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81 articles for “toxicity analysis”
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Molecular Pharmacokinetics and Structural Docking of Phenolic Acids for Targeting NF-κB Pathway Components in Inflammation and Fibrosis: A Computational Approach Toward Therapeutic Discovery
Abstract: Inflammation and Fibrosis are critical pathological processes associated with various chronic diseases, often mediated by the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling pathway. This study investigates the therapeutic potential of phenolic acids as modulators of the NF-κB pathway, aiming to identify novel ligands that can effectively interact with key components of this signaling cascade. A comprehensive computational approach was employed, utilizing molecular docking, pharmacological screening, and post-docking …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 3, Issue 1, 2025 · pp. 14–31 Read article
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Lab Reagents and Their Importance in Bio-chemistry
Abstract: Biochemical reagents are essential substances in the study of life at the molecular level. These reagents help scientists detect, identify, and quantify bio-molecules such as proteins, carbohydrates, nucleic acids, and enzymes in biological systems. They play a vital role in understanding metabolic reactions and physiological processes within living organisms. Biochemical reagents are generally classified into analytical, diagnostic, enzymatic, chromogenic, and buffer reagents, each serving a specific purpose in laboratory and …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 16, Issue 1, 2026 Read article
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Comparative Assessment of Methylparaben concentration in Cosmetic product, analyzed using Enzyme Biosensor and ultra-high-pressure liquid chromatography (UPLC): An approach towards detection of the environmental toxicant with higher accuracy and sensitivity.
Abstract: Methylparaben (MP) is one of the most widely used preservatives and is associated with a catalog of recently identified health hazards. Existing studies have also highlighted these compounds as environmental contaminants and toxicants that affect water quality and the associated microbial diversity of the habitat. The conventional methods for parabens detection is performed using chromatographic techniques, which assist in quantitative analysis of the group of compounds. However, the biggest challenge …
Published in Nano Trends – A Journal of Nano Technology & Its Applications · Vol. 28, Issue 2, 2025 Read article
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In Silico Exploration of Podophyllum Hexandrum-Derived Phytocompounds as Potential Therapeutics Against Small Cell Lung Cancer (SCLC): A Molecular Docking Approach
Abstract: Small Cell Lung Cancer (SCLC) is a fast-growing and aggressive type of lung cancer that spreads quickly strongly associated with smoking. It is characterized by symptoms, such as persistent cough, breathing difficulties, or hoarseness, though it can sometimes be asymptomatic which makes early detection challenging. The tumor suppressor gene TP53 is critical in regulating the cell cycle and preventing uncontrolled cell division. Mutations in TP53 result in the loss of …
Published in International Journal of Molecular Biotechnological Research · Vol. 3, Issue 1, 2025 · pp. 1–11 Read article
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Ag₂S–Ag Nanocomposites: A Bottom-Up Approach to Enhance Thermoelectric Power Factor at Near Room Temperature
Abstract: The intrinsic ductility, low toxicity, and naturally occurring abundance of silver sulphide (Ag₂S) have made it a potential thermoelectric material in recent years. However, high electrical resistance severely limits its practical application. Here, we present a thorough analysis of how metallic Ag nanoinclusions affect the structural, electrical, and thermoelectric characteristics of Ag₂S nanocomposites made using a simple bottom-up polyol approach. (Ag₂S)₁₋ₓAgₓ nanocomposites with an Ag content ranging from 0 to …
Published in International Journal of Electro-Mechanics and Material Behaviour · Vol. 4, Issue 1, 2026 · pp. 40–55 Read article
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Silver Nanoparticles Loaded Polyurethane Composites for Antibacterial Medical devices
Abstract: Polyurethane (PU) polymer is widely used in biomedical application. In our study we have combined polyurethane with silver nanoparticles to develop a nanocomposite material for antibacterial medical applications. Such combination has antibacterial properties and control the toxicity too. In current research we have mixed the different sizes and types of silver nanoparticles into the polyurethane matrix. The result was their antibacterial activity, mechanical strength, and biocompatibility. The antibacterial performance of …
Published in Journal of Polymer & Composites · Vol. 14, Issue 4, 2026 Read article
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Synthesis, characterization, and antibacterial activity of silver nanoparticles with expired minocycline as reducing agent: proposed as a recycling technique
