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71 articles for “Diabetes mellitus”
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A Review of Drug Design Techniques Assisted by Computers to Combat Diabetes
Abstract: Diabetes mellitus is a global health concern characterized by chronic hyperglycemia and associated complications. The creation of innovative medicines with enhanced efficacy and safety profiles continues to be a top focus, notwithstanding improvements in treatment. A useful method in drug development, computer-aided drug design (CADD) makes it easier to identify possible therapeutic candidates and optimise lead molecules. An extensive synopsis of CADD tactics used in the fight against diabetes is …
Published in Emerging Trends in Personalized Medicines · Vol. 2, Issue 1, 2025 · pp. 1–10 Read article
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Practical approach for Type 2 Diabetes: Role of DPP4 Inhibitors
Abstract: Dipeptidyl peptidase-4 inhibitors (DPP-4Is) have become essential in managing type 2 diabetes mellitus (T2DM) due to their ability to enhance incretin hormone activity, which promotes insulin secretion and inhibits glucagon release. These agents effectively lower HbA1c levels by 0.5–1.0%, are weight-neutral, and have a low risk of hypoglycemia, making them suitable for a broad patient population, including the elderly. The antidiabetic market in India is vast. Gliptin as group row …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 14, Issue 2, 2024 · pp. 20–26 Read article
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Anti-hyperglycemia Effects of Plant Secondary Metabolites Towards PKA/CREB Pathway Activation in Diabesity
Abstract: Objective: Diabesity, the amalgamation of diabetes and obesity, presents a significant global health challenge. This research carefully examines how plant secondary metabolites influence glucose regulation in diabetes using the PKA/CREB pathway, paying particular attention to diabesity—the combination of diabetes and obesity. Understanding the complex ways in which these metabolites affect metabolic health will help to identify new treatment approaches for managing diabetes and its associated problems. By conducting a thorough …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 2, Issue 1, 2024 · pp. 33–50 Read article
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The Role of Pyruvate Dehydrogenase in Non-Alcoholic Fatty Liver Disease: Therapeutic Insights and Future Directions
Abstract: Non-alcoholic fatty liver disorders (NAFLD) are defined by the accumulation of excess fat in the liver that has no other cause, such as drinking alcohol. Pyruvate dehydrogenase has been established as an alternative treatment for this disorder. NAFLD pathogenesis is complex and includes oxidative stress inflammatory processes and mitochondrial dysfunction. Impaired liver fatty acid oxidation and glucose oxidation are significant individuals in developing NAFLD, and strategies to reverse these defects …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 14, Issue 3, 2024 · pp. 44–51 Read article
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The Potential of Guava Leaf-Enriched Chocolate in Sugar-Free Anti-Diabetic Confectionery: A Review
Abstract: People of all age groups enjoy chocolate however, it is often linked to health issues like obesity, hypertension, diabetes, and cardiovascular diseases. This study aimed to develop a medicinal chocolate suitable for diabetic individuals by incorporating herbal ingredients. Specifically, guava leaves (Psidium guajava), known for their rich vitamin and antioxidant content and their ability to help regulate blood sugar, were used. The chocolate formulation included guava leaf powder, coffee, and …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 12, Issue 2, 2025 · pp. 55–63 Read article
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Post Covid-Sequela: Novel-Inception of DM: A Review
Abstract: As patients recovers from COVID 19 pandemic, a subset of the covid patients experienced a post covid condition with long term symptoms, few weeks after their discharge or recovery from the (SARS-CoV-2) infection. Hence, we tried to prove the hypothesis whether diabetes mellites is an afresh possible sequala of covid infection by systematically evaluating the consistently changing glucose level of the post covid patients. The databases PubMed and Google Scholar …
Published in Research and Reviews : A Journal of Immunology · Vol. 16, Issue 2, 2026 Read article
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In Vivo Hypoglycemic Activity of Aqueous Leaf and Root Extracts of Macaranga Barteri Müll. Arg. (Euphorbiaceae) In Swiss Albino Mice
Abstract: Background: Macaranga barteri Müll. Arg. is a perennial plant in the family Euphorbiaceae and is used in African traditional medicine for the management of several ailments, including diabetes. Although the leaves and stem bark have been studied for various pharmacological activities, little is known about the therapeutic value of the roots. Objective: This study evaluated the in vivo hypoglycemic activity of aqueous leaf and root extracts of M. barteri in …
