such as reducing human casualties, providing more accurate information, increasing efficiency and cost reduction, and improving crop yields. Nonetheless, …
Published in International Journal of Mechanical Dynamics and Systems Analysis · Vol. 2, Issue 2, 2024 · pp. 29–35 Read article
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Exploring The Therapeutical Potential Of Pongamia Pinnata For Herpes Simplex Virus Type 1 (HSV-1)
Abstract: Objective: Pongamia pinnata (L.), commonly known as Indian beech or pongam tree, is a tropical plant renowned for its medicinal properties in traditional medicine systems. Extracts derived from various parts of Pongamia pinnata have demonstrated antimicrobial, anti-inflammatory, and immunomodulatory activities. Such attributes make it a compelling candidate for exploring its therapeutic potential against HSV infections. Thymidine kinase is the target protein mostly used in the treatment of HSV1 infections. In …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 15, Issue 1, 2025 · pp. 1–9 Read article
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Experimental and Numerical Studies on Radial Tensile Strength of Composite Rotor
Abstract: This paper describes the experimental and numerical studies on the radial tensile strength (RTS) of composite rotor. Carbon/epoxy composite rotors were fabricated using a filament winding process and their radial tensile strength was determined by diametric tensile testing of composite C-rings. The radial tensile strength of the composite rotor was measured as ~ 22 MPa and the failure was found to occur circumferentially symmetric about the horizontal plane of the …
Published in Journal of Polymer & Composites · Vol. 13, Issue 1, 2025 · pp. 985–996 Read article
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Experimental Investigation of OPC Concrete with Incorporation of Glass Powder as Partial Substituent Material.
Abstract: This study presents an experimental survey aimed at evaluating the viability of incorporating glass powder (GP) as a partial substitute for cement in concrete matrix. The research focuses on assessing the effect of this sustainable alternative in concrete by investigating the various properties of fresh concrete such as workability, mechanical and durability aspects. Specimens were prepared with GP replacement to cement at 5%, 10%, 15%, and 20% levels, with comparative …
Published in Journal of Polymer & Composites · Vol. 13, Issue 1, 2025 · pp. 1058–1068 Read article
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Simulation and Experimental Analysis of Abuse Testing for Prediction of Life Cycle for Lithium Ion Battery Cell and Pack Level
Abstract: Lithium-ion batteries play a crucial role in contemporary technology, serving as the power source for everything from consumer gadgets to electric vehicles. However, their safety and longevity are significant influenced by the reperformance under extreme conditions, commonly referred to as ab use testing .This paper explores the simulation and analysis of ab use testing and life cycle prediction for lithium-ion batteries at both the cell and pack levels. Abuse testing …
Published in International Journal of Mechanical Dynamics and Systems Analysis · Vol. 2, Issue 2, 2024 · pp. 1–24 Read article
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Design and Development of Pedalled Powered Electricity Generation
Abstract: Pedal power energy harvesting transforms the mechanical energy produced by pedalling into electrical energy, which can be used to operate devices or saved for future use. The strategy utilizes the physical exertion of pedalling to generate a reliable and eco-friendly energy source. This project aims to develop, construct, and demonstrate a functional mechanism. The generator utilizes the motion of pedalling a regular bicycle to generate electricity. The main goal of …
Published in Journal of Alternate Energy Sources & Technologies · Vol. 16, Issue 1, 2025 · pp. 30–36 Read article
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Breakthroughs in Biotechnology for the Regulation of Infectious Diseases
Abstract: Infectious diseases have a heavy impact on both public health and the world’s economies. In most diseases, antibiotic resistance has become widespread over time. A variety of diseases comprising pneumonia, tuberculosis, and gonorrhea go through the same evolutionary processes, which include the formation of drug-resistant pathogens in response to selection pressure from medications and their potential extinction when drug use is ceased. Since the occurrence of drug resistance in serious …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 15, Issue 1, 2025 · pp. 1–25 Read article