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109 articles for “Biologic Therapies”
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Cadmium Toxicity: Oxidative Stress and Organ Dysfunction
Abstract: Due to continued anthropogenic mobilization, cadmium accumulation in the environment causes various health problems because of its diverse toxic effects, extremely lingering biological half life (20–30 years), low rate of excretion from the body and storage predominantly in soft tissue primarily liver and kidney. Cadmium is known to have numerous noxious effects, including nephrotoxicity, hepatoxicity, osteoporosis, cardiovascular toxicity, lung toxicity, and reproductive toxicity. The biologically significant ionic form of cadmium, …
Published in Research and Reviews: A Journal of Toxicology · Vol. 4, Issue 2, 2014 · pp. 14–31 Read article
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Exploring Phytochemicals from Ricinus Communis for Potential Therapeutic Applications in Rheumatoid Arthritis: An in-Silico Approach
Abstract: Aim: Rheumatoid arthritis (RA) is a long-term autoimmune condition characterized by the immune system mistakenly attacking the joints, leading to swelling, discomfort, and joint deformities. Current management strategies include anti-rheumatic drugs and biologics, which have limitations. This study aims to explore the therapeutic potential of Ricinus communis (castor bean plant) phytochemicals as plant-based therapies for autoimmune conditions, like RA. Methods: Phytochemicals from Ricinus communis were retrieved using the IMPPAT database, …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 3, Issue 1, 2025 · pp. 32–41 Read article
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Drug Resistance in Targeted Cancer Treatment: Clinical Difficulties, Molecular Mechanisms, and Emerging Strategies
Abstract: Targeted cancer therapy, which selectively inhibits the molecular mechanisms responsible for tumor growth and development, has revolutionized modern oncology. Targeted therapies have lower systemic toxicity and better therapeutic efficacy when compared to traditional chemotherapy. However, the emergence of medication resistance often limits the long-term efficacy of these treatments, ultimately resulting in treatment failure and disease progression. Drug resistance develops through a number of intricate biological processes and can be innate …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 17, Issue 1, 2026 · pp. 130–138 Read article
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Treatment of Synthetic Dye and Real Industrial Effluent Using Different Photo-catalysts
Abstract: Organic dyes are now one of the most common types of toxins released into the atmosphere, particularly from the textile sector. Organic dyes poisonous in nature and harmful to living organismsand ecosystems and Humans hence, therapy of these dangerous dyes before release into the environment is critical. Several ways have been used to solve this challenge, including physical, chemical, and biological methods. Photocatalysis is currently most of the advanced oxidationprocesses, …
Published in Journal of Catalyst & Catalysis · Vol. 9, Issue 1, 2022 · pp. 40–43 Read article
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Microbial Symphony: Understanding Biochemical Pathways for Precision Medicine and Beyond
Abstract: The human microbiome, an intricate ecosystem of microorganisms inhabiting the body, is a key regulator of host biochemistry and physiology. This review delves into the complex biochemical pathways influenced by the microbiome, spotlighting critical metabolites like short-chain fatty acids, bile acids, and tryptophan derivatives, which impact immune regulation, energy metabolism, and neurobehavioral functions. By examining interactions between the microbiome and the host, including the influence of genetic factors and metabolite-driven …
Published in International Journal of Antibiotics · Vol. 2, Issue 1, 2025 · pp. 28–43 Read article
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The Quiet Intruder: An Insidious Presentation of Primary Plasma Cell Leukemia and a Literature Review on Current Treatment Strategies
Abstract: Introduction: Primary plasma cell leukemia (pPCL) is a rare and aggressive plasma cell dyscrasia, defined by ≥5% circulating plasma cells, with poor prognosis and rapid progression. Case Presentation: A 66-year-old African–American female with no prior medical history presented with one week of fatigue, dehydration, and polydipsia. Laboratory evaluation revealed leukocytosis, severe thrombocytopenia, acute kidney injury (creatinine 4.03 mg/dL), and hypercalcemia (13.0 mg/dL) with suppressed PTH. Imaging showed intra-abdominal lymphadenopathy without …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 15, Issue 2, 2026 · pp. 1–5 Read article
