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445 articles for “expression”
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ALADIN and its Protein Interactions with the Nucleoproteins: An Insilico Analysis
Abstract: The nuclear pore complex (NPCs) are big, protein complexes made up of multiple units that traverse the nuclear envelope (NE), establishing a discerning channel between the cytoplasm and nucleus for the nucleocytoplasmic transport. It has different roles in cellular processes, like cell-cycle progression, control of gene expression, and signal transduction. NPC is a vast and complex structure, compiled from almost 30 proteins, termed nucleoporins. Earlier studies have shown that each …
Published in Research and Reviews : Journal of Computational Biology · Vol. 7, Issue 1, 2018 · pp. 28–31 Read article
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In Silico Analysis of Potential Drug Targets in E. coli as Anticancer Agents
Abstract: Escherichia coli is a bacteria which grows as symbiotic and pathogenic organism in humans that expresses with genes causing several diseases. Manipulation and control of genes of E. coli can become a solution for cure of diseases like cancer. Based on QSAR studies, Partial partial charges are neutral for all selected ligands. The surface area, mass and volume for Capsaicin is predicted more compared to other selected ligands. As the …
Published in Research and Reviews : Journal of Computational Biology · Vol. 8, Issue 2, 2019 · pp. 10–18 Read article
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Computational Software Assisted Multiple Therapeutic Targets Oriented Screening of Some Natural Alkaloid Compounds
Abstract: The current efforts endeavor towards the computational exploration of some interestingpharmacological potentials of some natural alkaloids by using the Schrodinger Maestro 9.1software. The excellence in therapeutics was screened against five most imperative targets:Cyclin-Dependent Kinase-5 (anti-cancer), Cycloxygenase-2 (anti-inflammatory), Proteinkinase C (anti-cancer), Dipeptidyl peptidase (anti-diabetic), and Angiotensin-1-ConvertingEnzyme (anti-hypertensive). The alkaloids which were previously reported to possessantibiotic activities against Bacillus subtilis, Staphylococcus aureus, and Mycobacteriumsmegmatis and anti-photo-oxidative, have now perceived to be multi-dimensional …
Published in Research and Reviews : Journal of Computational Biology · Vol. 8, Issue 2, 2019 · pp. 5–9 Read article
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To Find the Genes in the Arabidopsis thaliana at NCBI
Abstract: *Author for CorrespondenceNavni BajpaiE-mail: Navni.bajpai@gmail.com 1,2M.sc Biotechnology, Department of Bioscience, Institute of Management Studies, Ghaziabad U.P., India Received Date: January 28, 2022Accepted Date: March 02, 2022Published Date: March 12, 2022 Citation: Navni Bajpai, Sanjeev Singh. To Find the Genes in the Arabidopsis thaliana at NCBI. Research & Reviews: Journal of Computational Biology. 2021; 10(2): 16–19p.The SET domain is a conserved amino acid motif that is present in chromosomal proteins and …
Published in Research and Reviews : Journal of Computational Biology · Vol. 10, Issue 2, 2021 · pp. 16–19 Read article
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The Basics of Genomics, Proteogenomics: The Demands and Roles that Proteomics can Fulfil in Genome Annotation
Abstract: The science of genomes: scientists have only recently gone from analysing a few or a limited number of genes at a time to investigating thousands of genes, moving from the study of inheritance units to the investigation of an organism's entire genome. The science of genomes, or "genomics," was originally focused to determining DNA sequences (the nucleotide order on a specific fragment of DNA), but it quickly evolved to a …
Published in Research and Reviews : Journal of Computational Biology · Vol. 10, Issue 3, 2021 · pp. 10–12 Read article
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Revolutionizing Cancer Diagnosis: Unleashing the Tab Transformer's Power for Accurate Classification
Abstract: Gene expression platforms offer vast amounts of data that can be utilized for investigating diverse biological processes. However, the presence of redundant and irrelevant genes makes it challenging to identify crucial genes from high-dimensional biological data. To overcome this obstacle, researchers have introduced different feature selection (FS) methods. Developing more efficient and accurate feature selection techniques is essential for selecting important genes in complex biological information with multiple dimensions. In …
Published in Research and Reviews : Journal of Computational Biology · Vol. 12, Issue 2, 2023 · pp. 24–38 Read article
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Prevalence of Stippling in Attached Gingiva of Children: A Pilot Survey
Abstract: Stippling in attached gingiva is considered a sign of health. There are no reports on the prevalence of stippling in India. This study aims to describe the prevalence of gingival stippling in children aged between three and six years. The study is conducted as a pilot cross-sectional survey among residents of an Indian village. Participants included 125 children aged between three and six years that were clinically examined for the …