Published in Research and Reviews : Journal of Veterinary Science and Technology · Vol. 15, Issue 2, 2026 Read article
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Novel Nanotherapeutics for the Management of Diabetes
Abstract: Diabetes is a severe chronic disorder with hyperglycemia, either due to dysfunctional pancreas(Type I) or due to malfunctioned glucose utilizing entities like: liver, straight muscle or adipocytes (Type II). Type 1 or Insulin-dependent/Juvenile diabetes and Type 2 Diabetes Mellitus or Non-Insulin dependent/Adult-onset diabetes are the two broad classifications of diabetes. In case of type 1 diabetes injectable insulin is the major form of medication given and in case of Type …
Published in Nano Trends – A Journal of Nano Technology & Its Applications · Vol. 26, Issue 1, 2024 · pp. 46–67 Read article
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Gut Microbiome Dysbiosis During Metabolic Disorders: Diabetes
Abstract: Understanding the intricate interplay between gut microbiome dysbiosis and diabetes is crucial due to the escalating prevalence and impact of diabetes mellitus globally. This comprehensive review examines the current understanding of this relationship, elucidating how alterations in the gut microbiome composition contribute to diabetes pathogenesis by influencing metabolic homeostasis, immune regulation, and insulin resistance. Dysregulation of gut microbial communities leads to shifts in diversity and abundance, exacerbating chronic low-grade inflammation …
Published in Emerging Trends in Metabolites · Vol. 1, Issue 2, 2024 · pp. 56–75 Read article
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Revolutionizing Diabetes Management: Nanostructured Biosensors for Real-time Monitoring
Abstract: Chronic metabolic disease known as diabetes mellitus, which is characterized by dysregulated blood glucose levels, is becoming a major global health concern. The implementation of automated insulin administration systems and continuous glucose monitoring (CGM) has shown promise in the management of diabetes. Nanostructured biosensors, leveraging the unique properties of nanomaterials, offer enhanced sensitivity, selectivity, and biocompatibility, making them ideal candidates for real-time monitoring and personalized treatment. This article delves into …
Published in Journal of Nanoscience, NanoEngineering & Applications · Vol. 14, Issue 1, 2024 · pp. 49–70 Read article
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Diabetes Risk & Al Nutrition Assistant
Abstract: The rising prevalence of diabetes mellitus has emerged as a major global health challenge. Early identification of individuals at risk, combined with personalized lifestyle-based interventions, can significantly reduce future complications. This study presents an AI-driven Nutrition Assistant integrated with a Diabetes Risk Prediction model. The system uses a machine learning classification approach to estimate the likelihood of diabetes based on clinical and nutritional factors, including body mass index, glucose levels, …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 13, Issue 1, 2026 · pp. 31–38 Read article
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Insulin : Comprehensive review on its Crucial Role in Metabolism and Disease Management
Abstract: Insulin's pivotal function lies in meticulously regulating blood sugar levels, thus guaranteeing cells access to the necessary energy for optimal functionality. When there is a rise in blood sugar, after a meal, the releases insulin gets released from the pancreas to facilitate the uptake of glucose by cells. Insulin primarily acts on muscle, fat, and liver cells, promoting the uptake of glucose from the blood. Another way to store glucose …
Published in International Journal of Virus Studies · Vol. 1, Issue 1, 2024 · pp. 37–43 Read article
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Diabetes Risk Prediction from Survey Data Using Machine Learning Algorithms
Abstract: Diabetes mellitus represents one of the most significant global health challenges, affecting millions worldwide and leading to severe complications if left undiagnosed or poorly managed. Early detection and risk assessment are crucial for preventing the progression of this chronic condition. This research presents a comprehensive machine learning approach for predicting diabetes risk using survey-based health parameters. The study implements and compares four prominent classification algorithms: Logistic Regression, K-Nearest Neighbors (KNN), …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 4, Issue 2, 2026 Read article
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Challenges in Diabetes Management Barriers and Support Systems in North India
