Search
1646 articles for “SIM”
-
Neuro-Symbolic Agentic AI for Autonomous Scientific Discovery: Integrating Deep Reinforcement Learning, Quantum Simulation, and XAI-Audited LLM Hypothesis Generation in Drug Target Identification
Abstract: The exponential growth of multi-omics data and the increasing complexity of disease-associated protein interactomes have rendered conventional drug target identification pipelines computationally and epistemologically inadequate. This paper presents the Neuro-Symbolic Agentic AI for Scientific Discovery (NS-AASD) framework, a unified architecture that cohesively integrates deep reinforcement learning (DRL) exploration strategies, variational quantum simulation (VQS) of protein conformational dynamics, and XAI-audited large language model (LLM) hypothesis generation within an autonomous scientific discovery …
Published in Research and Reviews : Journal of Computational Biology · Vol. 15, Issue 2, 2026 Read article
-
A novel similarity measure for interval value picture fuzzy Environment and extended TOPSIS
Abstract: Correct decision-making is the most arduous task in our daily life. The decisions are hard to make in the multi-criteria decision-making (MCDM) problems due to ambiguous and unexpected information. In order to cope with such uncertainties in the data, a new decision-making approach has been developed using a newly defined similarity measure under the framework of interval-valued picture fuzzy set (IVPFS), as an extension of picture fuzzy sets (PFS). In …
Published in Research & Reviews: Discrete Mathematical Structures · Vol. 11, Issue 1, 2024 · pp. 1–10 Read article
-
Exploring The Therapeutical Potential Of Pongamia Pinnata For Herpes Simplex Virus Type 1 (HSV-1)
Abstract: Objective: Pongamia pinnata (L.), commonly known as Indian beech or pongam tree, is a tropical plant renowned for its medicinal properties in traditional medicine systems. Extracts derived from various parts of Pongamia pinnata have demonstrated antimicrobial, anti-inflammatory, and immunomodulatory activities. Such attributes make it a compelling candidate for exploring its therapeutic potential against HSV infections. Thymidine kinase is the target protein mostly used in the treatment of HSV1 infections. In …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 15, Issue 1, 2025 · pp. 1–9 Read article
-
Drug Repurposing of Anticancer Agents JP-8g and REDX05358 Against the Target Protein Plectin 1a in Epidemolysis Bullosa Simplex with Muscular Dystrophy (EBS-MD)
Abstract: Epidermolysis Bullosa Simplex with Muscle Dystrophy is a genetic disease affecting the skin and muscles which can be seen at birth or start at adulthood due to the mutation in the protein Plectin 1a (PLEC gene) causing skin blisters and muscle weakness. This protein is seen in sarcolemma, Z disks in skeletal muscles, hemidesmosomes in skin and cardiac muscles giving stability to cytoskeleton, playing a crucial role in neuromuscular transmission …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 3, Issue 2, 2025 · pp. 22–34 Read article
-
Modeling and Simulation of Radiative MHD Casson-Type Polymer Composite Flow over a Porous Wedge with Variable Thermal Source and Sink
Abstract: This study presents a numerical investigation of the radiative magnetohydrodynamic (MHD) flow and heat transfer characteristics of a Casson-type polymer fluid over a moving and extending porous wedge under the influence of a spatially varying heat source and sink. The Casson fluid model, representing a class of viscoplastic polymeric materials, is analyzed within the MHD framework to explore the combined effects of magnetic field intensity, rheological behavior, and porous medium …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 837–850 Read article
-
Experimental and Simulation Study on Reduction Kinetics of Magnetite Ore by using Hydrogen
Abstract: In the present work, magnetite ore fines pellets were prepared for a study of reduction kinetics using hydrogen gas. In the present work, various parameters are investigated to assess their influence on reduction kinetics with respect to hydrogen utilisation. The different input variables influence the process, yielding the reduction fraction. The effect of temperature on reduction kinetics with hydrogen flow rate was explored for the optimum value of these parameters. …
Published in Journal of Materials & Metallurgical Engineering · Vol. 16, Issue 1, 2026 Read article
-
Design and simulation of Solar Powered Automated Dual Rotor Mechanism for Sugarcane Harvesting
Abstract: Sugarcane being the vast cultivated cash crop of India’s agricultural economy has undoubtedly one of the most difficult harvesting processes. The existing mechanisms to harvest sugarcane are costly and are not affordable by rural based farmers. In this project a novel design mechanism is suggested that would serve the purpose of harvesting with least manpower, being cost effective and serving the purpose of cutting, stripping, sorting and loading of the …
