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698 articles for “Pro drugs”
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Diabetic Foot Ulcer Treated successfully with Unani Formulation (Sibr Zard, Amba Haldi, Mur Maki, and Gulnar) –A Case study
Abstract: Diabetic foot ulcer (DFU) is a distressing complication of diabetes mellitus. It is encountered in about 15% of patients living with DM. It is a major cause of morbidity and mortality. The patients with DFU are at the risk of prolonged hospitalization, infection, gangrene, amputation, and even death if effective wound care faculties are not provided. It is anticipated that approximately 50%-70% of all lower limb amputations are due to …
Published in Research & Reviews : A Journal of Unani, Siddha and Homeopathy · Vol. 11, Issue 2, 2024 · pp. 7–11 Read article
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Study The Effect of The Alcoholic and Hot Aqueous Extract of Costus specious on Some Bacterial Species
Abstract: Plant extracts are among the methods that have been used since ancient times in alternative medicine and are still developing until recently with the progress of science and modern technologies. These materials can be used in the composition of many pharmaceutical drugs. The current research aimed to evaluate the inhibitory effect of alcoholic and hot aqueous extract of the roots of Costus specious on some gram-positive and gram-negative bacteria (Enterococcus …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 14, Issue 3, 2024 · pp. 13–18 Read article
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Application of Natural and Synthetic Polymer-Based Disintegrants in the Design of Fast Dissolving Cefuroxime Axetil Tablet Composites
Abstract: The current paper examines how natural and synthetic polymer-based disintegrants can be used to design fast-soluble types of tablet composites. A model drug was chosen and tablets were prepared by the direct compression method using different polymeric excipients, such as guar gum, locust bean gum, sodium starch glycolate (SSG) and cross povidone. Eight formulations were prepared and tested on the basis of critical material and performance characteristics including thickness, hardness, …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 1348–1360 Read article
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Designing Aspects and Recent Advances in Digital Holographic Microscopy
Abstract: Recent advances in Digital Holographic Microscopy have been discussed in this paper, besides throwing some light on the designing aspects of optical components like beam splitter and neutral density filter for the optimization of system performance. Some important related subtopics like spectral resolution of digital holograms, and Fourier-synthesis holography have been technically discussed. The optimization of acoustical holographic components for use in renewable energy production is presented in this study. …
Published in Research & Reviews : Journal of Physics · Vol. 14, Issue 2, 2025 · pp. 06–18 Read article
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An Extensive Analysis of Computer-Aided Drug Design for Novel Psychotropic and Neurological Substances
Abstract: A comprehensive review of the use of computer-aided drug design (CADD) in the creation of innovative neurologic and neuropsychiatric medications is given in this article. It discusses the challenges in traditional drug discovery approaches and highlights the role of computational methods in accelerating the identification and optimization of drug candidates targeting psychiatric and neurological disorders. The method of finding new drugs has been completely transformed by Computer-Aided Drug Design (CADD), …
Published in International Journal of Brain Sciences · Vol. 1, Issue 2, 2024 · pp. 19–27 Read article
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Exploring Glucagon-like peptide-1 as a Target Protein for Diabetes Mellitus Treatment: Molecular Docking and Pharmacokinetic Analysis of Phytocompounds from Momordica charantia
Abstract: Objective: This study aimed to use molecular docking techniques to explore the potential of GLP-1 (glucagon-like peptide-1) as a target protein for the treatment of diabetes mellitus, a chronic metabolic disease marked by elevated blood glucose levels. Given its crucial role in maintaining insulin secretion and glucose homeostasis, GLP-1 may serve as a future target for diabetes therapy. Method: The study employed a multi-phase method. Initially, protein extraction was carried …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 2, Issue 1, 2024 · pp. 8–20 Read article
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Multitarget Molecular Docking Using Curcuma longa Phytocompounds for Polycystic Ovary Syndrome Treatment
