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84 articles for “multi agent”
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Comparative Study on Oro Dispersible Tablets of Candesartan Cilexetil Formulated with Natural and Synthetic Disintegrants
Abstract: Candesartan cilexetil, a BCS class II drug with low aqueous solubility and poor bioavailability (15%), poses challenges for oral delivery. To address this limitation, the present study focuses on polymer-based inclusion complexation and composite formulation strategies to enhance solubility and dissolution behavior. The drug was incorporated into β-cyclodextrin (β-CD), a cyclic oligosaccharide polymer, by the kneading method in different drug-to-carrier ratios. Among these, the 1:1 molar ratio complex exhibited the …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 687–695 Read article
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Physicochemical Transitions and Polymerization Dynamics in Multi-Generational Dentin Adhesives: A Critical Review of the Resin-Dentin Composite Interface
Abstract: Adhesive dentistry has undergone a transformative refinement over the past three decades, transitioning from technique-sensitive, multi-step etch-and-rinse protocols to streamlined universal formulations. This narrative review critically synthesizes evidence from thirty peer-reviewed investigations to evaluate the evolution of dentin bonding agents from the fourth through the eighth generations. The analysis places particular emphasis on the physicochemical dynamics of the resin-dentin interface, including interfacial bond strength metrics, marginal integrity, and microleakage behavior. …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 209–228 Read article
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Study of Social Trends Prediction Using AI
Abstract: AI (Artificial Intelligence) has fundamentally changed the ability to analyze social trends by using large datasets to develop predictions about human behavior, public sentiment, and global events. Using methodologies such as Natural Language Processing (NLP), Time-Series Forecasting, and Graph-Based Social Network Analysis, AI is able to find hidden correlations in a variety of available datasets, from social media to economic indicators to public records, and fundamentally changes decision-making based on …
Published in Journal of Artificial Intelligence Research & Advances · Vol. 12, Issue 3, 2025 · pp. 19–29 Read article
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Comprehensive Evaluation of Quercetin from Bauhinia purpurea for Its Anti-Acne and Anti-Inflammatory Potential, Including Advances in Quercetin-Loaded Nanogel Formulation
Abstract: Acne vulgaris is among the most prevalent chronic inflammatory dermatoses in clinical dermatology, afflicting a substantial proportion of the global adolescent and adult population. Conventional pharmacotherapies — including topical retinoids, benzoyl peroxide, and systemic antibiotics — remain the therapeutic mainstay; however, their long-term utility is progressively undermined by adverse cutaneous reactions, systemic toxicity, and the rising prevalence of antibiotic-resistant Cutibacterium acnes strains. These limitations have intensified scientific interest in plant-derived …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 13, Issue 2, 2026 Read article
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Phytotherapeutic Potential of Melaleuca: An Integrative Review of Phytochemistry and Antimicrobial, Antifungal, Antioxidant, and Antiviral Mechanisms
Abstract: Melaleuca alternifolia and other species of the Melaleuca genus stand out for the broad spectrum of pharmacological properties attributed to their bioactive compounds, such as monoterpenes, sesquiterpenes, flavonoids, and polyphenols. This study aimed to critically review and analyze scientific evidence produced between 2005 and 2025 regarding the antimicrobial, antifungal, antioxidant, and antiviral activities of Melaleuca, correlating its phytochemistry with molecular mechanisms of action. For this purpose, an integrative literature review …
Published in Research & Reviews : Journal of Herbal Science · Vol. 15, Issue 2, 2026 Read article
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Tools, Modern Drugs, and Latest Investigations for the Diagnosis and Treatment of Heart Failure: A Systematic Review of the General Causes
