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128 articles for “genomics”
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Gene Therapy in Modern Medicine: Promises and Challenge in Treating Genetic Diseases
Abstract: Gene therapy is a medical approach that focuses on altering or adjusting an individual’s genes to treat or prevent illnesses. The aim is to repair faulty genes or insert new ones into the body to combat diseases. Gene therapy can involve directly introducing modified or new genes into a patient’s cells or altering the genes already present in the patient’s body. This approach shows potential for treating a range of …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 2, Issue 2, 2024 · pp. 27–32 Read article
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The Future of Camelids in South America: Recent Developments and Prospects
Abstract: Camelids, including llamas, alpacas, vicuñas, and guanacos, have been central to South American culture, economy, and ecosystems for centuries. Known for their adaptability to harsh Andean climates, these species provide valuable resources, such as luxurious fiber, nutritious meat, and durable leather. In modern times, their importance has grown due to increasing demand for sustainable and ethically sourced products, coupled with their minimal environmental impact and significant contributions to rural livelihoods. …
Published in Research and Reviews : Journal of Veterinary Science and Technology · Vol. 14, Issue 2, 2025 · pp. 35–38 Read article
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Crispr Cas – Revolutionizing Modern Therapies and Beyond
Abstract: CRISPR-Cas technology has emerged as a transformative tool in modern molecular biology, revolutionizing both fundamental research and clinical applications. This RNA-guided gene-editing system enables precise and efficient genomic modifications, offering unprecedented potential for addressing genetic disorders, infectious diseases, and oncological conditions through innovative therapeutic interventions. The inherent specificity and programmability of CRISPR-Cas systems have facilitated breakthroughs in diverse fields, including precision medicine, regenerative therapies, and immuno-oncology. Beyond its therapeutic applications, …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 3, Issue 1, 2025 · pp. 25–38 Read article
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Role and impact of Dietary Antioxidants on Aging and Lifespan: A Review
Abstract: The effect of an antioxidant-rich diet on aging and lifespan has attracted significant scientific attention, primarily through the lens of the free radical theory of aging (FRTA). This theory suggests that oxidative stress caused by an accumulation of reactive oxygen species (ROS), accelerates aging and contributes to cellular damage. The accumulation of free radicals and the oxidative damage that is induced significantly contribute to the aging process. This imbalance plays …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 15, Issue 2, 2025 · pp. 60–70 Read article
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COVID-19 Resurgence in 2025: India’s Continuing Public Health Challenge
Abstract: The year 2025 has witnessed the resurgence of COVID-19, reigniting concerns at both global and national levels regarding the persistent threat posed by SARS-CoV-2. In early 2025, India witnessed a moderate resurgence of COVID‑19, characterized by the emergence of Omicron sub-variants and a rise in mild-to-moderate infections. As of mid-June, active COVID‑19 cases in India totaled approximately 6,000–7,400, with hotspots in Kerala (~2,100 cases), Delhi (~600), Maharashtra (~500), and several …
Published in International Journal of Tropical Medicines · Vol. 2, Issue 2, 2025 · pp. 16–23 Read article
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Scientific Trajectories in Indian Virology: Innovations, Institutions, and Impact
Abstract: India's substantial research on epidemiology, virology, and public health measures has helped the world understand viral infections better. This article gives an overview of virus research in India, starting with early studies on arboviruses and enteroviruses and going all the way up to current studies on new and re-emerging pathogens including SARS-CoV-2, Nipah, and Zika viruses. Over the decades, India has built a rich legacy in virus research through pioneering …
Published in International Journal of Vaccines · Vol. 2, Issue 2, 2025 · pp. 11–20 Read article
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Role of Artificial Intelligence in Simulation and Therapeutics in Neurodegenerative Diseases
Abstract: Neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, etc., are a cause of significant mortality rates due to a lack of curative treatments and their complex nature. Traditional therapeutic methodologies have several disadvantages such as slow diagnosis and a lack of effective treatments. They mainly focused on the management of the disease rather than curing it. The integration of artificial intelligence in the simulation and therapeutics of neurodegenerative …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 16, Issue 1, 2026 · pp. 19–29 Read article
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Explainable Artificial Intelligence in Personalized Medicine: Emerging Clinical Perspectives
Abstract: The convergence of artificial intelligence (AI) and precision medicine has transformed contemporary healthcare by enabling data-driven clinical decision-making, individualized therapeutic interventions, and predictive diagnostics. However, despite remarkable advances in machine learning (ML) and deep learning (DL), the widespread adoption of AI in healthcare remains constrained by the “black-box” nature of many computational systems. Clinicians, regulatory agencies, and patients increasingly demand transparency, interpretability, and trustworthiness in AI-guided medical recommendations. Explainable Artificial …
Published in Emerging Trends in Personalized Medicines · Vol. 3, Issue 2, 2026 · pp. 13–29 Read article
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Personalized Medicine: the impact of ferrofluids, clinical procedures, strategies, applications,challenges, current trends, and reseach opportunities.
