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541 articles for “Computational methods”
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Role of Machine Learning Principles for Efficient Nuclear Fuel Management and Design
Abstract: The introduction of machine learning (ML) and evolutionary computation methods in addressing complex nuclear fuel management challenges has brought a significant positive change in the domain of nuclear fuel management. Key applications include fuel assembly design optimization, core loading pattern determination, burnup calculation acceleration, fuel performance prediction, and spent fuel characterization. The analysis reveals significant improvements in computational efficiency, prediction accuracy, and optimization capabilities when ML techniques are properly integrated …
Published in Journal of Nuclear Engineering & Technology · Vol. 15, Issue 2, 2025 · pp. 22–33 Read article
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Investigation on Structural Behavior of RC Beam-Column Joints: State-of-the-art
Abstract: Beam-column joints (BCJs) are critical structural elements in buildings, influencing overall structural performance and safety. This review paper presents a comprehensive analysis of findings of research showing concern about various aspects of BCJs, focusing on eccentricity effect, numerical investigation, joint behavior, shear strength, retrofitting strategies, and recent advances. Through experimental studies, numerical simulations, and analytical approaches, various studies have made significant progress in understanding BCJ response to various loading circumstances …
Published in Journal of Polymer & Composites · Vol. 12, Issue 2, 2024 · pp. 40–68 Read article
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Molecular Docking Studies of Nyctanthes arbor-tristis Phytochemicals for Targeting TNF Receptor in Arthritis
Abstract: Rheumatoid Arthritis is an autoimmune disorder which results in inflammation. Tumor necrosis factor-alpha (TNF-α) is responsible for the progression of inflammatory arthritis by promoting immune cell activation and cytokine release. The present study explores the potential of bioactive compounds derived from Nyctanthes arbor-tristis (Parijat) in modulating TNF receptor activity through molecular docking. Computational methods were employed to evaluate the binding affinity of selected phytocompounds from N. arbor-tristis against the extracellular …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 3, Issue 2, 2025 · pp. 11–21 Read article
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Study of Proximity Points and Fixed Points
Abstract: This paper explores the concepts of proximity points and fixed points, which are fundamental in mathematical analysis and nonlinear functional analysis. Fixed-point theorems play a crucial role in optimization, game theory, differential equations, and dynamic systems. Proximity points, an extension of fixed points, provide a more generalized approach, allowing near-coincidence rather than exact identity. The study discusses classical fixed-point theorems, such as Banach’s contraction principle, Brouwer’s fixed-point theorem, and Schauder’s …
Published in Recent Trends in Mathematics · Vol. 1, Issue 2, 2024 · pp. 28–31 Read article
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Use of AI Tools to Create New Drugs
Abstract: The emergence of artificial intelligence in pharmaceutical research [in drug discovery] is a revolution in pharmaceutical research, often combining computational methods with traditional research methods to solve problems. This review article describes various applications of artificial intelligence at various stages of drug development and highlights significant advances and approaches. He explores the critical role of intelligence in drug design, polypharmacology, drug synthesis, drug repurposing, and prediction of drug properties, such …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 2, Issue 2, 2024 · pp. 22–49 Read article
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Gene prioritization of colorectal cancer using computational approach
Abstract: Colorectal cancer (CRC) continues to be a major worldwide health issue, underscoring the need to pinpoint crucial genetic elements influencing its initiation and advancement. In this investigation, we utilize sophisticated computational methods to prioritize potential genes linked to CRC development. Through the utilization of various bioinformatics tools and comprehensive methodologies, we systematically examine extensive microarray datasets to identify potential genetic contributors. Initially, a vast amount of CRC microarray data (approximately …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 2, Issue 1, 2024 · pp. 39–52 Read article
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Fundamental Principles of Fluid Behavior and Emerging Trends in Modern Fluid Mechanics Research
