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675 articles for “Novel”
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Pharmacokinetic Profiling and Molecular Docking of Carvacrol and Structural Analogs: Targeting Quorum Sensing Proteins to Disrupt Biofilm-Mediated Antimicrobial Resistance in Multidrug-Resistant Bacterial Pathogen
Abstract: Antibiotic resistance, particularly in Pseudomonas aeruginosa, has become a major global health threat, exacerbated by the organism's ability to form biofilms and regulate virulence through quorum sensing (QS). The LuxR and LasR receptors are key regulators in this process, influencing both pathogenicity and antibiotic resistance. This study investigates potential QS inhibitors targeting these receptors as a strategy to mitigate antibiotic resistance. The primary objective was to identify novel ligands that …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 3, Issue 2, 2025 · pp. 43–61 Read article
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Performance Evaluation of Hybrid Polymer Composite Materials for Electromagnetic Interference Shielding in Flexible and Wearable Electronic Devices
Abstract: Wearable electronic devices require novel hybrid polymer composites that offer flexible, lightweight and highly effective EMI shielding characteristics. The development and characterization of flexible polymer composites combining hard magnetic nanoparticles and electrically conductive fillers are explored. The suitability of thermoplastic polyurethane (TPU), polydimethylsiloxane (PDMS) and epoxy resins for use as EMI shielding composite matrices was evaluated in terms of their flexibility, stability and biocompatibility. Hybrid filler systems were developed to …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 630–648 Read article
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Formulation and Evaluation of Transdermal Patch to Enhance Treatment of Alopecia
Abstract: The improvement of novel topical sedate conveyance frameworks has picked up noteworthy consideration due to their potential in upgrading the helpful viability and persistent compliance whereas minimizing systemic side impacts. This thinks about centers on the definition and assessment of transdermal patches planned to discharge allicin, the essential naturally dynamic compound determined from garlic (Allium sativum) extricate. Allicin is eminent for its wide range of pharmacological properties, counting antimicrobial, anti-inflammatory, …
Published in Trends in Drug Delivery · Vol. 12, Issue 2, 2025 · pp. 20–33 Read article
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Exploring the Role of MAPK3 in Major Depressive Disorder: Molecular Docking, Dynamics, and Binding Free Energy Analysis of Natural Compounds as Alternatives to Conventional Drugs
Abstract: Major Depressive Disorder (MDD) is a prevalent neuropsychiatric disorder with limited treatment efficacy and significant side effects associated with conventional antidepressants. Recent studies have highlighted the role of mitogen-activated protein kinase 3 (MAPK3) in the mechanisms underlying MDD, positioning it as a potential target for the development of novel therapeutic drugs. In this study, we employed various computational approaches to explore natural compounds as viable alternatives to synthetic antidepressants. Researchers …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 3, Issue 2, 2025 · pp. 53–68 Read article
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Bedaquiline: An In-Depth Exploration into Its Antitubercular Significance
Abstract: Tuberculosis is still a leading infectious disease and a major threat to public health. Although there has been a slow decrease in the incidence over years, its “hard to kill nature” is responsible of about 2 million deaths in HIV infected individuals annually. Bedaquiline, a Diaryl-Quinoline drug was fast-track approved as an orphan drug to combat drug resistance. It shows potent activity against Mycobacterium tuberculosis by interfering with the production …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 12, Issue 2, 2025 · pp. 06–14 Read article
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Low-Grade Heat Recovery: Emerging Materials and Systems for Efficient Utilization
Abstract: Low-grade heat (LGH), generally characterized by temperatures below 200°C, constitutes a significant portion of wasted thermal energy in industrial, commercial, and even residential processes. Despite its vast availability, the efficient recovery and utilization of LGH remains underdeveloped due to its inherently low exergy content and the limitations of traditional heat recovery technologies. The creation of cutting-edge materials and creative system-level approaches for LGH recovery has accelerated significantly as companies continue …
Published in International Journal of Energy and Thermal Applications · Vol. 3, Issue 1, 2025 · pp. 24–29 Read article
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Brain Tumor Detection by Aggregating Deep Learning and GAN Models for Faster MRI image Synthesis