Published in Research and Reviews: A Journal of Dentistry · Vol. 4, Issue 1, 2013 · pp. 20–21 Read article
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Bone in Periodontal Health and Diseases: A Scoping Review
Abstract: Bone resorption is a basic physiologic process and central to the understanding of many key pathologies. Alveolar bone destruction is a hallmark of periodontal disease progression and its prevention is a key clinical challenge in treatment of periodontal disease. Bone loss is mediated by the host immune and inflammatory response to the microbial challenge. As individuals are not equally susceptible to the destructive effects of periodontal infections therefore, it is …
Published in Research and Reviews: A Journal of Dentistry · Vol. 12, Issue 1, 2021 · pp. 1–12 Read article
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Psychoactive and Physiological Homogeneity of Cannabis: A Literature Review: Actions of the Medical Plant that Takes Care of Itself
Abstract: Naturally occurring plants like Cannabis and the biologically ubiquitous alkaloids (e.g., morphine, quinine, and atropine) are composed of mostly physiological and psychoactive compounds. Extracts of the Cannabis plant are not alkaloid substances nor are they not related chemically to alkaloids, having no component nitrogen in their structures. Three species of Cannabis (marijuana) are recognized in scientific classifications: Cannabis sativa, Cannabis indicus and Cannabis ruderalis. Cannabis sativa is the species that …
Published in Research and Reviews : A Journal of Immunology · Vol. 7, Issue 2, 2017 · pp. 1–4 Read article
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Antibody Pharming in Transgenic Plants: An Overview
Abstract: Antibodies (Abs) are secreted large-sized glycoprotein products of terminally differentiated B cells in vertebrate species and since their discovery during 1890s, they have been widely used for diagnosis, prevention and treatment of diseases, epidemiology and life-science research. They have been traditionally produced in large amounts by repeated immunization of animals. Various techniques for production of full-length and fragments of antibody that have been introduced later are: (i). hybridoma technology during …
Published in Research and Reviews : A Journal of Immunology · Vol. 3, Issue 3, 2013 · pp. 1–10 Read article
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Women’s Experiences with Injectable Contraceptives (Depo Provera): A View from Vadodara, India
Abstract: Choice of contraceptive methods is a key element of family planning that benefits both women and providers. Offering a client choice can help increase contraceptive prevalence rates; so this study was conducted to explore users’ perspectives on Injectable Contraceptives (IC). This qualitative study employed semi structured in-depth interview technique. Sixty women, who had experience of using IC either at the time of study or in the past, were selected from …
Published in Research and Reviews : A Journal of Immunology · Vol. 4, Issue 3, 2014 · pp. 18–23 Read article
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Modern Vaccines with DIVA Capability: An Overview
Abstract: DIVA vaccines are designed to achieve twin-goals of the immunological protection of the host and the immunological differentiation of the infected from the vaccinated animals (DIVA) with a companion immunodiagnostic test. The DIVA strategy is used in countries that follow the vaccination path for elimination of an infectious disease and ultimately to achieve the disease-free status for international trade. This strategy has also been advocated for and adopted in the …
Published in Research and Reviews : A Journal of Immunology · Vol. 5, Issue 1, 2015 · pp. 1–12 Read article
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Vaccine Candidates and Animal Models for Kala-Azar
Abstract: Kala-azar or Visceral Leishmaniasis (VL) is a serious human disease in tropical regions and rapidly emerging as an opportunistic infection in HIV patients. The available treatment against VL is associated with toxicity and drug resistance. Even though the development of vaccines against VL is received limited attention. The only successful immunization strategy in humans has been leishmanization, which is based on the development of durable immunity after recovery from infection …
Published in Research and Reviews : A Journal of Immunology · Vol. 5, Issue 1, 2015 · pp. 29–35 Read article
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Immunologic Characteristics of Apparently Healthy Nigerians Exhibiting Abnormal SPE: A Preliminary Study
Abstract: Abnormal serum protein electrophoresis patterns have been discovered in apparently healthy Africans in Britain and Ghanaians living in Accra, Ghana. Conflicting reasons were suggested for this phenomenon. The aim of present study was to determine the prevalence and characteristics of serum protein electrophoresis (SPE) abnormalities in apparently healthy Nigerians living in Ogbomoso. Three hundred (300) apparently healthy subjects aged 20–30 years were selected for the study. SPE was performed on …