Abstract: Fluid behavior forms the foundation of numerous engineering technology and scientific applications, including aerospace flows, energy systems, and environmental processes. This paper presents a comprehensive overview of the fundamental principles governing fluid behavior, with a strong emphasis on their relevance to recent trends in fluid mechanic’s research. Core concepts such as fluid statics, fluid dynamics, and conservation laws are discussed to establish a solid theoretical framework. The study further examines …
Published in Recent Trends in Fluid Mechanics · Vol. 13, Issue 1, 2026 · pp. 14–21 Read article
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Description & Prevention of Omicron
Abstract: November 9, 2021, Botswana becomes the first country to recognise it (Nov 11 2021). The new variant (B.1.529) has been represented in 77 countries. Omicron presents 32 changes in spike protein Scribd, restricting the point of interaction with the ACE2 receptor protein. Computational shows and components’ recreation has been applied to investigate the collaboration between the SARS-CoV-2 RBD and the ACE2 receptor. The receptor-binding domain (RBD), which more barely joins …
Published in Research & Reviews: A Journal of Pharmacognosy Read article
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An in-silico toxicity study of the phytocompounds found in Pongamia pinnata leaves using the ProTox-II web server
Abstract: The aim of the current study was to determine the Insilco toxicity of the phytocompound present in the leaves of Pongamia pinnata. The leaves of Pongamia pinnata have long been used in traditional medicine for their therapeutic properties. Nowadays, herbal toxicity is a common problem caused by incorrect dosage. The FDA reviews the safety and effectiveness of herbal products only in response to patient or health care provider complaints—problems with …
Published in Research and Reviews : Journal of Crop science and Technology · Vol. 13, Issue 1, 2024 Read article
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Bimetallic Catalysis in Renewable Energy Applications: A Review
Abstract: The transition to renewable energy sources necessitates innovative catalytic solutions to improve efficiency and sustainability. Bimetallic catalysis, leveraging the synergistic effects of two distinct metals, has emerged as a promising strategy in various renewable energy applications. This review explores the unique properties and mechanisms of bimetallic catalysts, highlighting their roles in biomass conversion, hydrogen production, and CO2 reduction. We delve into the interplay of electronic and geometric effects in these …
Published in Journal of Catalyst & Catalysis · Vol. 11, Issue 2, 2024 · pp. 25–29 Read article
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Computational Identification of Antigenic Proteins and Epitopes in Hantavirus sp. for Drug Repurposing
Abstract: Hantavirus is an emerging virus that spreads from animals to humans and can cause serious illnesses like hantavirus pulmonary syndrome (HPS) and hemorrhagic fever with renal syndrome (HFRS). there are no FDA-approved treatments available for these diseases. This study explores in-silico drug repurposing as a strategy to identify potential therapeutic candidates. The physicochemical, secondary structure, antigenicity, and post-translational modification analysis of hantavirus proteins – specifically the glycoprotein precursor, N protein, …
Published in International Journal of Molecular Biotechnological Research · Vol. 3, Issue 1, 2025 · pp. 20–26 Read article
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Study of Algebraic Structures in Discrete Mathematics and Its Applications
Abstract: Algebraic structures such as groups, rings, fields, semi groups, and lattices form the foundational framework of discrete mathematics. These structures are defined by specific sets and operations that follow algebraic laws, enabling a systematic approach to problem-solving in various domains. This paper explores the theoretical principles of these algebraic systems and highlights their vital role in computer science, cryptography, automata theory, coding theory, and software engineering. By examining their properties …
Published in Emerging Trends in Symmetry · Vol. 1, Issue 1, 2025 · pp. 35–40 Read article
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Symmetry Breaking in Mathematical Models: Bifurcation, Chaos, and Pattern Formation
Abstract: Symmetry breaking serves as a central organizing principle in the understanding of nonlinear systems across physics, biology, chemistry, and engineering. When a system transitions from a symmetric state to an asymmetric configuration, it often signals the onset of new structures, dynamic behaviors, or even chaotic regimes. This review explores symmetry breaking from the theoretical and mathematical perspectives of bifurcation theory, chaos theory, and pattern formation. We discuss how small parameter …
Published in Emerging Trends in Symmetry · Vol. 1, Issue 2, 2025 · pp. 25–30 Read article
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Modulating Immune System of Mosquitoes with A Novel Salicylate Derivative: A Bioinformatics-Based Study
