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1680 articles for “BCS Class II/IV drugs”
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A Comprehensive Exploration of Method Validation and Development in Pharmaceutical Analysis: Focus on Vortioxetine Analysis
Abstract: The pharmaceutical industry relies on rigorous method validation to ensure the accuracy, precision, and reliability of analytical techniques employed in drug testing and quality control. This comprehensive exploration delves into the validation parameters and guidelines essential for method validation, emphasizing accuracy, precision, linearity, detection and quantitation limits, specificity, range, robustness, and ruggedness. Validation plays a pivotal role in guaranteeing high-quality products, adhering to good manufacturing practices (GMP), and optimizing manufacturing …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 11, Issue 1, 2024 · pp. 46–52 Read article
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Design and Development of Agrobot Using Feed Forward Network for Smart Farming Agriculture
Abstract: The Agrobot framework is a form of natural language processing that requires training to understand human language and meet user needs accordingly. The development of a chatbot tailored for the agricultural industry represents a significant advancement in agricultural technology. This chatbot serves as an interactive tool to assist farmers in various aspects of agricultural practices, including crop management, pest control, weather forecasting, and market information. The main objective of this …
Published in Journal of Advancements in Robotics · Vol. 11, Issue 1, 2024 · pp. 6–14 Read article
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A Review of Different Polymer and Plasticizers
Abstract: Plasticizer and polymer are essential components in the pharmaceutical industry, especially when creating both cutting-edge and conventional drug delivery systems. The differences between synthetic, semi-synthetic, and all-natural polymers are examined in this review to highlight their diverse qualities and uses. When designing drug delivery systems to target areas, the choice of polymer is crucial. Because of their repeatability and adaptability, synthetic polymers are widely used in the creation of precision …
Published in International Journal of Membranes · Vol. 1, Issue 1, 2024 · pp. 1–7 Read article
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Computational Screening of Vitex negundo Compounds for Potential Arthritis Therapies in India
Abstract: Objective: Arthritis is a pervasive medical condition that manifests as inflammation and discomfort within the joints. As of September 2021, arthritis has affected an estimated 180 million people in India, making it a substantial public health concern with a considerable impact on individuals' quality of life and healthcare systems. Therefore, using molecular docking, drug-likeness prediction, and ADME analysis, an effort was made to identify natural compounds from Vitex negundo, which …
Published in Research and Reviews : Journal of Computational Biology · Vol. 13, Issue 1, 2024 · pp. 01–18 Read article
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Research in the Unani System of Medicine: A Review
Abstract: The Unani system of medicine is one of the oldest medicine systems serving humanity till today, and that in itself is proof of the correctness of its principles. Acient living people and their disease management was possible because of these traditional medicine systems and Unani being one of these. As each science has its own basis and goals, so odes Unani science. Like all other sciences, its progress also requires …
Published in Research & Reviews : A Journal of Unani, Siddha and Homeopathy · Vol. 11, Issue 2, 2024 · pp. 17–22 Read article
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Regulatory Requirements for Pharmaceutical Product Registration in Zambia
Abstract: There is a significant burden of diseases in Zambia and its neighboring countries, such as malaria, HIV/AIDS, and other ailments. These health challenges necessitate a high consumption of pharmaceutical products. Currently, the majority of essential health drugs in Zambia are imported from outside of Africa. This reliance on external sources presents an opportunity for new investments in the local manufacturing of pharmaceutical products. Although Zambia may not be the largest …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 11, Issue 2, 2024 · pp. 33–41 Read article
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In Silico Analysis and Docking Study of the Active Phytocompounds of Bacopa monnieri Against Alzheimer Disease
Abstract: Objective: Alzheimer’s is a neurodegenerative disease and is the cause of 60–70% of cases of dementia. It infected a million people worldwide. An effort was undertaken to explore the potential of natural compounds found in Bacopa monnieri, a plant renowned for its extensive medicinal properties in Indian Ayurveda, to combat the disease. This was achieved through molecular docking studies, evaluation of drug-likeness, and comprehensive ADME (absorption, distribution, metabolism, and excretion) …