Published in International Journal of Robotics and Automation in Mechanics · Vol. 4, Issue 1, 2026 Read article
-
Dissipative Particle Dynamics Simulation Study on the Evolution of Photoinitiated Free Radical Polymerization Crosslinked Networks
Abstract: Gradient polymer materials overcome the limitations of conventional homogeneous polymers by integrating multiple distinct functionalities within a single continuous structure. Although photoinitiated free-radical polymerization offers excellent spatial and temporal control, the underlying microscopic mechanisms governing network evolution under non-uniform light fields remain poorly understood. In this study, a mesoscale dissipative particle dynamics (DPD) model was successfully developed to couple free-radical polymerization kinetics—including initiation, propagation, crosslinking, and termination—with exponential light attenuation …
Published in Journal of Polymer & Composites · Vol. 14, Issue 4, 2026 · pp. 142–158 Read article
-
DEM Simulation of Macro and Micro-scale Behavior of Granular Materials during Loading and Unloading
Abstract: The present paper aims at comparing the simulated stress-strain behavior of granular materials quantitatively with the experiment and exploring the evolution of the micro-scale behaviors during loading and unloading using the discrete element method (DEM). A numerical sample consisting of 9826 randomly generated spheres similar to the experiment was prepared. The numerically prepared isotropic sample was subjected to loading and unloading under strain controlled condition. It is noticed that the …
Published in Journal of Geotechnical Engineering Read article
-
Lamivudine And Dolutegravir Simultaneous Dosage Forms Determined and Validated Using The RP-UPLC Method
Abstract: RP-UPLC has been used to produce a straightforward, precise, and accurate approach for the simultaneous estimation of dolutegravir and lamivudine in a pharmaceutical dose form. A HSS C18 column of 2.8 x 50 mm and featuring particles with a size of 1.6 μm was used to process the chromatogram. A mixture of 70:30 Buffer Na2HPO4 and methanol made up the mobile phase, which was pushed across the column at a …
Published in Emerging Trends in Personalized Medicines · Vol. 1, Issue 1, 2024 · pp. 5–13 Read article
-
Rotational Speed Influence on Weld Temperature in Friction Stir Lap Joint of Aluminium Alloy 6061 Using Numerical Simulation
Abstract: The weld quality assessment in friction stir welding depends on the choice of suitable weld parameters. Rotational speed is one such parameter. The study utilizes a computational fluid dynamics model to examine the influence of various rotational on the workpiece and weld interface temperature. The workpiece selected for this study is an Aluminium Alloy 6061, while the tool employed is a truncated conical pin tool featuring a conical shoulder in …
Published in Journal of Polymer & Composites · Vol. 12, Issue 2, 2024 · pp. 235–245 Read article
-
Fabrication, Numerical Simulation and Compact Modeling of Ph-BTBT-C10 Organic Thin Film Transistor
Abstract: Flexible and cost-effective electronics have been necessitated by the advent of organic thin-film transistors (OTFTs). This study aims to study the performance of OTFT using a 2-decyl-7-phenyl-[1]benzothieno[3,2-b][1]benzothiophene (Ph-BTBT-C10) organic semiconductor. The paper also explore accurate device modeling for technology optimization and circuit design that supports device improvement. This research includes device fabrication, numerical simulation using TCAD, compact modeling, and parameter extraction. By combining temperature-dependent bandgap narrowing with existing theories, this …
Published in Journal of Polymer & Composites · Vol. 12, Issue 5, 2024 · pp. 1–18 Read article
-
Computational Biomodeling: Transforming Drug Design with Advanced Simulations
Abstract: Computational biomodeling has emerged as a transformative approach in the field of drug discovery, significantly enhancing the efficiency and precision of identifying and optimizing potential drug candidates. This article explores the various computational techniques utilized in drug design, including molecular docking, molecular dynamics (MD) simulations, free energy calculations, and virtual screening, and examines how these methods collectively contribute to the drug development process. The integration of these advanced simulations allows …
Published in Research and Reviews : Journal of Computational Biology · Vol. 13, Issue 3, 2024 · pp. 24–29 Read article
-
Simulation and Experimental Analysis of Abuse Testing for Prediction of Life Cycle for Lithium Ion Battery Cell and Pack Level
