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106 articles for “Biomarkers”
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Gene prioritization of colorectal cancer using computational approach
Abstract: Colorectal cancer (CRC) continues to be a major worldwide health issue, underscoring the need to pinpoint crucial genetic elements influencing its initiation and advancement. In this investigation, we utilize sophisticated computational methods to prioritize potential genes linked to CRC development. Through the utilization of various bioinformatics tools and comprehensive methodologies, we systematically examine extensive microarray datasets to identify potential genetic contributors. Initially, a vast amount of CRC microarray data (approximately …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 2, Issue 1, 2024 · pp. 39–52 Read article
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Comprehensive Analysis of MRSA Peptides Via Maldi
Abstract: The present study employed Matrix-Assisted Laser Desorption/Ionization Time-of-Flight mass spectrometry to analyze methicillin-resistant Staphylococcus aureus peptides, focusing on various parameters associated with mass-to-charge (m/z) values. Through systematic data collection and analysis, including time, intensity, signal-to-noise ratios, quality factors, resolutions, areas under the peaks, relative intensities, full widths at half maximum, Chi-squared values, and background peaks, comprehensive insights into the spectral characteristics of methicillin-resistant Staphylococcus aureus peptides were obtained. Methicillin-resistant Staphylococcus …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 15, Issue 2, 2024 · pp. 98–101 Read article
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AI-Enhanced Interpretation of Cardiac Troponins: Toward Predictive Precision in Myocardial Injury
Abstract: Background: Cardiac troponins (cTn) represent the gold standard biomarkers for myocardial injury detection, yet their interpretation remains challenging due to various confounding factors and clinical contexts. Artificial intelligence (AI) technologies provide remarkable possibilities to improve the interpretation of troponin levels by utilizing pattern recognition, predictive modeling, and clinical decision-making support. Objective: This review examines the current state and future potential of AI-enhanced cardiac troponin interpretation, focusing on machine learning applications, …
Published in Research and Reviews: A Journal of Medicine · Vol. 15, Issue 3, 2025 · pp. 1–9 Read article
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CB₁ Reverse Agonists: A Cheminformatic and Patent Landscape Study
Abstract: The endocannabinoid system plays a crucial role in numerous physiological functions, making cannabinoid receptor 1 (CB1) an attractive target for therapeutic development. This review provides a systematic analysis of patent filings from 2019 to 2023 that focus on small-molecule CB1 reverse agonists. It begins with an overview of the endocannabinoid system, highlighting CB1’s involvement in energy balance, pain regulation, and neuroinflammatory processes The main section of the review examines fifteen …
Published in International Journal of Cheminformatics · Vol. 3, Issue 2, 2025 · pp. 33–36 Read article
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Drug-Induced Liver Injury: Hepatotoxicity and Treatment - A Literature Review
Abstract: Drug-induced liver injury (DILI) is a major clinical and regulatory challenge, posing risks to patient safety and drug development worldwide. As the primary organ responsible for xenobiotic metabolism, the liver is particularly susceptible to toxic injury from prescription drugs, over-the-counter medications, herbal products, and dietary supplements. Drug-induced liver injury (DILI) accounts for a substantial proportion of acute liver failure cases and remains a leading cause of post-marketing drug withdrawal. Its …
Published in Research and Reviews: A Journal of Toxicology · Vol. 16, Issue 1, 2026 · pp. 1–17 Read article
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Uses of Nanotechnology in Medical Diagnostic Applications
Abstract: Nanoparticle and nanodevice is a boon for mankind to treat and deal with disease and medical diagnosis respectively. Nanotechnology is formed by the unity of chemistry, engineering, biology and medicine restricted to the nanoscale (about 1–100 nanometer (nm)). For example, early detection of malignant tumors and cancer biomarkers, which is impossible using conventional technologies. In here we will discuss nanosized sensors to identify different pathological parameters, foreign antigen and toxic …
Published in Research and Reviews : A Journal of Medical Science and Technology Read article
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Assessment of Hepatic Damage in Labeo rohita (Hamilton, 1822) Exposed to Azo dye C. I. Direct Green 6
Abstract: Textile industries are one of the major backbones of Indian economy. They are the major reason for contamination of water bodies and their toxicity to ecosystem is an alarming environmental issue. The present study was designed to evaluate the hepatotoxic effects of C.I. Direct Green 6 (DG 6), a commercially used textile azo dye on Labeo rohita fingerlings. For this, L. rohita fingerlings were exposed to three sublethal concentrations (2.5, …
