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1953 articles for “phosphoinositol-3-kinase pathway” (ranking capped at the first 2,000 matches — narrow the search to see the rest)
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3D Printing of Polymer-Based Functionally Graded Materials: Recent Developments and Challenges
Abstract: Additive manufacturing (AM), specifically 3D printing, has become a useful technique for fabricating functionally graded materials (FGMs) because it can facilitate the spatial distribution of materials. Polymer FGMs (P-FGMs) have gained a great deal of interest due to their lightweight, customizable, multifunctional properties. In comparison to conventional fabrication, 3D printing allows better control of composition and microstructure, which results in materials with controlled mechanical, thermal, and biological properties. This review …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 338–347 Read article
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Dual Nozzle 3D Printing of Basalt Fiber–Reinforced Polymer Composites
Abstract: Additive manufacturing or 3Dprinting involves building a three-dimensional object by layering materials based on a computer-created design. Generally, 3D printing using single nozzle process where as strength, quality, wastage, and post reinforcement are drawback of this system. To eliminate and to enhance strength, precise control of fiber reinforcement, good bonding, no need of secondary reinforcement the dual nozzle 3D printing is an emerging additive manufacturing technique. In this process the …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 620–630 Read article
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Mathematical Modelling and Experimental Analysis of a 3D Printed PLA UAV Propeller using NACA 4412 Airfoil
Abstract: The usage of unmanned aerial vehicles (UAVs) has grown significantly because they are cost-effective and easy to availability for many applications. However, researchers have focused on the designing for various UAV propeller/rotors geometries, including their aerodynamic performance and structural examination. An elegant, designed propeller can enhance the UAV's endurance limit and its reliability. This research focuses on designing of UAV propeller and its fabrication using Polylactic acid (PLA) material using …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 825–832 Read article
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3D Printed Martian Habitats and Challenges to Overcome
Abstract: In exploring the potential design and construction of Martian habitats, one of the key factors that need to be taken into account is the environmental condition on the surface of Mars, which is drastically different from that of Earth and poses unique challenges. Innovative designs and construction technologies must be utilized to overcome these obstacles. In addition, the building materials should be those that can be locally obtained and must …
Published in Research & Reviews : Journal of Space Science & Technology Read article
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Role of PI3K/AKT/mTOR Signaling Pathways in Breast Cancer
Abstract: Abstract: Breast cancer is among the most commonly diagnosed cancers and remains a leading cause of mortality among women globally. Although early detection and interventions aimed at curtailing tumor progression have significantly improved breast cancer survival rates, there is an ongoing demand for more potent systemic therapies to effectively prevent metastasis. A central pathway frequently associated with the growth, survival, and motility of breast cancer cells is the PI3K/AKT/mTOR signaling …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 14, Issue 1, 2025 · pp. 23–34 Read article
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Investigating the Surface Defects and Structural Integrity of 3D Printed Hydrogen Storage Cylinders in UAV Applications
Abstract: This research explores the processing and manufacturing challenges of 3D printed polymer composites for high-pressure hydrogen storage in UAVs. The study focuses on addressing surface integrity and structural robustness issues inherent in additive manufacturing. Finite Element Analysis (FEA) was conducted on four thermoplastic polymer ABS, PET-G, HDPE, and Nylon to assess their mechanical performance under 35 MPa of pressure. Results revealed that PET-G and ABS provided better stress distribution and …
Published in Journal of Polymer & Composites · Vol. 13, Issue 3, 2025 · pp. 161–191 Read article
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Effect of 3D Printing Process Parameters on the Tensile Strength of Polylactic Acid (PLA)
Abstract: This study employs the Taguchi approach to systematically analyze and optimize critical Fused Deposition Modeling (FDM) parameters, focusing on their effect on the tensile strength of 3D-printed Polylactic Acid (PLA) components. The study explores three levels of layer thickness (0.15 mm, 0.25 mm, and 0.3 mm), infill densities (25%, 50%, and 75%), and nozzle temperatures (200°C, 205°C, and 210°C) across three infill patterns: Triangular, Gyroid, and Zig-zag. A total of …
