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135 articles for “pharmacological potentials”
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Effectiveness of Habb-e-Suranjan and Roghan-e-Farfiyun in the Management of Waja-ul-Rukba (Knee Pain): A Review
Abstract: Introduction: Knee osteoarthritis is a painful condition that represents the degeneration of the cartilage and osteophyte formation in the knee joint, which affects millions of people worldwide. According to the Unani claimed text, accumulation of “madda” (substance) in joints, which is neither absorbed nor expelled, is due to the absence of Quawwat-e-Jazibah (power of absorption) and Quawwat-e-dafia (power of expulsion). Unani medicine presents a promising approach for managing knee osteoarthritis …
Published in Research & Reviews : A Journal of Unani, Siddha and Homeopathy · Vol. 12, Issue 2, 2025 · pp. 7–12 Read article
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Unveiling Insights and Strategies for Cognitive Mental Acuity
Abstract: This comprehensive review focuses on the intricate facets of cognition, emphasizing its multifaceted nature rooted in thought, experience and sensory perception. The role of key brain regions, such as the prefrontal cortex, temporal lobes, parietal cortex, occipital cortex and cerebellum, is elucidated in shaping various mental functions. The pathophysiology of cognitive decline is examined, linking specific impairments to damage in distinct brain regions. The study delves into pharmacological and non-pharmacological …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 14, Issue 1, 2024 · pp. 1–10 Read article
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A Comprehensive review on phytomedicinal activity of chirchita (Achyranthes aspera): an Indian Rural Medicinal Plant
Abstract: Because it is used to treat many types of diseases. Native to India, Achyranthes aspera (Chirchita) has been used in rural medicine for generations.This review explores the phytomedicinal significance of Achyranthes aspera, focusing on its bioactive compounds and the pharmacological activities that support its use in treating various ailments. This plant is a useful tool in traditional and alternative medicine. Because it has anti-inflammatory properties Antioxidants Antibacterial, anticancer and liver …
Published in International Journal of Tropical Medicines · Vol. 2, Issue 1, 2025 · pp. 74–85 Read article
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Perspectives on ‘Kamsaharitaki’: an Ayurvedic Formulation for COVID-19 related Multisystem Inflammatory Syndrome (MIS)
Abstract: Background and Aim: Angiotensin-converting enzyme 2 receptor (ACE2), together with Transmembrane protease serine 2 (TMPRSS2), is a protein receptor for SARS-CoV-2 virus in the host subject; expression of ACE2 and TMPRSS2 reveals the multidimensional character of COVID-19 infection. SARS-CoV-2 Prominently induces pulmonary and systemic injury with other synergistic mechanisms. Preexisting chronic inflammatory conditions markedly sustain and aggravate the severity and cytokine storm. Inflammatory responses are closely linked with COVID-19 severity …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy Read article
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Integrating Horticultural Techniques for the Propagation of Ethnomedicinal Pteridophytes in the Himalayan Region
Abstract: The Doon Valley, including the regions of Dehradun, Mussoorie, and Chakrata in Uttarakhand, India, is rich in ecological and medicinal plant diversity. This study focuses on the geographical distribution, habitats, and medicinal applications of 28 pteridophyte species found in these regions. Detailed field observations and data collection from various scientific journals, databases, and publications have contributed to understanding the traditional and pharmacological uses of these plants. The results show that …
Published in International Journal of Trends in Horticulture · Vol. 1, Issue 2, 2024 · pp. 1–19 Read article
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In Silico Exploration of Podophyllum Hexandrum-Derived Phytocompounds as Potential Therapeutics Against Small Cell Lung Cancer (SCLC): A Molecular Docking Approach
Abstract: Small Cell Lung Cancer (SCLC) is a fast-growing and aggressive type of lung cancer that spreads quickly strongly associated with smoking. It is characterized by symptoms, such as persistent cough, breathing difficulties, or hoarseness, though it can sometimes be asymptomatic which makes early detection challenging. The tumor suppressor gene TP53 is critical in regulating the cell cycle and preventing uncontrolled cell division. Mutations in TP53 result in the loss of …
Published in International Journal of Molecular Biotechnological Research · Vol. 3, Issue 1, 2025 · pp. 1–11 Read article
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A Traditional Indian Unani Dynamic Drug Amla (Emblica Officinalis) And Its Unani Pharmacological Activities In The Light of Recent Experimental Studies: A Comprehensive Review
Abstract: Since ancient times, plants have been essential to human development, serving as a primary source of natural remedies. The challenges associated with producing synthetic medications, along with their potential side effects and high costs, have driven researchers around the world to focus on the study of medicinal plants. In recent years, numerous publications have highlighted the role of plant-derived bioactive compounds in treating a wide range of human ailments, underscoring …
Published in Research & Reviews : A Journal of Unani, Siddha and Homeopathy · Vol. 11, Issue 3, 2024 · pp. 21–29 Read article
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Melanogenic Inhibitory Effects of Sesamum indicum Phytocompounds Towards CDK 2, c-KIT, and BRAF.