Abstract: Objective: The primary goal of this research is to understand and describe specific aspects of molecular interaction, it includes studying various aspects such as binding affinity, binding mode, and stability of the ligand-protein complex. Molecular docking is a computational technique used to predict the preferred orientation of one molecule to a second when bound together to form a stable complex. In this study, molecular docking will be employed to stimulate …
Published in International Journal of Molecular Biotechnological Research · Vol. 2, Issue 1, 2024 · pp. 15–28 Read article
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Preoperative Use of Midazolam vs Dexmedetomidine for Anxiolysis in Day-Care Surgery
Abstract: Surgical procedures trigger significant fear and anxiety that can adversely affect physiological responses and recovery outcomes. This prospective, randomized, double-blinded clinical trial compared the anxiolytic efficacy and safety of intravenous midazolam and dexmedetomidine in 60 patients undergoing day-care surgery. Primary outcomes included anxiety scores measured by STAI and sedation assessed by the OAAS scale at multiple perioperative time points. Secondary outcomes assessed in the study included detailed evaluation of hemodynamic …
Published in Research and Reviews: A Journal of Medicine · Vol. 16, Issue 1, 2026 · pp. 7–12 Read article
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An Optimize Formulation to Synthesis of size Controlled Hydrophobic Starch Acetate Nanoparticles using Box- Behnken Design
Abstract: The best way to improve the overall performance of native starch is by chemical modification. In recent years, hydrophobically modified starch has attracted considerable attention for the design and manufacture of novel nanoparticulate drug delivery carriers. The purpose of this research was to synthesize hydrophobic starch nanoparticles (NPs) and to optimize process factors through the use of response surface methodology (RSM). The corn starch acetate (CSA) NPs was synthesized using …
Published in Journal of Polymer & Composites Read article
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A Systematic Review of Method Development and Validation for Ramipril Analysis Using Hplc in Cardiovascular Research
Abstract: The field of analytical chemistry encompasses a variety of methods that are crucial in determining the chemical composition of different substances. UV-visible spectroscopy and high-performance liquid chromatography (HPLC) are two widely utilized methods that are the subject of this article. UV-visible spectroscopy uses the Beer-Lambert law to quantify light absorption, which can provide information about the concentration of absorbing species. The method is based on how light and matter interact, …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 15, Issue 2, 2024 · pp. 37–44 Read article
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Big Data in Chemistry: Problems and Answers
Abstract: The rapid growth of experimental and computational chemistry data, researchers now have access to vast datasets, presenting both significant opportunities and challenges. This paper explores the primary challenges associated with managing, processing, and utilizing big data in chemistry, including data heterogeneity, integration across various scales and systems, lack of standardized formats, and the need for advanced tools for data analysis. Additionally, the paper discusses the ethical concerns of data ownership, …
Published in International Journal of Cheminformatics · Vol. 2, Issue 1, 2024 · pp. 9–14 Read article
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IoT-Based Automated Medication Management System
Abstract: An Internet of Things (IoT)-based automated medication dispenser with an integrated alert system is presented in this research. The device is managed by an ESP32 microcontroller, which is paired with a Real-Time Clock (RTC) module to ensure medication is dispensed at the correct time. To facilitate the dispensing process, the system uses servo and stepper motors to rotate the medication carousel and release the appropriate dosage. To determine whether the …
Published in International Journal of Solid State Innovations & Research · Vol. 3, Issue 1, 2025 · pp. 16–21 Read article
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Formulation and Evaluation of Aqueous Azadirachta indica Phytosome
Abstract: A phytosome is a complex created through the union of a natural compound, typically a plant extract, with a phospholipid. Phospholipids play a crucial role in cell membranes, possessing a structure comprising a hydrophilic (water-attracting) head and hydrophobic (water-repelling) tails. This distinctive structure enables phospholipids to construct lipid bilayers, fundamental elements of cell membranes. Phytosome increases the bioavailability, and absorption of active chemical constituents in the extract with the help …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 11, Issue 1, 2024 · pp. 17–30 Read article
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Rheological Studies of a Cross-Linked Polymer Gel System