Abstract: Brain tumors comprise a global health challenge that, in order to be treated and organized, need early and accurate diagnosis. Usually conducted through medical imaging, brain tumor detection techniques have problems of accuracy, efficiency, and confidentiality. Issues of limited datasets, strict privacy laws that provide restrictions on data sharing, and the necessity for specialized expertise on medical image analysis relegates modern methodologies to vulgar charades. For patient prognosis, treatment planning, …
Published in International Journal of Brain Sciences · Vol. 2, Issue 2, 2025 · pp. 45–53 Read article
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Chronic Obstructive Pulmonary Disease (COPD) in Younger Adults: Challenges and Considerations – A Review
Abstract: Chronic Obstructive Pulmonary Disease (COPD) phenomenon rapidly converting into chronic significant health issues for many young adults. A disease calculated for older age gives way to early-onset COPD, which creates new issues for diagnosing and treating the illness and even interacts with the quality of life. The article reviews the epidemiology, risk factors, pathophysiology, clinical presentation, and treatment considerations related to this set of conditions. From those risk factors, early-onset …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 15, Issue 3, 2025 · pp. 08–19 Read article
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3D-Printed Polymeric Drug Delivery Systems for Personalized Medicine
Abstract: Personalized medicine has revolutionized healthcare by tailoring treatments to individual patient needs. Among the emerging technologies, 3D printing has demonstrated immense potential in fabricating polymeric drug delivery systems with precise control over drug release, dosage, and bioavailability. These systems offer customized therapeutic solutions, improving efficacy while reducing adverse effects. This paper provides an overview of 3D-printed polymeric drug delivery systems, discussing the types of polymers used, fabrication techniques, applications in …
Published in Journal of Polymer & Composites · Vol. 13, Issue 4, 2025 · pp. 313–325 Read article
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Advancements in Machine Learning: A Comprehensive Review of Algorithms, Applications, and Future Directions
Abstract: Gaining knowledge of Machine learning (ML)-guided format algorithms leverage predictive models to generate novel devices with optimized properties across several domains, which include drug discovery, fabric synthesis, and biomolecular engineering. Selecting an effective format set of policies consists of identifying appropriate hyperparameters, predictive models, and generative mechanisms to maximize format fulfilment. This study introduces an established method for set of policies requirements, ensuring that generated designs meet predefined fulfilment criteria, …
Published in Recent Trends in Programming languages · Vol. 12, Issue 2, 2025 · pp. 17–33 Read article
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Advancements in Polymeric Capillary Materials for Chromatographic Applications
Abstract: Traditionally, glass capillaries have been the material of choice due to their inertness, transparency, and precision in delivering small sample volumes. However, glass capillaries have significant drawbacks, including fragility, limited flexibility, and difficulties in modification for specialized applications. Recent advancements in polymer chemistry have introduced novel polymeric capillary materials that offer several advantages over conventional glass capillaries. Additionally, they exhibit enhanced durability and resistance to a broad range of chemicals, …
Published in Journal of Polymer & Composites · Vol. 13, Issue 4, 2025 · pp. 137–144 Read article
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Bio-inspired Thermo-responsive and Self-Healing Polymer–PCM Hybrids for Next-Generation Smart Textile Applications
Abstract: The integration of phase change materials (PCMs) into flexible polymers represents a promising strategy for developing smart textiles with advanced thermal regulation and mechanical adaptability. However, the challenges of PCM leakage, poor mechanical strength, and durability under cyclic stress have limited their practical applications. In this study, we present a novel self-healing and elastic composite based on thermoplastic polyurethane (TPU) incorporating 30 wt% microencapsulated PCM (mPCM) and dynamic disulfide bonds …
Published in Journal of Polymer & Composites · Vol. 13, Issue 4, 2025 · pp. 228–238 Read article
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Mind-Machine Synergy: The Evolution and Future of Brain-Computer Interfaces
Abstract: Brain-Computer Interfaces (BCIs) represent a transformative technology that enables the direct communication between the human brain and external devices, bypassing the traditional output mechanisms, such as speech or physical movement. BCIs hold the potential to revolutionize fields, such as healthcare, neuroscience, and human-computer interaction by providing new ways to restore lost functions, enhance cognitive abilities, enable seamless communication, and create novel user experiences across various platforms and environments. This article …
Published in International Journal of Brain Sciences · Vol. 2, Issue 2, 2025 · pp. 19–31 Read article
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Development of Chilli Pedicle Powder Fiber Reinforced with Palmyra Sprouts for Sustainable Biodegradable Composites and Its Mechanical Characterization