Published in Research and Reviews : Journal of Computational Biology · Vol. 13, Issue 2, 2024 · pp. 1–13 Read article
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Comprehensive Evaluation of Herbal Plants for Cancer Prevention
Abstract: Since cancer continues to be a major cause of morbidity and death globally, effective prevention measures are desperately needed. As the world’s cancer burden increases, interest in alternative cancer prevention methods, particularly the use of herbal medicine, is also increasing. With their rich history and diverse phytochemical composition, medicinal plants provide a great opportunity for the development of disease prevention strategies. This review explores the potential of various plants, including …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 12, Issue 2, 2025 · pp. 01–07 Read article
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Plant Disease Detection Using Machine Learning
Abstract: Plant diseases significantly threaten global crop yields and affect both nutritional safety and farmer income. Accurate and early detection of plant diseases is essential for effective intervention and treatment. In this study, we used the CNN model (convolutional neural network) to explore a deep learning-based approach for plant disease classification. The model was trained and evaluated on a large dataset encompassing 38 different classes of plant disease, including healthy leaves. …
Published in Journal of Multimedia Technology & Recent Advancements · Vol. 12, Issue 2, 2025 · pp. 07–19 Read article
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Emerging Therapies in Respiratory Tract Infections: Current Advances and Future Perspectives
Abstract: The impact of respiratory tract infections (RTI) as a global public health problem continues to be high morbidity and mortality rates. The development of novel therapeutic approaches stemmed from the fact that conventional treatment strategies, antibiotics, antivirals, antifungals etc. have become increasingly ineffective because of rise of antimicrobial resistance (AMR). Next generation therapies, such as novel antimicrobial agents, host directed therapies and novel drug delivery systems have come on the …
Published in Recent Trends in Infectious Diseases · Vol. 2, Issue 2, 2025 · pp. 17–25 Read article
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Polymer Chemistry-Driven Approaches for Improved Therapeutic Delivery
Abstract: Polymer chemistry has revolutionized pharmaceutical technology by enabling the development of advanced drug delivery systems with improved precision, stability, and therapeutic outcomes. This review explores the role of polymer design, synthesis, and functionalization in the development of responsive and targeted drug carriers. Emphasis is placed on various types of polymers—biodegradable, synthetic, natural, and stimuli-responsive—and their suitability for drug delivery platforms such as nanoparticles, micelles, hydrogels, dendrimers, and implants. The physicochemical …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 Read article
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Evaluating the Efficiency of LLMs-SA (Sentiment Analysis) via Social Media Texts
Abstract: Sentiment analysis (SA) is becoming popular in business and scientific communities as the processing of natural language (NLP), computational linguistics, text analytics, image-based processing or video- based processing is used in extracting and mining subjective information in the web, social network, etc. It is able to detect positive, negative or neutral information and can be selected to absorb polarity, sentiments, urgency and goals of mount importance. The majority of the …
Published in Journal of Computer Technology & Applications · Vol. 16, Issue 3, 2025 Read article
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An Efficient CNN Model for Automated Cotton Leaf
Abstract: Timely and accurate identification of cotton leaf diseases are essential for maintaining healthy crop production and minimizing agricultural losses. Early detection allows farmers to take preventive or corrective measures, reducing the risk of disease spread and improving overall yield. In this study, we propose a Convolutional Neural Network (CNN) based model for the automated classification of cotton leaf diseases using image-based detection techniques. The model is trained on a diverse …
Published in Research and Reviews : Journal of Crop science and Technology · Vol. 14, Issue 3, 2025 · pp. 01–10 Read article
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Neuropharmacological Mechanisms of Psychedelics: Advancing Treatment Strategies for Mental Health Disorder
Abstract: The resurgence of interest in the therapeutic potential of psychedelic drugs has caused a major upheaval in the field of psychiatry in recent years. This review's main goal is to thoroughly examine the possible benefits of psychedelic drugs in the field of psychiatry, with a focus on how they might be used as psychotherapy aids. Given their widespread use in therapeutic settings, clinical trials involving MDMA, psilocybin, ketamine, and LSD …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 15, Issue 3, 2025 · pp. 67–79 Read article
