Search
105 articles for “Antigen”
-
A Review on Unmasking Merkel Cell Polyomavirus: From Discovery to Cancer Driver
Abstract: Merkel cell polyomavirus (MCPyV) is a small, non-enveloped, circular double-stranded DNA virus belonging to the Polyomaviridae family, first characterized in 2008. Epidemiological data suggest widespread exposure, with seroprevalence rates approaching 80% in adults. While primary infection is typically asymptomatic, rare integration events in Merkel cells can initiate oncogenesis, yielding Merkel cell carcinoma (MCC), a neuroendocrine skin cancer with a five-year survival rate under 60%. This review integrates findings from six …
Published in International Journal of Virus Studies · Vol. 2, Issue 2, 2025 · pp. 6–11 Read article
-
Surajmukhi (Helianthus annuus L.): Medicinal Importance in Unani Literature and Modern Evidence
Abstract: Helianthus annuus L. (Sunflower), belonging to the family Asteraceae, is a well-recognized plant in both traditional and modern systems of medicine. In Unani medicine, it is described under the name “Shams-ul-Nahar,” attributed with specific Mizaj (temperament) and pharmacological actions. The plant is considered to possess a hot and moist temperament (Har Ratab), and different parts, including its seeds, oil, and leaves, have been employed in classical formulations. Sunflower seeds are …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 14, Issue 3, 2025 · pp. 68–75 Read article
-
IoT Network Security Employing KVS Approach: Novel Approach to IoT Security with B-Cell Inspired Models Implemented using Artificial Intelligence
Abstract: The Internet of Things (IoT), which links billions of devices that gather, analyse, and send data, is growing quickly. Although there are many benefits to this interconnection, there are also serious security risks. Conventional security measures frequently struggle to keep up with the dynamic and diverse nature of IoT environments. Innovative security ideas are being investigated in response, and the B-Cell concept, also known as the Kutubuddin Vahida Sultana (KVS) …
Published in Journal of VLSI Design Tools and Technology · Vol. 15, Issue 3, 2025 · pp. 36–46 Read article
-
DRUG INDUCED IMMUNE MEDIATED NEPHRITIS: MOLECULAR MECHANISM , PATHWAYS AND CLINICAL IMPLICATIONS
Abstract: Drug-induced immune-mediated nephritis (DI-IMN) has become a more widely known cause of acute kidney injury (AKI), with the potential for development to chronic kidney disease if not detected and treated promptly. T-cell hypersensitivity to pharmaceuticals, such as antibiotics, proton pump inhibitors, nonsteroidal anti-inflammatory drugs, and immunological drugs, are the major causes for it. Beyond clinical burden, DI-IMN reflectsintricate molecular interactions that sustain interstitial inflammation and tubular injury. These interactions include …
Published in International Journal of Toxins and Toxics · Vol. 3, Issue 1, 2026 · pp. 13–29 Read article
-
Emerging Digital Trends in Virology Software: Optimizing Viral Discovery, Surveillance,and Patient Management.
Abstract: Virology and antiviral therapeutics are being reshaped by rapid advances in computational tools, automation platforms, and virus-focused digital health applications. Software systems now span the entire virology value chain, from in silico viral target identification and antigen design, to AI-supported clinical trial management for vaccines and antivirals, to post-marketing pharmacovigilance and patient-facing mobile tools. This review examines current and emerging software trends relevant to virus studies, emphasizing applications in viral …
Published in International Journal of Virus Studies · Vol. 3, Issue 1, 2026 · pp. 29–38 Read article
-
India’s Pioneering Advancements in Vaccinology: Challenges and Milestones – Part 2
Abstract: India has become a global leader in vaccinology, playing a vital role in developing, producing, and distributing vaccines that protect millions of lives. By embracing advances in molecular immunology, recombinant antigen technology, and virus-like particle (VLP) platforms, the country has created affordable vaccines against major diseases, including poliovirus, rotavirus, and SARS-CoV-2. National initiatives, like Mission Indradhanush and Vaccine Maitri, have helped expand immunization coverage, improve public health, and share vaccines …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 16, Issue 2, 2026 · pp. 1–21 Read article
-
Tsetse Flies and African Trypanosomiasis: Biology, Epidemiology, and Integrated Vector Control.