Abstract: Personalized medicine has shown progressive development and evolution in health care systems. It is considered as transformative emerging medicine encorporating advanced technologies including genomics, AI as thinking partner, and nanotechnology in a greater extent. The quest for painless injection, lesstoxicity, rapid cell separation, and gene sequencing make ferrofluid the focus of personalized medicine. Currently, magnetic nanoparicles and ferrofluides are becoming driving force of personalized medicine. However, contronlling and managing nanoscale …
Published in Emerging Trends in Personalized Medicines · Vol. 3, Issue 2, 2026 Read article
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Artificial Intelligence in Microbiological Research: Methods, Applications and Implications
Abstract: Artificial Intelligence (AI) is revolutionising microbiological research by enabling the rapid analysis of complex biological data and improving the accuracy, efficiency, and reliability of scientific investigations. Recent advances in machine learning, deep learning, and bioinformatics have transformed AI into a powerful tool for studying microorganisms, their genetic composition, evolutionary patterns, and interactions with hosts and the environment. AI-driven computational models can process large and complex datasets far more efficiently than …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 16, Issue 2, 2026 Read article
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Recombinant Protein Manufacturing Using Actinomycetes as Host Cells
Abstract: Actinobacteria are highly sought-after for use as cell factories or bioreactors in the pharmaceutical, agricultural, industrial, and environmental sectors. The commercial production of these proteins as recombinants and the biochemical and structural characterization of key proteins have been made possible by the genome sequencing of numerous species of actinomycetes. In this regard, better expression vectors that may be used with actinomycetes are required. As discussed in this article, recent developments …
Published in Research & Reviews: A Journal of Bioinformatics Read article
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Construction and Development of pSB111 Bar Plasmid Vector for Activation Tagging
Abstract: To get desired traits and to know the precise expression patterns of genes in the plant, Agrobacterium tumefaciens has been widely employed in the generation of transgenic plants using plasmid vectors. Many methods are come forward to establish the gene expression of unknown genes but in these techniques gene alteration isthe main drawback orsometimesit islethal to organisms also, to overcome these problems activator tag method developed to know the specific …
Published in Research & Reviews : Journal of Botany Read article
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A Molecular Docking Study: Targetting HIV-1 Integrase Protein Against Selected Phytocompounds from Calophyllum Lanigerum
Abstract: Objectives: The most common form of HIV that causes AIDS is HIV-1. The World Health Organization has estimated roughly 75 million plus HIV-1 infections till date and roughly 40 million deaths (as of 2021). Thus, this study was done to identify natural compounds from Calophyllum lanigerum, a medicinal plant largely endemic to South-East Asia, to inhibit the spread of this disease. It did so by using molecular docking methods, Lipinski …
Published in International Journal of Molecular Biotechnological Research · Vol. 1, Issue 2, 2023 · pp. 43–55 Read article
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Deciphering Th-Related Gene Interactions in Chronic Spontaneous Urticaria: Bioinformatics Insights and Drug Affinity Exploration
Abstract: Objective: There has been a great deal of interest in how inflammatory dermatosis and The cell interact, but the etiopathogenesis of chronic spontaneous urticaria (CSU) is still inadequately comprehended. Through bioinformatics techniques, the purpose of this work is to elucdate the molecular mechanism underlying Th-related genes in CSU and seeks to find the highest affinity drug. Methods: The CSU RNA expression profiling dataset provided the basis for the investigation. The …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 2, Issue 1, 2024 · pp. 1–15 Read article
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Efficacy of Combination Therapy with Osimertinib and Afatinib in epidermal growth factor receptor-mutant non-small-cell lung cancer Patients
