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661 articles for “system complexity”
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Epigenetic Modifications in Health, Disease, and Precision Therapeutics (From Genome to Epigenome)
Abstract: Introduction: Epigenetic alterations play a crucial role in regulating gene expression in both normal physiological and disease states. These reversible modifications—such as DNA methylation, histone acetylation, phosphorylation, ubiquitination, and chromatin remodelling—are increasingly implicated in complex diseases including cancer and neurodegenerative disorders. Despite advances in standard therapeutic approaches, patient responses remain variable, largely due to genetic heterogeneity and epigenetic dysregulation. This highlights the need for incorporating epigenetic understanding into personalized medicine. …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 15, Issue 1, 2026 Read article
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Investigation to Enhance Performance of Finned U-Tube Shell-and-Tube Heat Exchangers Using Epoxy Based Polymer Composite Material
Abstract: Shell-and-tube heat exchangers remain indispensable in thermal engineering systems; however, conventional metallic configurations often face challenges related to corrosion, weight, and limited thermal optimization. In this study, a novel approach is proposed by integrating epoxy-based polymer composite materials with finned U-tube geometries to enhance thermo-hydraulic performance while addressing material limitations of traditional systems. The work focuses on the development and evaluation of a hybrid heat exchanger comprising a mild steel …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 618–633 Read article
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Dioxin Sources, Types, Toxicity, and Removal Technologies: A Review
Abstract: This review provides a comprehensive investigation of dioxin, an endocrine-disrupting compound, and its impacts on environment and human health. Dioxin have antagonistic effects on hormones. It is pivotal to identify the origin of dioxin exposure for the well-being of environment and human health. Hence, the sources of dioxin, its dispersion, concentrations in air, water and soil medias, and health effects are discussed in detail. Endocrine disrupting compounds are categorized into …
Published in Journal of Industrial Safety Engineering · Vol. 11, Issue 1, 2024 · pp. 11–19 Read article
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Advanced Document Query System
Abstract: For knowledge-intensive businesses, large document libraries contain a plethora of information. Massive, chaotic, collections of documents that are unstructured have emerged from this rapid increase. Even if accessing or storing these documents has become easier, finding the required critical information in these vast document collections has become more difficult. NLP (natural language processing) is one of the techniques used to retrieve the information that is required from a huge chunk …
Published in International Journal of Computer Science Languages · Vol. 2, Issue 2, 2024 · pp. 26–35 Read article
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Enhancing Smart Grid Resilience Through AI-Based Fault Classification
Abstract: Traditional power grids can be developed into smart grids, and they are comprised of the latest information and communication technologies (ICTs), which are based on establishing the relationship between the conventional electricity systems along with the usage of smart meters and distributed generation. This dynamic improves energy efficiency and the integration of renewables. Well, the dynamic and reversible power injection from Distributed Energy Resources (DERs) creates substantial operational problems. These …
Published in International Journal of Algorithms Design and Analysis Review · Vol. 4, Issue 1, 2026 · pp. 10–15 Read article
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A Review of Locking Protocols for Concurrency Control in Parallel Databases
Abstract: In modern database systems, many transactions may run at the same time. When several users try to access the same data or update the data simultaneously, then it creates a problem such as inconsistency data, lost updates or misinformation and may lead to conflicts between the transactions and deadlocks. To avoid these types of issues and maintain the correctness of the database, concurrency control protocols are mainly used. This paper …
Published in Journal of Advanced Database Management & Systems · Vol. 13, Issue 2, 2026 Read article
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The Therapeutic Potential of Nutraceutical in Diabetes Management: A Comprehensive Review
Abstract: Diabetes is a long-term and complex condition characterized by high blood sugar levels resulting from inadequate insulin production, ineffective insulin function, or a combination of both. Various nutraceuticals used in clinical settings have shown beneficial impacts on a range of biochemical and clinical markers related to diabetes. In many traditional medical systems, hypoglycemic agents derived from plants are used to treat, manage, and prevent diabetes mellitus. These plant extracts have …
