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1680 articles for “BCS Class II/IV drugs”
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An Approach towards in Management of Chronic Kidney Disease
Abstract: The current international guidelines define and classify the chronic kidney disease (CKD) as decreased kidney function shown by decreased glomerular filtration rate (GFR). Glomerular filtration rate of 60 ml/min/1.73 m 2 for at least 3 months is a marker for kidney damage. The underlying causes for chronic kidney disease are proteinuria and hypertension. It is the main cause of CKD in many high-, middle- and low-income countries. In different countries, …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 12, Issue 1, 2025 · pp. 9–15 Read article
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A Comparative Study of Atibalāmūla Kvātha and Bhūmyāmalakī Cūrṇa in the Management of Diabetic Sensory Polyneuropathy
Abstract: Bhūmyāmalakī and atibalāmūla is being used in certain hospital since long time with satisfactory results in the patients of diabetic sensory polyneuropathy. An observational study on the use of these plants in diabetic polyneuropathy is published in a peer reviewed journal. Therefore it was selected to evaluate the individual effect of bhūmyāmalakī and atibalāmūla in comparison with the combination of both the drugs in the patients of diabetic sensory polyneuropathy.
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 8, Issue 3, 2023 · pp. 1–11 Read article
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Antifungal Susceptibility Pattern of Candida Species Isolates from Dehradun City Hospitals
Abstract: The present investigation on the topic entitled “Antifungal susceptibility analysis of Candida species isolates from Dehradun City hospital.” was accomplished in the Doon University Microbiology laboratory (P.G.) and Hospital, Dehradun, Uttarakhand, during the period of February 2021 to July 2021. A total of 42 clinical samples were collected from patients, suspected of candidiasis from Dehradun city hospitals. Clinical samples were collected from oral cavity, blood, vaginal fluid and urine of …
Published in Research and Reviews : A Journal of Immunology · Vol. 14, Issue 1, 2024 Read article
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A Structure-based Design Approach to Catharanthus roseus Phytoconstituents as Potential Inhibitors of B-Cell Lymphoma 6 Protein
Abstract: Objectives: Lymphoma is a cancerous disease. It develops into millions of people worldwide. Identify the naturally active compounds from Catharanthus roseus, they have multiple values in the medicinal field of Siddha, and Indian Ayurveda are used as a disease-preventing agent. Drug illness prediction, toxicity prediction, statistical information, molecular docking, as well as absorption, distribution, metabolism, and excretion (ADME) analysis are used to predict the fit ligand as a drug. Methods: …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 1, Issue 2, 2023 · pp. 14–34 Read article
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Molecular Docking Study: Targeting mycobacterium leprae ML2640 Protein Using Active Compounds from Coscinium fenestratum
Abstract: Objectives: Leprosy is an infectious disease in skin, peripheral nerve and mucosa of upper airway. Around 70% of this infection is caused by Mycobacterium leprae, which was discovered during1873. Multi drug therapy is used for the treatment, still multiple drug resistance and reactions has been reported among patients. Hence, this work focused on identifying bioactive compounds from Coscinium fenestratum that can target mycobacterium leprae ML2640 protein by in-silico approach. Method: …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 1, Issue 2, 2023 · pp. 21–33 Read article
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Machine Learning Based Early Cataract Detection: A Predictive Modeling Approach
Abstract: Cataracts, characterized by dense cloudy areas in the eye’s lens, afflict more than 50% of elderly individuals, leading to impaired vision and potential blindness. Detecting cataracts at an early stage is crucial to facilitate simpler treatments, as neglecting the condition may necessitate complex eye surgery. To address this issue, we are creating a predictive system that identifies cataract disease by analyzing user-provided eye features. To achieve this, we leverage OpenCV, …
Published in International Journal of Computer Science Languages · Vol. 1, Issue 2, 2023 · pp. 1–8 Read article
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“DEVELOPMENT AND CHARACTERIZATION OF PHYTOSOMES FOR THE TREATMENT OF ANTI-CANCER ACTIVITY BY USING THE Spirulina (Arthospira Plantesis) EXTRACT”
Abstract: This study aims to investigate and evaluate spirulina's anticancer properties.The current research is centred on obtaining a Spirulina-containing drug. The goal is to design and create Phytosomes, characterizing them based on relevant and crucial parameters. The process of solvent evaporation was utilized in the creation of Phytosomes. Various parameters such as zeta potential, particle size, infra-red spectral analysis, % drug content, encapsulation efficiency, and % drug release (% DR) were …