Abstract: Heart failure (HF) diagnosis and treatment present formidable challenges, given the absence of a definitive single test. This systematic literature review aims to comprehensively analyze the current landscape of diagnostic tools, modern drugs, and latest investigative approaches in HF management. Recognizing the complexity of HF etiology, this systematic review emphasizes the importance of advanced diagnostic methods, such as genetic testing and artificial intelligence applications. The systematic review was conducted to …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 13, Issue 1, 2024 · pp. 1–10 Read article
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Bacteriophages- A New Frontier in Medicine
Abstract: Bacteriophages, or phages, are viruses that specifically target and infect bacteria, offering an innovative alternative to traditional antibiotic treatments, especially in the face of rising antibiotic resistance. The resurgence of phage therapy has been driven by the increasing prevalence of multidrug-resistant bacterial strains and the slowdown in the development of new antibiotics. Phages, unlike antibiotics, target specific bacterial strains, reducing the impact on the natural microbiota and potentially offering a …
Published in International Journal of Virus Studies · Vol. 1, Issue 2, 2024 · pp. 31–35 Read article
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Comparative Study of Structural and Optical Properties of Bismuth Ferrite Nanoparticles for Photovoltaic Applications Synthesized via Different Sol-Gel Methods
Abstract: Pure multiferroic bismuth ferrite (BiFeO3) nanoparticles were successfully synthesized using an energy-efficient, low-temperature sol-gel method, comparing two distinct approaches: auto-combustion and non-auto-combustion. To ensure phase stability, the precursor solution's pH was strictly maintained between 1 and 2 using ammonia solution (NH4OH), while ethylene glycol (C2H6O2) was employed as a chelating agent for the Fe3+ and Bi3+ cations. All samples underwent a final annealing process at 500 °C to promote crystallization. …
Published in Journal of Materials & Metallurgical Engineering · Vol. 16, Issue 1, 2026 · pp. 83–94 Read article
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AI-Integrated Graphene-Modified Polymer Interfaces for Real-Time Crack Detection and Autonomous Healing in Smart Concrete Structures
Abstract: This study presents the design and development of a graphene-reinforced multifunctional polymer composite interface engineered for structural reinforcement, self-sensing, and autonomous healing applications in cementitious systems. A thermosetting polymer matrix embedded with graphene nanoplatelets (0.25–1.5 wt.%) was developed to establish a conductive polymer nano-composite network. Electrical characterization confirmed a distinct percolation threshold at ~0.6–0.8 wt.%, beyond which a sharp increase in conductivity was observed due to the formation of interconnected …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 30–42 Read article
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Revisiting the Role of Mindfulness-based Stress Reduction in the Management of Rheumatoid Arthritis
Abstract: Rheumatoid arthritis (RA) is a type of arthritis characterized by a chronic inflammatory disorder that primarily affects the lining of the synovial joints resulting in progressive disability in the movement of diarthrodial joints and arthralgia. It is a debilitating disease associated with premature death and socioeconomic burdens. Its pathogenesis is multifactorial with an individual course of progression where psychological stress is considered to be one of the risk factors associated …
Published in International Journal of Vaccines · Vol. 1, Issue 1, 2024 · pp. 19–28 Read article
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REVIEW OF PHARMACOEPIGENETICS: BRIDGING EPIGENETICS AND PERSONALIZED MEDICINE
Abstract: Pharmacoepigenetics is an emerging field that explores how alterations in gene expression, independent of DNA sequence changes, influence individual responses to drugs. Unlike pharmacogenetics, which focuses primarily on genetic variation, pharmacoepigenetics integrates genetic, environmental, and lifestyle factors to explain interindividual differences in drug efficacy, toxicity, and resistance. Key epigenetic mechanisms including DNA methylation, histone modifications, non-coding RNAs, and RNA methylation play critical roles in regulating drug metabolism and therapeutic outcomes. …
Published in International Journal of Molecular Biotechnological Research · Vol. 4, Issue 1, 2026 Read article
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Enhancing Mechanical Properties of Fiber-Reinforced Composites Through Sorghum Husk and Unsaturated Polyester Resin.
