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412 articles for “Gene targeting”
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An AAV Vector for Inducible Gene Expression Preferentially in Muscles
Abstract: Adeno associated viral (AAV) vectors has been used widely in gene therapy and efforts have been made to improve their utility by adding genetic elements that would enable targeting transgene expression to particular cells or tissues of interest and permitting on/off regulation of expression. In this study, we designed a recombinant AAV9 variant PHP.eB vector with muscle creatine kinase (Mck)-derived enhancers, a synthetic muscle-expression promoter, in combination with a third-generation …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 1, Issue 2, 2023 · pp. 46–61 Read article
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Thalassemia and its management – A review article
Abstract: Thalassemia is a hemoglobinopathy burdening India making it earn title of Thalassemia capital of world. Studying last decade, the overall prevalence worldwide and incidence rates have declined but prevalence rates were high in east and Southeast Asian countries. Screening for carriers and affected individuals and genetic counselling are promising approaches for reducing soaring cases and reducing the further spread. Thalassemia affects various organs due to iron overload and haemolysis leading …
Published in International Journal of Tropical Medicines · Vol. 2, Issue 1, 2025 · pp. 60–73 Read article
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Development of a Dual Axis Solar Tracking System Using LDR Sensor for Roof-Top Applications
Abstract: The energy demand in the country has been increasing very rapidly and it is very difficult to fulfil this increasing demand with the conventional methods of energy generation. So, the use of renewable sources for energy generation is increasing rapidly with the help of Indian government policies. Indian government has announced that it will generate 175 GW from renewable sources of energy by 2022, out of which 100 GW will …
Published in Recent Trends in Sensor Research & Technology · Vol. 3, Issue 3, 2016 · pp. 21–26 Read article
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A review on Design of Gene Therapy and Its Potential for Craniofacial Regeneration
Abstract: One of the most talked-about topics of the 21st century is gene therapy, which holds the promise of treating many diseases. Current gene therapy research explores a wide range of potential treatments, such as enhancing the body’s immune response to tumors, promoting the formation of new blood vessels in the heart to mitigate heart attacks, and preventing HIV replication in AIDS patients. Gene therapy involves the introduction, alteration, or replacement …
Published in Emerging Trends in Personalized Medicines · Vol. 2, Issue 2, 2025 · pp. 6–12 Read article
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SQL Injection: A Hazard to Databases Security via Web Application
Abstract: Databases are the first target of the hackers. Weak authentication is one of biggest reason for which we lose our confidential data. We usually share our sensitive information such as debit/credit card numbers, SSN etc. without caring for the fact that when our system will interact in the internet through the WWW environment, huge amount of data is being created which may have user’s personal information. It may cause a …
Published in Journal of Advanced Database Management & Systems · Vol. 3, Issue 1, 2016 · pp. 30–36 Read article
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Multifactorial Diseases Becoming the Epigenetic Factor for the Genz
Abstract: This comprehensive paper investigates the complex interplay between multifactorial diseases, particularly obesity and cardiovascular disease (CVD), and their relationship with epigenetic mechanisms, highlighting the transgenerational implications of these interactions. The multifaceted nature of obesity and CVD, involving genetic predisposition, environmental influences, and epigenetic modifications, underscores the intricate pathways contributing to disease susceptibility and progression. Drawing upon a synthesis of diverse research findings, the paper elucidates the critical role of genetic …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 2, Issue 1, 2024 · pp. 16–22 Read article
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The DVB-H Standard: Comparative Analysis of the Results Obtained for Various Modulation Techniques and Different Code Rates
Abstract: DVB-H happens to be the technical specification for the transmission of digital TV to mobile telephones and PDAs—handheld receivers. Published as a formal standard, DVB-H is a physical layer specification designed to facilitate the proficient delivery of IP-encapsulated data over terrestrial networks. The making of DVB-H, which is closely associated with DVB-T, also entailed modifications of some other DVB standards dealing with data broadcasting, service Information, etc. It can be …