Abstract: In this research, expired minocycline, a broad-spectrum tetracycline antibiotic, was employed as both a reducing and stabilizing agent for the eco-friendly synthesis of silver nanoparticles. This sustainable method avoids the use of toxic chemical reducing agents, providing a greener alternative for nanoparticle production. The synthesized silver nanoparticles were analyzed using several characterization techniques, such as UV-Vis’s spectroscopy, scanning electron microscopy, transmission electron microscopy, and Edex analysis, to assess their structural, …
Published in Journal of Nanoscience, NanoEngineering & Applications · Vol. 16, Issue 1, 2026 · pp. 30–43 Read article
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Extraction Properties of Mangifera indica Seed Kernels: A Comprehensive Analysis of Their Industrial Potential
Abstract: Mango (Mangifera indica) is widely regarded as one of the world's finest fruits, with a rich nutritional profile, including fiber, riboflavin, carotene, and ascorbic acid. Among its lesser-known components, the mango seed kernel offers significant nutritional and industrial value. Mango kernels are composed of protein, fat, carbohydrates, crude fiber, and ash, and contain bioactive compounds such as polyphenols, phytosterols, and tocopherols. The fat extracted from mango seed kernels has shown …
Published in Journal of Petroleum Engineering & Technology · Vol. 15, Issue 1, 2025 · pp. 22–28 Read article
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Harnessing Microbial and Phytoremediation Techniques for Sustainable Remediation of Heavy Metals in Black Cotton Soils
Abstract: Black cotton soils, renowned for their fertility and moisture retention capabilities, face significant challenges due to heavy metal contamination, posing threats to both agricultural productivity and environmental integrity. This review paper presents a comprehensive overview of bioremediation strategies aimed at mitigating heavy metal pollution in black cotton soils. The paper underscores the importance of addressing heavy metal (HM) contamination, emphasizing the need for exploring bioremediation techniques, as it sets the …
Published in Journal of Polymer & Composites · Vol. 12, Issue 5, 2024 · pp. 193–201 Read article
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The Clinical Landscape of Wogonin: Advancing Targeted Treatments for Chronic Diseases
Abstract: The traditional Chinese medicinal herb Scutellaria baicalensis Georgi, commonly known as Chinese skullcap or Huang-Qin, has long been used to treat a variety of conditions, including cancer, viral infections, and seizures. Its pharmacological effects are largely attributed to the high concentration of flavones, particularly wogonoside, and its aglycone derivative, wogonin. Among the bioactive compounds found in S. baicalensis, wogonin has garnered the most scientific attention due to its potent therapeutic …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 12, Issue 1, 2025 · pp. 46–52 Read article
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Toxicological Optimization and Assessment of Buccal Films Containing Felodipine Co-crystals to Enhance Bioavailability
Abstract: The preformulation study of felodipine was carried out and it was found that the drug is poorly water soluble. The co-crystals were prepared using three different co-formers sorbitol, ascorbic acid and oxalic acid. The solublity enhancement was observed in combination with sorbitol compared to other co-formers used. The characterization of co crystals was performed like PXRD, FTIR, SEM Analysis. XRD results indicates the amorphous form of the drug. The co-crystals …
Published in Research and Reviews: A Journal of Toxicology · Vol. 14, Issue 2, 2024 · pp. 10–29 Read article
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Polymer Chemistry Perspectives: Applying the Water Quality Index (WQI) for Groundwater Quality Assessment
Abstract: Through the utilization of polymers' special qualities, such as their capacity to concentrate analytes and their affinity for particular pollutants, we establish a strong framework for assessing groundwater quality. A more thorough understanding of groundwater contamination is made possible by the integration of polymer-based techniques with the WQI, empowering stakeholders to decide on remediation and water resource management strategies with knowledge. The quality of groundwater, especially shallow groundwater, is being …
Published in Journal of Polymer & Composites · Vol. 13, Issue 1, 2025 · pp. 119–124 Read article
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In Silico Docking Analysis to Identify Therapeutic Benzoic Acid Derivatives for Acute Myeloid Leukaemia
Abstract: Background: The study is anchored to initiate subjugation against modern cancer therapy for Acute Myeloid Leukaemia (AML) which involves natural therapeutics as an alternative therapy that would degrade the prospect of adverse side effects along with anti-cancer properties. Objectives: Collate the various characteristics of Giltertinib with natural benzoic acid derivative phytochemicals for a disquisition regarding their similarities and differences in the context of providing adverse side effects. Methods: ADME toxicity …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 1, Issue 2, 2023 · pp. 50–63 Read article
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Characterization Of Senna Occidentalis (Link.) Seed Extract