Published in Emerging Trends in Metabolites · Vol. 2, Issue 1, 2025 · pp. 20–27 Read article
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Application of Drug Delivery using Nano- technology to Cure Mental Disorders (Schizophrenia)
Abstract: Nanotechnology involves the manipulation of the count at an atomic scale to create novel systems, materials, and devices. This groundbreaking era holds substantial potential for scientific development across various domain names, which includes manufacturing, patron items, electricity, substances, and remedies. In current times, the sphere of prescribed drugs has witnessed a brilliant surge in the usage of nanotechnology for the improvement of revolutionary medications. Schizophrenia, a neuropsychiatric disorder affecting the …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 14, Issue 1, 2024 · pp. 51–65 Read article
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Role of Reinforcement Learning in Improvement of Semiconductor Doping
Abstract: The semiconductor industry faces increasing challenges in achieving optimal doping profiles as device dimensions shrink and performance requirements intensify. Traditional doping optimization methods, while effective, often struggle with the complex, multi-dimensional parameter spaces characteristic of modern semiconductor manufacturing. This study explores the transformative role of reinforcement learning (RL) in improving semiconductor doping processes, examining how RL algorithms can autonomously optimize doping parameters to enhance device performance, reduce manufacturing costs, and …
Published in Journal of Semiconductor Devices and Circuits · Vol. 12, Issue 2, 2025 · pp. 23–34 Read article
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Innovations in Targeted Drug Discovery for Personalized Medicine
Abstract: Personalized medicine is revolutionizing modern healthcare by custoizing treatment plans to match an individual’s genetic makeup, protein expression, and metabomlic characteristics. Also referred to as precision medicine, this approach seeks to improve therapeutic outcomes, reduce adverse effects, and make efficient use of healthcare resources. The incorporation of various omics technologies—including genomics, proteomics, transcriptomics, metabolomics, and epigenomics—has greatly advanced our ability to understand disease biology and molecular variations specific to each …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 12, Issue 3, 2025 · pp. 19–41 Read article
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Autonomous Agentic AI for Adaptive Cure Optimization and Defect Prevention in Thermoset Polymer Composite Manufacturing
Abstract: Thermoset polymer composites occupy a central position in modern structural manufacturing, from aircraft fuselages to wind-turbine blades. Despite progress in resin chemistry and fiber architecture, the “cure process” that transforms compliant preforms into load-bearing structures remains difficult to manage. Manufacturers encounter ‘voids’, “interlaminar delaminations”, and “spring-back distortion” when curing complex or thick-section parts. The cause is not ignorance of the relevant physics, but rather that ‘temperature’, ‘chemistry’, ‘rheology’, and ‘mechanics’ …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 301–320 Read article
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Evolution of Kinematic and Dynamic Design in Robotic Mechanisms: A Systematic Overview
Abstract: The field of robotics has experienced significant advancements in both kinematic and dynamic design, driven by the growing need for precision, adaptability, and autonomy in mechanical systems. Early robotic mechanisms were predominantly rigid and operated based on simple serial architectures, offering limited degrees of freedom and relying heavily on analytical formulations for motion planning and control. Over time, the demand for greater dexterity and operational versatility led to the development …
Published in Trends in Machine design · Vol. 12, Issue 2, 2025 · pp. 38–43 Read article
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Challenges faced by upper indus basin (UIB) communities due to climate change
Abstract: The Upper Indus Basin (UIB) communities are heavily dependent on water resources for their sustenance. The region relies on glacial and snowmelts for irrigation water, energy, domestic and irrigation uses. Climate change poses threat to vulnerable region all around the world, and Upper Indus Basin (UIB) is no different. The variability in climatic conditions such change in precipitation pattern and temperature fluctuations have disrupted the agriculture practices of the region …
Published in International Journal of Environmental Planning and Development Architecture · Vol. 2, Issue 1, 2024 · pp. 11–20 Read article
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A Review of Machine and Deep Learning Techniques for Cyber Security