Published in Journal of Polymer & Composites · Vol. 13, Issue 5, 2025 · pp. 128–140 Read article
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Progress in Renal Tumor Surgery: The Role of 3D Surgical Planning in Partial Nephrectomy
Abstract: Renal cell carcinoma is the most common form of kidney cancer, representing 2–3% of global cases, with the highest incidence in Western Europe. For small renal tumors, partial nephrectomy is the preferred treatment, where the tumor is surgically removed. This procedure does not affect oncological outcomes, allowing part of the kidney to remain functional. During tumor removal, the surgeon minimizes excessive bleeding and improves visibility by cutting off the arterial …
Published in Research and Reviews : Journal of Surgery · Vol. 14, Issue 3, 2025 · pp. 35–40 Read article
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Molecular Docking Analysis of Phytocompounds from Ficus hispida Aagainst Epidermal Growth Factor Receptor Kinase Domain
Abstract: The Epidermal Growth Factor Receptor (EGFR) kinase domain plays a key role in cancer, as it promotes tumour growth and helps cancer cells survive, making it an important focus for developing treatments. Through comprehensive computational analysis, this study investigates the anticancer potential of phytocompounds from Ficus hispida, a medicinal plant renowned for its diverse bioactive compounds, as novel EGFR inhibitors. Molecular docking techniques using Py Rx software were employed to …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 3, Issue 2, 2025 Read article
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Molecular Docking Analysis of Phytocompounds from Ficus hispida Against Epidermal Growth Factor Receptor Kinase Domain
Abstract: The Epidermal Growth Factor Receptor (EGFR) kinase domain plays a key role in cancer, as it promotes tumour growth and helps cancer cells survive, making it an important focus for developing treatments. Through comprehensive computational analysis, this study investigates the anticancer potential of phytocompounds from Ficus hispida, a medicinal plant renowned for its diverse bioactive compounds, as novel EGFR inhibitors. Molecular docking techniques using Py Rx software were employed to …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 3, Issue 2, 2025 · pp. 48–62 Read article
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Molecular Docking and Interaction of Anthocyanin Derivatives in Regulating Hippo-taz Pathway for Renal Injuries
Abstract: Introduction: The Hippo pathway plays a pivotal role in renal disease, with Yes-associated protein (YAP) exhibiting promise for combined treatments. The crucial evaluation of YAP-targeted drug safety and efficacy through preclinical studies is imperative. Additionally, α-SMA and SMAD3 emerge as potential therapeutic targets in renal fibrosis, driving ongoing research toward innovative interventions. Materials and Methods: In the systematic identification of therapeutic secondary metabolites, Anthocyanin derivatives were methodically retrieved from the …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 2, Issue 1, 2024 · pp. 23–38 Read article
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Parametric optimization and validation of novel 3D scanning approach for sustainable manufacturing of patient-specific orthodontic retainers
Abstract: The purpose of the proposed study is to identify the ideal procedure parameters for 3D scanning a denture in order to produce customised orthodontic retainers that can be produced sustainably. However, pilot investigations rarely explore parameters like scanning angle, light intensity, or scanning distance. In order to lower acquisition error, the suggested study examines a method for forecasting the ideal values of the previously indicated scanning parameters. Based on the …
Published in Journal of Polymer & Composites · Vol. 12, Issue 2, 2024 · pp. 265–278 Read article
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Optimizing PLA Filament Production for Enhanced 3D Printing Performance
Abstract: This research explores the optimization of polylactic acid (PLA) filament production to improve its performance in 3D printing applications. PLA is a widely used biodegradable polymer known for its eco-friendliness and ease of processing in additive manufacturing. The study investigates various parameters affecting PLA filament production, including material purity, extrusion temperature, filament diameter consistency, and cooling methods. Furthermore, the research evaluates how these fabrication parameters influence the printability of PLA …
Published in International Journal of Energy and Thermal Applications · Vol. 2, Issue 1, 2024 · pp. 21–29 Read article
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A Comparative Review of AI-driven 3D Modelling for Simplified Photogrammetry and Object Acquisition