Published in Recent Trends in Electronics Communication Systems · Vol. 8, Issue 4, 2021 · pp. 8–17 Read article
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The DVB-H Standard: Comparative Analysis of The Results Obtained for Various Modulation techniques and Different Code Rates
Abstract: DVB-H happens to be the technical specification for the transmission of digital TV to mobile telephones and PDAs - handheld receivers. Published as a formal standard DVB-H is a physical layer specification designed to facilitate the efficient delivery of IP-encapsulated data over terrestrial networks. The creation of DVB-H, which is closely related to DVB-T, also entailed modifications of some other DVB standards dealing with data broadcasting, service Information, etc. It …
Published in Recent Trends in Electronics Communication Systems · Vol. 8, Issue 1, 2021 · pp. 8–18 Read article
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Scorpion Poison-A Clinical Review
Abstract: Scorpion Venom is a Tasteless. It is slightly acidic in nature. The initial drop is more or less colourless but the subsequent one are translucent in normal conditions. The striated muscles in the stinger allow regulation of the amount of venom ejected, which is usually 0.1-0.6 mg. The venom dries up into a powdery mass, which later forms elongated whitish crystals, which gets dissolved in water. Lethal dose of Mesobuthus …
Published in Research and Reviews: A Journal of Toxicology · Vol. 11, Issue 2, 2024 · pp. 10–21 Read article
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In Silico Designing of Triazolothiadiazine as Anticancer Agents
Abstract: Cancer is irregular growth of cells and formation of tumor. There are approximately 9.6 million death reported globally. It is caused by physical or genetic factor. There are various targets for the inhibition of growth of cancerous cells. Inhibition of colchicines binding site of tubulin is promising target in field of cancer management. In this study, we designed 25 novel thiazole and triazolothiadiazine derivatives as colchicine binding site inhibitors and …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 6, Issue 1, 2019 · pp. 10–20 Read article
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Gene Expression Profiling in Autism Spectrum Disorder: A Microarray Analysis Using Gse42133
Abstract: Autism Spectrum Disorder (ASD) is a diverse neurodevelopmental disorder characterized by difficulties in social interaction, communication impairments, and restricted or repetitive patterns of behavior. Despite its increasing prevalence, the underlying molecular mechanisms remain poorly understood. Advances in transcriptomics offer opportunities to investigate the gene expression changes that may contribute to ASD pathophysiology. In this study, the microarray dataset GSE42133 was analyzed, which comprises gene expression profiles from peripheral blood samples …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 13, Issue 1, 2026 · pp. 37–48 Read article
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Genetic Algorithm Based Optimal Volt/Var Control of Distribution Systems with Distributed Generation
Abstract: In this paper, new voltage regulation algorithms have been proposed for Distribution System (DS) equippedwith Distributed Generation (DG). Due to the ever increasing power demand, the power system sector isfacing too many challenges to fulfill that demand and also to supply power with proper acceptable quality.Distributed generation is one of the most efficient solutions to meet the increasing demand. When integratedwith the grid, it has its own technical as well …
Published in Journal of Power Electronics and Power Systems · Vol. 1, Issue 1-2-3, 2011 · pp. 28–46 Read article
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Role of Crispr-Cas9 in Plants
Abstract: The innovative CRISPR Cas9 system has emerged as a game changing genetic engineering tool in years offering levels of precision, efficiency and flexibility in editing the genomes of various organisms, including plants. This summary aims to provide an examination of the role of CRISPR Cas9, in modifying plant genomes highlighting its benefits, drawbacks and possible uses. Thanks to its versatility and user-friendly nature CRISPR Cas9 technology has expedited studies in …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 14, Issue 3, 2024 · pp. 1–10 Read article
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Role of Epigenetic Mechanisms in Lung Fibrosis: Therapeutic Opportunities and Challenges
