Search
202 articles for “PD”
-
An Immunohistochemical Study to Assess the Role of Myofibroblasts in Diagnosing and Predicting the Outcome of Oral Squamous Cell Carcinoma
Abstract: Background: Squamous cell carcinoma (SCC) accounts for approximately 94% of all oral malignancies, hence establishing oral squamous cell carcinoma (OSCC) as one of the top 10 most prevalent malignant tumors. Cells with several functions, such as macrophages and myofibroblasts, play a vital role in the biological behavior of tumors. This study aimed to assess and evaluate the prevalence of myofibroblasts (MF) and macrophages in SCCs occurring in the oral region. …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 2, Issue 1, 2024 · pp. 13–17 Read article
-
In-silico Approach of Few Selected Phytoconstituents on Newer Cancer Targets
Abstract: Background: Cancer’s high death rates are mainly due to, drug resistance and unmet medical demands. It necessitates novel anticancer medications. AI tools aid in efficient and faster drug discovery by analyzing data, modeling processes and optimizing pipeline stages. Aim: The aim of this present study is to evaluate phytoconstituents against novel and newer cancer targets. Methodology: The ligands Daidzein, Resveratrol and Genistein were targeted against the Glutamate dehydrogenase (PDB ID …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 15, Issue 3, 2024 · pp. 12–17 Read article
-
The Role of Pyruvate Dehydrogenase in Non-Alcoholic Fatty Liver Disease: Therapeutic Insights and Future Directions
Abstract: Non-alcoholic fatty liver disorders (NAFLD) are defined by the accumulation of excess fat in the liver that has no other cause, such as drinking alcohol. Pyruvate dehydrogenase has been established as an alternative treatment for this disorder. NAFLD pathogenesis is complex and includes oxidative stress inflammatory processes and mitochondrial dysfunction. Impaired liver fatty acid oxidation and glucose oxidation are significant individuals in developing NAFLD, and strategies to reverse these defects …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 14, Issue 3, 2024 · pp. 44–51 Read article
-
Performance Analysis of Schmitt Trigger Circuit for Noise-Free Chips
Abstract: At lower nodes of complementary metal-oxide semiconductor (CMOS) technology, noise within a chip increase due to a drastic increment in interconnects within a given area. To improve the noise immunity of a chip, a Schmitt trigger circuit is used as a buffer instead of a simple CMOS inverter at various intervals along the metal interconnect. The use of a Schmitt trigger circuit not only makes the chip noise immune but …
Published in Journal of VLSI Design Tools and Technology · Vol. 14, Issue 3, 2024 · pp. 11–20 Read article
-
Computational Investigation of Withania somnifera Compounds Targeting S. pombe SMN YG-Dimerin Spinal Muscular Atrophy: Insights from Molecular Docking Analysis
Abstract: Objectives: The primary objective of this study is to determine the potential of phytochemical constituents of Withania somnifera in treating spinal muscular atrophy, an autosomal recessive genetic neurodegenerative disorder, through computational techniques. To investigate the binding affinity of phytocompound to the target protein S. pombe SMN YG-Dimer through molecular docking. Besides, evaluating the pharmacological attributes of phytochemical constituents to assess their ability as an ideal prospect for developing therapeutic medication. …
Published in Research and Reviews : Journal of Computational Biology · Vol. 13, Issue 2, 2024 · pp. 39–52 Read article
-
Non-Enzymatic Glycation in Alzheimer’s and Parkinson’s Disease: A Molecular Approach to Pathology and Recent Advances
Abstract: Non-enzymatic glycation, a biochemical process by which reducing sugars spontaneously bind to proteins, leads to the formation of advanced glycation end-products (AGEs), which have emerged as critical contributors to the pathogenesis of several neurodegenerative diseases, particularly Alzheimer’s disease (AD) and Parkinson’s disease (PD). The accumulation of AGEs can significantly alter protein structure, stability, and function, triggering a cascade of detrimental effects, including increased oxidative stress, heightened neuroinflammation, and the promotion …
Published in International Journal of Molecular Biotechnological Research · Vol. 2, Issue 2, 2024 · pp. 36–41 Read article
-
Exploring The Therapeutical Potential Of Pongamia Pinnata For Herpes Simplex Virus Type 1 (HSV-1)