Published in Research and Reviews : Journal of Veterinary Science and Technology Read article
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Multiple Sclerosis: A Systematic Review of a Neurological Disorder
Abstract: The inflammatory illness known as multiple sclerosis (MS) is brought on by outside influences that affect a biologically vulnerable host. It has 3 separate diagnostic phases: the pre-clinical phase, which can only be discovered by MRI; the relapsing-remitting (RRMS) phase, which again is defined by bouts of neurological malfunction accompanied by remission; and the progressing phase, which often develops from either the relapse phase. Unfortunately, the majority of relapse MS …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 1, Issue 1, 2023 · pp. 53–71 Read article
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Recent Update on Advanced Drug Delivery System
Abstract: Over the past decade, there has been a growing interest in the use of artificial intelligence (AI) technology for analysing and interpreting biological or genetic data, accelerating drug discovery, and identifying selective small-molecule modulators or rare molecules in addition to predicting their behaviour. The use of artificial neural networks (ANNs) for the rapid analysis of massive amounts of data, the development of novel hypotheses and treatment plans, the prediction of …
Published in International Journal of Advance in Molecular Engineering · Vol. 1, Issue 1, 2023 · pp. 22–30 Read article
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Tools, Modern Drugs, and Latest Investigations for the Diagnosis and Treatment of Heart Failure: A Systematic Review of the General Causes
Abstract: Heart failure (HF) diagnosis and treatment present formidable challenges, given the absence of a definitive single test. This systematic literature review aims to comprehensively analyze the current landscape of diagnostic tools, modern drugs, and latest investigative approaches in HF management. Recognizing the complexity of HF etiology, this systematic review emphasizes the importance of advanced diagnostic methods, such as genetic testing and artificial intelligence applications. The systematic review was conducted to …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 13, Issue 1, 2024 · pp. 1–10 Read article
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A Review on Nano-emulsion for Delivery of Anti-cancer Drugs
Abstract: Cancer disease is characterized by abnormal cell growth. Malignant growth treatments have progressed significantly, yet there is a requirement for development in particularity and feeling of dread toward foundational harmfulness. Nanotechnology is the reconciliation of nanoscience into medication by the utilization of nanoparticles. The appearance of nanoscience in disease conclusion and treatment will assist clinicians with better surveying and oversee patients and further develop the medical care framework and administrations …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 15, Issue 1, 2024 · pp. 7–13 Read article
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Ulcerative Colitis- An Ayurvedic Review And Treatment – A Case Study
Abstract: Ulcerative colitis (UC) is a chronic autoimmune disease that causes inflammation and ulcers of the Large intestine. It is one of the most common GI disorder. Usually the pain affects only the intestinal mucosa and sub mucosa, causing small ulcers in the intestinal lining called ulcers. In most of patients, the disease begins from the anus and continues to spread. Its pathogenesis is multi factorial and includes genetic predisposition, epithelial …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 13, Issue 1, 2024 · pp. 31–39 Read article
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Wearable Devices Incorporating Nanostructured Biosensors: Enabling Real-Time Monitoring and User-Friendly Interfaces
Abstract: Wearable devices incorporating nanostructured biosensors have emerged as a revolutionary technology, enabling real-time monitoring of various physiological parameters and biomarkers. These devices leverage the unique properties of nanostructured materials, such as high surface-to-volume ratio, enhanced sensitivity, and improved electrical and optical characteristics, to achieve exceptional performance in terms of sensitivity, selectivity, and response time. This chapter explores the recent advancements in wearable devices with nanostructured biosensors, highlighting their applications in …
Published in Journal of Nanoscience, NanoEngineering & Applications · Vol. 14, Issue 1, 2024 · pp. 13–21 Read article
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Global Burden of Major Depressive Disorder: Prevalence, Diagnosis, and Impact: A Comprehensive review