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Molecular Docking and Pharmacokinetic Profiling of the Phytocompounds of Jatropha curcas as Antagonist for Salmonella typhi
Abstract: Background: Typhoid is an infection caused by the Gram-negative bacterium, Salmonella enterica serovar typhi. The study assessed the potential use of Jatropha curcas as a typhoid fever therapy alternative to traditional medications. The ability to uncover novel drug indications for currently available medications using in silico methods has increased thanks to the wealth of pharmacological and biological knowledge that is available. Objective: In this study, we assessed the potential inhibitory …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 1, Issue 1, 2023 · pp. 67–81 Read article
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Navigating the Challenges of COVID-19: A Guide for Mental and Behavioural Health
Abstract: The COVID-19 epidemic has posed unique encounters globally, impacting various aspects of daily life, including mental and behavioral health. The present study attempts to prepare a guide with ways and means to navigate the challenges of the COVID-19 pandemic. This guide provides comprehensive insights and strategies for individuals to navigate these challenges effectively. The study began by addressing the psychosomatic effect of the pandemic, such as increased anxiety, depression, PTSD, …
Published in International Journal of Behavioral Sciences · Vol. 2, Issue 2, 2025 · pp. 1–15 Read article
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Navigating the Depths of Cancer Stem Cells: Unraveling Resistance Mechanisms and Emerging Therapeutic Strategies
Abstract: In the past few decades, comprehensive evidence has convincingly established the presence of cancer stem cells (CSCs) as a minor subset within tumors, contributing to an unusually elevated level of cellular diversity within the malignancy. CSCs are functionally identified by their capacity for self-renewal and differentiation, frequently influenced by signals from their surrounding microenvironment. The interconnected transcriptional, post-transcriptional, metabolic, and epigenetic regulatory networks govern the biological characteristics of CSCs. CSCs …
Published in Recent Trends in Infectious Diseases · Vol. 1, Issue 2, 2024 · pp. 14–18 Read article
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The Dual Crisis: Antibiotic Resistance and the Discovery Void – A Review of Novel Therapeutic Strategies and Non-Traditional Approaches
Abstract: The global rise of antimicrobial resistance (AMR) has emerged as one of the most critical public health challenges of the 21st century, threatening to undermine decades of therapeutic success and rendering conventional antibiotic regimens increasingly ineffective. Parallel to the escalating resistance rates is a profound “discovery void,” characterised by a steep decline in the development of new antibiotic classes since the late 20th century. Together, these two interconnected crises create …
Published in International Journal of Antibiotics · Vol. 3, Issue 1, 2026 · pp. 47–65 Read article
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The use of Genetics and Proteomics in the Finding of Therapeutic Targets
Abstract: Gene medicine is overcoming long-standing health issues that have confounded humanity. To fully comprehend and apply gene medicine, it is vital to grasp how it works at the molecular level. Currently, various technologies may be utilized to find pharmacological targets; the two most prominent are genomic and proteomic methods. In this paper, we go over how to use genomic and proteomic approaches to find pharmacological targets in depth. These materials …
Published in Research and Reviews : Journal of Computational Biology · Vol. 11, Issue 1, 2022 · pp. 9–12 Read article
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Protective Effects Of Curcumin Against Osteoporosis And Its Molecular Mechanism
Abstract: One of the most prevalent metabolic disorders is osteoporosis (OP), which primarily affects postmenopausal women and the elderly. It is often associated with gradual loss of bone density, ongoing destruction of bone microstructure, and increased risk of osteoporosis. Pharmacotherapy is the primary approach for treating and preventing osteoporosis. However, persistent medication therapy invariably results in drug responses and particular adverse effects. Therefore, scientists continue to search for new monomeric compounds …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 11, Issue 1, 2024 · pp. 16–23 Read article
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Chompound contaning oxadiazole derivatives and their potential therapeutic uses.