Abstract: Plastic, a versatile synthetic polymer, holds considerable significance and utility in human society due to its manifold applications. However, its deleterious ecological ramifications have spurred growing apprehensions. This has galvanized the pursuit of ecologically amicable substitutes, propelling interest in the domain of composite materials. Composites are formulated by amalgamating diverse substances, and in this context, Styrene Diluted Unsaturated Polyester Resin (SDUPR) is melded with natural constituents. Among these organic constituents, …
Published in Journal of Polymer & Composites · Vol. 13, Issue 2, 2025 · pp. 59–65 Read article
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Impact of Therapeutics on Carbapenem-Resistant Acinetobacter baumannii
Abstract: Acinetobacter baumannii, a formidable pathogen in healthcare settings, poses a significant threat due to its propensity to cause nosocomial infections. This bacterium exhibits several attributes that enable it to evade the human body's natural defenses. A. baumannii's remarkable adaptability is highlighted by its ease in acquiring antibiotic resistance determinants, rendering it challenging to treat. Its ability to thrive in hospital environments underscores the urgent need for stringent infection control practices …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 14, Issue 2, 2024 · pp. 1–11 Read article
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Advanced Polymer-Based Packaging Composite with Metal Oxide Nanofillers: Synthesis, Characterization, and Applications
Abstract: The development of high-performance polymeric composites for food packaging applications has gained significant attention in recent years due to increasing concerns about food safety, durability, and environmental impact. The increasing demand for active packaging materials that not only protect food but also extend shelf life has led to extensive research into polymer-based antimicrobial composites. Traditional packaging materials, including plastics, ceramics, and metals, often lack bioactive properties and can contribute to …
Published in Journal of Polymer & Composites · Vol. 13, Issue 5, 2025 · pp. 56–63 Read article
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Cardiotoxicity Associated with Tyrosine Kinase Inhibitors in Philadelphia Chromosome-Positive Leukemias: An Overview of Mechanisms, Clinical Implications, and Management Strategies
Abstract: Tyrosine kinase inhibitors have greatly enhanced the outlook for individuals diagnosed with Philadelphia chromosome-positive leukemias, including chronic myeloid leukemia and acute lymphoblastic leukemia. However, these therapeutic agents are associated with Cardiotoxicities and can manifest as left ventricular dysfunction, which may progress to heart failure, along with electrocardiographic abnormalities, dysrhythmias, hypertension, myocardial ischemia, and thromboembolic events. The unclear frequency of drug-induced cardiovascular complications, coupled with uncertainties regarding their reversibility and long-term …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 13, Issue 3, 2024 · pp. 18–24 Read article
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Viral Chronicles: The Ever-Evolving Saga of COVID-19
Abstract: Coronaviruses, belonging to the family of RNA viruses, have recently captured global attention owing to their remarkable ability to infect a diverse array of species, ranging from animals to humans. These viral agents, recognized by their characteristic crown-like morphology when observed through electron microscopy, have a historical association with zoonotic diseases. Previous examples include Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and Middle East Respiratory Syndrome Coronavirus (MERS-CoV). The term "Corona" …
Published in International Journal of Virus Studies · Vol. 1, Issue 1, 2024 · pp. 16–25 Read article
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Formulation and Evaluation of Herbal Face Serum
Abstract: The cosmetics industry has witnessed steady growth over the past decade, driven largely by an expanding youth demographic. Globally, women are increasingly conscious of their skin focusing not only complexion improvement but also wrinkle reduction and the maintenance of a youthful, radiant appearance. This trend has stimulated rising demand across a wide range of skincare products. In response, the objective of this study is to formulate, develop, and evaluate an …
Published in Research & Reviews : Journal of Herbal Science · Vol. 14, Issue 3, 2025 · pp. 30–40 Read article
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Architectured Multiphase Polymeric Carriers with Microstructural Gradients: Synergistic Filler Effects for the Precision Delivery in Tuberous Plant Systems
Abstract: In this paper, 50 papers were reviewed to analyse the design, techniques, and applications of polymer composite systems for delivering agrochemicals against major tuberous plant pathogens, including fungi, bacteria, and nematodes. Primary tuber plant pathogens affecting yield are studied, followed by a study of control strategies. This is followed by a study of the basic properties of polymer composites, including the significance of natural and synthetic polymers. Then, the study …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 940–949 Read article
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Self-Healing Polymer Nanocomposites: A Comprehensive Review of Design Strategies, Mechanisms, and Emerging Applications
Abstract: Self-healing polymer nanocomposites (SHPNs) are a new class of materials that can autonomously repair themselves to prolong their lifetime and improve their application performance. Herein, we provide a comprehensive overview of the design strategies, healing mechanisms, and emerging applications of SHPNs. Incorporating nanofillers (nanoparticles, nanofibers, and/or nanotubes) into polymer matrices leads to requisite functionalization that significantly enhances mechanical properties and is essential in self-healable products including improved cross-linking, high dispersion, …
Published in Journal of Polymer & Composites · Vol. 13, Issue 4, 2025 · pp. 281–293 Read article
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Ethnopharmacological Insights: Uncovering Plant-Based Neuroprotective Treatments for Neurodegenerative Disorders
Abstract: The development of plant-based therapies for neurodegenerative diseases holds significant promise due to the therapeutic potential of natural compounds, such as Laurus nobilis, Aronia melanocarpa, and celastrol. This review identifies critical literature gaps in the current research, including inconsistent extraction methods, lack of clinical trials, insufficient documentation of long-term effects, limited mechanistic insights, and poor bioavailability. Addressing these gaps through standardization, rigorous clinical trials, advanced delivery systems, and comprehensive ethnopharmacological …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 12, Issue 1, 2025 · pp. 13–18 Read article