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Research and Reviews : Journal of Computational Biology

The Basics of Genomics, Proteogenomics: The Demands and Roles that Proteomics can Fulfil in Genome Annotation

  1. Harshita Yadav

Abstract

The science of genomes: scientists have only recently gone from analysing a few or a limited number of genes at a time to investigating thousands of genes, moving from the study of inheritance units to the investigation of an organism's entire genome. The science of genomes, or "genomics," was originally focused to determining DNA sequences (the nucleotide order on a specific fragment of DNA), but it quickly evolved to a more functional level—studying gene expression profiles and roles. The purpose of this chapter is to review the basic assumptions and definitions that underpin genomics, as well as to clarify essential concepts and methodologies that genomics rely is based on.

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