Published in International Journal of Antibiotics · Vol. 1, Issue 1, 2024 · pp. 10–22 Read article
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The Utilization of Oil Entrapped Floating Alginate Beads in a Gastroretentive Delivery System is Intended to Improve the Bioavailbility of Telmisartan Incorporating Principles of Bioinformatics
Abstract: Oil entrapped floating calcium alginate beads of Telmisartan were successfully prepared using sodium alginate as polymer and two different oil phases of mineral oil and olive oil by emulsion gelation method. The FT-IR spectra of final optimized formulation confirms no drug- polymer incompatibility. The floating time of beads was found to be more than 12 hrs suggesting that the method used for prepration was effective. The floating time of optimized …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 11, Issue 1, 2024 · pp. 21–38 Read article
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Exploring the Applications and Advancements of Copper and Copper Alloys in Modern Manufacturing Processes
Abstract: For industrial uses, copper represents one of the greatest technical materials offered. This review paper discusses on the history of copper and copper alloys, salient features of wrought and cast copper alloys, physical and chemical characteristics of copper alloys, classification of copper alloys, design for manufacturing of copper alloys, mechanical properties of cast copper alloys, role of lead in copper alloys and applications of copper alloys in various engineering industries. …
Published in International Journal of Industrial and Product Design Engineering · Vol. 1, Issue 2, 2023 · pp. 1–9 Read article
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Quantum Computing: A Review
Abstract: The field of quantum computing is rapidly evolving and holds the potential to fundamentally change our approach of tackling complex problems. In this research, the fundamentals of quantum computing and some possible uses for it are examined. Also, a general review of classical computing and its shortcomings in several specific problem-solving scenarios is outlined. Qubits serve as the foundational elements of quantum computing. The different kinds of quantum bits, or …
Published in Journal of Software Engineering Tools & Technology Trends · Vol. 11, Issue 1, 2024 · pp. 30–42 Read article
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Standard Manufacturing Procedure (SMP) of Jaharamohara Bhasma Prepared by two Methods
Abstract: Introduction: Jaharamohara (Serpentine) is an important drug of Ayurveda and Unani medicine. In the literature of Rasashastra it is classified under Sikta Varga (group of silica containing drugs). In classical texts, different Bhavana Dravya (levigating material) are advised for the preparation of Jaharamohara Bhasma which enhances its potency. However, no work has been done till date to standardize Jaharamohara Bhasma by two different methods. Aim: An attempt has been made …
Published in Research and Reviews : A Journal of Ayurvedic Science, Yoga and Naturopathy · Vol. 11, Issue 1, 2024 · pp. 1–13 Read article
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Fast Dissolving Oral Thin Films: A Review
Abstract: Fast-dissolving oral thin films (FDOFs) represent a significant advancement in drug delivery technology, offering advantages over traditional solid dosage forms, especially for patients with swallowing difficulties. FDOFs dissolve rapidly in the mouth, releasing the active ingredient without the need for water or chewing. They have picked up ubiquity due to their comfort, taste veiling capabilities, and progressed persistent compliance. Ideal drugs for FDOFs should possess characteristics such as solubility, stability, …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 11, Issue 1, 2024 · pp. 24–31 Read article
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Unraveling Ulcerogenesis: A Comprehensive Delve of Enteric & Nonenteric Ulcers
Abstract: Enteric ulcers present a multifaceted landscape encompassing both peptic and non-peptic varieties, demanding a thorough exploration of their manifestations, causes, and pathophysiology. At the forefront of understanding lie pivotal factors such as Helicobacter pylori infection, nonsteroidal anti-inflammatory drugs usage, lifestyle choices, and stress, each wielding significant influence over ulcer development and progression. The intricate interplay of these factors underscores the complexity of enteric ulcer etiology. Helicobacter pylori infection—a prevalent culprit—inflicts …
Published in Research and Reviews: A Journal of Medicine · Vol. 14, Issue 1, 2024 · pp. 25–40 Read article
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A Machine Learning Based Artificial Intelligence Model for Detecting Heart Illness