Abstract: In this review, we will discuss about the major depressive disorders on the basis of neurobiological changes. MDD, a prevalent psychiatric condition, manifests as a complex interplay of genetic, environmental, and physiological factors with a substantial impact on individuals and societies globally. Here the clinical assessment is fully based on diagnosis and the statistical manual for mental disorder, 5th edition (DSM-5). The pathophysiology involves Diagnosis alterations in neurotransmitter systems, dysregulation …
Published in Emerging Trends in Metabolites · Vol. 1, Issue 1, 2024 · pp. 54–62 Read article
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Review on an Extensive Examination of Current Trends and Advances in Dentistry
Abstract: This comprehensive review delves into current trends and recent advancements shaping the field of dentistry across multiple disciplines. It covers oral anatomy, diagnostic methodologies, preventive and restorative dentistry, prosthodontics, endodontics, periodontics, orthodontics, oral surgery, pediatric dentistry, dental education, and ethical considerations.The article explores advancements in imaging technologies, biomarkers, and dental materials, as well as innovations in preventive care, dental implants, root canal therapies, and periodontal treatments. It emphasizes the integration …
Published in Research and Reviews: A Journal of Dentistry · Vol. 15, Issue 2, 2024 · pp. 26–31 Read article
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Centre Stage of Wireless Sensors in Healthcare: Application and Remote Patient Management
Abstract: The efficiency of wireless sensors in healthcare is greatly influenced by technological progress. The capabilities of these devices have been improved by advancements in wireless communication, data analytics, and sensor technologies. Patients may wear more comfortable, smaller, and more precise modern sensors. They have the ability to track many different physiological characteristics, ranging from simple vital signs to more intricate biomarkers. Understanding the massive volumes of data produced by wireless …
Published in Journal of Microcontroller Engineering and Applications · Vol. 11, Issue 2, 2024 · pp. 10–16 Read article
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Advances in Non-Invasive NIR-Techniques for Gout Detection and Measurement
Abstract: Recent advancements in non-invasive near-infrared (NIR) spectroscopy techniques have significantly improved the detection and measurement of gout, a common form of inflammatory arthritis. Traditional diagnostic methods for gout, such as joint aspiration and crystal analysis, are invasive and can be uncomfortable for patients. In contrast, NIR spectroscopy offers a promising alternative by enabling real-time, non-invasive assessment of uric acid levels and related biomarkers associated with gout. The integration of portable …
Published in International Journal of Toxins and Toxics · Vol. 2, Issue 1, 2025 · pp. 1–8 Read article
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Advances in Nanotechnology-based Biosensors: Enhancing Sensitivity and Specificity in Biomedical Diagnostics
Abstract: This study provides an in-depth exploration of the rapidly evolving field of nanotechnology-based biosensors, emphasizing their significant impact on biomedical diagnostics. The integration of cutting-edge nanomaterials, including nanoparticles, nanowires, and quantum dots, has catapulted biosensing technology to new heights, yielding unprecedented gains in sensitivity and specificity, and revolutionizing the detection of biomolecules. The study highlights various types of nanobiosensors, including optical, electrochemical, and magnetic, each offering unique advantages for detecting …
Published in Nano Trends – A Journal of Nano Technology & Its Applications · Vol. 26, Issue 2, 2024 · pp. 26–32 Read article
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Stiff Person Syndrome: Advances in Understanding, Diagnosis, and Treatment of a Rare Autoimmune Disorder
Abstract: Stiff Person Syndrome (SPS) is a rare and complex autoimmune neurological disorder characterized by progressive muscle stiffness, rigidity, and painful spasms. This chapter provides a comprehensive overview of SPS, exploring its pathophysiology, clinical presentation, diagnostic challenges, and current treatment approaches. We discuss the latest research findings, including the role of autoantibodies, genetic factors, and environmental triggers in the development of SPS. The chapter examines various diagnostic methods, emphasizing the importance …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 14, Issue 3, 2024 · pp. 35–43 Read article
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An Insilico Study of Isobutrin and Phosphorylase Kinase - A Ray of Hope for Psoriasis Patients – Clinical Hypothesis
Abstract: Psoriasis is a chronic, hyper-proliferative and inflammatory skin disease. Increased levels of the calmodulin-containing enzyme, namely, phosphorylase kinase (PhK), were observed in the human epidermis of the active psoriasis cases. Thus PhK is a potential biomarker for the diagnosis and progression of the skin disease, namely, psoriasis. The search for the potential molecules that could supress the over expression of PhK is underway and any break-through in this direction leads …
Published in International Journal of Cheminformatics · Vol. 2, Issue 1, 2024 · pp. 1–8 Read article