Abstract: The present study aims to compare the interactions of a novel derivative of salicylic acid, 5-(2-nitroethynl) salicylic acid (5-SANA, salicylic acid nitroalkene), and salicylic acid with the critical residues of mosquito’s juvenile hormone binding protein (mJHBP). Given the better water solubility of 5-SANA and salicylic acid, it is believed that they can interact quicker than the natural substrate, juvenile hormone (JH), with the cavity of mJHBP, a circulating protein in …
Published in Research and Reviews : A Journal of Immunology · Vol. 16, Issue 1, 2026 · pp. 1–5 Read article
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A Knowledge Graph Approach for Breast Cancer Diagnosis and Data Sharing Platform Implementation in the Context of Human Papillomavirus Infection
Abstract: Background: Breast cancer remains among the most prevalent malignancies in women worldwide, and effective diagnosis and data integration continue to challenge clinical practice. Diagnostic reports from mammography and ultrasound contain rich clinical information that is often under-utilised due to heterogeneous formats and limited data-sharing infrastructure. In the context of human papillomavirus (HPV) infection, which may influence oncogenic pathways and data complexity, advanced computational methods offer new solutions to this problem. …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 15, Issue 1, 2026 Read article
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AI-Driven Precision Nutrition: Advancing Personalized Dietary Systems for Public Health Equity in Resource-Constrained Environments
Abstract: The dual burden of malnutrition and diet-related non-communicable diseases (NCDs) represents a growing global public health challenge, particularly in low- and middle-income countries. Traditional dietary guidelines are largely population-based and fail to account for individual variability in genetics, metabolism, lifestyle, and environmental exposure. This limitation has led to the emergence of precision nutrition, an evolving field that integrates biological data and computational intelligence to deliver personalized dietary recommendations. This paper …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 15, Issue 1, 2026 Read article
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Review on Computer-Aided Drug Design in RAS Inhibitor Discovery
Abstract: This review explores the utilization of computer-aided drug design (CADD) methodologies in the discovery of inhibitors targeting the RAS pathway, a pivotal signaling cascade implicated in various cancers. Through an extensive examination of computational tools, methodologies, challenges, and recent advancements, this review aims to provide insights into the role of CADD in accelerating RAS inhibitor discovery. The discovery of effective inhibitors targeting the RAS pathway is of paramount importance in …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 11, Issue 3, 2024 · pp. 7–14 Read article
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Entangled Shields: Securing Digital Systems in the Quantum Cryptographic Revolution
Abstract: Quantum computing utilizing principles of superposition and entanglement is poised to revolutionize the computational landscape, presenting unprecedented challenges and opportunities across various disciplines. Among these, cryptography stands at the forefront due to its reliance on computational hardness assumptions, which Quantum algorithms, such as Grover’s and Shor’s, can efficiently exploit. This study explores theoretical foundations and practical applications of quantum-safe cryptographic primitives, such as lattice-based cryptography, hash-based signature schemes, code-based systems, …
Published in Recent Trends in Parallel Computing · Vol. 12, Issue 2, 2025 · pp. 33–43 Read article
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Unveiling the Role of Lead Molecules in CADD: A Systematic Review
Abstract: The word "medicate plan" alludes to the objective creation of modern drugs. Arbitrary screening of engineered compounds, engineered of organically dynamic compounds based on actually happening drugs, amalgamation of basic analogs of actually happening lead particles, and usage of the bioisosteric hypothesis are a few of the strategies that have been utilized. As a result, the most recent drift in medicate plan is to either completely enhance a lead or …
Published in International Journal of Membranes · Vol. 1, Issue 1, 2024 · pp. 37–43 Read article
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Solving Optimization Problems Using the Graphical Method of Linear Programming
Abstract: Linear programming is a mathematical optimization technique used for maximizing or minimizing a linear objective function while satisfying a set of linear constraints. This method plays a crucial role in various industries, including manufacturing, finance, transportation, and supply chain management. Among the different approaches to solving linear programming problems, the graphical method provides a simple and intuitive way to visualize and solve problems involving two decision variables. By plotting constraints …
Published in Research & Reviews : Journal of Statistics · Vol. 14, Issue 2, 2025 · pp. 01–08 Read article