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335 articles for “Safety evaluation”
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Toxicological Profiling and Safety Assessment of NASAT 2.0: A Conceptual Framework for Adaptive Nanoparticle Therapy in Rabies
Abstract: Rabies, caused by the highly neurotropic Rabies lyssavirus, remains one of the most enigmatic and universally lethal infectious diseases known to modern medicine. Once clinical symptoms manifest following successful neuroinvasion, the fatality rate approaches absolute certainty (approximately 99.9%), a staggering statistic that has remained largely unchallenged despite massive, concurrent advances in modern virology, critical care medicine, and cellular immunology. Current late-stage therapeutic protocols, most notably the widely debated Milwaukee Protocol, …
Published in Research and Reviews: A Journal of Toxicology · Vol. 16, Issue 2, 2026 · pp. 1–19 Read article
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In Silico Screening of Terminalia chebula Phytocompounds as Potential Inhibitors of NTCP and DDB1 in Hepatitis B Virus Infection
Abstract: Hepatitis B virus (HBV) infection is a major global health concern, and chronic carriers are at risk of developing cirrhosis, hepatocellular carcinoma (HCC), and even death. Existing treatments can effectively inhibit viral replication, but they achieve little eradication of the virus because of covalently closed circular DNA (cccDNA) retention. In this investigation, bioactive compounds of Terminalia chebula, a plant known for its hepatoprotective and antiviral properties in traditional medicine, were …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 13, Issue 1, 2026 · pp. 33–44 Read article
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Uttarabasti in Female Infertility: A Retrospective Analysis of Clinical Outcomes and Safety Profile
Abstract: Background: Uttarabasti (UB) is a specialized Panchakarma procedure involving intrauterine instillation of medicated Sneha, classically indicated in Yonivyapad and Vandhyatwa. It facilitates targeted local drug delivery, bypassing gastrointestinal metabolism and enabling direct therapeutic action at the uterine level. In Ayurvedic understanding, UB achieves Garbhashaya Shuddhi and Apana Vata Anulomana — the two primary pathological corrections considered essential in Vandhyatwa. Infertility affects an estimated 10–15% of couples globally, with a substantial …
Published in Research and Reviews : A Journal of Ayurvedic Science, Yoga and Naturopathy · Vol. 13, Issue 2, 2026 Read article
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Uttarabasti in Female Infertility: A Retrospective Analysis of Clinical Outcomes and Safety Profile
Abstract: Background: Uttarabasti (UB) is a specialized Panchakarma procedure involving intrauterine instillation of medicated Sneha, classically indicated in Yonivyapad and Vandhyatwa. It facilitates targeted local drug delivery, bypassing gastrointestinal metabolism and enabling direct therapeutic action at the uterine level. In Ayurvedic understanding, UB achieves Garbhashaya Shuddhi and Apana Vata Anulomana — the two primary pathological corrections considered essential in Vandhyatwa. Infertility affects an estimated 10–15% of couples globally, with a substantial …
Published in Research and Reviews : A Journal of Ayurvedic Science, Yoga and Naturopathy · Vol. 13, Issue 2, 2026 · pp. 1–14 Read article
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Fracture Mechanics-based Assessment of Welded Joints in Structural Steel Components
Abstract: In many engineering applications, connection by welding are essential to the structural integrity of steel components. However, because of the intricate interplay between material qualities, welding techniques, and structural stress conditions, evaluating the dependability and safety of these welded connections continues to be a difficult challenge. A systematic framework that evaluates the behavior of cracks and faults in welded joints is provided by fracture mechanics, which also offers insights into …
Published in International Journal of Fracture Mechanics and Damage Science · Vol. 1, Issue 2, 2023 · pp. 16–22 Read article
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Herbal Medicines and Complementary Therapies: Their Role, Types, and Applications
Abstract: Medicinal plants are used in herbal medicine to treat and prevent illnesses. This includes the use of standardized and titrated botanical extracts in addition to common and traditional medicines from different cultures. The safety of a treatment may be suggested by its long history and deep cultural roots in traditional medical systems, but this does not always imply that it is effective. This is especially important in herbal medicine, since …
Published in Emerging Trends in Personalized Medicines · Vol. 2, Issue 1, 2025 · pp. 40–53 Read article
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Environment, Health and Safety Management by Risk Assessment of Activities in Construction Project Site