Published in Research and Reviews : A Journal of Immunology · Vol. 5, Issue 3, 2015 · pp. 1–6 Read article
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Assessment of Animal Trials Conducted on Protectivity of Potential Sub-unit and Recombinant Vaccines against Pasteurella multocida B:2
Abstract: Haemorrhagic septicaemia, caused by Pasteurella multocida serotypes B:2 and E:2, is an acute, fatal and septicaemic disease of bovines occurring as catastrophic epizootics in most tropical regions of Asia and Africa. As chemotherapeutic treatment of P. multocida infections is expensive and ineffective, prevention of disease outbreaks following immunization is the most potent tool. Although, various vaccine formulations as alum precipitated, oil adjuvant, multiple emulsion and live attenuated vaccines are currently …
Published in Research and Reviews : A Journal of Immunology · Vol. 6, Issue 2, 2016 · pp. 1–12 Read article
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Progress from the Traditional Vaccines to Novel Rational Vaccine Designs
Abstract: Vaccines are among the most valuable assets for saving human and animal lives. The vaccines discovered and designed on the Pasteurian principles laid the foundations of the traditional vaccine regime during the late-19th century. Some traditional vaccine designs proved remarkably successful, while others had safety or efficacy problems, and still others failed- particularly those against diseases caused by non-cultivable, hyper-variable or opportunist pathogens, or those requiring cellular immunity. The problems …
Published in Research and Reviews : A Journal of Immunology · Vol. 6, Issue 3, 2016 · pp. 17–31 Read article
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Hematopoietic stem progenitor cells reduce the proliferation of Tregs via regulation of IL-12/STAT4 signaling during chronic stress
Abstract: Abstract. Physical or psychological chronic stress mediates the impaired immune response by inducing the proliferation of regulatory T cells (Tregs). Our recent studies showed that hematopoietic stem progenitor cells (HSPCs) significantly modulated the immune system. HSPCs prevented stress-induced lymphocyte apoptosis, exerting a protective effect in chronic stress-induced immune responses. Thus, whether HSPCs could prevent the proliferation of Tregs in conditions of chronic stress was assessed in the present study. Injection …
Published in Research and Reviews : A Journal of Immunology · Vol. 12, Issue 3, 2022 · pp. 1–10 Read article
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Development and Applications of a Simple Chalcone- Based Low Molecular Weight Ligand for Treating Nosocomial Infections due to Staphylococcus aureus and Escherichia coli
Abstract: Abstract Inspired from the available biological data of several imperative therapeutic scaffolds in several medicinal chemistry databases, thiophene-containing chalcone compounds were identified and the molecule was designed for treating various nosocomial infections. In one of the recent rational exploration, (E)-3-(4-methoxyphenyl)-1-(thiophen-2-yl)prop-2-en-1-one was synthesized in a single-step reaction, characterized comprehensively by using a few sophisticated spectroscopic instruments such as FT-IR spectroscopy, mass spectroscopy, and 1H-NMR spectroscopy, as well as CHN analyzer, and …
Published in Research and Reviews: A Journal of Medicine · Vol. 10, Issue 2, 2020 · pp. 14–18 Read article
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The study on the isolation, culture, differentiation and transplantation of neural stem cells from brain of crossbred white rat in the neonatal period
Abstract: We have studied for isolating neural stem cells from brain tissue of neonatal crossbred white rat, culturing and transplanting into local cerebral ischemic reperfusion model rat. We performed digestion of brain tissue, primary culture and subculture of segregated cells, measured number of neurosphere and growth index and ratio of cell survival, and identified expression of nestine from cultured cells, investigated engraftment of NSCs into ill brain tissue after transplantation of …
Published in Research and Reviews: A Journal of Medicine · Vol. 12, Issue 2, 2022 · pp. 13–19 Read article
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Benzimidic Acid Derivatives as Potential Anti-Escherichia coli Agent for Preventing Nosocomial Infections
Abstract: Based on the global fame of benzimidic acid/benzoic acid derivatives in exhibiting antimicrobial activities against a variety of pathogens (particularly nosocomial infections), two novel compounds (S1 and S2) of benzimidic acid scaffold were rationally designed from a hydrazine derivative and fabricated using the conventional synthesis technique. Through sophisticated instruments, the molecules were comprehensively characterized and investigated for antibacterial activity against pathogenic Escherichia coli strain (MTCC 2961). The novel benzimidic compound …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 9, Issue 1, 2020 · pp. 11–15 Read article