Abstract: Lithium-ion batteries play a crucial role in contemporary technology, serving as the power source for everything from consumer gadgets to electric vehicles. However, their safety and longevity are significant influenced by the reperformance under extreme conditions, commonly referred to as ab use testing .This paper explores the simulation and analysis of ab use testing and life cycle prediction for lithium-ion batteries at both the cell and pack levels. Abuse testing …
Published in International Journal of Mechanical Dynamics and Systems Analysis · Vol. 2, Issue 2, 2024 · pp. 1–24 Read article
-
HFSS-Based Helix Antenna Design Optimization and Simulation
Abstract: This project uses HFSS (High-Frequency Structure Simulator) to simulate, develop, and analyze the performance of a helix antenna for (a particular purpose, such as broadband wireless or satellite communication). Because of their distinctive structural characteristics, helix antennas are well-suited for a variety of high-frequency applications by balancing compactness, high gain, and wide bandwidth. In this work, we parametrically analyze important design parameters including pitch, radius, number of turns, and wire …
Published in Recent Trends in Sensor Research & Technology · Vol. 12, Issue 1, 2025 · pp. 29–35 Read article
-
The Role of AI in Modern Circuit Design and Simulation
Abstract: The integration of artificial intelligence (AI) in circuit design and simulation is revolutionizing the electronics industry by enabling faster, more efficient, and innovative design processes. This article explores the transformative role of AI in automating tasks traditionally reliant on manual expertise, such as schematic generation, component optimization, and fault detection. It highlights how machine learning algorithms and generative AI tools are improving design accuracy, reducing time-to-market, and enabling cost-effective prototyping. …
Published in Journal of Semiconductor Devices and Circuits · Vol. 12, Issue 1, 2025 · pp. 9–14 Read article
-
Modeling of ZnO Based Nano Sensor Device for Evaluating Electronic Interaction with NO2 Pollutant: Combining Multiphysics Simulation and DFT Study
Abstract: This study focuses on the designing and modeling of a sensor device employing zinc oxide (ZnO) nanowires (NWs), and the evaluation of the chemical response of the same in the presence of nitrogen dioxide (NO2), which is an acute harmful pollutant for human health and environment. Experimentally synthesized ZnO nanostructures were used as the basis for modeling of the ZnO NWs based sensor device along with a single ZnO NW, …
Published in Journal of Polymer & Composites · Vol. 13, Issue 2, 2025 · pp. 211–219 Read article
-
Sliding Mode Control of SolidWorks Designed Robotic Manipulator Co-simulated in MATLAB
Abstract: This study proposes a Sliding mode control (SMC) algorithm for controlling three degrees of freedom (3DOF) robotic arm. This concept was inspired by seeing the increasing of potential applications of robotic arm in automation industry, mainly in the applications like pick and place. The 3DOF robotic arm is designed in SolidWorks and then it is imported to MATLAB for simulation purposes. Initially, simulations are done by using the conventional PID …
Published in International Journal of Advanced Control and System Engineering · Vol. 1, Issue 1, 2023 · pp. 7–14 Read article
-
Simulation And Analysis of Radio Frequency Energy Harvesting System Operating at 2.45 GHz Frequency
Abstract: — This paper proposed study of an RF energy harvesting system at 2.45 GHz using a rectifier and an antenna so called rectenna. Inset-fed micro-strip rectangular patch antenna array is fabricated. The rectifier circuit, employing Schottky diodes (HSMS-2850), converts AC power from the antenna to DC for RF detection. Analysis of the antenna's design and parameters such as directivity, return loss, gain, and VSWR is done using high-frequency simulator software …
Published in Journal of Microwave Engineering and Technologies · Vol. 11, Issue 1, 2024 · pp. 7–15 Read article
-
Improving Parachute Efficiency: The Function of LS- Dyna in Fluid-structure Interaction Simulation
Abstract: As an accompaniment to assessment of DGA Aeronautical Systems created a simulation and model-building capability to gain a better understanding of the parachute dynamic behavior and to maximize the parachute systems flight tests. This work reports on the latest developments in Arbitrary Lagrangian mathematical (ALE) methods for analyzing the properties of the quasi-steady state descent phases and canopy inflation. Thus far, none of the simulations of the endless mass type …
Published in Journal of Experimental & Applied Mechanics · Vol. 15, Issue 1, 2024 · pp. 44–56 Read article