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89 articles for “in-vitro release study”
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Advancements in Solubility Enhancement Through Liquisolid Compact Technology: A Comprehensive Review
Abstract: The study examines Liquisolid Compact Technology as an innovative approach for improving the bioavailability and solubility of drugs that are poorly soluble in water. Liquisolid systems, comprising solid carriers and liquid drugs, offer advantages such as improved drug release and bioavailability, reduced manufacturing costs, and controlled drug delivery. The technique involves dissolving or suspending the drug in non-volatile solvents, adding carrier materials, super disintegrants, and coating materials, and then compressing …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 11, Issue 2, 2024 · pp. 25–34 Read article
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Development and Assessment of Levetiracetam Microspheres Utilizing Synthetic and Natural Polymers: A Biomedical Engineering Perspective
Abstract: In the present study, comparative study of Levetiracetam loaded microspheres using Ethyl cellulose as synthetic and Sodium alginate as natural polymers was done. Solvent evaporation and ionic gelation technique has been successfully employed to produce Levetiracetam loaded ethyl cellulose and sodium alginate microspheres with optimal drug encapsulation that sustained the drug release over a period of time. Based on the pre-formulation studies E1 to E4 and S1 to S4 batches …
Published in International Journal of Biomedical Innovations and Engineering · Vol. 2, Issue 1, 2024 · pp. 1–18 Read article
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Formulation and Characterization of Liquisolid Tablet of Skeletal Muscle Relaxants and Anti-Inflammatory Drugs
Abstract: Baclofen is a skeletal muscle relaxants and nimesulide is a Non- steroidal anti- inflammatory drug (NSAID). Baclofen is used in the treatment of muscle spasm, arthritis and spondylitis. NSAID’s are preferred to reduce the symptoms caused by muscle spasm i.e., severe pain and fever. Hence combination of drug is used to minimise the frequent use of the drug. The main objective of the present work was to enhance solubility and …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 2, Issue 2, 2015 · pp. 6–14 Read article
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Formulation and Evaluation of Curcumin Loaded Transferosomal Nasal In-Situ Gel for Alzheimer’s Disease
Abstract: Objective: To develop a novel delivery of curcumin by formulating its transfersome into nasal in situ gel. Methods: Curcumin transfersomes were prepared by thin film hydration method. Optimization of the formulation was performed using Design Expert software. Formulation and characterization of optimized batch of curcumin transfersomes were performed. The nasal in situ gel was prepared by incorporating the optimized transfersome. Results: The pH, drug content, in-vitro drug release profile and …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 6, Issue 2, 2019 · pp. 19–31 Read article
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Formulation and Evaluation of an Antifungal Emulgel Containing Carbopol 940 as Gelling Agent
Abstract: Emulgels have emerged as one of the most intriguing topical distribution systems as they have dual release control system, i.e., gel and emulsion. The main purport of the present study was to develop and evaluate topical emulgel system for Fluconazole, antifungal agent, utilizing different polymers namely carbopol 940. In addition, light liquid paraffin as oil, Tween-20 and Span-20 as emulsifiers and propylene glycol and methyl alcohol as co-surfactant were culled …
Published in Trends in Drug Delivery · Vol. 2, Issue 1, 2015 · pp. 28–37 Read article
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Characterization of Tabletting Properties of Mango Gum
Abstract: The aim of the study is to elucidate the physical, thermal, sorption, and functional properties of a mango gum obtained from the stem of Mangifera indica were characterized viz. elemental analysis, Fourier transmittance infrared, particle size analysis, thermogravimetric analysis, differential scanning colorimetry, scanning electron microscopy, and X-ray powder diffraction. Mango gum had a glass transition temperature (Tg) and melting peak of 90 and 318.795°C, respectively. This material showed a 14.59% …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 1, Issue 2, 2014 · pp. 22–30 Read article
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Qualitative and Quantitative Effects of Non-Thermal Atmospheric Pressure Plasma and ErCr: YSGG Laser Activation on Surface Remineralization and Fluoride Release of Three Different Fluoride Varnishes
Abstract: Dental caries remains a prevalent oral health concern worldwide, prompting ongoing research into innovative approaches for caries prevention and management. This experimental investigation endeavors to conduct a comparative assessment of the bioactivity, fluoride release kinetics, shear bond strength, and compressive strength of glass ionomer cement (GIC) augmented with three distinct types of inorganic bioactive nanoparticles. Bioactive nanoparticles have garnered interest in dental materials for their potential to enhance material properties …