Abstract: Tsetse flies (Glossina spp.) are hematophagous dipterans confined to sub-Saharan Africa and serve as cyclical vectors of human African trypanosomiasis (HAT) and African animal trypanosomiasis (AAT), with major implications for human health, livestock productivity, and rural development. An integrated understanding of tsetse biology, parasite transmission, climate, and land–use–driven distribution shifts, and the comparative performance of control tools—especially insecticides and sterile insect technique (SIT)—is essential for designing sustainable elimination strategies. HAT …
Published in International Journal of Insects · Vol. 3, Issue 1, 2026 · pp. 21–28 Read article
-
Immunological Mechanisms Underlying Autoimmune Disorders: Recent Advances and Therapeutic Implications
Abstract: A diverse range of illnesses known as autoimmune disorders are typified by dysregulated immune responses against self-antigens, which result in tissue damage and persistent inflammation. Understanding the genetic, epigenetic, and environmental variables that contribute to autoimmune pathogenesis has advanced significantly during the last ten years. Current disease models have been transformed by new understandings of immunological tolerance mechanisms such as the functions of regulatory T cells, cytokine networks, and the …
Published in Research and Reviews : A Journal of Immunology · Vol. 16, Issue 1, 2026 · pp. 21–25 Read article
-
Early Life Nutrition as a Determinant of Long-Term Vaccine Immunogenicity in Livestock: Mechanisms, Practical Strategies, and Species-Specific Considerations
Abstract: Early life represents a critical period for immune system development in livestock, during which nutritional exposures can exert long lasting effects on vaccine immunogenicity. Although vaccination is a cornerstone of infectious disease control in food producing animals, marked variability in vaccine induced immune responses is frequently observed under commercial conditions. Growing evidence suggests that this variability is partly driven by differences in early nutritional status, which can influence immune maturation, …
Published in International Journal of Vaccines · Vol. 3, Issue 1, 2026 · pp. 15–26 Read article
-
Systematic Review on: Peptic Ulcer and Its Management
Abstract: Peptic ulcer disease (PUD), which affects 5–10% of people worldwide, is still a significant global health concern. Gastric acid and pepsin's corrosive effects cause mucosal injury in the stomach, duodenum, or lower oesophagus. Long-term use of nonsteroidal anti-inflammatory drugs (NSAIDs) and Helicobacter pylori infection are the primary reasons. This review's goal is to examine PUD's aetiology, risk factors, pathophysiology, clinical symptoms, diagnostic methods, and evidence-based treatment modalities. PubMed, Google Scholar, …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 16, Issue 1, 2026 · pp. 60–64 Read article
-
Monoclonal antibodies in targeted cancer therapy advances, resistance mechanisms, and next-gen formats (Bispesifics, ADCs)
Abstract: Breast cancer is one of the leading causes of cancer-related morbidity and death worldwide, which emphasizes the need for more effective and focused treatment strategies. antibody-mediated drug delivery techniques. Specifically, antibody–drug conjugates (ADCs) have emerged as a potential approach that combines the specificity of monoclonal antibodies with the potent cytotoxicity of anticancer drugs. By selectively targeting tumor-associated antigens, ADCs enhance drug accumulation within cancer cells while minimizing systemic toxicity associated …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 17, Issue 2, 2026 · pp. 62–79 Read article
-
Next-Generation mRNA Vaccines: Applications Beyond COVID-19
Abstract: Messenger RNA (mRNA) vaccine technology has become a paradigm shift in contemporary medicine and, with remarkable success in the COVID-19 pandemic, has opened the door to a new wave of vaccines development. In contrast to the traditional vaccine methods, mRNA vaccines are based on the synthetic genetic code that allows host cells to express target antigens, thus eliciting strong humoral and cellular immunity. The speed of development, efficacy, scalability of …
Published in International Journal of Vaccines · Vol. 3, Issue 2, 2026 · pp. 15–26 Read article
-
Review on Effect of the Chemical Composition of some Pharmaceutical Vaccines and their Biochemical Efficacy with Chemical Techniques
Abstract: Chemical compounds are fundamental components in the formulation of medicines and vaccines, playing a critical role in ensuring their safety, stability, and effectiveness. Vaccines contain a combination of active and inactive ingredients, including weakened or inactivated viruses or bacteria, toxins, preservatives, stabilizers, adjuvants, antibiotics, and minerals. The active ingredient is an antigen, which stimulates the body's immune system to recognize and defend against specific infectious diseases. Adjuvants, such as aluminum …