Abstract: The current research study aimed to present the development and mechanical characterization of a novel biodegradable composite material, Chilli Pedicle Powder fiber reinforced with Palmyra sprouts, which might be of significant importance to replace conventionally used synthetic fibers from nature in an eco-friendly way. With rising global needs in sustainable materials in multiple industries, like automotive, construction, and packaging industries, it was required to find an alternative biodegradable source that …
Published in Journal of Polymer & Composites · Vol. 13, Issue 4, 2025 · pp. 433–441 Read article
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Unveiling the Silent Threat: The Escalation and Defence Against Antibiotic Resistance
Abstract: The global challenge of antibiotic resistance presents a significant risk to public health, driven by multifaceted factors worldwide. This issue, akin to the impacts of climate change, requires concerted efforts at national and international levels to mitigate its consequences. Antibiotics have revolutionized modern medicine, enabling critical interventions like surgeries, transplants, and cancer treatments. However, without global collaboration, we face significant setbacks across medical, social, and economic domains. Initiatives to address …
Published in International Journal of Antibiotics · Vol. 2, Issue 2, 2025 · pp. 1–26 Read article
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Innovations in Tuberculosis Management: Advancements in Drug-Resistant TB Treatment and Rapid Diagnostics
Abstract: Tuberculosis (TB) remains one of the deadliest infectious diseases worldwide, exacerbated by the increasing prevalence of drug-resistant strains, such as multidrug-resistant (MDR-TB) and extensively drug-resistant TB (XDR-TB). Despite advancements in first-line and second-line treatments, resistance to conventional antibiotics has complicated therapeutic strategies, necessitating novel approaches. This mini review explores emerging advancements in TB treatment, including gene editing technologies, such as CRISPR, which offer potential for precise targeting of drug-resistant bacterial …
Published in International Journal of Antibiotics · Vol. 2, Issue 2, 2025 · pp. 1–7 Read article
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In-Silico Screening of Phytochemicals for Identification of Alternative Therapy for Thyroid Cancer
Abstract: Thyroid cancer remains a significant health concern globally, necessitating the exploration of novel therapeutic alternatives to improve treatment outcomes. This study targets COT kinase (Cancer Osaka Thyroid Kinase), a protein implicated in the progression of thyroid cancer, using molecular docking methods with various phytochemicals to identify potential therapeutic compounds. PyRx and Discovery Studio were employed to evaluate the interactions and binding affinities of a diverse set of natural compounds with …
Published in International Journal of Toxins and Toxics · Vol. 2, Issue 2, 2025 · pp. 31–55 Read article
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Randomized Latent Vectors for Enhanced Reinforcement Learning Exploration
Abstract: This paper investigates Random Latent Exploration (RLE), a novel reinforcement learning technique that enhances exploration using randomized latent vector conditioning. I evaluate RLE’s performance across various environments, including discrete control tasks (FourRoom), continuous control (IsaacLab), and complex visual domains (Atari games). The core approach augments traditional reward functions with intrinsic rewards, calculated as the dot product between state features and periodically resampled latent vectors. The policy and value networks are …
Published in Current Trends in Signal Processing · Vol. 15, Issue 3, 2025 · pp. 19–25 Read article
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Software Development for Computers That Are Brand New
Abstract: The purpose of this study is to present a novel method to software development that is intended to answer the issues that are constantly changing in the realm of computer programming and application development. The demand for software solutions that are superior in terms of efficiency, scalability, and adaptability has substantially increased in tandem with the rapid advancement of technology. The development approach that has been offered integrates contemporary methods …
Published in Journal of Open Source Developments · Vol. 12, Issue 2, 2025 · pp. 07–18 Read article
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Automatic Brake Failure Indication with Auxiliary Braking System
Abstract: Accidents in vehicles often happen due to diverse factors, with brake failure being a significant contributor resulting from inadequate maintenance and product defects. To protect human lives and reduce the risk of accidents, effective monitoring of brake systems is vital in the automotive industry. Vehicle safety encompasses not only the prevention of accidents but also the mitigation of their adverse effects on human health. Today’s cars come with innovative safety …
Published in Journal of Automobile Engineering and Applications · Vol. 12, Issue 2, 2025 · pp. 1–7 Read article