Published in Journal of Polymer & Composites · Vol. 12, Issue 5, 2024 · pp. 292–303 Read article
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Formulation Development and Evaluation Technique for Immediate and Modified Release Capsule
Abstract: The development and evaluation of formulations for immediate-release (IR) and modified-release (MR) capsules represent a critical aspect of pharmaceutical dosage form design, offering distinct advantages in terms of drug release profiles and therapeutic outcomes. This study focuses on the formulation strategies, techniques, and evaluation methods used to develop both IR and MR capsules. Immediate-release capsules are designed to disintegrate quickly in the gastrointestinal tract, ensuring rapid drug absorption, while modified-release …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 3, Issue 1, 2025 · pp. 1–9 Read article
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Novel Synthesis of Encapsulated Super Paramagnetic Iron Nanoparticles (Fe3O4) and its Evaluation in Drug Delivery System
Abstract: Nanoparticles can be defined as solid, submicron, colloidal particles ranging in size from 10–100 nm in diameter, generally but not necessarily made of natural or synthetic polymers, in which drugs can be adsorbed, entrapped, that exhibit new or enhanced size-dependent properties as compared to microparticles. Iron oxide nanoparticles are often magnetic by nature, which means that they obey Coulomb’s law, and can be manipulated by an external magnetic field gradient. …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 7, Issue 2, 2016 · pp. 11–24 Read article
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“DEVELOPMENT AND CHARACTERIZATION OF PHYTOSOMES FOR THE TREATMENT OF ANTI-CANCER ACTIVITY BY USING THE Spirulina (Arthospira Plantesis) EXTRACT”
Abstract: This study aims to investigate and evaluate spirulina's anticancer properties.The current research is centred on obtaining a Spirulina-containing drug. The goal is to design and create Phytosomes, characterizing them based on relevant and crucial parameters. The process of solvent evaporation was utilized in the creation of Phytosomes. Various parameters such as zeta potential, particle size, infra-red spectral analysis, % drug content, encapsulation efficiency, and % drug release (% DR) were …
Published in International Journal of Antibiotics · Vol. 1, Issue 1, 2024 · pp. 10–22 Read article
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Development and Characterization of Ondansetron containing Chewing Gum Formulations for Preventing Vomiting and Motion Sickness
Abstract: AbstractChewing gums are portable drug delivery devices that can deliver medications via the buccal route for either local or systemic absorption. Without water, it can be administered discretely. Antiemetic medication is combined with the gum base in medicated chewing gums, which are chewed rather than ingested. These formulations contain Ondansetron, Polyvinyl alcohol, Carboxymethyl agorase, Peppermint oil, Polyethylene glycol (PEG-400), Calcium carbonate, Synthetic gum base, Propyl paraben, and Ascorbic acid. The …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 9, Issue 3, 2022 · pp. 15–28 Read article
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Influence of Polymeric Carriers on the pH-Modifying Properties of Intracanal Medicaments in Root Canal Treatment
Abstract: Calcium hydroxide (CH) preparations and medicated gutta-percha are widely used intracanal medicaments in root canal treatment. These materials often incorporate polymeric carriers to deliver the CH payload and influence its therapeutic effect. This in-vitro study investigates the impact of different polymeric carriers on the pH-modifying properties of intracanal medicaments within the root canal system. The research focuses on two key aspects: (1) the ability of the polymers to control the …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 967–974 Read article
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Biopolymer-Based 3D Composite Scaffolds for Bone Tissue Engineering: Photothermal-Responsive Systems with Controlled Pt (IV) Prodrug Release
Abstract: Biopolymer-based composite scaffolds have attracted significant attention as multifunctional platforms at the intersection of polymer science, regenerative medicine, and cancer nanotherapy. In this study, a dual-functional scaffold was developed for simultaneous osteosarcoma treatment and bone regeneration using poly (L-lactic acid) (PLLA) reinforced with bioactive glass (BG) and integrated with a glutathione-responsive platinum (IV) prodrug system (PDA@Pt). To improve interfacial adhesion, photothermal conversion efficiency, and tumor-specific activation, the Pt (IV) prodrug …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 351–361 Read article
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Design of Nanoparticle Drug Delivery System for NonSteroidal Anti Inflammatory Agents in the Treatment of Autoimmune Diseases