Abstract: Derivatives of oxadiazole or furadi azole rings constitute a significant class of heterocyclic substances. Oxadiazole is a heterocyclic, five-membered ring with two carbons, one oxygen atom, two nitrogen atoms, and two double bonds. They are produced by substituting two nitrogen (-N =) atoms for two methylene groups (= CH) in furan. The furan ring's aromaticity was significantly decreased by substituting these groups, resulting in a conjugated diene character. There were …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 15, Issue 1, 2024 · pp. 68–74 Read article
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Quorum Sensing and Biofilm Dynamics in Pathogens: An Evolving Frontier in Infectious Disease
Abstract: Bacterial and fungal pathogens rarely act as solitary invaders. Instead, they engage in sophisticated chemical communication known as quorum sensing (QS) to coordinate population-wide behaviours and construct structured, multicellular biofilm communities. These biofilms, composed of extracellular polymeric substances, not only facilitate microbial persistence on biotic and abiotic surfaces but also confer remarkable protection against host immune defenses and antimicrobial therapies. QS systems act as central regulators of biofilm dynamics, orchestrating …
Published in International Journal of Pathogens · Vol. 3, Issue 1, 2026 · pp. 18–23 Read article
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Revolutionizing Drug Delivery: Recent Advances in Pharmaceutical Dosage Forms
Abstract: Recent advances in pharmaceutical dosage forms revolutionize drug delivery, prioritizing targeted therapy and patient well-being. Enhanced drug carriers address complex medical challenges, from high-grade gliomas to ocular drug delivery, maximizing therapeutic efficacy while minimizing adverse effects. Traditional dosage forms like tablets and capsules undergo meticulous formulation and manufacturing processes, integrating Quality by Design principles for consistent product quality. Liquid formulations encounter stability challenges, necessitating rigorous stability testing and pH monitoring. …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 13, Issue 1, 2024 · pp. 77–89 Read article
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Revolutionizing Vaccine Development:The Transformative Role of Bioinformatics in Designing Next-Generation Immunotherapies
Abstract: Vaccines have long been central to the prevention and control of infectious diseases, dramatically reducing morbidity and mortality worldwide. In the modern era, the integration of bioinformatics has revolutionized vaccine development by enabling rapid, precise, and cost-effective identification of potential vaccine targets. This seminar explores the multifaceted applications of bioinformatics in vaccinology, including antigen discovery, epitope prediction, structural modeling, molecular docking, and immunoinformatics-driven vaccine design. Special emphasis is placed on …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 12, Issue 3, 2025 · pp. 19–33 Read article
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Computational and Molecular Aspects of DNA Profiling in Forensic and Biomedical Sciences
Abstract: DNA profiling has changed many diverse modern sectors, from health and criminal justice to ancestry research and animal conservation. It is one of the most important scientific instruments of our time. This technique makes it possible to identify people, analyze family relationships, and learn more about biology by looking at unique genetic markers in a person’s DNA. DNA profiling has changed the way forensic science works by making it easier …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 13, Issue 1, 2026 · pp. 14–18 Read article
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Role of Epigenetic Mechanisms in Lung Fibrosis: Therapeutic Opportunities and Challenges
Abstract: Lung fibrosis poses a serious risk to one's health since it might result in respiratory failure due to an abnormal accumulation of fibrotic tissue in the lungs. Epigenetic mechanisms, such as histone changes, DNA methylation, and non-coding RNAs, closely control gene expression patterns and cellular processes associated with lung fibrosis. Anomalies in DNA methylation patterns connected to changes in gene expression profiles and disturbances in fibrotic signalling pathways are potential …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 13, Issue 2, 2024 · pp. 9–20 Read article
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The Importance of DNA Profiling Today
Abstract: DNA profiling has changed a lot of sectors, from health and criminal justice to ancestry research and animal conservation. It is one of the most important scientific instruments of our time. This technique makes it possible to identify people, analyse family relationships, and learn more about biology by looking at unique genetic markers in a person's DNA. DNA profiling has changed the way forensic science works by making it easier …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 4, Issue 1, 2026 Read article
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Metabolites in Modern Medicine: Decoding the Future of Health and Diseases
Abstract: The end products of many metabolic processes in cells are called metabolites. Each reaction contributes a specific metabolite. Metabolites act as fingerprints of on-going biological processes. Constant changes in cellular composition due to both environmental and internal factors. By analysing the types and presence of metabolites, scientists can effectively reconstruct the inner workings of a cell or organism. In the past, analysing metabolites was a slow and tedious process, often …
Published in Emerging Trends in Metabolites · Vol. 1, Issue 2, 2024 · pp. 1–13 Read article