Abstract: Background: The prevalence of Diabetes mellitus is ever growing in India and management of the disease is hindered by socio-economic, healthcare, and psychosocial barriers. Insofar as economic and social barriers pose challenges ranging from limited access to medical care, social stigma, specialist support leading to improper glycemic control, which is a strong predictor for diabetes complications, morbidity and mortality. Moreover, developing an understanding of systemic challenges and available supports is …
Published in Emerging Trends in Metabolites · Vol. 2, Issue 2, 2025 Read article
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Exploring Type-II Diabetes Potential of Phyto-Derived Carbon Dots
Abstract: The integration of phytoconstituents with carbon dots (C-dots) presents a novel and sustainable approach to the development of nanotherapeutics for type 2 diabetes mellitus (T2DM). C-dots, zero-dimensional carbon-based nanomaterials, exhibit unique physicochemical properties including high fluorescence, tunable surface chemistry, biocompatibility, and low toxicity. Their ability to enhance the solubility, bioavailability, and targeted delivery of poorly soluble phytochemicals renders them highly suitable for biomedical applications. This study explores the synthesis of …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 16, Issue 3, 2025 · pp. 08–25 Read article
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SGLT2 Inhibitors in Heart Failure and Chronic Kidney Disease: Expanding Therapeutic Horizons beyond Glycemic Control
Abstract: Heart failure (HF) and chronic kidney disease (CKD) are closely related clinical diseases that significantly increase morbidity and death worldwide. The co-occurrence of both conditions is frequently referred to as the "cardio-renal syndrome," in which the failure of one organ hastens the decline of the other. The original purpose of sodium–glucose cotransporter-2 (SGLT2) inhibitors was to treat type 2 diabetic mellitus (T2DM) by reducing blood sugar levels. Nevertheless, new data …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 16, Issue 2, 2026 Read article
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Diabetic Foot Ulcer Treated successfully with Unani Formulation (Sibr Zard, Amba Haldi, Mur Maki, and Gulnar) –A Case study
Abstract: Diabetic foot ulcer (DFU) is a distressing complication of diabetes mellitus. It is encountered in about 15% of patients living with DM. It is a major cause of morbidity and mortality. The patients with DFU are at the risk of prolonged hospitalization, infection, gangrene, amputation, and even death if effective wound care faculties are not provided. It is anticipated that approximately 50%-70% of all lower limb amputations are due to …
Published in Research & Reviews : A Journal of Unani, Siddha and Homeopathy · Vol. 11, Issue 2, 2024 · pp. 7–11 Read article
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Non-Invasive Glucose Monitoring Device Using Max30102 Sensor
Abstract: Diabetes mellitus is a chronic metabolic disorder affecting millions globally, requiring continuous blood glucose monitoring to prevent complications such as cardiovascular disease, kidney failure, neuropathy, and retinopathy. Conventional invasive finger- prick techniques result in pain, skin irritation, and an increased risk of infection, which lowers patient compliance, particularly in young patients and the elderly. This paper presents a non-invasive glucose monitoring prototype using the MAX30102 optical biosensor interfaced with the …
Published in Journal of Instrumentation Technology & Innovations · Vol. 16, Issue 1, 2026 · pp. 36–44 Read article
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Clinical experience with Ayurvedic Treatment in Case of Rheumatoid Arthritis – Ayurvedic review and Case study
Abstract: Rheumatoid arthritis is the most found inflammatory auto immune disease with unknown etiology. Many clinical features and treatment strategies of RA are associated with multiple joint diseases. The clinical phenotype of Rhematoid arthritis is a symmetrical, deformed polyarthritis of small and large joints, which is often associated with features of the disease. The treatment typically involves ongoing management with periods of worsening symptoms followed by periods of improvement. Features of …
Published in Research and Reviews : A Journal of Ayurvedic Science, Yoga and Naturopathy · Vol. 11, Issue 2, 2024 · pp. 1–8 Read article
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A Review on The effect of Polycystic Ovary Syndrome on some Hormonal and Metabolic Disturbances in Women
Abstract: Polycystic ovary syndrome (PCOS) is a common hormonal condition that affects women of reproductive age. It usually begins to appear during adolescence. The ovaries produce an abnormal amount of "androgens", which are male sex hormones that are usually found in women in small quantities. Ovarian syndrome causes hormonal imbalances, irregular menstrual cycles, increased cysts in the ovaries, in addition to hair growth all over the body, acne, and pain in …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 15, Issue 1, 2025 · pp. 21–28 Read article