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The Impact of Nanotechnology in Transforming Neuro-oncology - A Comprehensive Review
Abstract: The treatment of central nervous system (CNS) tumours, including aggressive malignancies like glioblastoma, faces significant challenges. The blood–brain barrier (BBB) blocks nearly 98% of small-molecule drugs from achieving therapeutic levels in the brain, and the heterogeneity of these tumours frequently contributes to treatment resistance and poor outcomes. Traditional approaches, including chemotherapy and radiotherapy, are hindered by systemic toxicity and inadequate drug penetration. Nanotechnology provides a promising alternative, as nanoparticles (NPs) …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 627–637 Read article
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Passenger car fuel economy: Insights from big data analytics
Abstract: The increasing availability of real-world vehicle telematics through On-Board Diagnostics II (OBD-II) systems has enabled data-driven evaluation of passenger car fuel economy beyond conventional laboratory-based test cycles. While standardized certification procedures ensure repeatability, they often fail to capture the influence of real-world traffic conditions, driver behaviour, and transient vehicle operation. This study presents a structured Big Data Analytics (BDA) approach for analysing high-frequency OBD-II data collected from a gasoline passenger …
Published in Journal of Automobile Engineering and Applications · Vol. 13, Issue 1, 2026 · pp. 8–19 Read article
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ML Model Comparison for Sentiment Analysis Across Diverse Datasets
Abstract: Analyzing sentiment is crucial for understanding public opinion on various issues in marketing, politics, and social sciences. This study compares the performance of seven different machine learning algorithms for sentiment classification, focusing on their effectiveness, accuracy, and complexity. The research is conducted on a pre-processed dataset with balanced text samples, utilizing feature extraction methods such as Term Frequency-Inverse Document Frequency (TF-IDF). The performance assessment criteria consist of accuracy, precision, recall, …
Published in Journal of Operating Systems Development & Trends · Vol. 12, Issue 2, 2025 · pp. 26–33 Read article
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The Dual Crisis: Antibiotic Resistance and the Discovery Void – A Review of Novel Therapeutic Strategies and Non-Traditional Approaches
Abstract: The global rise of antimicrobial resistance (AMR) has emerged as one of the most critical public health challenges of the 21st century, threatening to undermine decades of therapeutic success and rendering conventional antibiotic regimens increasingly ineffective. Parallel to the escalating resistance rates is a profound “discovery void,” characterised by a steep decline in the development of new antibiotic classes since the late 20th century. Together, these two interconnected crises create …
Published in International Journal of Antibiotics · Vol. 3, Issue 1, 2026 · pp. 47–65 Read article
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Design and Evaluation of Thermo-Responsive Poly(N-isopropylacrylamide)-Based Polymeric Nanoparticles for Temperature-Triggered Intratumoral Release of Doxorubicin in Solid Tumors
Abstract: Thermo-responsive polymeric systems have emerged as promising platforms for targeted intratumoral drug delivery in cancer therapy. This study aimed to develop and evaluate poly(N-isopropylacrylamide) (PNIPAM)-based polymeric nanoparticles as intelligent carriers for temperature-responsive delivery of doxorubicin (DOX) to solid tumors. Nanoparticles were synthesized via free radical polymerization using N-isopropylacrylamide as a thermoresponsive monomer and N,N′-methylenebisacrylamide as a crosslinker, forming a stable network with a tunable lower critical solution temperature (LCST).The optimized …
Published in Journal of Polymer & Composites · Vol. 14, Issue 4, 2026 · pp. 159–168 Read article
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Strategies for the Development and Optimization of Orally Disintegrating Tablets (ODTs) to Improve Bioavailability and Patient Compliance
Abstract: Background: Pharmaceutical scientists have developed Orally Disintegrating Tablets (ODTs) to advance patient drug acceptance and biological system availability through simplified medi-cation delivery especially for children and senior citizens and people who cannot swallow pills regularly. The oral disintegrating tablets dissolve in the mouth within thirty seconds or less (USP 701) while needing no additional liquid thus making them suitable for both emergency treatments. Objective: The research examines ODT development strategies …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 13, Issue 2, 2026 Read article