Abstract: This study centers around the improvement of an artificial intelligence- and computerized reasoning-based heart sickness determination framework. We exhibit how AI can help with foreseeing whether an individual will get cardiovascular infection. In this review, a Python-based application for medical care research is created since it is more reliable and helps track and lay out many kinds of well-being observing applications. We show information handling, which incorporates working with all …
Published in Journal of Computer Technology & Applications · Vol. 15, Issue 1, 2024 · pp. 50–58 Read article
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Efficacy of Combination Therapy with Osimertinib and Afatinib in epidermal growth factor receptor-mutant non-small-cell lung cancer Patients
Abstract: Treatment options for patients with non-small-cell lung cancer who have epidermal growth factor receptor mutations are constrained by the emergence of resistance to epidermal growth factor receptor tyrosine kinase inhibitors. Osimertinib or afatinib alone, when tested in a laboratory model, led to the formation of drug-resistant clones harboring epidermal growth factor receptor secondary mutations. However, combining these drugs prevented the emergence of such mutations. In a Phase II clinical trial, …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 13, Issue 1, 2024 · pp. 13–24 Read article
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Experimental Analysis Of Thermal Behaviour Of Phase Change Materials In Cooling Applications Of Roof Top Building Slabs
Abstract: In this research article, different phase change materials are incorporated inside the slabs to reduce the heat transfer from the roof. Experiments are conducted during summer season March 2021 to the time lag decrement factor and heat flux to that of results are compared with RCC slab to that of Green material I (CaCl26H2O) and Green Roof with Green material II (48%CaCl2+4.3%NaCl+0.4%KCl+47.3%H2O). On comparison Green Slab II is having better …
Published in Journal of Polymer & Composites · Vol. 12, Issue 3, 2024 · pp. 102–114 Read article
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An Open Labelled Parallel Arm Randomized Clinical Trial of Tuvaraka Oil Prepared By Two Different Method In The Management of Pama
Abstract: In Ayurveda, all skin diseases have classified mainly into two groups i.e., Mahakushtha (major skin diseases) and Kshudrakushtha (minor skin diseases). Tuvaraka [Hydnocarpus laurifolia (Dessnt).Sleumer] is one among the most useful drugs for the treatment of Kushtha (Various skin diseases) and Madhumeha (Diabetes Melitus). Pama is described under Kshudra Kushtha. which can be correlates with scabies. Aim: To evaluate the clinical efficacy of Tuvaraka oil prepared by modified method and …
Published in Research & Reviews : Journal of Herbal Science · Vol. 13, Issue 1, 2024 · pp. 29–36 Read article
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Using Multitarget Molecular Docking to Examine the Antiviral Potential of Clerodendrum Phlomidis against Measles
Abstract: Objective: Measles, a viral disease caused by a member of the Paramyxoviridae virus family, is highly contagious and characterized by a respiratory illness and a maculopapular rash on the skin. Children are the main victims of the illness. In the context of drug development, this study investigates the efficacy of phytocompounds derived from Clerodendrum phlomidis against the target protein of the measles virus. Methods: The 7SKS protein was retrieved from …
Published in International Journal of Molecular Biotechnological Research · Vol. 1, Issue 2, 2023 · pp. 32–42 Read article
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Revolutionizing Agriculture: Botani Scan’s Deep Learning for Plant Disease Diagnosis
Abstract: Crop disease detection is of key importance because of its role in food safety but infrastructural issues still hamper diagnosis in most regions worldwide. Accurate plant disease identification is essential to secure food, predicting yield decline and managing epidemic outbursts. The advent of digital cameras along with the progress of computer vision technology brings to light the mounting demands for the development of automated disease detection methods in precision agriculture, …
Published in Journal of Telecommunication, Switching Systems and Networks · Vol. 11, Issue 1, 2024 Read article
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A Study of Clinical Education Practice of Clinical Instructors Accompanying Nursing Students of Kashmir Division, Deployed for Clinical Posting in SKIMS Soura
Abstract: Introduction: Clinical education also called clinical teaching, is one of the practical based approaches whereby the students are exposed to natural and practical settings. Clinical education refers to the process of educating and training healthcare professionals, such as medical students, nurses, or other allied health professionals, in a real-world clinical setting. This form of teaching is crucial for translating theoretical knowledge into practical skills and fostering the development of clinical …
Published in Journal of Nursing Science & Practice · Vol. 14, Issue 2, 2024 · pp. 32–38 Read article