Abstract: Objective: Melanoma is thought to be the fifth most frequent cancer in the US population, despite cancer being the most common cause of death in the globe. BRAF, CDK2, and c-KIT proteins are regarded as potential therapeutic agents since mutations in these proteins are the primary cause of melanoma. For the investigation of their pharmacological properties and therapeutic activities against the target proteins, Sesamum indicum L. and its phytocompounds were …
Published in International Journal of Bioinformatics and Computational Biology Read article
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Anti-hyperglycemia Effects of Plant Secondary Metabolites Towards PKA/CREB Pathway Activation in Diabesity
Abstract: Objective: Diabesity, the amalgamation of diabetes and obesity, presents a significant global health challenge. This research carefully examines how plant secondary metabolites influence glucose regulation in diabetes using the PKA/CREB pathway, paying particular attention to diabesity—the combination of diabetes and obesity. Understanding the complex ways in which these metabolites affect metabolic health will help to identify new treatment approaches for managing diabetes and its associated problems. By conducting a thorough …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 2, Issue 1, 2024 · pp. 33–50 Read article
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Flaxseed-Based Drug Delivery Systems: Advancing Colon Cancer Treatment
Abstract: Flaxseed (Linum usitatissimum) has long been appreciated for its rich nutritional profile, including essential fatty acids (such as α-linolenic acid), plant fibers, and lignans. Recent research has focused on its potential as a novel drug delivery system (DDS) for the treatment of colon cancer. This review explores the bioactive constituents of flaxseed, their pharmacological activities, and innovative approaches to the use of flaxseed extracts in drug delivery for the treatment …
Published in Emerging Trends in Personalized Medicines · Vol. 2, Issue 1, 2025 · pp. 54–59 Read article
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Repurposing Liv-52 For Primary Sclerosing Cholangitis: A Computational Docking And Pharmacokinetic Study To Evaluate Its Bile Flow-Regulating Potential
Abstract: Primary Sclerosing Cholangitis (PSC) is a long-term liver disease where the bile ducts become inflamed and scarred over time. This scarring can block the flow of bile, leading to liver damage and, eventually, liver failure. The etiology of PSC remains largely unknown, and current treatment options are limited, highlighting the need for novel therapeutic strategies. This study aims to repurpose Liv-52, a traditional herbal formulation known for its hepatoprotective properties, …
Published in Research and Reviews : Journal of Computational Biology · Vol. 14, Issue 2, 2025 Read article
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Stilbenes: A Molecular Docking and ADMET Analysis Approach on an Emerging Resource for Scavenging Reactive Oxygen Species in the Field of Colon Malignancy
Abstract: Objective: Colon malignancy, also referred to as colon cancer, originates as precancerous polyps in the colon or rectum, which have the potential to thrive and progress into cancerous tumors over time. This study delves into various bioactive compounds (from natural sources like plants) to assess their potential efficacy in inhibiting colon malignancy as compared to conventional methods. Methods: The objective of this study was to employ computational methodologies to evaluate …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 14, Issue 3, 2024 · pp. 29–38 Read article
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Prediction of Molecular Targets for Anthraquinone and Its Analogs for Treatment of Good Pasteur Syndrome
Abstract: Objective: In order to find prospective molecular targets for the treatment of Good Pasteur Syndrome (GPS), a rare autoimmune disease that affects the kidneys and other organs, computational methods and network pharmacology were applied in this work. The goal of the study is to identify particular human proteins that might interact with anthraquinone and its analogues as well as to uncover potential mechanisms of action by which these drugs might …
Published in International Journal of Bioinformatics and Computational Biology Read article
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Valeton Phytoconstituents from Curcuma Phaeocaulis as Prion Protein Mutant V210I Inhibitors: A Computational Docking and Virtual Screening Study
Abstract: Objective: Creutzfeldt-Jakob disease (CJD), a neurological disorder that is sporadic, fatal, communicable, and worsens rapidly, is caused by abnormal folding of prion proteins. Identifying and assessing the potential of phytocompounds from the Curcuma phaeocaulis Valeton plant as a new therapeutic candidate aimed at the treatment of CJD is the objective of this research article. Methods: In this experiment, we assessed outcomes following an in-silico assessment to design a new oral …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 1, Issue 2, 2023 · pp. 1–16 Read article