Abstract: Senna occidentalis (L.) Link commonly known as "coffee senna" or majamfari/rai dore in Hausa is a plant with a long history of traditional and medicinal uses against diseases such as inflammation, pains, and diabetes. This study presents characterization of the bioactive compounds of the seed extracts. Physicochemical analysis of seed powder was carried out following standard procedures. Qualitative phyto-chemical contents were determined for the presence and absence of major metabolites. …
Published in Research & Reviews : Journal of Botany · Vol. 13, Issue 3, 2024 · pp. 13–22 Read article
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Quantitative Mass Balance Modelling for the Synthesis and Production of Ten High-Volume Insecticides
Abstract: This study presents a detailed quantitative mass balance analysis for the industrial synthesis and production of ten high-volume insecticides: acequinocyl, acetamiprid, acynonapyr, alpha-cypermethrin, benzpyrimoxan, bifenazate, bifenthrin, bistrifluron, broflanilide, and bromofos, focusing on material flows, process efficiencies, and environmental implications. These compounds, spanning diverse chemical classes like neonicotinoids, pyrethroids, and meta-diamides, are essential for crop protection but pose challenges due to resource-intensive syntheses and waste generation. For each insecticide, standardized manufacturing …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 16, Issue 3, 2025 · pp. 36–55 Read article
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Facile Synthesis of SnO2/g-C3N4 nanocomposite for the photocatalytic degradation of Methylene Blue dye under visible light irradiation
Abstract: This work reports the nanoscale samples of pure tin dioxide (SnO₂), graphitic carbon nitride (g-C₃N₄), and their composite (SnO₂/g-C₃N₄) were successfully synthesized using the co-precipitation technique. The synthesized materials were extensively analyzed using multiple characterization techniques such as Powder X-ray Diffraction (PXRD), High-Resolution Scanning Electron Microscopy (HR-SEM), Energy-Dispersive X-ray Spectroscopy (EDAX), Fourier Transform Infrared Spectroscopy (FTIR), UV-Visible Spectroscopy, and High-Resolution Transmission Electron Microscopy (HR-TEM). Results from PXRD and EDAX confirmed …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 1835–1845 Read article
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Determination and Study of The Effect of High Concentrations from Heavy Metals in Environmental Samples
Abstract: This study focused on determining the concentrations of heavy metal ions to assess the environmental pollution levels of five T stations. Based on this, five samples were collected from different environments in Najaf Governorate, and the levels of heavy metal pollution were compared with the permissible values set by the World Health Organization. The research study concerned measurements of the increase and decrease in the concentration of elements and minerals …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 16, Issue 2, 2025 · pp. 77–84 Read article
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Copper Sulfide Semiconducting Nanoparticles for Antibacterial Applications: Synthesis Strategies, Mechanisms and Performance – A Review
Abstract: Copper sulfide nanoparticles (CuS NPs) have drawn growing attention as a next-generation antibacterial platform, owing to their tunable structural, optical, and catalytic properties. This review consolidates current evidence on CuS NP synthesis, mechanisms, and antibacterial performance, comparing chemical and green synthesis routes alongside the effects of morphology, doping, and surface modification. Mechanistically, CuS NPs act through several overlapping pathways, including reactive oxygen species generation, bacterial membrane disruption, ion release, and …
Published in Journal of Polymer & Composites · Vol. 14, Issue 4, 2026 Read article
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Steam Activated Carbon Material from the Fruit Shells of Sterculia foetida for Energy and Environmental Applications
Abstract: Steam activation of the biochar from Sterculia foetida forms a green route for the synthesis of activated carbon material with high specific surface area (1017 m2/g). The corresponding value with a chemical activating agent (K2CO3) is much lower (596 m2/g). Structural parameters of the activated carbon materials were deduced from XRD studies. Moreover the thermal stability of the activated carbon materials from steam activation is nearly 100°C higher than that …
Published in Journal of Water Pollution & Purification Research · Vol. 11, Issue 1, 2024 · pp. 23–33 Read article
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Self-Healing Polymeric Composites Reinforced with Green Synthesized Nanoparticles
Abstract: The development of sustainable self-healing polymeric materials is critical for enhancing durability and service life in advanced engineering applications. In this study, zinc oxide (ZnO), magnesium oxide (MgO), and ferric oxide (Fe₂O₃) nanoparticles were green-synthesized using Allium cepa extract and incorporated into epoxy-based polymeric composites to improve mechanical, thermal, and self-healing properties. This bio-based synthesis is eco-friendly and safe alternative to harsh chemical techniques, utilizing natural antioxidants to stabilize the …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 305–314 Read article