Abstract: The constructing development enterprise is developing all over the world. The construction activities and work is a strong part of the wealth in India. it gives opportunities for employment for a wide range of people in the country. The aims of this study are to find out the regular practice of health and safety risk calculations, risk communication and risk management; and the environment health and safety management planning for …
Published in Journal of Industrial Safety Engineering · Vol. 9, Issue 2, 2022 · pp. 17–29 Read article
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Use of Multi Criteria Decision Making Methods in Assessment of Occupational Safety and Health
Abstract: Assessment of Occupational Safety and Health (OSH) of process plants is an important aspect in safety management. Quantitative assessment is necessary to compare the OSH status of different plants. For this purpose, usually, an evaluation team is constituted which evaluates the OSH performance based on the available OSH related information. The evaluation team arrives at a decision through discussions and mutual agreement. However, while working in a group, there always …
Published in Journal of Industrial Safety Engineering · Vol. 6, Issue 3, 2019 · pp. 25–34 Read article
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Production, Characterization and Toxicological Evaluation of Eco-Friendly Flavolipid Biosurfactant
Abstract: At present majority of surfactants are chemically synthesized. Nevertheless, in recent years, much attention has been directed towards biosurfactants due to their broad range of functional properties, there are cheaper as they can be produced from alternative sources. They have applications in the fields, such as: oil recovery process, as an additive in food processing industry, pharmaceuticals preparations, energy saving technologies etc. As they are being microbial derivatives, it is …
Published in Research and Reviews: A Journal of Toxicology · Vol. 4, Issue 1, 2014 · pp. 16–21 Read article
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Wind and Earthquake Mitigation: The Impact of Dampers on Tall Structures
Abstract: This paper provides an in-depth examination of the effects of both earthquake and wind loading on high-rise buildings situated across various terrain categories and seismic zones. The research underscores the critical importance of accounting for lateral loads in the design of reinforced concrete structures, as this consideration is essential for maintaining structural stability and ensuring the safety of occupants. The study focuses on identifying the critical design loads for multistory …
Published in Journal of Structural Engineering and Management · Vol. 11, Issue 2, 2024 · pp. 75–83 Read article
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PERFORMANCE-BASED WIND RESPONSE ANALYSIS OF TALL RCC IREGULAR STRUCTURES USING AUTODESK REVIT AND ROBOT STRUCTURAL ANALYSIS
Abstract: The increasing trend of vertical construction has made wind effects a critical consideration in the design of tall reinforced concrete (RCC) buildings. The response of such structures is largely governed by their geometric configuration, stiffness characteristics, and modelling accuracy under wind loading conditions Wind loads are evaluated based on standard provisions such as IS 875 (Part 3): 2015, which provide essential guidelines for structural safety This study focuses on evaluating …
Published in Journal of Structural Engineering and Management · Vol. 13, Issue 3, 2026 Read article
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Optimizing Anesthesia for Major Surgery: The Role of Sequential Combined Spinal-Epidural Technique
Abstract: The Combined Spinal Epidural (CSE) approach has been widely employed over the last decade because it achieves rapid onset and substantial blockage while also allowing for the modification or prolongation of the block. Background: Sequential spinal-epidural anesthesia (SSEA) combines the rapid onset and dense blockade of spinal anesthesia with the prolonged duration and adjustable analgesia of epidural anesthesia. This technique is particularly beneficial in major surgeries requiring prolonged operative time …
Published in Research and Reviews : Journal of Surgery · Vol. 14, Issue 2, 2025 · pp. 12–18 Read article
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A Comparative Analytical Study on Gandhaka Ointment Prepared by Two Different Oleaginous Bases – As a Thesis Article
Abstract: Gandhaka (purified sulphur) is broadly used in Ayurvedic dermatological preparations, particularly in Malahara Kalpana (ointment formulations), due to its well-known antimicrobial and skin-healing properties. Although classical Ayurvedic texts, such as Rasa Shastra and Bhaishajya Kalpana, do not directly mention Gandhaka ointment, Rasatarangini by Acharya Sadanand Sharma describes four discrete methods for preparing Gandhaka Taila (sulphur-infused oil). In this study, the third method was selected to prepare Gandhaka Taila using two …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 14, Issue 3, 2025 · pp. 27–39 Read article
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Clinical Evaluation of Efficacy of a Polyherbal Unani Formulation (Mentioned in Makhzan-Ul-Ilaj) in the Management of Warm-e-Lauzatain-Haad (Acute Tonsillitis)