Abstract: Objective: Pongamia pinnata (L.), commonly known as Indian beech or pongam tree, is a tropical plant renowned for its medicinal properties in traditional medicine systems. Extracts derived from various parts of Pongamia pinnata have demonstrated antimicrobial, anti-inflammatory, and immunomodulatory activities. Such attributes make it a compelling candidate for exploring its therapeutic potential against HSV infections. Thymidine kinase is the target protein mostly used in the treatment of HSV1 infections. In …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 15, Issue 1, 2025 · pp. 1–9 Read article
-
Neurodegeneration and Cognitive Decline: Causes, Consequences, and Treatment Approaches
Abstract: Neurodegenerative diseases gradually destroy nerve cells, often leading to fatal outcomes. The phrase includes a wide range of clinical problems, such as a variety of Neurological conditions include movement disorders, like Parkinson’s disease (PD) and progressive cognitive impairments, with Alzheimer’s disease (AD) being the most common among them. A loss of neurones and synaptic connections, typically in later life, is a prevalent feature of Usually, the onset and development of …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 3, Issue 1, 2025 · pp. 47–59 Read article
-
Screening of Newer Phytoconstituents on Novel Enzymes for their Biological Activity
Abstract: Background: Hyperlipidemia and gout are prevalent metabolic disorders significantly impacting global health. The xanthine oxidase and HMG-CoA reductase pathways play pivotal roles in the pathophysiology of these conditions. This study explores the potential of natural phytoconstituents—daidzein, resveratrol, and genistein—as dual inhibitors for these enzymatic targets, offering insights into innovative therapeutic strategies. Aim: To evaluate the potential of natural phytoconstituents—daidzein, resveratrol, and genistein—as dual inhibitors of xanthine oxidase and HMG-CoA reductase …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 16, Issue 1, 2025 · pp. 81–86 Read article
-
Evaluating the Role of Platelet Indices, with a Focus on Immature Platelet Fraction (IPF), in Differentiating Hyper-Destructive and Hypo-Productive Thrombocytopenia: A Study from Ludhiana, Punjab, India
Abstract: Background: Thrombocytopenia, characterized by a reduction in platelet count, is commonly observed in clinical settings. Its etiology can be broadly classified into hyper-destructive thrombocytopenia, where platelets are destroyed at an accelerated rate, and hypo-productive thrombocytopenia, where platelet production is impaired. Differentiating between these two causes is essential for effective management. The Immature Platelet Fraction (IPF) has emerged as a promising non-invasive diagnostic tool to distinguish these causes. Objectives: The primary …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 14, Issue 2, 2025 Read article
-
Biopolymer-Based 3D Composite Scaffolds for Bone Tissue Engineering: Photothermal-Responsive Systems with Controlled Pt (IV) Prodrug Release
Abstract: Biopolymer-based composite scaffolds have attracted significant attention as multifunctional platforms at the intersection of polymer science, regenerative medicine, and cancer nanotherapy. In this study, a dual-functional scaffold was developed for simultaneous osteosarcoma treatment and bone regeneration using poly (L-lactic acid) (PLLA) reinforced with bioactive glass (BG) and integrated with a glutathione-responsive platinum (IV) prodrug system (PDA@Pt). To improve interfacial adhesion, photothermal conversion efficiency, and tumor-specific activation, the Pt (IV) prodrug …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 351–361 Read article
-
Stationary Wavelet and Recursive Least Square Filtering Based Fetal ECG Data Extraction from Composite Abdominal Signal
Abstract: This paper introduces a fast methodology for fetal ECG extraction based on stationary wavelet and noise canceler adaptive filter with the recursive least square filter. Firstly, signals are preprocessed by moving averaging filter for removing baseline wander. The stationary wavelet and the recursive least square filter is applied on preprocessed signal that effectively separates the maternal ECG and extracts fetal ECG (fECG) from the abdominal ECG. Finally, fetal ECG(fECG) is …
Published in Current Trends in Signal Processing · Vol. 7, Issue 2, 2017 · pp. 46–58 Read article
-
Design of Digital Frequency Sensitive Phase Detector and study its Phase Response
Abstract: In this paper, a digital frequency sensitive phase detector (PD) with voltage controlled phase response is presented. This scheme is based on classical type flip-flop phase detectors and an improved PD operating on both edges of the input sequence. Phase-to-voltage response characteristic control is accomplished by the additional feedback of the low-pass filter output voltage to reset the control pin input. In this paper, we have presented a simulated frequency …