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Hydro-alcoholic Extract of Herbal Formulation and Evaluation of Papaya leaf And Orange Peel for treatment of Dengue Fever
Abstract: The fastest-spreading viral disease in the world is dengue contamination, which is spread by mosquitoes. Carica papaya leaf juice aids in raising the platelet count, and it occurs primarily in tropical and subtropical countries. The primary goal of this study is to inform medical experts about the use of Carica papaya leaf extract formulations (SYRUP) to treat dengue fever, a potentially fatal illness. Approach: To cure this illness, a water …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 16, Issue 1, 2025 · pp. 23–33 Read article
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Terminalia arjuna: The Medicinal Tree
Abstract: Over 85% of the medications used in both conventional and alternative medical systems come from plant sources. The stem bark of Terminalia arjuna (T. arjuna) is rich in minerals, flavonoids, and glycosides. T. arjuna bark is unique because flavonoids have been shown to have anti-inflammatory, lipid-lowering, and antioxidant properties, and glycosides are cardiotonic. A variety of topics related to its ethnomedical, phytochemical, pharmacological, and clinical significance to different medical conditions …
Published in Research and Reviews : A Journal of Ayurvedic Science, Yoga and Naturopathy · Vol. 12, Issue 3, 2025 · pp. 27–34 Read article
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Extrapolations of Periwinkle Secondary Metabolites as Multitarget Inhibitor of Breast Cancer Proteins
Abstract: Objective: Breast cancer is considered one of the most common and dangerous forms of cancer. It is a significant public health issue on a global scale. The study estimates that 10.0 million people will die from cancer this year, and 19.3 million people will develop the disease overall (BC). In this computation approach, nowadays emphasizes new drug discovery, the target protein epidermal growth factor receptor (EGFR) (5UGB), estrogen receptor (ER) …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 1, Issue 1, 2023 · pp. 36–49 Read article
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Personalized Medicine: the impact of ferrofluids, clinical procedures, strategies, applications,challenges, current trends, and reseach opportunities.
Abstract: Personalized medicine has shown progressive development and evolution in health care systems. It is considered as transformative emerging medicine encorporating advanced technologies including genomics, AI as thinking partner, and nanotechnology in a greater extent. The quest for painless injection, lesstoxicity, rapid cell separation, and gene sequencing make ferrofluid the focus of personalized medicine. Currently, magnetic nanoparicles and ferrofluides are becoming driving force of personalized medicine. However, contronlling and managing nanoscale …
Published in Emerging Trends in Personalized Medicines · Vol. 3, Issue 2, 2026 Read article
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Role of Gastric Receptors in Gastrointestinal Disorder
Abstract: The established and potential roles of cholecystokinin1 and cholecystokinin2 receptors in gastrointestinal and metabolic diseases are analyzed, along with findings from human studies involving agonists and antagonists. While there is considerable evidence implicating cholecystokinin1R in various diseases such as pancreatic disorders, motility disorders, tumor growth, satiety regulation, and cholecystokinin-deficient states, its specific role in these conditions remains ambiguous. Conversely, the role of cholecystokinin2R in physiological (e.g., atrophic gastritis) and pathological …
Published in International Journal of Biomedical Innovations and Engineering · Vol. 2, Issue 2, 2024 · pp. 37–49 Read article
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A Review: Homeopathic Remedies and Their Potential Neurological Implications in Depression and Asthma
Abstract: Homeopathy, based on the principle “like cures like”, has gained popularity as a complementary treatment for chronic diseases, including depression and asthma. Both health conditions have a profound impact on the quality of life of individuals and are often treated with pharmacological interventions such as antidepressants and bronchodilators. This review reviews homeopathic remedies used to treat depression and asthma, evaluating the available clinical evidence. Although some studies suggest that homeopathy …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 15, Issue 1, 2025 · pp. 15–20 Read article