Abstract: Nowadays in the digital landscape, cyber threats and attacks are increasing in an exponential manner, posing server risks to organizations and critical infrastructures. Data breaches often result from sophisticated threat models that exploit vulnerabilities in networks, systems and user behaviors. Cyber solutions are increasingly incorporating machine learning and deep learning to prevent and mitigate these security issues. These technologies have the potential to detect anomalies, classify threats and predict potential …
Published in Journal of Computer Technology & Applications · Vol. 16, Issue 3, 2025 · pp. 01–07 Read article
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Diet-Gene Interactions in Farm Animals: Molecular Dynamics, Gene Expressions, Signalling Pathways and Precision Nutrition for Sustainable Productivity
Abstract: Diet-gene interactions represent a central mechanism through which nutrition influences growth, health, and productivity in farm animals. Recent advances in molecular biology and genetics have revealed that nutrients act not only as metabolic substrates but also as signalling molecules capable of modulating gene expression, cellular pathways, and epigenetic regulation. This review synthesizes current knowledge on the molecular dynamics of nutrient utilization in farm animals, with emphasis on nutrigenomic responses, nutrient …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 4, Issue 1, 2026 Read article
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Development of Spanish Version of Home-Based Video Module of Balance Exercises for Peripheral Vestibular Disordered Patients
Abstract: Any disturbances affecting one or more of the balance organs lead to imbalance difficulties and as a consequence, the quality of life of the affected individuals can be seriously affected, especially if the episodes end with injuries or even fatal accidents. Bal Ex is the first home-based video guided workout that was created by Zainun and her colleagues in 2009. Ten languages are currently supported by Bal Ex, including Cantonese, …
Published in International Journal of Brain Sciences · Vol. 1, Issue 2, 2024 · pp. 33–41 Read article
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Big Data in Chemistry: Problems and Answers
Abstract: The rapid growth of experimental and computational chemistry data, researchers now have access to vast datasets, presenting both significant opportunities and challenges. This paper explores the primary challenges associated with managing, processing, and utilizing big data in chemistry, including data heterogeneity, integration across various scales and systems, lack of standardized formats, and the need for advanced tools for data analysis. Additionally, the paper discusses the ethical concerns of data ownership, …
Published in International Journal of Cheminformatics · Vol. 2, Issue 1, 2024 · pp. 9–14 Read article
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Digital Innovation in Heritage Management: Exploring possibilities of I-BIM and H-BIM through Borobudur Temple and Dhanyakuriya
Abstract: Heritage buildings are vital links to our past, embodying the architectural, cultural, and historical significance of earlier eras. Their preservation has become increasingly complex due to environmental degradation, structural aging, and the evolving urban landscape. This paper investigates the application of Heritage Building Information Modelling (H-BIM) as a comprehensive methodology for documenting and conserving these structures. H-BIM leverages advanced digital technologies such as photogrammetry, laser scanning, and Geographic Information System …
Published in Journal of Construction Engineering, Technology & Management · Vol. 16, Issue 2, 2026 Read article
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Embracing Health, Safety, and a Greener Environment in the Construction of Offshore Structures
Abstract: Offshore infrastructure (oil and gas platforms, offshore wind farms, subsea cables, ports, and associated works) plays a vital role in energy, communications, and trade. However, construction activities offshore create complex safety, public health and environmental risks from worker injuries and exposure to hazardous substances, to marine pollution and ecosystem damage with downstream human health effects. This paper reviews the hazards, regulatory and management frameworks, lessons from major incidents, and practical …
Published in Journal of Offshore Structure and Technology · Vol. 12, Issue 3, 2025 · pp. 30–41 Read article
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Enhancement of Horizontal Jet Impingement Heat Transfer Analysis on Vertical Flat Plate
Abstract: This research investigates the heat transfer characteristics and heat flux distribution associated with parallel jet impingement on a vertical flat plate. A comprehensive computational fluid dynamics (CFD) analysis is carried out and systematically validated against available experimental data to ensure the accuracy and reliability of the numerical model. The jet length is maintained constant at 12 mm, while the jet-to-plate separation distance is varied at 6, 12, 18, and 24 …
Published in Journal of Experimental & Applied Mechanics · Vol. 17, Issue 1, 2026 · pp. 65–80 Read article