Published in Journal of Microwave Engineering and Technologies · Vol. 8, Issue 3, 2021 · pp. 43–51 Read article
-
Design and Performance Analysis of Full Adder Cell using FinFET Technique at 32nm Technology
Abstract: AbstractIn this paper, discussed is the comparative analysis of complementary MOS (CMOS) and dual gate-FinFET (fin shaped field effect transistor) based full adder cell design. To reduce the average power, average current and maximum current of 1-bit full adder circuit a new high DG-FinFET technique is presented. Use of double-gate FinFET technology provides low leakage and high performance operation. For MOSFET transistor model, a predictive technology model (PTM) BSIM4 and …
Published in Journal of Microelectronics and Solid State Devices · Vol. 4, Issue 3, 2017 · pp. 1–8 Read article
-
Determination of Accurate Molecular Weights of Cationic Polyacrylamide Polymers through Advanced Gel Permeation Chromatography Triple Detection Technique
Abstract: AbstractGel permeation chromatography along with refractive index detector or UV detector provides relative molecular weight information along with PDI with respect to standard used. If standards are of different nature than sample such relative results just are used to compare polymers and co-polymers among themselves. These detectors fail to reveal information about other important polymer characters like size of polymer in solution (hydrodynamic volume), branching pattern and intrinsic viscosity which …
Published in Journal of Polymer & Composites · Vol. 2, Issue 2, 2023 · pp. 24–28 Read article
-
Studies on Nanostructured Nickel Thin Film Coatings Deposited using Pulsed DC Magnetron Sputtering Process
Abstract: The purpose of this research work is to investigate the mechanical properties of nickel thin film. The nickel thin films were coated on glass substrate using pulse PDC power supply magnetron sputtering process in argon atmosphere. The effect of substrate temperature, effect of duty cycle and mechanical properties of nickel thinfilms has been presented in this paper. Coating deposited with substrate temperature at 250°C, had lower surface roughness (Ra<3 nm) …
Published in Journal of Thin Films, Coating Science Technology & Application · Vol. 2, Issue 1, 2015 · pp. 8–14 Read article
-
Single Bit Low-Power High-Speed Full Adder
Abstract: This paper presents a high-speed low-power full adder cells that lead to have a reduced power-delay product (PDP). A comparison against other full-adder structure as having low PDP, in terms of speed, power consumption and area of cells is carried out. This paper contains, a hybrid 1-bit full adder design employing both complementary metal-oxide semiconductor (CMOS) and transmission gate logic styles. First implemented was the design for 1 bit then …
Published in Journal of VLSI Design Tools and Technology · Vol. 7, Issue 3, 2017 · pp. 55–60 Read article
-
Designing of GaAs Based Resonant Tunneling Diode and Nano Scale Applications with Considering NEGF
Abstract: Present situation of eletronic area in the world required small devices as well as low power dissipation and ultra high speed application. At this moment the presence of resonant tunneling diode can over come this type of problem and take a big role in nanoscale digital and analog applications.In this researh article is to demonestrated effect of asymmetric barrier with respect to symmetric barrier and digital inverter and THz analog …
Published in Journal of VLSI Design Tools and Technology · Vol. 5, Issue 1, 2015 · pp. 1–18 Read article
-
Single Bit Low-Power High-Speed Full Adder
Abstract: This paper presents a high-speed low-power full adder cells that lead to have a reduced power-delay product (PDP). A comparison against other full-adder structure as having low PDP, in terms of speed, power consumption and area of cells is carried out. This paper contains, a hybrid 1-bit full adder design employing both complementary metal-oxide semiconductor (CMOS) and transmission gate logic styles. First implemented was the design for 1 bit then …
Published in Journal of VLSI Design Tools and Technology · Vol. 7, Issue 2, 2017 · pp. 55–60 Read article
-
Homogeneous and Heterogeneous Analysis of Water and Ethylene Glycol Based Cu Nano-particle
Abstract: The flow of heat in water Ethylene glycol (C2H6O2) copper based small size particles between two parallel freezing discs along with homogeneous and heterogeneous reactions are greatly and heavily affected by magnetic field. Here, I have considered Magnetic Hydro Dynamics effect perpendicular to the plane surface, while, bottom disk will be considered to be porous. The basic equations such as Navier-stokes, energy, Homogenous and Heterogonous reactions will be used for …
Published in Recent Trends in Fluid Mechanics · Vol. 9, Issue 3, 2022 · pp. 44–55 Read article