Abstract: Aim: The aim of the present study is to develop nanoparticle drug delivery system for naproxen and ibuprofen. Methodology: Ibuprofen nanoparticles were prepared by nanoprecipitation technique. Naproxen nanoparticles were prepared by desolvation technique. By adapting continuous addition method and intermittent addition, five formulations were prepared with each polymer. The obtained nanoparticles were evaluated for particle size, zeta potential, yield, drug content, entrapment efficiency and loading capacity. In vitro drug dissolution …
Published in Nano Trends – A Journal of Nano Technology & Its Applications · Vol. 23, Issue 1, 2021 · pp. 26–33 Read article
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Stomach Mimicry of A-Forte for Pharmacokinetic Insight
Abstract: Drug absorption from solid dosage forms after oral administration depends on the release of the drug substance from the drug product, the dissolution or solubilization of the drug under physiological conditions, and the permeability across the gastrointestinal tract. In vitro dissolution may be relevant to the prediction of in vivo performance. To evaluate the in vitro dissolution of A-forte, a siddha proprietary medicine and the influencing factors, a study of …
Published in Research & Reviews : A Journal of Unani, Siddha and Homeopathy · Vol. 2, Issue 2, 2015 · pp. 8–12 Read article
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Fabrication and Characterization of Diacerein Loaded Nanosponge for Topical Delivery
Abstract: Diacerein, an anti-inflammatory drug, which comes under BCS class II, commonly used in treatment of osteoarthritis has limited by its poor solubility and bioavailability when administered topically. This study aimed to develop and evaluate diacerein-loaded nanosponges gel using varying concentrations of ethyl cellulose and polyvinyl alcohol (PVA) to enhance its delivery. Nanosponges were prepared using an emulsion solvent evaporation technique, with different ratios of ethyl cellulose (0.05-0.250%) and PVA (0.2-0.3%). …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 12, Issue 2, 2025 · pp. 26–46 Read article
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Biodegradable and Natural Fiber-Reinforced Polymer Composites for Antimicrobial Coatings in Biomedical Applications
Abstract: Since they make medical equipment more biocompatible and practical, biomedical polymers are quite crucial for the advancement of medical technologies. One of the most exciting applications for biomedical polymers is their possible use as protective drug coatings for devices. These coatings aim to limit bacterial binding and biofilm growth, two key causes of illnesses acquired after implantation. Scientists are searching for fresh approaches to combat microorganisms as the issue of …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 392–405 Read article
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Advanced Ointment Formulation: An Insightful Review of Innovation and Efficacy
Abstract: This review provides an in-depth exploration of the evolution of ointment formulations, particularly considering the increasing prevalence of fungal infections and the growing demand for effective antifungal treatments. Traditional ointment formulations, while useful, often face significant challenges, such as inadequate penetration into the skin, poor bioavailability, and undesirable textures that limit their efficacy. As a result, there has been a shift toward more advanced, innovative formulations that aim to address …
Published in Nano Trends – A Journal of Nano Technology & Its Applications · Vol. 27, Issue 1, 2025 · pp. 14–23 Read article
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Formulation Development of Antihypertensive Buccal Patches and Characterisation
Abstract: Buccal patches containing atenolol and nifedipine were fabricated from mucoadhesive polymers like chitosan and hydroxypropyl methylcellulose (HPMC) 15CPS for the purpose of prolonging drug release and improving their bioavailability. The fabricated films were smooth, uniform and the colour was brown with good flexibility. The weight and thickness of all the formulations were found to be uniform. The drug content was in the range of 95–98%, indicating drug uniformity. Swelling index …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 2, Issue 2, 2015 · pp. 15–27 Read article
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Formulation and Evaluation of Saliva Substitute
Abstract: The development and evaluation of saliva substitutes play a vital role in managing xerostomia, a condition marked by insufficient saliva production that adversely affects oral health and overall well-being. This study investigates various formulations of saliva substitutes intended to replicate the functionality of natural saliva. The key goals are to assess their moisturizing effectiveness, physical and chemical properties, and in vitro performance. These formulations generally incorporate hydrators, lubricants, thickeners, and …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 11, Issue 3, 2024 · pp. 32–47 Read article