Abstract: Lung fibrosis poses a serious risk to one's health since it might result in respiratory failure due to an abnormal accumulation of fibrotic tissue in the lungs. Epigenetic mechanisms, such as histone changes, DNA methylation, and non-coding RNAs, closely control gene expression patterns and cellular processes associated with lung fibrosis. Anomalies in DNA methylation patterns connected to changes in gene expression profiles and disturbances in fibrotic signalling pathways are potential …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 13, Issue 2, 2024 · pp. 9–20 Read article
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Molecular Docking Analysis of Berberis aristata Phytocompounds as Potential Growth Factor Receptor Blockers in Cancer Therapy
Abstract: Middle-aged and older women are susceptible to breast cancer (BC), a potentially fatal condition. When breast cancer is diagnosed, the median age is 62. Breast cancer diagnoses in women under 45 are comparatively uncommon, whereas the bulk of breast cancer diagnoses occur in women 62 and older. Growth factor receptors are interesting therapeutic targets because of their critical role in the pathophysiology of cancer. Vascular endothelial growth factor receptors (VEGFR-2) …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 3, Issue 2, 2025 · pp. 1–10 Read article
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Deepfake Detection Using Resnext50
Abstract: Due to the recent advancements in Artificial Intelligence (AI), technologies it has led to the rapid development in the modification of audio, video, and image manipulation techniques. This AIgenerated media content is referred to as "Deep Fakes". AI-based tools can exploit and manipulate media in increasingly believable ways like super-imposing a person’s face on another person’s body or creating copies of a public person’s voice. A range of papers has …
Published in Journal Of Network security · Vol. 10, Issue 1, 2022 · pp. 39–45 Read article
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An Evaluation of Photodynamic Therapy in Dentistry with a Focus on Surgical Applications
Abstract: Throughout the centuries, various forms of light therapy have found applications in medical settings. These include phototherapy for neonatal jaundice, psoralen molecules combined with ultraviolet A light (PUVA) in dermatology, and techniques like photodynamic therapy (PDT) and photodetection. In recent years, the emergence of antibiotic-resistant strains, such as methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecalis, has necessitated the exploration of alternative treatment options. Photodynamic antimicrobial chemotherapy (PACT) has arisen as …
Published in Research and Reviews : Journal of Surgery · Vol. 12, Issue 3, 2023 · pp. 1–9 Read article
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Induction of Apoptosis using Gene Therapy in the Treatment of Cancer
Abstract: Gene therapy is the treatment of a genetic disease through the insertion of normal or genetically altered genes into cells in order to replace or make up for the non-functional or missing genes. A major application of gene therapy is the induction of apoptosis to inhibit metastases or cure cancer. Besides the identification of the target site, the choice of a suitable vector system for gene delivery is also critical …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 2, Issue 3, 2013 · pp. 6–10 Read article
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A Bioinformatics Approach for the Identification of Genes Responsible for Biofilm Formation in Candida Species
Abstract: Candida biofilm is one of the attributes for drug resistance in candidiasis. Candida biofilms are found on prosthetics, catheters, and implanted devices leads to biofouling. Genes such as ALS1, CDR1, ERG11, HWP1, LIP4 and WOR1 code for biofilm. In this study, bioinformatics tools have been used for data mining and analysis of genes responsible for biofilm formation in Candida tropicalis. Genes responsible for biofilm were tabulated via PubMed search, based …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 9, Issue 1, 2019 · pp. 79–87 Read article
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Liposomes as Therapeutic Vehicles: Advancing Targeted Drug Delivery in Healthcare
Abstract: Liposomes represent an innovative approach to targeted drug delivery. These tiny, lipid-based vesicles can encapsulate medications, allowing them to travel directly to diseased cells while minimizing impact on healthy tissues. By using liposomes, medications can improve their effectiveness while reducing side effects, leading to better overall treatment results.. Their structure enables a controlled release of the drug, which can be particularly beneficial for therapies requiring sustained action. This technology holds …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 11, Issue 3, 2024 · pp. 39–46 Read article