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48 articles for “US-FDA”
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The Ames Test in Twenty-first Century
Abstract: Since the 19th century, industrial development has increased exposure to mutagens and possible carcinogens. In order to avoid these health risks, several techniques have been developed to recognize genotoxins. In the 1970s, Dr. Bruce Ames and colleagues, studying the histidine operon of Salmonella typhimurium, observed that histidine (−) auxotroph mutants were reverted to histidine (+) upon exposure to a mutagen. The researchers further observed that known carcinogens were mutagenic to …
Published in Research and Reviews: A Journal of Toxicology · Vol. 2, Issue 1, 2012 · pp. 23–37 Read article
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Supportive Therapy Play a Vital Role in the Treatment of Leukemia: A Review
Abstract: Leukemia is a major burden worldwide. The anomalous production of white blood cells (WBC) is responsible for producing leukemia; these cells are also known as blasts. A study indicated that thousands of patients are detected every year with leukemia risk worldwide. The risk factor including chemical exposure, ionizing radiations, cigarette smoking is the major causes for developing leukemia. There are four types of leukemia and number of genes involved are …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 8, Issue 3, 2018 · pp. 1–8 Read article
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An Update on HIV-2 Infection
Abstract: Human immunodeficiency virus type 2 (HIV–2) infection is an important cause of disease in a number of regions of the world. But the knowledge about this infection is sparse. Prevalence data on HIV-2 is heterogeneous. HIV-2 has a lower infectivity than HIV-1 which can be related to the lower RNA levels in this virus. The rate of progression to Acquired Immunodeficiency Syndrome (AIDS) in HIV-2-infected patients is highly variable making …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 8, Issue 2, 2018 · pp. 34–42 Read article
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An Overview of Gene Therapy
Abstract: Gene therapy is a revolutionary technique in medical science that seeks to cure or stop illnesses by means of introducing, altering, or quieting genes inside a patient's cells. Advancements in molecular biology, genetics, and biotechnology have propelled this field forward markedly changed over the last few decades. The underlying idea of gene therapy is to introduce genetic material into target cells via viral or non-viral vectors to rectify faulty genes, …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 16, Issue 3, 2025 · pp. 89–105 Read article
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Targeted Delivery of Nanoparticle Based Taxanes for Breast Cancer Treatment: A Review
Abstract: The most common type of cancers in women is breast cancer. In United States, it is the second common cause of death in women. Metastatic cancer is the advanced stage of breast cancer, which is related to the distribution of cancerous cells from breast tissues to different areas of the body. Over the past numerous years, taxanes are bound to perform a huge role in the management and treatment of …
Published in Trends in Drug Delivery · Vol. 6, Issue 3, 2019 · pp. 36–51 Read article
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Integrative Network Biology Analysis of GSE6011 Uncovers Molecular Signatures in Duchenne Muscular Dystrophy
Abstract: Duchenne muscular dystrophy (DMD) is a rare, severe neuromuscular disorder demonstrated by progressive skeletal muscle deterioration and premature mortality. Despite advances in supportive care, no definitive cure exists, highlighting the need to explore novel molecular targets. The current study aimed to uncover key dysregulated genes and molecular pathways in DMD through a dataset-specific network biology approach. Publicly available microarray data (GSE6011) from DMD quadriceps muscle biopsies of 22 patients and …
Published in Research and Reviews : Journal of Computational Biology · Vol. 14, Issue 3, 2025 · pp. 36–48 Read article
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Stability Indicating HPLC Method for Drugs Indicated for Helicobacter Pylori-associated Ulcers
Abstract: Normal 0 false false false EN-US X-NONE AR-SA MicrosoftInternetExplorer4 Triple therapy regimen that comprises a proton pump inhibitor likes Omeprazole, antibiotics like Doxycycline and Tinidazole can be used for treatment of peptic ulceration which is caused by H. pylori. A validated HPLC method was developed as a stability-indicating HPLC method for these drugs and its impurities. New method overcame interference between Doxycycline and its epimer on achiral column by using …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 6, Issue 1, 2015 · pp. 28–46 Read article
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Computational Identification of Antigenic Proteins and Epitopes in Hantavirus sp. for Drug Repurposing
Abstract: Hantavirus is an emerging virus that spreads from animals to humans and can cause serious illnesses like hantavirus pulmonary syndrome (HPS) and hemorrhagic fever with renal syndrome (HFRS). there are no FDA-approved treatments available for these diseases. This study explores in-silico drug repurposing as a strategy to identify potential therapeutic candidates. The physicochemical, secondary structure, antigenicity, and post-translational modification analysis of hantavirus proteins – specifically the glycoprotein precursor, N protein, …
Published in International Journal of Molecular Biotechnological Research · Vol. 3, Issue 1, 2025 · pp. 20–26 Read article