Published in International Journal of Photochemistry and Photochemical Research · Vol. 4, Issue 2, 2026 · pp. 01–09 Read article
-
Overcoming Obstacles to an HIV-1 Cure: Advances in Genome Editing, Immune System Reprogramming, and Viral Reservoir Elimination
Abstract: Human immunodeficiency virus type-1 (HIV-1) continues to represent a major global health challenge despite the remarkable success of antiretroviral therapy (ART). Although ART effectively suppresses viral replication and prolongs survival, it cannot eradicate the virus due to the persistence of long-lived latent reservoirs. In recent years, innovative therapeutic strategies have been explored with the aim of achieving either a functional remission or complete viral elimination. Advances in genome-editing technologies, particularly …
Published in International Journal of Virus Studies · Vol. 3, Issue 2, 2026 Read article
-
Anthrax Toxin Time-Resolved Absorption and Resonance FT-IR and Raman Biospectroscopy and Density Functional Theory (DFT) Investigation of Vibronic-Mode Coupling Structure in Vibrational Spectra Analysis
Abstract: Anthrax toxin is a three-protein exotoxin that is secreted by the bacterium's virulent strains, the anthrax causative agent Bacillus anthracis. Harry Smith first found the toxin in 1954. Anthrax toxin consists of a protein called a protective antigen (PA) binding cell protein and two enzyme parts called an edema factor (EF) and a deadly factor (LF). These three protein components act together to impart their physiological effects. Assembled complexes containing …
Published in Research and Reviews : Journal of Computational Biology · Vol. 8, Issue 2, 2019 · pp. 23–51 Read article
-
IN SILICO SCREENING AND EVALUATION OF SOME METABOLITES FROM MOMORDICA CHARANTIA IN THE TREATMENT OF PEPTIC ULCERS
Abstract: Peptic ulcers are also called as or duodenal ulcers or gastric ulcers that are open sores generally develop in the lining of the stomach due to food and climatic factors. H. pylori infections are potentially the most dangerous and are linked to several diseases like diabetes, cancer, cardiovascular diseases, etc. In the present study, in silico screening and evaluation of some metabolites from Momordica charantia like Momorcharin, Momordicin, Metformin, Pioglitazone, …
Published in Research and Reviews : Journal of Computational Biology · Vol. 10, Issue 1, 2021 · pp. 5–13 Read article
-
Status of Dengue in Different Regions of Southern Bengal
Abstract: Introduction: Dengue is an endemic disease affecting various parts of the world, including India. At present, it isone of the major global health problems that need an immediate attention. The aim of our study was to determine the sero-prevalance and clinic-epidemiological data of dengue in few districts of Southern Bengal.Methodology: A total of 11,846 cases of either sex or age groups were included, followed by a detailed clinical and physical …
Published in Research and Reviews: A Journal of Health Professions · Vol. 11, Issue 1, 2021 · pp. 11–19 Read article
-
Comparative Immunology: A Journey of Immunity
Abstract: Comparative immunology is a branch of immunology which deals with study of immune systems during evolution. With the introduction of a journal, Developmental and Comparative Immunology and the establishment of International Society of Developmental and Comparative Immunology (ISDCI) in or around 1977, comparative immunology has become an established branch. Immune system is divided into two major groups: adaptive (clonal and specific) and innate (nonclonal and nonspecific). Invertebrates have cellular and …
Published in Research and Reviews : A Journal of Immunology · Vol. 2, Issue 2, 2012 · pp. 1–5 Read article
-
Isolation and Characterization of “Heavy Chain Antibody” Variable Domain Gene of Indian Desert Camel (Camelus dromedarius, L.)
Abstract: Camelids have “heavy chain antibodies” (HCAbs) of IgG isotype (IgG2 and IgG3 subtypes) and lack light chains and heavy chain constant domain 1 (CH1) in their structure. The molecular biological features of VHH (i.e., antigen binding variable domain of HCAbs) gene isolated from Indian desert camel were examined as a prelude to construct VHHs-phage display library. VHH cDNA was synthesized by reverse transcription-polymerase chain reaction (RT-PCR) from B lymphocyte mRNA, …
Published in Research and Reviews : A Journal of Immunology · Vol. 3, Issue 1, 2013 · pp. 22–31 Read article
-
Antibody Pharming in Transgenic Plants: An Overview
Abstract: Antibodies (Abs) are secreted large-sized glycoprotein products of terminally differentiated B cells in vertebrate species and since their discovery during 1890s, they have been widely used for diagnosis, prevention and treatment of diseases, epidemiology and life-science research. They have been traditionally produced in large amounts by repeated immunization of animals. Various techniques for production of full-length and fragments of antibody that have been introduced later are: (i). hybridoma technology during …
Published in Research and Reviews : A Journal of Immunology · Vol. 3, Issue 3, 2013 · pp. 1–10 Read article