Abstract: Treatment options for patients with non-small-cell lung cancer who have epidermal growth factor receptor mutations are constrained by the emergence of resistance to epidermal growth factor receptor tyrosine kinase inhibitors. Osimertinib or afatinib alone, when tested in a laboratory model, led to the formation of drug-resistant clones harboring epidermal growth factor receptor secondary mutations. However, combining these drugs prevented the emergence of such mutations. In a Phase II clinical trial, …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 13, Issue 1, 2024 · pp. 13–24 Read article
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Advancements and Challenges of Modern Breeding over Conventional Breeding
Abstract: Plant breeding dates back thousands of years, when people first deliberately bred plants based on visually pleasing characteristics. The domestication of wild plants aided this process, resulting in the evolution of numerous breeding strategies over time. Conventional breeding, which is distinguished by selective breeding based on superior performance, used procedures such as pure-line selections, mass selection, backcross breeding, recurrent selection, and hybridization. While effective, classical breeding procedures were time-consuming and …
Published in Research and Reviews : Journal of Crop science and Technology · Vol. 13, Issue 1, 2024 · pp. 1–5 Read article
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Machine Learning Approaches in Breast Cancer Diagnosis: Current Trends and Future Perspectives
Abstract: Since cancer is still one of the world's top causes of death, precise and effective detection techniques must be developed. Machine learning (ML) approaches have shown promise in recent years for enhancing cancer prognosis and detection. This paper presents a comprehensive review of the application of ML in cancer detection, focusing on various modalities including medical imaging, genomic data, and clinical records. We highlight the challenges associated with traditional cancer …
Published in International Journal of Radio Frequency Innovations · Vol. 2, Issue 1, 2024 · pp. 14–20 Read article
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Current Perspectives of Prader -Willi Syndrome: A Multisystem Approach
Abstract: Prader-Willi syndrome (PWS) is a genetic disorder with multisystem involvement, caused by the lack of expression of genes on the paternally inherited chromosome 15q11.2-q13 region from paternal 15q11-q13 deletions (about 60%) or maternal uniparental disomy 15 or both. It is a complex and contiguous gene disorder which affects the multiple systems with many clinical presentations especially hypothalamic insufficiency. The clinical features are characterized by short stature position, developmental delay, cognitive …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 14, Issue 2, 2024 · pp. 42–48 Read article
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The Effect of Alcoholic, Aqueous and Crude Extracts of Lemon citrus Seeds on Staphylococcus and Klebsiella Bacteria
Abstract: Five isolates of staphylococcus bacteria identified by phytic were obtained and activated on solid saline mannitol medium, where the colonies appeared in a golden color. Three extracts of dry lemon seeds were prepared (raw, 1% aqueous extract, 1% alcoholic extract). It was celebrated that the aqueous quotation was added operative on bacterial progress than the alcoholic and rudimentary sources. Three isolates of Klebsiella bacteria identified by VITEK were also obtained, …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 14, Issue 3, 2024 · pp. 32–36 Read article
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Pharmacogenomics and Precision Medicine: An Evolving Analytical Clinical Tools for Future Medicine – A Narrative Review
Abstract: The term Pharmacogenomics is coined as an emerging field that exactly examines how the genetic variations influence the individual responses towards medications. This discipline in turn integrates the pharmacology as well as genomics to facilitate the personalized medicine, encouraging the healthcare providers to tailor their drug therapies based on individual patient’s genetic profile. Key applications include optimizing drug efficacy, minimizing adverse effects, and enhancing treatment outcomes across various medical fields, …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 15, Issue 3, 2024 · pp. 44–52 Read article