Abstract: The petroleum accumulations are found associated with water and it is rarely obtained without accompanying water production. Water production is a major technical, environmental, and economic challenge associated with oil and gas extraction. Rheological findings are of fundamental importance for the development, manufacture and processing of innumerable products. Polymeric gels exhibit a wide range of rheological properties and they are stable both mechanically and thermally in most cases thus are …
Published in Journal of Petroleum Engineering & Technology · Vol. 16, Issue 2, 2026 · pp. 13–26 Read article
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Nano-Therapeutics in Diabetes Mellitus: Revolutionizing Diagnosis, Treatment, and Drug Delivery
Abstract: Diabetes mellitus is a chronic metabolic disorder in which blood glucose concentration remains high over an extended duration, resulting in significant lethal complications, including neuropathy, nephropathy and cardiovascular diseases. However, conventional diabetes management strategies, including insulin therapy and oral hypoglycemic agents, rarely exhibit poor bioavailability, high doses, off target delivery, etc. Nanotechnology has brought the rise of diabetes treatment revolution, by overcoming the challenges present in standard treatment, owing to …
Published in Trends in Drug Delivery · Vol. 12, Issue 2, 2025 · pp. 08–19 Read article
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Chewable Healthcare: The Rising Impact of Gummy Supplements in Modern Medicine
Abstract: Gummy supplements, a chewable dosage form historically associated with pediatric vitamin products, are increasingly recognized as a versatile platform for delivering a wide range of nutraceutical and pharmaceutical agents. Their consumer appeal lies in their palatability, convenience, and the ability to overcome swallowing difficulties—a significant barrier to adherence in multiple patient populations. Recent advances in formulation science have expanded the potential of gummy supplements beyond basic vitamin delivery to include …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 12, Issue 3, 2025 · pp. 52–68 Read article
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Advances in Polymer Chemistry: The Role of Polymer Composites in Modern Applications
Abstract: Polymer composites have gained immense significance in various industries due to their superior mechanical, thermal, and chemical properties, making them highly versatile materials. These composites are formed by combining polymer matrices with reinforcing agents such as fibers, nanoparticles, or other fillers to enhance specific properties. The field of polymer chemistry plays a crucial role in the development and optimization of these materials, ensuring their suitability for diverse applications. This paper …
Published in Journal of Polymer & Composites · Vol. 13, Issue 3, 2025 · pp. 51–56 Read article
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Formulation and Evaluation of herbal multipurpose cream
Abstract: Multipurpose creams are semi-solid preparations used to lower the risk of skin disorders and fight wrinkles. The primary goal of the research is to produce multipurpose creams utilizing various herbs and then analyze their efficacy. The herbs utilized in the preparations include dried bael leaf powder, amla powder, neem powder and bael leaves. The article emphasizes the importance of topical drug delivery systems in dermatology, highlighting the benefits of delivering …
Published in Recent Trends in Cosmetics · Vol. 1, Issue 2, 2024 · pp. 44–57 Read article
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Molecular Docking of Saraca asoca (Ashoka) Phytocompounds for Ovarian Cancer Therapy
Abstract: Objective: One of the top five cancers that causes death in women is ovarian cancer, with increases awareness till date the rate of survival is unpredictable. Even though there are advance treatments introduced, chemotherapy is most suggested to the ovarian cancer patients but the rate of relapses increased and the tumors get resistant towards the drugs. This present study is to evaluate the interaction of phytocompounds from Saraca asoca an …
Published in International Journal of Molecular Biotechnological Research · Vol. 2, Issue 2, 2024 · pp. 27–35 Read article
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Photochemically Assisted LC–MS Method Development and Validation for Stability-Indicating Determination of Glasdegib in Rat Plasma
Abstract: A simple, precise, and cost-effective LC–MS method was successfully developed for the determination of Glasdegib in rat plasma. The method optimization was carried out by systematically varying key chromatographic parameters, including flow rate, injection volume, analyte concentration, and mobile phase composition, to achieve optimal sensitivity and resolution. A C18 Hypersil BDS column (150 mm × 4.6 mm, 3.5 µm particle size) was used for chromatographic separation, offering effective peak shape …
Published in International Journal of Photochemistry and Photochemical Research · Vol. 4, Issue 1, 2026 · pp. 11–20 Read article