Design of Nanoparticle Drug Delivery System for NonSteroidal Anti Inflammatory Agents in the Treatment of Autoimmune Diseases

A. Krishna Sailaja

Abstract

Aim: The aim of the present study is to develop nanoparticle drug delivery system for naproxen and ibuprofen. Methodology: Ibuprofen nanoparticles were prepared by nanoprecipitation technique. Naproxen nanoparticles were prepared by desolvation technique. By adapting continuous addition method and intermittent addition, five formulations were prepared with each polymer. The obtained nanoparticles were evaluated for particle size, zeta potential, yield, drug content, entrapment efficiency and loading capacity. In vitro drug dissolution studies were performed for all the formulations of these two drugs to determine percentage of drug release. Further studies were carried out for the best formulation to develop into a gel. Results: In desolvation technique for naproxen, among all the formulations, F5-D was considered as best formulation because of its good stability (–22.3 mv), mean particle size (488.6 nm), higher entrapment efficiency (92.2%), and higher drug loading capacity (39.9%). In nanoprecipitation technique, C3 formulation prepared by using 0.6%w/v PVA as a stabilizer was found to be the best with highest entrapment efficiency (78%), greater stability (–49.8 mV), with mean particle diameter of 586.9 nm and it was able to sustain the release for about 9 h. Conclusions: Nanoparticle drug delivery system was developed for Naproxen and ibuprofen. All the formulations were evaluated, and comparative study was performed. The optimized formulations were loaded into Carbopol gel.

Abstract

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