Abstract: The field of photogrammetry, historically reliant on guide strategies, is undergoing a transformation with the emergence of AI-powered 3d modeling answers. This assessment work delves into this evolving panorama by using evaluating and comparing various AI-pushed gear presented by means of exclusive businesses. The study in particular makes a specialty of their effectiveness in simplifying photogrammetry workflows and facilitating the acquisition of 3D gadgets. The analysis contains a diverse range …
Published in Journal of Artificial Intelligence Research & Advances · Vol. 11, Issue 2, 2024 · pp. 21–32 Read article
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Anti-hyperglycemia Effects of Plant Secondary Metabolites Towards PKA/CREB Pathway Activation in Diabesity
Abstract: Objective: Diabesity, the amalgamation of diabetes and obesity, presents a significant global health challenge. This research carefully examines how plant secondary metabolites influence glucose regulation in diabetes using the PKA/CREB pathway, paying particular attention to diabesity—the combination of diabetes and obesity. Understanding the complex ways in which these metabolites affect metabolic health will help to identify new treatment approaches for managing diabetes and its associated problems. By conducting a thorough …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 2, Issue 1, 2024 · pp. 33–50 Read article
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Advanced Design and Prototyping with Fabrication, Architecture, And Material Design Techniques For 3D Printing Hybrid Polymer Composites
Abstract: Hybrid polymer composites are big steps forward in the field of 3D printing. They combine different materials to improve their engineering qualities, usefulness, and use potential. This essay looks at the advanced design and testing methods needed to use 3D printing to make and create mixed polymer materials. First, we look at material design methods, with a focus on choosing plastics and support materials that help the composite have the …
Published in Journal of Polymer & Composites · Vol. 12, Issue 4, 2024 · pp. 22–36 Read article
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Cardiotoxicity Associated with Tyrosine Kinase Inhibitors in Philadelphia Chromosome-Positive Leukemias: An Overview of Mechanisms, Clinical Implications, and Management Strategies
Abstract: Tyrosine kinase inhibitors have greatly enhanced the outlook for individuals diagnosed with Philadelphia chromosome-positive leukemias, including chronic myeloid leukemia and acute lymphoblastic leukemia. However, these therapeutic agents are associated with Cardiotoxicities and can manifest as left ventricular dysfunction, which may progress to heart failure, along with electrocardiographic abnormalities, dysrhythmias, hypertension, myocardial ischemia, and thromboembolic events. The unclear frequency of drug-induced cardiovascular complications, coupled with uncertainties regarding their reversibility and long-term …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 13, Issue 3, 2024 · pp. 18–24 Read article
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Bridging Reality and Virtuality Through Gesture-controlled 3D Holography
Abstract: The continuous advancement of technology has led to the development of innovative techniques and devices aimed at enriching users’ experiences. The technology creates an immersive experience that blurs the lines between virtual and real worlds by allowing users to manipulate three-dimensional holograms with natural hand gestures. Among these advancements, holography emerges as a promising avenue for creating immersive visual displays. However, traditional holographic systems often struggle to provide truly engaging …
Published in Trends in Opto-electro & Optical Communication · Vol. 14, Issue 3, 2024 · pp. 1–10 Read article
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Fabrication of Belt for Backpack for Students to Reduce the Musculoskeletal Disorders using ABS material 3D Printing
Abstract: In the present study, the design and development of a composite-based belt aim to reduce the excessive burden on the backs of schoolchildren, which often leads to musculoskeletal disorders (MSD). The belt is designed using CATIA 3D modeling software and fabricated on an FDM-based 3D printer with ABS polymer. The design process focuses on addressing physical stress caused by heavy backpacks and prolonged use of electronic devices, both of which …
Published in Journal of Polymer & Composites · Vol. 13, Issue 1, 2025 · pp. 1110–1117 Read article
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Design for Additive Manufacturing (DFAM) Leveraging 3D Printing to Optimize Machine Components
Abstract: Design for Additive Manufacturing (DFAM) is a new methodology that focuses on maximizing the special potential of 3D printing technologies to optimize machine components. Contrasting to traditional manufacturing processes, additive manufacturing (AM) makes it feasible to create complicated shapes that would be impossible or difficult to do using standard methods like casting or machining. This study explores the principles of DFAM, including the advantages it offers in terms of design …
Published in International Journal of Machine Systems and Manufacturing Technology · Vol. 2, Issue 2, 2024 · pp. 9–14 Read article