Abstract: Background: Warm-e-Lauzatain-Haad (Acute Tonsillitis) is an inflammatory condition of the palatine tonsils characterized by throat pain, fever, odynophagia and general discomfort. It is particularly common among adolescents and young adults and contributes substantially to outpatient visits and missed academic or workdays. In Unani medicine Warm-e-Lauzatain is described as a hot inflammatory swelling arising from deranged humors, exposure to irritants or descending catarrhal matter. Classical Unani texts including Makhzan-ul-Ilaj, advocate the …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 15, Issue 1, 2026 · pp. 13–22 Read article
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Clinical Evaluation of Efficacy of Acacia arabica (Aqaqia) in Uterine Prolapse (Nutue Rehm)
Abstract: Uterine prolapse (Nutue Rehm) still remains an issue of major health concern affecting large population of women in both developing and developed countries. Estimate suggests that 50% of parous women have some degree of genital prolapse for quite a long period. The objectives of the study were to evaluate the efficacy and safety of Acacia arabica (aqaqia) in the management of Nutue Rehm and to improve the quality of life …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 3, Issue 2, 2014 · pp. 8–16 Read article
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Role of Ukemi (Falling Techniques) in Injury Reduction among Beginner Judo Players
Abstract: Judo is a dynamic martial art that involves throwing, grappling, and ground-fighting techniques, making safe falling skills an essential component of training. Among these skills, Ukemi, commonly known as falling techniques or breakfalls, plays a vital role in minimizing the risk of injuries during practice and competition. Beginner judo players are particularly vulnerable to injuries because they often lack proper body control, balance, coordination, and confidence while falling. As a …
Published in Recent Trends in Sports · Vol. 3, Issue 2, 2026 · pp. 22–31 Read article
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Water Sanitation and Waterborne Disease Incidence among Households: A Cross-Sectional Study
Abstract: The study was conducted to assess water sanitation practices and the incidence of waterborne diseases among households in a selected ward of Koodalloor Panchayath, Kottayam, Kerala. The objectives were to assess the sources of household water, evaluate water sanitation and safety practices, and identify the incidence of waterborne diseases among family members during the previous year. A community-based descriptive study design was adopted. A total of 138 households were selected …
Published in Journal of Nursing Science & Practice · Vol. 16, Issue 2, 2026 · pp. 26–30 Read article
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Kisunla (Donanemab): A Novel Breakthrough Illuminating a Path to Better Alzheimer’s Outcomes
Abstract: Background: Alzheimer’s disease (AD) is a progressive neurodegenerative condition marked by cognitive decline, memory loss, and loss of independence. Despite decades of extensive research, disease-modifying treatments have been limited in success. Recent therapeutic advancements have led to the development of monoclonal antibodies targeting amyloid-beta (Aβ) plaques, particularly the pyroglutamate-modified variant, a key pathological hallmark of AD. Objectives: This review aims to explore the therapeutic potential of Donanemab (Kisunla), a novel …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 15, Issue 3, 2025 · pp. 37–45 Read article
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Fire Safety in Healthcare Facilities: An Indian Perspective
Abstract: Fire protection and safety measures in hospitals are of utmost importance to ensure the safety of patients, staff, and visitors. Due to the patients' limited mobility, hospitals are more susceptible to fire disasters. Short-circuits, basements being used as storehouse, inappropriate storage of flammable liquids, improper power supply load, false ceiling panel lined with thermocol, faulty electric wirings, and overheating leading to burning of wires are some of the common causes …
Published in Journal of Industrial Safety Engineering · Vol. 13, Issue 1, 2026 · pp. 8–12 Read article
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Comparative Efficacy and Safety of Safinamide and Rasagiline in the Treatment of Parkinson’s Disease: A Meta-Analysis and Systematic Review
Abstract: Background: Recent studies have suggested Rasagiline and Safinamide monotherapy as potential management options for Parkinson’s disease. Parkinson’s disease, a neurological disorder characterized by tremors and movement difficulties, necessitates treatments aimed at managing clinical symptoms. Levodopa remains the primary effective treatment for Parkinson’s disease symptoms; however, its long-term use often leads to motor complications in many patients. Additional therapeutic drugs, such as dopamine agonists and monoamine oxidase B inhibitors, including Safinamide …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 14, Issue 3, 2024 · pp. 74–91 Read article